Abstract：
OBJECTIVES:The objectives of this study were to: (1) develop a novel multifunctional composite with nanoparticles of silver (NAg), 2-methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); and (2) investigate biofilm-inhibition via the multifunctional nanocomposite against three species of periodontal pathogens for the first time. METHODS:The multifunctional nanocomposite was fabricated by incorporating NAg, MPC, DMAHDM and NACP into the resin consisting of pyromellitic glycerol dimethacrylate (PMDGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). Three species (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum) were tested for metabolic activity (MTT), live/dead staining, polysaccharide production and colony-forming units (CFU) of biofilms grown on resins. RESULTS:Incorporation of 0.08% to 0.12% NAg, 3% MPC, 3% DMAHDM and 30% NACP did not compromise the mechanical properties of the composite (p > 0.1). The multifunctional nanocomposite reduced protein adsorption to nearly 1/10 of that of a commercial control (p < 0.05). For all three species, the biofilm CFU was reduced by about 5 and 1 orders of magnitude via the nanocomposite containing NAg + MPC + DMAHDM, compared to commercial control and the composite with MPC + DMAHDM, respectively. CONCLUSIONS:The novel multifunctional nanocomposite achieved the greatest reduction in metabolic activity, polysaccharide and biofilm growth of three periodontal pathogens. CLINICAL SIGNIFICANCE:The strongly-antibacterial, multifunctional composite is promising for treating root lesions, alleviating periodontitis and protecting the periodontal tissues.
journal_name
J Dentjournal_title
Journal of dentistryauthors
Xiao S,Wang H,Liang K,Tay F,Weir MD,Melo MAS,Wang L,Wu Y,Oates TW,Ding Y,Xu HHKdoi
10.1016/j.jdent.2018.12.001subject
Has Abstractpub_date
2019-02-01 00:00:00pages
17-26eissn
0300-5712issn
1879-176Xpii
S0300-5712(18)30420-2journal_volume
81pub_type
杂志文章abstract：OBJECTIVE:This study evaluated the effects of surface preparation and the application time of adhesives on the resin-dentine bond strengths with universal adhesives. METHODS:Sixty molars were cut to exposed mid-coronal dentine and divided into 12 groups (n=5) based on three factors; (1) adhesive: G-Premio Bond (GP, GC...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2016.02.001
更新日期：2016-04-01 00:00:00
abstract：:Pain following removal of impacted third molar teeth has proven to be a useful clinical model for evaluating oral analgesics. Moreover, as the underlying pathophysiology becomes elucidated the model serves as a tool for monitoring the relative contributions of different pain events, including peripheral and central se...
journal_title：Journal of dentistry
pub_type： 杂志文章,评审
doi：10.1016/0300-5712(94)90084-1
更新日期：1994-12-01 00:00:00
abstract：OBJECTIVES:This in vitro study examined the resistance to displacement offered by guide planes and the displacement mechanics of a bilateral bounded saddle cast cobalt chrome alloy removable partial denture framework under conditions simulating an average initial fit. METHODS:A specially designed model mouth jig fitte...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(01)00016-1
更新日期：2001-05-01 00:00:00
abstract：:Meta-analysis is a formalized method of combining results of different studies to provide conclusions about the effectiveness of a treatment modality. The aims of this study were to use meta-analysis to determine the clinical performance of posterior composite restorations using the assessment criteria of the USPHS gu...
journal_title：Journal of dentistry
pub_type： 杂志文章,meta分析
doi：10.1016/0300-5712(94)90143-0
更新日期：1994-02-01 00:00:00
abstract：:A significant correlation was found between the number of mutans streptococci in saliva and the proportional distribution of these microorganisms in pooled plaque from the margins of all restorations. At high salivary numbers there was a tendency towards a higher porportion of mutans streptococci in plaque from the ma...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(92)90130-5
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVES:Evaluate erosive potential of beverages, using exposure times from 3 to 30 min, and to analyse the relationship between erosion and several drink parameters. METHODS:pH, calcium, phosphate and fluoride concentration, saturation, titratable-acidity to pH 5.5 and the viscosity of sixteen beverages were measur...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2012.09.004
更新日期：2012-12-01 00:00:00
abstract：INTRODUCTION:Quantification of collagen degradation is an important parameter to evaluate dentin caries progression or the efficacy of caries prevention aid. The aim of this study was to validate the simple light microscopic technique (LM) to evaluate collagen degradation by comparing with hydroxyproline assay techniqu...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2016.01.001
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:To determine the influence of hard and soft splints with two thicknesses on the stress transmission to the tooth supporting the splint and the opposite tooth. METHODS:Continuous vertical forces up to 500N were applied to two opposite first molar phantom teeth using a universal loading machine. Deformation wa...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(00)00026-9
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVES:The purpose of the study was to evaluate gloss and color changes of resin composites after exposure to different bleaching agents. METHODS:Products used, were: Nite White ACP (10% carbamide peroxide gel), Crest Classic and Supreme Whitestrip (6.5% and 14% hydrogen peroxide strips, accordingly). A hybrid (He...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2010.06.006
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVES:Methacrylic compounds such as 2-hydroxyethyl methacrylate (HEMA), triethylene glycol dimethacrylate (TEGDMA) and bisphenol A glycerolate (1 glycerol/phenol) dimethacrylate (Bis-GMA) are largely present in auto- or photopolymerizable composite resins. Since the polymerization reaction is never complete, these...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2006.07.008
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVES:The aim of this research was to evaluate the effect of titanium tetrafluoride on dentine permeability in comparison with sodium fluoride and acidulated phosphate fluoride to determine their contribution to acid resistance of dentine. METHODS:Thirty-two dentine discs were prepared from extracted mandibular m...
journal_title：Journal of dentistry
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-5712(99)00029-9
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:The present study tested the central hypothesis that selective demineralisation of dentine extrafibrillar minerals by lowering the phosphoric acid concentration improves the quality of the resin-dentine interface. METHODS:Dentine surfaces were etched with different concentrations of phosphoric acid (1, 5, 10...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2016.07.008
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:Silver compounds have been used for their medical properties for centuries and in dentistry for more than a century. The aim of this review is to examine the evidence supporting the therapeutic use of silver in dentistry and the outcomes from the clinical trials, as well as mode of action and biocompatibility...
journal_title：Journal of dentistry
pub_type： 杂志文章,评审
doi：10.1016/j.jdent.2012.03.009
更新日期：2012-07-01 00:00:00
abstract：:In the present study Class II resin composite restorations were placed under in vivo and in vitro conditions. For the in vivo part. Class II preparations were cut in teeth destined for extraction for orthodontic reasons. The preparations were completed with the gingival margin in enamel and restored using six differen...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(93)90026-m
更新日期：1993-06-01 00:00:00
abstract：OBJECTIVES:To make an inventory of clinical studies on veneer restorations (VRs) using a meta-analysis review procedure and to aggregate an overall survival result for four types of VRs. METHODS:From the dental literature published from 1983 to November 1996, papers were selected using an in- and exclusion protocol in...
journal_title：Journal of dentistry
pub_type： 杂志文章,meta分析
doi：10.1016/s0300-5712(97)00023-7
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVES:This in vivo study compared the antibacterial effect of a self-etch adhesive with and without the brominated monomer 12-methacryloyloxydodecyl-pyridinium bromide (MDPB) on carious dentin after selective caries removal. METHODS:10 patients showing deep primary carious lesions at two posterior teeth without p...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103555
更新日期：2020-12-17 00:00:00
abstract：OBJECTIVES:This paper reports the findings of a study on the roles of dental nurses in cross-infection control in general dental practices and who were undergoing training for their initial certificate. The research aimed to find out what factors in their vocation gave them satisfaction, what caused stress and the bear...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(95)00094-1
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVES:To detect any differences in the propensity of unstimulated and stimulated, individual whole saliva to cause in vitro staining by chlorhexidine and tea. METHODS:Unstimulated and stimulated human saliva was collected on a daily basis and used to coat optically clear acrylic specimens. Specimens were subjecte...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(02)00053-2
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:To examine the effect of incorporating arginine in a 5% sodium fluoride (NaF) varnish on its remineralization potential and HGF-1 cytotoxicity. METHODS:Experimental varnishes were prepared using two arginine variants: l-arginine (Arg) and l-arginine monohydrochloride (Arg.HCl) at 2%, 4%, & 8% w/v. with cont...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103411
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:There is no consensus on whether incisal coverage is a risk or a protective factor in preparations for ceramic veneers. OBJECTIVE:The aim of this systematic review and meta-analysis was to evaluate the survival rates of preparation designs for ceramic veneers with and without incisal coverage. METHODS:Prim...
journal_title：Journal of dentistry
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jdent.2016.06.004
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:Proanthocyanidins (PACs) are biocompounds mimicking native collagen cross-links. The effective and practical delivery of any biocompound is pivotal for clinical usage. The aim was to investigate the dentin biomodification and effective formation of dentin-resin biointerfaces of two highly bioactive PAC-rich ...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2020.103354
更新日期：2020-08-01 00:00:00
abstract：:An even fitting surface is essential to obtain and maintain a healthy oral mucosa in denture wearers. The present study was designed to clarify the relationship between the surface roughness of oral mucosa and its reproduction in the corresponding fitting surface of acrylic dentures. A silicone elastomer/epoxy replica...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(94)90201-1
更新日期：1994-06-01 00:00:00
abstract：OBJECTIVES:To measure aspects of fizzy drink consumption in a social environment to inform the development of a laboratory testing regime. METHODS:This was an observational study in which participants were invited to attend one of four pizza and soft drink parties. All such foods and drinks were served in an air condi...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2015.08.008
更新日期：2015-11-01 00:00:00
abstract：:Enamel blocks bearing artificial caries are used in intra-oral appliances for cariogenicity tests. These blocks are often sterilised to prevent the possibility of cross-infection via this route. This study therefore aimed to determine the effect of sterilisation methods on the structural integrity of artificial enamel...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/s0300-5712(98)00064-5
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVES:Full-ceramic systems can be produced by different techniques (layering, heatpressing, CAD/CAM) and have various compositions with different crystalline contents that may affect the optical properties of laminate restorations. METHODS:A total of 60 specimens were prepared from e.max Press, e.max CAD, Empress...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2012.11.013
更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:Midterm-evaluation of a 5-year prospective clinical splitmouth-investigation on survival rate and long-term behavior of all-ceramic partial coverage restorations (PCRs) on molars. Pressed ceramic and CAD/CAM fabricated PCRs were compared. METHODS:80 vital molars of 25 patients were restored with all-ceramic...
journal_title：Journal of dentistry
pub_type： 临床试验,杂志文章
doi：10.1016/j.jdent.2009.04.006
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to investigate the novel mesocellular siliceous foams (MCF) containing CaCO3 nanoparticles (denoted as CMCF) combined with phosphoric acid could occlude dentinal tubules through the formation of biomimetic crystal barrier. METHODS:Ultrastructures of MCF and CMCF were examined by tr...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2019.02.007
更新日期：2019-04-01 00:00:00
abstract：:The bacteriological contamination of pumice slurry in polishing units in a dental clinical area (high risk), a production laboratory (medium risk), and a non-clinical teaching laboratory (low risk), was investigated. Slurry samples taken from all three areas were found to be heavily contaminated with pathogenic organi...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/0300-5712(90)90030-i
更新日期：1990-10-01 00:00:00
abstract：OBJECTIVES:To examine the removal rate of sound and carious dentine using bioactive glass air-abrasion and investigate abrasive particle retention of alumina and bioactive glass on abraded dentine. METHODS:Crushed bioactive glass was investigated as an alternative air-abrasive to alumina at air pressures of 138, 413 a...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2007.12.004
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVES:All-ceramic crowns have become increasingly used also in the posterior regions, but there are only few studies documenting the clinical outcome of these restorations. The aim was therefore to present the 3-year outcome of zirconia (NobelProcera) single crowns. METHODS:All patients treated with porcelain-ven...
journal_title：Journal of dentistry
pub_type： 杂志文章
doi：10.1016/j.jdent.2009.06.002
更新日期：2009-09-01 00:00:00
