Abstract:
:Low molecular weight nucleoside gelators hold great promise in drug delivery and particularly for the delivery of biologics because of their excellent biocompatibility. However, the influence of these gelators on protein aggregation inhibition has not yet been studied. Protein aggregation is the most significant cause of protein instability and can severely impact the biological activity of the protein, impairing the quality and safety of the formulation. Herein, we report the ability of a nucleoside-based gelator, N4-octanoyl-2'-deoxycytidine, to inhibit protein aggregation. Using turbidimetric, spectroscopic, and microscopic methods, we demonstrate that protein aggregation inhibition is dependent on gelator concentration. Moreover, we have found that the protein is still functionally active in the hydrogel.
journal_name
Mol Pharmjournal_title
Molecular pharmaceuticsauthors
Johnson L,Faidra Angelerou MG,Surikutchi BT,Allen S,Zelzer M,Marlow Mdoi
10.1021/acs.molpharmaceut.8b01013subject
Has Abstractpub_date
2019-01-07 00:00:00pages
462-467issue
1eissn
1543-8384issn
1543-8392journal_volume
16pub_type
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