Abstract:
:The advent of RNA-sequencing and microarray technologies has led to rapid growth of transcriptome data generated for a wide range of organisms, under various cellular, organ and individual conditions. Since the number of possible combinations of intercellular and extracellular conditions is almost unlimited, cataloging all transcriptome conditions would be an immeasurable challenge. Gene coexpression refers to the similarity of gene expression patterns under various conditions, such as disease states, tissue types, and developmental stages. Since the quality of gene coexpression data depends on the quality and quantity of transcriptome data, timely usage of the growing data is key to promoting individual research in molecular biology. COXPRESdb (http://coxpresdb.jp) is a database providing coexpression information for 11 animal species. One characteristic feature of COXPRESdb is its ability to compare multiple coexpression data derived from different transcriptomics technologies and different species, which strongly reduces false positive relationships in individual gene coexpression data. Here, we summarized the current version of this database, including 23 coexpression platforms with the highest-level quality till date. Using various functionalities in COXPRESdb, the new coexpression data would support a broader area of research from molecular biology to medical sciences.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Obayashi T,Kagaya Y,Aoki Y,Tadaka S,Kinoshita Kdoi
10.1093/nar/gky1155subject
Has Abstractpub_date
2019-01-08 00:00:00pages
D55-D62issue
D1eissn
0305-1048issn
1362-4962pii
5193330journal_volume
47pub_type
杂志文章abstract::Mutant AraC proteins were selected for their ability to induce but not to repress, or their ability to repress but not to induce the araBAD operon. One such unusual mutant is able to bind to the araI site with an affinity only two to three-fold weaker than the wild type AraC protein, but the mutant protein was shown, ...
journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/13.14.5019
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abstract::Here we examined the role of cellular vitamin C in genotoxicity of carcinogenic chromium(VI) that requires reduction to induce DNA damage. In the presence of ascorbate (Asc), low 0.2-2 microM doses of Cr(VI) caused 10-15 times more chromosomal breakage in primary human bronchial epithelial cells or lung fibroblasts. D...
journal_title:Nucleic acids research
pub_type: 杂志文章
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
pub_type: 杂志文章
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journal_title:Nucleic acids research
pub_type: 杂志文章
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
pub_type: 杂志文章,评审
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更新日期:2021-01-08 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
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journal_title:Nucleic acids research
pub_type: 杂志文章
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/gkn292
更新日期:2008-07-01 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/gkf385
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/gkm938
更新日期:2008-01-01 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
pub_type: 杂志文章
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journal_title:Nucleic acids research
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