Abstract:
:In patients with damage to the primary visual cortex (V1), residual vision can guide goal-directed movements to targets in the blind field without awareness. This phenomenon has been termed blindsight, and its neural mechanisms are controversial. There should be visual pathways to the higher visual cortices bypassing V1, however some literature propose that the signal is mediated by the superior colliculus (SC) and pulvinar, while others claim the dorsal lateral geniculate nucleus (dLGN) transmits the signal. Here, we directly test the role of SC to ventrolateral pulvinar (vlPul) pathway in blindsight monkeys. Pharmacological inactivation of vlPul impairs visually guided saccades (VGS) in the blind field. Selective and reversible blockade of the SC-vlPul pathway by combining two viral vectors also impairs VGS. With these results we claim the SC-vlPul pathway contributes to blindsight. The discrepancy would be due to the extent of retrograde degeneration of dLGN and task used for assessment.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Kinoshita M,Kato R,Isa K,Kobayashi K,Kobayashi K,Onoe H,Isa Tdoi
10.1038/s41467-018-08058-0subject
Has Abstractpub_date
2019-01-11 00:00:00pages
135issue
1issn
2041-1723pii
10.1038/s41467-018-08058-0journal_volume
10pub_type
杂志文章abstract::Scanning probe microscopy has emerged as a primary tool for exploring and controlling the nanoworld. A critical part of scanning probe measurements is the information transfer from the tip-surface junction to the measurement system. This process reduces responses at multiple degrees of freedom of the probe to relative...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7550
更新日期:2015-03-13 00:00:00
abstract::Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02790-9
更新日期:2018-02-02 00:00:00
abstract::Approximately 30% of ERα breast cancer patients relapse with metastatic disease following adjuvant endocrine therapies. The connection between acquisition of drug resistance and invasive potential is poorly understood. In this study, we demonstrate that the type II keratin topological associating domain undergoes epig...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09676-y
更新日期:2019-05-09 00:00:00
abstract::Within all physical disciplines, it is accepted that wave transport is predetermined by the existence of disorder. In this vein, it is known that ballistic transport is possible only when a structure is ordered, and that disorder is crucial for diffusion or (Anderson-)localization to occur. As this commonly accepted p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3533
更新日期:2013-01-01 00:00:00
abstract::Tandem organic solar cells are based on the device structure monolithically connecting two solar cells to broaden overall absorption spectrum and utilize the photon energy more efficiently. Herein, we demonstrate a simple strategy of inserting a double bond between the central core and end groups of the small molecule...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20431-6
更新日期:2021-01-08 00:00:00
abstract::Planar neural networks and interfaces serve as versatile in vitro models of central nervous system physiology, but adaptations of related methods to three dimensions (3D) have met with limited success. Here, we demonstrate for the first time volumetric functional imaging in a bioengineered neural tissue growing in a t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4997
更新日期:2014-06-05 00:00:00
abstract::Human ether-a-go-go-related gene (hERG) potassium channels determine cardiac action potential and contraction duration. Human uterine contractions are underpinned by an action potential that also possesses an initial spike followed by prolonged depolarization. Here we show that hERG channel proteins (α-conducting and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5108
更新日期:2014-06-17 00:00:00
abstract::ASXL2 is frequently mutated in acute myeloid leukaemia patients with t(8;21). However, the roles of ASXL2 in normal haematopoiesis and the pathogenesis of myeloid malignancies remain unknown. Here we show that deletion of Asxl2 in mice leads to the development of myelodysplastic syndrome (MDS)-like disease. Asxl2-/- m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15456
更新日期:2017-06-08 00:00:00
abstract::Cellular events that occur across the seminiferous epithelium in the mammalian testis during spermatogenesis are tightly coordinated by biologically active peptides released from laminin chains. Laminin-γ3 domain IV is released at the apical ectoplasmic specialization during spermiation and mediates restructuring of t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2171
更新日期:2012-01-01 00:00:00
abstract::Recent progress in the understanding of percolation theory points to cation-disordered lithium-excess transition metal oxides as high-capacity lithium-ion cathode materials. Nevertheless, the oxygen redox processes required for these materials to deliver high capacity can trigger oxygen loss, which leads to the format...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01115-0
更新日期:2017-10-17 00:00:00
abstract::Exfoliated two-dimensional (2D) sheets can readily stack to form flexible, free-standing films with lamellar microstructure. The interlayer spaces in such lamellar films form a percolated network of molecularly sized, 2D nanochannels that could be used to regulate molecular transport. Here we report self-assembled cla...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8602
更新日期:2015-07-13 00:00:00
abstract::Much of the world's Li deposits occurs as basinal brines in magmatic orogens, particularly in continental volcanic arcs. However, the exact origin of Li enrichment in arc magmatic systems is not clear. Here, we show that, globally, primitive arc magmas have Li contents and Li/Y ratios similar to mid-ocean ridge basalt...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19106-z
更新日期:2020-10-20 00:00:00
abstract::The interface between LaAlO(3) and SrTiO(3) possesses a range of intriguing properties, notably a proposed connection between the surface state of the LaAlO(3) and the conductivity buried in the SrTiO(3). Here we study the effect of the surface adsorption of a variety of common laboratory solvents on the conductivity ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1501
更新日期:2011-10-11 00:00:00
abstract::Liquids cooled towards the glass transition temperature transform into amorphous solids that have a wide range of applications. While the nature of this transformation is understood rigorously in the mean-field limit of infinite spatial dimensions, the problem remains wide open in physical dimensions. Nontrivial finit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09512-3
更新日期:2019-04-03 00:00:00
abstract::Genetic factors and mechanisms underlying food allergy are largely unknown. Due to heterogeneity of symptoms a reliable diagnosis is often difficult to make. Here, we report a genome-wide association study on food allergy diagnosed by oral food challenge in 497 cases and 2387 controls. We identify five loci at genome-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01220-0
更新日期:2017-10-20 00:00:00
abstract::Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01698-8
更新日期:2017-11-14 00:00:00
abstract::Stress is a major cause of poor health and mortality in humans and other social mammals. Close social bonds buffer stress, however much of the underlying physiological mechanism remains unknown. Here, we test two key hypotheses: bond partner effects occur only during stress (social buffering) or generally throughout d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13361
更新日期:2016-11-01 00:00:00
abstract::NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger si...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07573-4
更新日期:2018-12-05 00:00:00
abstract::Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6969
更新日期:2015-01-19 00:00:00
abstract::Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs expressing fibroblast activation protein alpha (FAP) and haem oxygenase-1 (HO-1), which are also fou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05346-7
更新日期:2018-07-27 00:00:00
abstract::Plant survival depends on seed germination and progression through post-germinative developmental checkpoints. These processes are controlled by the stress phytohormone abscisic acid (ABA). ABA regulates the basic leucine zipper transcriptional factor ABI5, a central hub of growth repression, while the reactive nitrog...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9669
更新日期:2015-10-23 00:00:00
abstract::Thermal melanism theory states that dark-colored ectotherm organisms are at an advantage at low temperature due to increased warming. This theory is generally supported for ectotherm animals, however, the function of colors in the fungal kingdom is largely unknown. Here, we test whether the color lightness of mushroom...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10767-z
更新日期:2019-06-28 00:00:00
abstract::Trigonal tellurium (Te) is a chiral semiconductor that lacks both mirror and inversion symmetries, resulting in complex band structures with Weyl crossings and unique spin textures. Detailed time-resolved polarized reflectance spectroscopy is used to investigate its band structure and carrier dynamics. The polarized t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17766-5
更新日期:2020-08-10 00:00:00
abstract::Electron motion in chemical bonds occurs on an attosecond timescale. This ultrafast motion can be driven by strong laser fields. Ultrashort asymmetric laser pulses are known to direct electrons to a certain direction. But do symmetric laser pulses destroy symmetry in breaking chemical bonds? Here we answer this questi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3177
更新日期:2013-01-01 00:00:00
abstract::Assembly and maturation of synapses at the Drosophila neuromuscular junction (NMJ) depend on trans-synaptic neurexin/neuroligin signalling, which is promoted by the scaffolding protein Syd-1 binding to neurexin. Here we report that the scaffold protein spinophilin binds to the C-terminal portion of neurexin and is nee...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9362
更新日期:2015-10-16 00:00:00
abstract::Since the 1970s, it has been known that black-hole (and other) horizons are truly thermodynamic. More generally, surfaces which are not horizons have also been conjectured to behave thermodynamically. Initially, for surfaces microscopically expanded from a horizon to so-called stretched horizons, and more recently, fo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05433-9
更新日期:2018-07-30 00:00:00
abstract::How do descending inputs from the brain control leg motor circuits to change how an animal walks? Conceptually, descending neurons are thought to function either as command-type neurons, in which a single type of descending neuron exerts a high-level control to elicit a coordinated change in motor output, or through a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19936-x
更新日期:2020-12-02 00:00:00
abstract::Proteogenomics enable the discovery of novel peptides (from unannotated genomic protein-coding loci) and single amino acid variant peptides (derived from single-nucleotide polymorphisms and mutations). Increasing the reliability of these identifications is crucial to ensure their usefulness for genome annotation and p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03311-y
更新日期:2018-03-02 00:00:00
abstract::To reconstruct the evolutionary origin of multicellular animals from their unicellular ancestors, the genome sequences of diverse unicellular relatives are essential. However, only the genome of the choanoflagellate Monosiga brevicollis has been reported to date. Here we completely sequence the genome of the filastere...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3325
更新日期:2013-01-01 00:00:00
abstract::A synthetic biology method based on heterologous biosynthesis coupled with genome mining is a promising approach for increasing the opportunities to rationally access natural product with novel structures and biological activities through total biosynthesis and combinatorial biosynthesis. Here, we demonstrate the adva...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15664-4
更新日期:2020-04-14 00:00:00