Abstract：
BACKGROUND:Paediatric Cryptococcus gattii disease is rare, with only two previous cases recorded in the Northern Territory (NT) over the last 54 years. Immune reconstitution inflammatory syndrome (IRIS) is a recognised complication of C. gattii infection, even in the absence of an identified immunodeficiency syndrome; however, limited paediatric data exist. We present a series of three paediatric patients treated for C. gattii infection in the NT during 2016/2017. CASE DISCUSSIONS:All three cases were males aged 8-13 years at the time of presentation. Two were Aboriginal Australians from remote NT communities, and the third was a Timorese child from a remote district in Timor-Leste. All cases had evidence of brain cryptococcomas, and two had associated pulmonary lesions. Each child was treated with a 6-week induction phase of intravenous liposomal amphotericin and flucytosine and then continued on a 2-year course of eradication oral fluconazole. Persistent high intracranial pressure (ICP) complicated each case, requiring serial lumbar punctures and, in two cases, insertion of ventriculoperitoneal shunts. All three cases were diagnosed with IRIS between 5 and 10 weeks after commencement of antifungal treatment and were managed with high-dose corticosteroids, which were weaned slowly (6-20 months post-commencement). CONCLUSIONS:Paediatric C. gattii disease is rare, although three recent cases in the NT highlight some of the challenges involved in managing the infection, including persistent raised ICP and complications such as IRIS. There is a need for further collaborative research into paediatric C. gattii disease.
journal_name
J Paediatr Child Healthjournal_title
Journal of paediatrics and child healthauthors
O'Brien MP,Ford TJ,Currie BJ,Francis JRdoi
10.1111/jpc.14321subject
Has Abstractpub_date
2019-08-01 00:00:00pages
943-947issue
8eissn
1034-4810issn
1440-1754journal_volume
55pub_type
杂志文章abstract：OBJECTIVE:To assess the diagnostic error rate among echocardiograms undertaken by individuals other than paediatric cardiologists in our referral area. METHODOLOGY:External group: The charts and echocardiographic results of all patients who had undergone outside echocardiograms between January 1996 and December 1999 w...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2001.00695.x
更新日期：2001-08-01 00:00:00
abstract：:The ability to detect subclinical signs of the microvascular complications of diabetes during adolescence and our increased understanding of risk factors for their development provide an opportunity to prevent irreversible organ damage. Glycaemic control makes a major contribution to the risk and progression of microv...
journal_title：Journal of paediatrics and child health
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doi：10.1111/j.1440-1754.1996.tb01531.x
更新日期：1996-02-01 00:00:00
abstract：:Intoxications, both accidental and intentional, are common in children and adolescents and often require hospitalisation and intensive treatment. Antiepileptic drugs are a possible cause of poisoning and intoxications because this category of medications has shown a rising trend in recent years. They might be responsi...
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journal_title：Journal of paediatrics and child health
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更新日期：2020-12-09 00:00:00
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doi：10.1046/j.1440-1754.2002.00708.x
更新日期：2002-02-01 00:00:00
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journal_title：Journal of paediatrics and child health
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更新日期：2017-07-01 00:00:00
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journal_title：Journal of paediatrics and child health
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doi：10.1046/j.1440-1754.1998.00234.x
更新日期：1998-08-01 00:00:00
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journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2003.00117.x
更新日期：2003-04-01 00:00:00
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journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.1993.tb00439.x
更新日期：1993-02-01 00:00:00
abstract：:The recently released World Health Organization growth charts are methodologically robust, as well as clinically useful tools for monitoring the growth of children. They have been endorsed by premier organisations such as the Royal College of Paediatrics and Child Health (UK), Canadian Pediatric Society, Australian Br...
journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1754.2011.02214.x
更新日期：2012-02-01 00:00:00
abstract：OBJECTIVE:To determine the aetiology, symptoms and outcome of extreme sodium derangement in a paediatric inpatient population. METHODOLOGY:A retrospective study of children with extreme disturbance of their plasma sodium (> or = 165 mmol/L or < or = 115 mmol/L) admitted to a tertiary referral centre during a 72-month ...
journal_title：Journal of paediatrics and child health
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doi：10.1111/j.1440-1754.1997.tb00986.x
更新日期：1997-02-01 00:00:00
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journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1046/j.1440-1754.2002.00761.x
更新日期：2002-04-01 00:00:00
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journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2007.01142.x
更新日期：2007-07-01 00:00:00
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更新日期：2020-10-14 00:00:00
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journal_title：Journal of paediatrics and child health
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doi：10.1046/j.1440-1754.2003.00238.x
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更新日期：2020-10-27 00:00:00
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更新日期：2017-09-01 00:00:00
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journal_title：Journal of paediatrics and child health
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doi：10.1111/j.1440-1754.2006.00974.x
更新日期：2006-12-01 00:00:00
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journal_title：Journal of paediatrics and child health
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journal_title：Journal of paediatrics and child health
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更新日期：2012-12-01 00:00:00
abstract：:Post-mortem investigation of sudden death in young people frequently reveals no overt cause for the death. Full investigation is hampered if tissue or blood is not retained for DNA analysis. We report a post mortem molecular diagnosis of long QT syndrome in a 12-year-old boy diagnosed with epilepsy who died suddenly p...
journal_title：Journal of paediatrics and child health
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doi：10.1111/j.1440-1754.2004.00498.x
更新日期：2004-11-01 00:00:00
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journal_title：Journal of paediatrics and child health
pub_type： 杂志文章
doi：10.1111/j.1440-1754.2005.00663.x
更新日期：2005-08-01 00:00:00
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journal_title：Journal of paediatrics and child health
pub_type： 杂志文章,meta分析,评审
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更新日期：2012-09-01 00:00:00
abstract：AIM:To determine the rates of early intervention (EI) service use in extremely preterm (EP, <28 weeks' gestation) or extremely low birthweight (ELBW, <1000 g) infants between 1991 and 2013, and identify biological or socio-economic factors associated with receiving EI. METHODS:Participants comprised consecutive EP or ...
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pub_type： 杂志文章
doi：10.1111/jpc.13668
更新日期：2018-01-01 00:00:00
