Cell death pathologies: targeting death pathways and the immune system for cancer therapy.


:Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse conditions. Regulated cell death has historically been exclusively associated with classical apoptosis; however, increasing evidence indicates that several alternative mechanisms orchestrate multiple death pathways, such as ferroptosis, entosis, necroptosis and immunogenic cell death, each with distinct underlying molecular mechanisms. Although pharmacological targeting of cell death pathways has been the subject of intensive efforts in recent decades with a dominant focus on targeting apoptosis, the identification of these novel death pathways has opened additional venues for intervention in cancer cells and the immune system. In this mini-review, we cover some recent progress on major recently emerged cell death modalities, emphasizing their potential clinical and therapeutic implications. We also discuss the interplay between cell death and immune response, highlighting the potential of the combination of traditional anticancer therapy and immunocheckpoint blockade. While attempting to stimulate discussion and draw attention to the possible clinical impact of these more recently emerged cell death modalities, we also cover the major progress achieved in translating strategies for manipulation of apoptotic pathways into the clinic, focusing on the attempts to target the anti-apoptotic protein BCL2 and the tumour suppressor p53.


Genes Immun


Genes and immunity


Pentimalli F,Grelli S,Di Daniele N,Melino G,Amelio I




Has Abstract


2019-09-01 00:00:00














  • Follow-up investigation of 12 proposed linkage regions in multiple sclerosis.

    abstract::Multiple sclerosis (MS) is an autoimmune disease with overwhelming evidence for genetic determination, and for which a maternal parent-of-origin effect has been reported. As with many complex diseases, multiple suggestive linkage signals have been observed. However, the only unambiguous association and linkage identif...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Herrera BM,Cader MZ,Dyment DA,Bell JT,Ramagopalan SV,Lincoln MR,Orton S,Chao MJ,Sadovnick AD,Ebers GC

    更新日期:2006-07-01 00:00:00

  • The major histocompatibility complex-encoded class I-like HFE abrogates endocytosis of transferrin receptor by inducing receptor phosphorylation.

    abstract::The major histocompatibility complex-encoded gene, Hfe, has been implicated to play a pivotal role in hereditary hemochromatosis, a common autosomal recessive disorder of iron metabolism. The recent finding that a physical interaction between HFE and transferrin receptor establishes a functional link between HFE and t...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Salter-Cid L,Brunmark A,Peterson PA,Yang Y

    更新日期:2000-10-01 00:00:00

  • Association between adult-onset Still's disease and interleukin-18 gene polymorphisms.

    abstract::Recently, we reported that serum concentration of IL-18 is strikingly high in patients with adult-onset Still's disease (AOSD). The aim of the present study was to screen for genetic polymorphisms in the human IL-18 (hIL-18) gene and to determine the association of polymorphisms with susceptibility to AOSD. We investi...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Sugiura T,Kawaguchi Y,Harigai M,Terajima-Ichida H,Kitamura Y,Furuya T,Ichikawa N,Kotake S,Tanaka M,Hara M,Kamatani N

    更新日期:2002-11-01 00:00:00

  • Complexity in the host response to Salmonella Typhimurium infection in AcB and BcA recombinant congenic strains.

    abstract::The host response to Salmonella infection is controlled by its genetic makeup. Using the mouse model of typhoid fever, several genes were found to influence the outcome of Salmonella infection, including Nramp1 (Slc11a1). In order to improve our knowledge of genetic determinants of the mouse response to acute Salmonel...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Roy MF,Riendeau N,Loredo-Osti JC,Malo D

    更新日期:2006-12-01 00:00:00

  • Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes.

    abstract::Biologic treatment of type 1 diabetes (T1D) with agents including anti-CD3 (otelixizumab and teplizumab), anti-CD20 (rituximab), LFA3Ig (alafacept), and CTLA4Ig (abatacept) results in transient stabilization of insulin C-peptide, a surrogate for endogenous insulin secretion. With the goal of inducing more robust immun...

    journal_title:Genes and immunity

    pub_type: 杂志文章,随机对照试验


    authors: Linsley PS,Greenbaum CJ,Rosasco M,Presnell S,Herold KC,Dufort MJ

    更新日期:2019-04-01 00:00:00

  • The human G1m1 allotype associates with CD4+ T-cell responsiveness to a highly conserved IgG1 constant region peptide and confers an asparaginyl endopeptidase cleavage site.

    abstract::The human G1m1 allotype comprises two amino acids, D12 and L14, in the CH3 domain of IGHG1. Although the G1m1 allotype is prevalent in human populations, ~40% of Caucasiods are homozygous for the nG1m1 allotype corresponding to E12 and M14. Peptides derived from the G1m1 region were tested for their ability to induce ...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Stickler MM,Reddy A,Xiong JM,Hinton PR,DuBridge R,Harding FA

    更新日期:2011-04-01 00:00:00

  • A CTLA-4 gene polymorphism at position -318 in the promoter region affects the expression of protein.

    abstract::CTLA-4 is an important negative regulator of the immune system. The regulation of the CTLA-4 gene (Ctla-4) transcription is poorly understood. A single nucleotide polymorphism (SNP) at -318 in the Ctla-4 promoter region is associated with certain autoimmune diseases. Since the -318 SNP occurs in a potential regulatory...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Wang XB,Zhao X,Giscombe R,Lefvert AK

    更新日期:2002-06-01 00:00:00

  • The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.

    abstract::The proteases of the lectin pathway of complement activation, MASP-1 and MASP-2, are encoded by two separate genes. The MASP1 gene is located on chromosome 3q27, the MASP2 gene on chromosome 1p36.23-31. The genes for the classical complement activation pathway proteases, C1r and C1s, are linked on chromosome 12p13. We...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Stover C,Endo Y,Takahashi M,Lynch NJ,Constantinescu C,Vorup-Jensen T,Thiel S,Friedl H,Hankeln T,Hall R,Gregory S,Fujita T,Schwaeble W

    更新日期:2001-05-01 00:00:00

  • Rare mutations in TNFRSF13B increase the risk of asthma symptoms in Swedish children.

    abstract::TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) mutations seem to be associated with autoimmunity and common variable immunodeficiency in humans. Because of its role in immune responses, we investigated the association between TACI mutations and infection proneness/asthma symptom...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Janzi M,Melén E,Kull I,Wickman M,Hammarström L

    更新日期:2012-01-01 00:00:00

  • The contribution from interleukin-27 towards rheumatoid inflammation: insights from gene expression.

    abstract::We aimed to assess expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis (RA), including in extra-articular, subcutaneous rheumatoid nodules. Comparing between nodules and joint synovia, significantly elevated expression of IL27A within nod...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Millier MJ,Lazaro K,Stamp LK,Hessian PA

    更新日期:2020-08-01 00:00:00

  • Genetic susceptibility to visceral leishmaniasis in The Sudan: linkage and association with IL4 and IFNGR1.

    abstract::Longitudinal studies in Sudan show ethnic differences in incidence and clinical phenotypes associated with Leishmania donovani. Immunologically, bias in type 1 vs type 2 cytokine responses is important. To determine whether polymorphisms at IL4/IL9 or IFNGR1 contribute to susceptibility, we examined 59 multicase famil...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Mohamed HS,Ibrahim ME,Miller EN,Peacock CS,Khalil EA,Cordell HJ,Howson JM,El Hassan AM,Bereir RE,Blackwell JM

    更新日期:2003-07-01 00:00:00

  • Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.

    abstract::Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disease affecting >4,00,000 individuals in the United States. Population and family-based studies have suggested that there is a strong genetic component. Numerous genomic linkage screens have identified regions of interest for MS loci....

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: McCauley JL,Zuvich RL,Bradford Y,Kenealy SJ,Schnetz-Boutaud N,Gregory SG,Hauser SL,Oksenberg JR,Mortlock DP,Pericak-Vance MA,Haines JL

    更新日期:2009-10-01 00:00:00

  • Interactome analysis of gene expression profile reveals potential novel key transcriptional regulators of skin pathology in vitiligo.

    abstract::Selective destruction of epidermal melanocytes is central to vitiligo (VL), a common acquired, autoimmune depigmentory disorder of the skin. Like other autoimmune diseases, the pathogenesis of VL is obscure and both multifactorial and polygenic. The prevailing theory is that VL may be part of an autoimmune diathesis. ...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Dey-Rao R,Sinha AA

    更新日期:2016-01-01 00:00:00

  • Mutations in RNA Polymerase III genes and defective DNA sensing in adults with varicella-zoster virus CNS infection.

    abstract::Recently, deficiency in the cytosolic DNA sensor RNA Polymerase III was described in children with severe primary varicella-zoster virus (VZV) infection in the CNS and lungs. In the present study we examined adult patients with VZV CNS infection caused by viral reactivation. By whole exome sequencing we identified mut...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Carter-Timofte ME,Hansen AF,Christiansen M,Paludan SR,Mogensen TH

    更新日期:2019-03-01 00:00:00

  • Association of multiple sclerosis with ILT6 deficiency.

    abstract::Multiple sclerosis (MS) is an autoimmune disorder of multifactorial etiology. Family studies have shown strong genetic contributions. Linkage analyses have revealed several regions harboring risk genes including chromosome region 19q13. ILT6 is one of the most interesting candidate genes, since ILTs are involved in th...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Koch S,Goedde R,Nigmatova V,Epplen JT,Müller N,de Seze J,Vermersch P,Momot T,Schmidt RE,Witte T

    更新日期:2005-08-01 00:00:00

  • Complex haplotypic structure of the central MHC region flanking TNF in a West African population.

    abstract::TNF polymorphisms have been associated with susceptibility to malaria and other infectious and inflammatory conditions. We investigated a sample of 150 West African chromosomes to determine linkage disequilibrium (LD) between 25 SNP markers located in an 80 kb segment of the MHC Class III region encompassing TNF and e...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Ackerman HC,Ribas G,Jallow M,Mott R,Neville M,Sisay-Joof F,Pinder M,Campbell RD,Kwiatkowski DP

    更新日期:2003-10-01 00:00:00

  • The helminth Trichuris suis suppresses TLR4-induced inflammatory responses in human macrophages.

    abstract::Recent clinical trials in patients with inflammatory diseases like multiple sclerosis (MS) or inflammatory bowel disease (IBD) have shown the beneficial effects of probiotic helminth administration, although the underlying mechanism of action remains largely unknown. Potential cellular targets may include innate immun...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Ottow MK,Klaver EJ,van der Pouw Kraan TC,Heijnen PD,Laan LC,Kringel H,Vogel DY,Dijkstra CD,Kooij G,van Die I

    更新日期:2014-10-01 00:00:00

  • Genome-wide expression analysis suggests unique disease-promoting and disease-preventing signatures in Pemphigus vulgaris.

    abstract::To evaluate pathogenetic mechanisms underlying disease development and progression in the autoimmune skin disease Pemphigus vulgaris (PV), we examined global peripheral blood gene expression in patients and healthy controls. Our goals were to: (1) assign blood gene expression signatures to patients and controls; (2) i...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Dey-Rao R,Seiffert-Sinha K,Sinha AA

    更新日期:2013-12-01 00:00:00

  • Irf4 is a positional and functional candidate gene for the control of serum IgM levels in the mouse.

    abstract::Natural IgM are involved in numerous immunological functions but the genetic factors that control the homeostasis of its secretion and upholding remain unknown. Prompted by the finding that C57BL/6 mice had significantly lower serum levels of IgM when compared with BALB/c mice, we performed a genome-wide screen and fo...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Côrte-Real J,Rodo J,Almeida P,Garcia J,Coutinho A,Demengeot J,Penha-Gonçalves C

    更新日期:2009-01-01 00:00:00

  • Genetic diversity of the HLA-G coding region in Amerindian populations from the Brazilian Amazon: a possible role of natural selection.

    abstract::HLA-G has an important role in the modulation of the maternal immune system during pregnancy, and evidence that balancing selection acts in the promoter and 3'UTR regions has been previously reported. To determine whether selection acts on the HLA-G coding region in the Amazon Rainforest, exons 2, 3 and 4 were analyze...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Mendes-Junior CT,Castelli EC,Meyer D,Simões AL,Donadi EA

    更新日期:2013-12-01 00:00:00

  • Genetic control of susceptibility to infection with Plasmodium chabaudi chabaudi AS in inbred mouse strains.

    abstract::To identify genetic effects modulating the blood stage replication of the malarial parasite, we phenotyped a group of 25 inbred mouse strains for susceptibility to Plasmodium chabaudi chabaudi AS infection (peak parasitemia, survival). A broad spectrum of responses was observed, with strains such as C57BL/6J being the...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Laroque A,Min-Oo G,Tam M,Radovanovic I,Stevenson MM,Gros P

    更新日期:2012-02-01 00:00:00

  • Genetic epistasis between killer immunoglobulin-like receptors and human leukocyte antigens in Kawasaki disease susceptibility.

    abstract::Kawasaki disease (KD) is a pediatric acute multisystemic vasculitis complicated by development of coronary artery lesions. The breakthrough theory on KD etiopathogenesis points to pathogens/environmental factors triggered by northeastern wind coming from China. Natural Killer cells and T lymphocytes express the inhibi...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Bossi G,Mannarino S,Pietrogrande MC,Salice P,Dellepiane RM,Cremaschi AL,Corana G,Tozzo A,Capittini C,De Silvestri A,Tinelli C,Pasi A,Martinetti M

    更新日期:2015-10-01 00:00:00

  • Polygenic risk assessment reveals pleiotropy between sarcoidosis and inflammatory disorders in the context of genetic ancestry.

    abstract::Sarcoidosis is a complex disease of unknown etiology characterized by the presence of granulomatous inflammation. Though various immune system pathways have been implicated in disease, the relationship between the genetic determinants of sarcoidosis and other inflammatory disorders has not been characterized. Herein, ...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Lareau CA,DeWeese CF,Adrianto I,Lessard CJ,Gaffney PM,Iannuzzi MC,Rybicki BA,Levin AM,Montgomery CG

    更新日期:2017-03-01 00:00:00

  • Finnish case-control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis.

    abstract::Several studies have identified the PTPN22 allelic variant 1858 C/T that encodes the R620W amino-acid change as a putative susceptibility factor in autoimmune diseases. The current study was undertaken to examine a large cohort of Finnish rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) subjects using...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Seldin MF,Shigeta R,Laiho K,Li H,Saila H,Savolainen A,Leirisalo-Repo M,Aho K,Tuomilehto-Wolf E,Kaarela K,Kauppi M,Alexander HC,Begovich AB,Tuomilehto J

    更新日期:2005-12-01 00:00:00

  • Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.

    abstract::IRF-5 is a transcription factor activated by toll like receptor (TLR)7 and TLR9 during innate immune responses. IRF-5 activates not only Type I IFN, but also inflammatory cytokines. Most importantly, a genetic variation in the IRF-5 gene shows a strong association with autoimmune diseases such as Lupus. Here, we repor...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Fang CM,Roy S,Nielsen E,Paul M,Maul R,Paun A,Koentgen F,Raval FM,Szomolanyi-Tsuda E,Pitha PM

    更新日期:2012-07-01 00:00:00

  • RGMA and IL21R show association with experimental inflammation and multiple sclerosis.

    abstract::Rat chromosome 1 harbors overlapping quantitative trait loci (QTL) for cytokine production and experimental models of inflammatory diseases. We fine-dissected this region that regulated cytokine production, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), anti-MOG anti...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Nohra R,Beyeen AD,Guo JP,Khademi M,Sundqvist E,Hedreul MT,Sellebjerg F,Smestad C,Oturai AB,Harbo HF,Wallström E,Hillert J,Alfredsson L,Kockum I,Jagodic M,Lorentzen J,Olsson T

    更新日期:2010-06-01 00:00:00

  • Mhc class I haplotypes associated with survival time in simian immunodeficiency virus (SIV)-infected rhesus macaques.

    abstract::In both human immunodeficiency virus-infected humans and simian immunodeficiency virus (SIV)-infected macaques, genes encoded in the major histocompatibility complex (MHC) class I region are important determinants of disease progression. However, compared to the human human lymphocyte antigen complex, the macaque MHC ...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Sauermann U,Siddiqui R,Suh YS,Platzer M,Leuchte N,Meyer H,Mätz-Rensing K,Stoiber H,Nürnberg P,Hunsmann G,Stahl-Hennig C,Krawczak M

    更新日期:2008-01-01 00:00:00

  • Novel SNPs in the CD18 gene validate the association with MPO-ANCA+ vasculitis.

    abstract::Wegener granulomatosis (WG), microscopic polyangiitis (MP), and Churg-Strauss syndrome (CSS) are characterized by the presence of anti-neutrophil cytoplasmic antibodies (ANCA). Anti-myeloperoxidase (MPO)-ANCA are a typical feature of MP and CSS, while anti-proteinase 3 (PRTN3)-ANCA are highly specific for WG. Several ...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Meller S,Jagiello P,Borgmann S,Fricke H,Epplen JT,Gencik M

    更新日期:2001-08-01 00:00:00

  • Identification, characterization, and evolution of a primate beta-defensin gene cluster.

    abstract::Defensins are members of a large diverse family of cationic antimicrobial peptides that share a signature pattern consisting of six conserved cysteine residues. Defensins have a wide variety of functions and their disruption has been implicated in various human diseases. Here we report the characterization of DEFB119-...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Radhakrishnan Y,Hamil KG,Yenugu S,Young SL,French FS,Hall SH

    更新日期:2005-05-01 00:00:00

  • Gene--gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis.

    abstract::Aggressive periodontitis (AgP) is a multifactorial disease. The distinctive aspect of periodontitis is that this disease must deal with a large number of genes interacting with one another and forming complex networks. Thus, it is reasonable to expect that gene-gene interaction may have a crucial role. Therefore, we c...

    journal_title:Genes and immunity

    pub_type: 杂志文章


    authors: Scapoli C,Mamolini E,Carrieri A,Guarnelli ME,Annunziata M,Guida L,Romano F,Aimetti M,Trombelli L

    更新日期:2011-09-01 00:00:00