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Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration.

Abstract：

Purpose:To evaluate and correlate the functional treatment response using microperimetry (MP3) with the morphological findings on optical coherence tomography angiography (OCTA) in wet AMD pre- and post-treatment with anti-vascular endothelial growth factor (VEGF). This was a single-centre prospective, interventional study. Methods:Patients with wet AMD were treated with 3 injections of intravitreal anti-VEGF at monthly intervals for 3 months and followed at 1, 2, 3, and 6 months postinjection. Using "overlay" features, morphologic characteristics of OCTA at the site of choroidal neovascular membrane (CNVM) lesion were analyzed and correlated functionally with MP3. Data were collected including visual acuity at presentation and follow-up with multimodal imaging features, treatment details, complications (if any), and treatment given for that complication. Descriptive observational analysis and paired t-test was used to compare the appearance of the neovascular network on OCTA imaging with retinal sensitivity on MP3. Results:OCTA in the pretreatment phase revealed CNVM as an abnormal vascular network arising from the choroid and invading the subretinal space. On MP3, decreased retinal sensitivity was observed corresponding to the area of CNVM. Post-treatment, OCTA revealed reduction in abnormal vascular network in 51 (91.07%) eyes that correlated with increased retinal sensitivity at the corresponding area on MP3. Statistical analysis showed baseline mean retinal sensitivity at the site of CNVM as 320.07 dB, which improved to 521.53 and 730.20 dB at 1 and 3 months postinjection follow-up, respectively. Conclusion:Combining the findings of OCTA and MP3 using "overlay" features gives us precise information of structure-function correlation at presentation and also in response to treatment. It also helps to improve patient's compliance, confidence to treatment, and their understanding of the disease process as well.

journal_name

Indian J Ophthalmol

journal_title

Indian journal of ophthalmology

authors

Nagpal M,Khandelwal J,Juneja R,Mehrotra N

doi

10.4103/ijo.IJO_866_18

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

1790-1795

issue

eissn

0301-4738

issn

1998-3689

pii

IndianJOphthalmol_2018_66_12_1790_245643

journal_volume

pub_type

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Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration.