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NATURE文献大全abstract::The optics of the eye cause different wavelengths of light to be differentially focused at the retina. This phenomenon is due to longitudinal chromatic aberration, a wavelength-dependent change in refractive power. Retinal image quality may consequently vary for the different classes of cone photoreceptors, cells tune...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/417174a
更新日期:2002-05-09 00:00:00
abstract::Deaf children whose access to usable conventional linguistic input, signed or spoken, is severely limited nevertheless use gesture to communicate. These gestures resemble natural language in that they are structured at the level both of sentence and of word. Although the inclination to use gesture may be traceable to ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/34646
更新日期:1998-01-15 00:00:00
abstract::Spacecraft observations show that the presence of lightning activity is not confined to the terrestrial atmosphere, but is also found in the atmospheres of Venus, Jupiter and Saturn. Lightning activity may also occur in Titan's thick atmosphere. Calculations show that lightning produces a significant fraction of the...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/328509a0
更新日期:1987-08-06 00:00:00
abstract::A steady electric field of 30 mV across a single embryonic muscle cell produces accumulation of acetylcholine receptors toward one pole of the cell within 1 h. The movement is electrophoretic in nature and the accumulation results in the formation of stable, metabolically independent receptor aggregates. ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/275031a0
更新日期:1978-09-07 00:00:00
abstract::Seismological observations have revealed the existence of low-velocity and high-attenuation zones above the discontinuity at 410 km depth, at the base of the Earth's upper mantle. It has been suggested that a small amount of melt could be responsible for such anomalies. The density of silicate melt under dry condition...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature04352
更新日期:2006-01-12 00:00:00
abstract::The formation of condensed (compacted) protein phases is associated with a wide range of human disorders, such as eye cataracts, amyotrophic lateral sclerosis, sickle cell anaemia and Alzheimer's disease. However, condensed protein phases have their uses: as crystals, they are harnessed by structural biologists to elu...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature25971
更新日期:2018-04-04 00:00:00
abstract::The primary action of a family of mitogens including bombesin, bradykinin, vasopressin and alpha-thrombin is to activate the hydrolysis of polyphosphoinositides. Hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by phospholipase C is mediated through coupling of surface receptors to a GTP-binding pro...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/326800a0
更新日期:1987-04-23 00:00:00
abstract::The recent discoveries of RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. RNA interference has been used as a research tool to control the expression of specific genes in numerous experimental organisms and has potential as a therapeutic strategy to reduce ...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature02872
更新日期:2004-09-16 00:00:00
abstract::MicroRNAs (miRNAs) mediate post-transcriptional gene regulation through association with Argonaute proteins (AGOs). Crystal structures of archaeal and bacterial homologues of AGOs have shown that the MID (middle) domain mediates the interaction with the phosphorylated 5' end of the miRNA guide strand and this interact...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09039
更新日期:2010-06-10 00:00:00
abstract::In the absence of a firm link between individual meteorites and their asteroidal parent bodies, asteroids are typically characterized only by their light reflection properties, and grouped accordingly into classes. On 6 October 2008, a small asteroid was discovered with a flat reflectance spectrum in the 554-995 nm wa...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature07920
更新日期:2009-03-26 00:00:00
abstract::A non-discriminatory base analogue, or universal base, would be an invaluable component of oligonucleotide probes and primers for solving the design problems that arise as a result of the degeneracy of the genetic code, or when only fragmentary peptide sequence data are available. We have designed an alternative to pr...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/369492a0
更新日期:1994-06-09 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 评论,新闻
doi:10.1038/d41586-018-07165-8
更新日期:2018-11-01 00:00:00
abstract::Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing arachidonic acid release from phospholipids rather than inhibiting the cyclooxygenase. As in other cells, this steroid action depends on receptor occupation and de novo protein/RNA biosynthesis. We have previously shown in guinea p...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/287147a0
更新日期:1980-09-11 00:00:00
abstract::The cloning and characterization of 'clock gene' families has advanced our understanding of the molecular control of the mammalian circadian clock. We have analysed the human genome for additional relatives, and identified new candidate genes that may expand our knowledge of the molecular workings of the circadian clo...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/35057006
更新日期:2001-02-15 00:00:00
abstract::In this Letter, Supplementary Fig. 1 was missing. This error has been corrected online. ...
journal_title:Nature
pub_type: 已发布勘误
doi:10.1038/s41586-019-1207-2
更新日期:2019-05-01 00:00:00
abstract::Muscarinic receptors of cardiac pacemaker and atrial cells are linked to a potassium channel (IK.ACh) by a pertussis toxin-sensitive GTP-binding protein. The dissociation of G-proteins leads to the generation of two potential transducing elements, alpha-GTP and beta gamma. IK.ACh is activated by G-protein alpha- and b...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/337557a0
更新日期:1989-02-09 00:00:00
abstract::Calcium-dependent protease (calcium protease) is apparently involved in a variety of cellular processes. Here we have attempted to clarify the role and regulatory mechanism of calcium protease by analysing its structure. The complete primary structure of calcium protease (relative molecular mass (Mr) 80,000 (80K), 705...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/312566a0
更新日期:1984-12-06 00:00:00
abstract::The TE1 family of transposable elements (TEs) of Drosophila consists of unusually large transposons, cytologically visible in larval polytene chromosomes as one or more bands. They are composite elements, as their termini consist of foldback (FB) sequences which are themselves transposable. The location of FB elements...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/316081a0
更新日期:1985-07-04 00:00:00
abstract::Mammalian neurons contain at least three types of excitatory amino-acid receptors, selectively activated by N-methyl-D-aspartate (NMDA) or aspartate, (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate ((S)-AMPA) and kainate. An important aspect of NMDA receptors is their regulation by a variety of factors such...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/345347a0
更新日期:1990-05-24 00:00:00
abstract::Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the comple...
journal_title:Nature
pub_type: 杂志文章,评审
doi:10.1038/nature05813
更新日期:2007-04-26 00:00:00
abstract::The kinesin superfamily is a class of microtubule-based mechano-enzymes involved in intracellular transport and chromosome movements. Molecules that move towards either the plus end or the minus end of microtubules are represented within the family. The motor domains of these molecules exhibit considerable sequence ho...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/376271a0
更新日期:1995-07-20 00:00:00
abstract::The most severe excursions in the Earth's climatic history are thought to be associated with Proterozoic glaciations. According to the 'Snowball Earth' hypothesis, the Marinoan glaciation, which ended about 635 million years ago, involved global or nearly global ice cover. At the termination of this glacial period, ra...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature03176
更新日期:2005-01-13 00:00:00
abstract::Contraction of cardiac muscle depends on a transient rise of intracellular calcium concentration ([Ca2+]i) which is initiated by the action potential. It has, however, also been suggested that [Ca2+]i can fluctuate in the absence of changes in membrane potential. The evidence for this is indirect and comes from observ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/304735a0
更新日期:1983-08-25 00:00:00
abstract::C-type (Ca(2+)-dependent) animal lectins such as mannose-binding proteins mediate many cell-surface carbohydrate-recognition events. The crystal structure at 1.7 A resolution of the carbohydrate-recognition domain of rat mannose-binding protein complexed with an oligomannose asparaginyl-oligosaccharide reveals that Ca...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/360127a0
更新日期:1992-11-12 00:00:00
abstract::CYCLINS are proteins synthesized during each cell cycle and abruptly destroyed in each mitosis. Cyclins have been implicated in the induction of mitosis and are associated with the serine-threonine protein kinase p34cdc2 as components of mitosis promoting factor (MPF). On the basis of conserved sequence motifs cyclins...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/346760a0
更新日期:1990-08-23 00:00:00
abstract:: ...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/d41586-018-07642-0
更新日期:2018-12-01 00:00:00
abstract::The TGF-beta/activin/BMP cytokine family signals through serine/threonine kinase receptors, but how the receptors transduce the signal is unknown. The Mad (Mothers against decapentaplegic) gene from Drosophila and the related Sma genes from Caenorhabditis elegans have been genetically implicated in signalling by membe...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/381620a0
更新日期:1996-06-13 00:00:00
abstract::Drosophila melanogaster is one of the most well studied genetic model organisms; nonetheless, its genome still contains unannotated coding and non-coding genes, transcripts, exons and RNA editing sites. Full discovery and annotation are pre-requisites for understanding how the regulation of transcription, splicing and...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature09715
更新日期:2011-03-24 00:00:00
abstract::The Ca2+ + Mg2+-activated ATPase of the sarcoplasmic reticulum is responsible for the active Ca2+ transport of this membrane system, the key feature of which is the formation of an energy-rich phosphorylated transport enzyme (EP) and its conversion. To understand the Ca2+-transport mechanism, it is essential to clarif...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/290271a0
更新日期:1981-03-19 00:00:00
abstract::Phelan-McDermid syndrome (PMDS) is a complex neurodevelopmental disorder characterized by global developmental delay, severely impaired speech, intellectual disability, and an increased risk of autism spectrum disorders (ASDs). PMDS is caused by heterozygous deletions of chromosome 22q13.3. Among the genes in the dele...
journal_title:Nature
pub_type: 杂志文章
doi:10.1038/nature12618
更新日期:2013-11-14 00:00:00