Diagnostic accuracy of i-scan image enhancement for real-time endoscopic diagnosis of small colorectal polyps: a meta-analysis.

Abstract:

Objective:i-Scan is a digital image enhancement technology, reported to improve diagnostic performance during endoscopy. Previous studies have investigated the accuracy of i-scan for distinguishing between neoplastic and non-neoplastic colonic polyps and suggested diagnostic accuracy close to that required for use in routine clinical practice. The aim of this study was to perform a meta-analysis of the available literature investigating diagnostic accuracy for i-scan optical diagnosis when made in real time for colorectal polyps <10 mm in size. Data sources:The databases of Medline, Embase and the Cochrane Library were searched for relevant studies. Methods:A bivariate random effects model was used to produce pooled sensitivity and specificity values, and univariable meta-regression was applied for subgroup analysis. Results:The meta-analysis included 15 studies, and diagnosis of 2817 polyps. The area under the hierarchical summary receiver-operating characteristic curve was 0.96. The pooled sensitivity of i-scan optical diagnosis was 0.92 (95% confidence interval 0.85-0.95). The specificity was 0.90 (95% confidence interval 0.83-0.94). Conclusions:This meta-analysis updates and summarizes the available evidence concerning the diagnostic performance of i-scan for small colorectal polyps. An acceptable degree of accuracy was found, showing potential to support a 'resect and discard' strategy for colonic polyps. There was not found to be a significant difference in diagnostic performance between different clinical settings (i.e. teaching hospitals or general hospitals).

authors

Glover B,Patel N,Ashrafian H,Teare J

doi

10.1177/1756284818814948

subject

Has Abstract

pub_date

2018-12-06 00:00:00

pages

1756284818814948

eissn

1756-283X

issn

1756-2848

pii

10.1177_1756284818814948

journal_volume

11

pub_type

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