Prognostic significance of expression of Myogenin and OCT4 in glioma.

Abstract:

BACKGROUND:Glioma is the most common extracranial solid tumor of children. The malignant (cancer) cells form in neural crest cell of the adrenal gland. In this study we investigate the expressions of Myogenin and OCT4 in Glioma which might be used as prognostic makers for this deteriorated disease. METHODS:We used Quantitative Fluorescence PCR (QF-PCR), Enzyme-linked immunosorbent assay (ELISA), and Western-blotting to measure the expression level of Myogenin and OCT4 in surgical removed Glioma from 41 patients in our hospital. RESULTS:Compared to the healthy children the expression of Myogenin and OCT4 was significantly increased in both mRNA and protein level in Glioma tumor cells. In addition, these expressions increased as glioma deterioration. CONCLUSIONS:These findings suggesting the expression of Myogenin and Oct4 may be useful indicators for predicting the prognosis of children with glioma.

journal_name

Minerva Pediatr

journal_title

Minerva pediatrica

authors

Zheng N,Zhang D,Liu X

doi

10.23736/S0026-4946.18.05396-3

subject

Has Abstract

pub_date

2018-12-03 00:00:00

eissn

0026-4946

issn

1827-1715

pii

S0026-4946.18.05396-3

pub_type

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