Abstract：
:Accumulating evidence suggests that autism spectrum disorder (ASD) may be conceptualized within a framework of reward processing impairments. The Social Motivation Theory of Autism posits that reduced motivation to interact with people and decreased pleasure derived from social interactions may derail typical social development and contribute to the emergence of core social communication deficits in ASD. Neuroinflammation may disrupt the development of mesolimbic dopaminergic systems that are critical for optimal functioning of social reward processing systems. This neuroinflammation-induced disturbance of mesolimbic dopaminergic functioning has been substantiated using maternal immune activation rodent models whose offspring show aberrant dopaminergic corticostriatal function, as well as behavioral characteristics of ASD model systems. Preclinical findings are in turn supported by clinical evidence of increased mesolimbic neuroinflammatory responses in individuals with ASD. This review summarizes evidence for reward processing deficits and neuroinflammatory impairments in ASD and examines how immune inflammatory dysregulation may impair the development of dopaminergic mesolimbic circuitry in ASD. Finally, future research directions examining neuroinflammatory effects on reward processing in ASD are proposed.
journal_name
Biol Psycholjournal_title
Biological psychologyauthors
Greene RK,Walsh E,Mosner MG,Dichter GSdoi
10.1016/j.biopsycho.2018.12.008subject
Has Abstractpub_date
2019-03-01 00:00:00pages
1-12eissn
0301-0511issn
1873-6246pii
S0301-0511(18)30150-9journal_volume
142pub_type
杂志文章,评审abstract：:Effects of predictability of threat on potentiation of the startle reflex were investigated by presenting participants with predictable and unpredictable electric shocks. Shocks were presented either paired with a visual cue (paired condition) or unrelated to the presentation of the visual cues (unpaired condition). I...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2007.05.005
更新日期：2007-09-01 00:00:00
abstract：:Men outperform women in mental rotation by about one standard deviation. Prenatal exposure to testosterone has been suggested as one cause. In animals it has been shown that a female fetus located between two male ones is exposed to higher levels of testosterone. It is still unclear whether intra-uterine hormone trans...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2010.11.002
更新日期：2011-01-01 00:00:00
abstract：:Ninety-seven female students were assigned to groups consisting of 55 infrequent and 42 frequent binge drinkers. The groups were compared on self-report measures of impulsivity, sensation seeking, and alexithymia, as well as several measures relevant to neural and genetic mechanisms, such as brain activation during a ...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2014.01.005
更新日期：2014-03-01 00:00:00
abstract：:This study examined the role of shifts in plasma volume on lipid and immune reactions to stress. Lipid, immune, rheological, and cardiovascular reactions to exercise and mental stress in 51 patients with suspected coronary artery disease were determined. Blood pressure and heart rate were measured during and blood sam...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/s0301-0511(03)00113-3
更新日期：2004-02-01 00:00:00
abstract：:Pharmacological reinforcement has been identified as a major factor in the maintenance of cigarette smoking. Smokers seem to seek an individually characteristic level of nicotine intake and adjust their smoking parameters in order to obtain this dose. The purpose of this study was to investigate the differences in nic...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/0301-0511(85)90051-1
更新日期：1985-08-01 00:00:00
abstract：:In reply to Verleger's commentary, I first clarify what the term "MRP overlap" implies; by means of a simple additive simulation it is shown that overlap between a stable P300 and a MRP that moves in time with reaction-time, may cause two types of artefacts--amplitude reduction and double peaking of P300. Following Ve...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/0301-0511(88)90005-1
更新日期：1988-08-01 00:00:00
abstract：:Performance deficits are usually evident following both extended wakefulness (sleep deprivation effects) and immediately upon awakening from sleep (sleep inertia effects). In order to determine whether sleep inertia effects are qualitatively different from sleep deprivation effects, performance on addition tests, Stan...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/0301-0511(88)90034-8
更新日期：1988-12-01 00:00:00
abstract：:The somatic marker hypothesis (Damasio, Tranel, & Damasio, 1991) is a controversial theory asserting that somatic activities implicitly bias human behavior. In this study, we examined the relationship between choice behaviors in the Iowa Gambling Task and patterns of skin conductance responses (SCRs) within a healthy ...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/s0301-0511(03)00093-0
更新日期：2003-12-01 00:00:00
abstract：:We investigated the possible involvement of the brainstem in the pathology of obsessive-compulsive disorder. Brainstem auditory evoked potentials (BAEPs) were collected from a population of neurotics (100 patients), including a group of 50 subjects suffering from obsessive-compulsive disorder (OCD) and the rest having...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/s0301-0511(97)00032-x
更新日期：1998-05-01 00:00:00
abstract：:The present study investigated differences in ERP parameters related to intelligence. For that purpose 74 individuals (Intelligence: M=107; S.D.=12; range 73-135), of average creativity passively listened to two tones and performed two auditory, and two visual oddball tasks while their EEG was recorded. The approximat...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/s0301-0511(00)00076-4
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:The neuropeptide oxytocin (OT) has been shown to play a role in variety of cognitive and social processes and different hypotheses have been put forth to explain OT's effects on brain and behavior in humans. However, these previous explanatory accounts do not provide information about OT-related temporal mod...
journal_title：Biological psychology
pub_type： 杂志文章,评审
doi：10.1016/j.biopsycho.2020.107917
更新日期：2020-07-01 00:00:00
abstract：:Several studies suggest that inhibition difficulties among people with ASD might be related to atypical cardiac vagal control. We examined how low versus high baseline heart rate variability (HRV) influences prepotent response inhibition in 31 males with autism spectrum disorder (ASD; mean age: 32.2; mean IQ: 107.8) c...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2017.07.006
更新日期：2017-09-01 00:00:00
abstract：:Interhemispheric transfer measured via differences in right- or left-handed motoric responses to lateralized visual stimuli, known as the crossed-uncrossed difference (CUD), is one way of identifying patterns of processing that are vital for understanding the transfer of neural signals. Examination of interhemispheric...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2018.05.008
更新日期：2018-07-01 00:00:00
abstract：:The approach-withdrawal and valence-arousal models highlight that specific brain laterality profiles may distinguish depression and anxiety. However, studies remain to be conducted in multiple clinical populations that directly test the diagnostic specificity of these hypotheses. The current study compared electroence...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2010.08.001
更新日期：2010-10-01 00:00:00
abstract：:Past psychological theory and research suggest two opposing relationships between effort and reward valuation. Cognitive dissonance theory and research suggest that increased effort is associated with increased reward valuation, whereas theory and research on effort discounting suggest that increased effort is associa...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2020.107910
更新日期：2020-07-01 00:00:00
abstract：:The electrophysiological correlates of error processing were investigated in patients with borderline personality disorder (BPD) using event-related potentials (ERP). Twelve patients with BPD and 12 healthy controls were additionally rated with the Barratt impulsiveness scale (BIS-10). Participants performed a Go/Nogo...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2005.08.006
更新日期：2006-05-01 00:00:00
abstract：:Some properties of principal components analysis (PCA) and simple structure rotation, which are relevant to the study of event-related potentials (ERPs), were examined both in theory and with simulated data. The analysis casts some doubt on whether it is useful and desirable to rotate the loading pattern of a PCA of E...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/0301-0511(81)90024-7
更新日期：1981-12-01 00:00:00
abstract：:Post-traumatic stress disorder (PTSD) is characterised by alterations in the function of the autonomic nervous system. However, it is unclear if this dysfunction is threat-related or related to arousing stimuli in general. Pupillometry offers a simple non-invasive measure of ANS activity that can separate parasympathe...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2020.107922
更新日期：2020-07-01 00:00:00
abstract：:In this study, to investigate the influence of incidental emotions on decision making in high-anxious individuals, participants were required to perform a monetary gambling task. Behavioral and electroencephalography responses were recorded to explore the stages of option assessment and outcome evaluation during decis...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2016.11.009
更新日期：2017-02-01 00:00:00
abstract：:The cerebral processing of emotion has been the subject of a number of recent studies, but results relating to hemispheric asymmetry have been quite mixed. The present study attempted to clarify and extend findings in this area by examining the differential effects of cognitive and affective sets on hemisphere asymmet...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/0301-0511(87)90100-1
更新日期：1987-02-01 00:00:00
abstract：:To gain more insight into the development of action control, the current brain potential study examined response selection, activation, and selective inhibition during choice- and stop-signal processing in three age groups (8-, 12-, and 21-year-olds). Results revealed that age groups differed in the implementation of ...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2014.06.003
更新日期：2014-10-01 00:00:00
abstract：:Interoceptive accuracy is frequently assessed using the Heartbeat Counting Task (HCT), requiring participants to count the number of times their heart beats. The HCT validity has been questioned, as participants may perform the task by estimating, rather than counting, their felt heartbeats. Participants could estimat...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2020.107904
更新日期：2020-07-01 00:00:00
abstract：:Cardiac activity has long been considered as a psychophysiological marker of adaptive psychological adjustment. Irregularities in autonomic nervous system activity have long been implicated in both externalizing and disinhibitory behaviors. The present study used a battery of assessments in children ages 4.5-5.5 years...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2011.01.007
更新日期：2011-03-01 00:00:00
abstract：:This task-switching ERP study of 16 young participants investigated whether increased RT slowing on stay trials and faster RTs on switch trials for frequent than infrequent switching are explained by an activation or preparation account. The activation account proposes that task sets are maintained at a higher baselin...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2012.07.005
更新日期：2012-10-01 00:00:00
abstract：:To examine the role of perceived control in pain perception, fibromyalgia patients and healthy controls participated in a reaction time experiment under different conditions of pain controllability. No significant differences between groups were found in pain intensity and unpleasantness ratings. However, during the e...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2016.09.007
更新日期：2016-12-01 00:00:00
abstract：:When one of the two hemispheres directs visuospatial attention to some contralateral location, this may imply that inhibition is exerted on the other hemisphere. In the dual rapid serial visual presentation task, two targets (T1 and T2) occur among two different visual streams, rapidly presented left and right. We rep...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：:The study compares 5 auditory event-related potential (ERP) components (P1 to P3) after 3 tones differing in pitch and rarity, and contrasts the mismatch negativity (MMN) between them in 12 children with attention-deficit hyperactivity disorder (ADHD; mean 10.2 years of age), 12 healthy controls pairwise matched for a...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/0301-0511(96)05189-7
更新日期：1996-04-12 00:00:00
abstract：:The review summarizes and integrates findings from 40 years of event-related potential (ERP) studies using pictures that differ in valence (unpleasant-to-pleasant) and arousal (low-to-high) and that are used to elicit emotional processing. Affective stimulus factors primarily modulate ERP component amplitude, with lit...
journal_title：Biological psychology
pub_type： 杂志文章,评审
doi：10.1016/j.biopsycho.2007.11.006
更新日期：2008-03-01 00:00:00
abstract：:Integrating the implicit-affect-primes-effort model (Gendolla, 2012, 2015) with the principles of motivational intensity theory (Brehm & Self, 1989) we investigated if the effort mobilization deficit observed in people exposed to fear primes (vs. anger primes) in a difficult short-term memory task could be compensated...
journal_title：Biological psychology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.biopsycho.2016.03.014
更新日期：2016-05-01 00:00:00
abstract：:The aim of the study was to examine the modulating effects of coping style on the response to psychosocial stress in remitted major depression (MD) and healthy controls. Thirty-three participants with a lifetime history of MD, who were in remission, and 32 age- and gender-matched healthy controls were recruited from a...
journal_title：Biological psychology
pub_type： 杂志文章
doi：10.1016/j.biopsycho.2014.09.008
更新日期：2014-12-01 00:00:00
