当前位置： SCI文献检索 > JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY期刊下所有文献 > Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors.

Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors.

Abstract：

:HGF/c-Met signalling pathway plays an important role in the development of cancers. A series of 6,7-dimethoxy-4-anilinoquinolines possessing benzimidazole moiety were synthesised and identified as potent inhibitors of the tyrosine kinase c-Met. Their in vitro biological activities against three cancer cell lines (A549, MCF-7, and MKN-45) were also evaluated. Most of these compounds exhibited moderate to remarkable potency. Among them, compound 12n showed the most potent inhibitory activity against c-Met with IC50 value of 0.030 ± 0.008 µM and it also showed excellent anticancer activity against the tested cancer cell lines at low micromolar concentration. Molecular docking verified the results and revealed the possible binding mode of the most promising compound 12n into the ATP-binding site of c-Met kinase.

journal_name

J Enzyme Inhib Med Chem

journal_title

Journal of enzyme inhibition and medicinal chemistry

authors

Zhang QW,Ye ZD,Shen C,Tie HX,Wang L,Shi L

doi

10.1080/14756366.2018.1533822

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

124-133

issue

1

eissn

1475-6366

issn

1475-6374

journal_volume

34

pub_type

杂志文章

相关文献

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY文献大全
  • Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents.

    abstract：:An array of novel spiro imidazolidine derivatives was synthesized in dry media and was screened for their anti-microbial activities. Structure-activity relationship results revealed that compounds 22, 23 against P.aeruginosa, 24 against S.aureus, 24, 25 against K.pneumonia, 27 against S.aureus, β-H.streptococcus, 29 a...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2010.503611

    authors： Kanagarajan V,Thanusu J,Gopalakrishnan M

    更新日期：2011-04-01 00:00:00

  • N-Pyridinyl(methyl)-indole-1- or 3-propanamides and propenamides acting as topical and systemic inflammation inhibitors.

    abstract：:In this study, the synthetic way to new N-pyridinyl(methyl)indolylpropanamides acting as non acidic NSAIDs has been described. Pharmacomodulation was carried out at N(1) and C(5) of the indole ring and at the level of the propanamide chain. N(3)-pyridinylmethyl-[1(4-chlorobenzyl-5-chloroindol-3-yl)propanamide represen...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360802208251

    authors： Dassonville A,Lardic M,Breteche A,Nourrisson MR,Le Baut G,Grimaud N,Petit JY,Duflos M

    更新日期：2008-10-01 00:00:00

  • Synthesis, activity and mechanism of alkoxy-, carbamato-, sulfonamido-, thioureido-, and ureido-derivatives of 2,4,5-trimethylpyridin-3-ol against inflammatory bowel disease.

    abstract：:Inflammatory bowel disease (IBD) is a chronic immuno-inflammation in gastrointestinal tract. We have evaluated the activity of the compounds to inhibit the adhesion of monocytes to colon epithelial cells is triggered by a pro-inflammatory cytokine, tumour necrosis factor (TNF)-α. The in vitro activity of the compounds...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756366.2019.1677637

    authors： Chaudhary CL,Gurung P,Jang S,Banskota S,Nam TG,Kim JA,Jeong BS

    更新日期：2020-12-01 00:00:00

  • Design and synthesis of pyridazinone-substituted benzenesulphonylurea derivatives as anti-hyperglycaemic agents and inhibitors of aldose reductase - an enzyme embroiled in diabetic complications.

    abstract：:Thirty new aryl-pyridazinone-substituted benzenesulphonylurea derivatives (I-XXX) were synthesized and evaluated for their anti-hyperglycaemic activity in glucose-fed hyperglycaemic normal rats. Twenty-three compounds (III-XI, XIV-XVII, XIX-XXIV, XXVI and XXVIII-XXX) showed more or comparable area under the curve (AUC...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2016.1142986

    authors： Yaseen R,Pushpalatha H,Reddy GB,Ismael A,Ahmed A,Dheyaa A,Ovais S,Rathore P,Samim M,Akthar M,Sharma K,Shafi S,Singh S,Javed K

    更新日期：2016-12-01 00:00:00

  • Relative binding affinity of novel steroids to androgen receptors in hamster prostate.

    abstract：:The in vivo and in vitro antiandrogenic activity of four aromatic esters 10a-10d, one aliphatic ester 10e based on the pregna-4,16-diene-6, 20-dione structure and two aromatic 17c, 17d and two aliphatic valeroyloxy esters 17a, 17b based on the more saturated 4-pregnene-6,20-dione skeleton was examined. The biological ...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360500148924

    authors： Cabeza M,Heuze I,Sánchez M,Bratoeff E,Ramírez E,Rojas A,Orozco A,Mungía A,Agustín G,Cuatepotzo L,Gonzalez C,Palma S,Padilla D,Perez V,Jimenez G

    更新日期：2005-08-01 00:00:00

  • (Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies.

    abstract：:Several (thiazol-2-yl)hydrazone derivatives from 2-, 3- and 4-acetylpyridine were synthesized and tested against human monoamine oxidase (hMAO) A and B enzymes. Most of them had an inhibitory effect in the low micromolar/high nanomolar range, being derivatives of 4-acetylpyridine selective hMAO-B inhibitors also at lo...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2014.987138

    authors： D'Ascenzio M,Chimenti P,Gidaro MC,De Monte C,De Vita D,Granese A,Scipione L,Di Santo R,Costa G,Alcaro S,Yáñez M,Carradori S

    更新日期：2015-12-01 00:00:00

  • In vitro and in vivo trypanocidal activity of the ethyl esters of N-allyl and N-propyl oxamates using different Trypanosoma cruzi strains.

    abstract：:The trypanocidal activity of N-allyl (NAOx) and N-propyl (NPOx) oxamates and that of the ethyl esters ofN-allyl (Et-NAOx) and N-propyl (Et-NPOx) oxamates were tested on cultured epimastigotes (in vitro) and murine trypanosomiasis (in vivo) using five different T. cruzi strains. NAOx and NPOx did not penetrate intact e...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360601051233

    authors： Aguirre-Alvarado C,Zaragoza-Martínez F,Rodríguez-Páez L,Nogueda B,Baeza I,Wong C

    更新日期：2007-04-01 00:00:00

  • Inhibitors of type 1 17beta-hydroxysteroid dehydrogenase with reduced estrogenic activity: modifications of the positions 3 and 6 of estradiol.

    abstract：:Breast cancer is the second most frequent cancer affecting women. Among all endocrine therapies for the treatment of breast cancer, inhibition of estrogen biosynthesis is becoming an interesting complementary approach to the use of antiestrogens. The enzyme type 1 17beta-hydroxysteroid dehydrogenase (17beta-HSD) plays...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360500043307

    authors： Tremblay MR,Boivin RP,Luu-The V,Poirier D

    更新日期：2005-04-01 00:00:00

  • A comparison of the reactivating efficacy of a novel bispyridinium oxime K203 with currently available oximes in VX agent-poisoned rats.

    abstract：:The ability of a novel bispyridinium oxime K203 to reactivate VX agent-inhibited acetylcholinesterase was compared with the reactivating efficacy of four commonly used oximes (obidoxime, trimedoxime, methoxime, HI-6) using in vivo model. Our results showed that the reactivating efficacy of the oxime HI-6 is higher tha...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2012.681652

    authors： Kassa J,Zdarova Karasova J,Sepsova V

    更新日期：2013-08-01 00:00:00

  • CD26/DPPIV cell membrane expression and DPPIV activity in plasma of patients with acute leukemia.

    abstract：:CD26/DPPIV (dipeptidil peptidase IV) displays an array of diverse functional properties, with a role in the development of several human cancers. This enzyme is found mainly anchored in the membrane of cells although it also has an enzymatically active plasma isoform. The regulation of biological activities of cytokin...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360802334800

    authors： de Andrade CF,Bigni R,Pombo-de-Oliveira MS,Alves G,Pereira DA

    更新日期：2009-06-01 00:00:00

  • Antioxidant phenylpropanoid glycosides from Buddleja davidii.

    abstract：:Phytochemical investigations on the n-BuOH-soluble fraction of the whole plant of Buddleja davidii led to the isolation of the phenylpropanoid glycosides 1-10. Their structures were determined by 1D and 2D NMR spectroscopic techniques. All the compounds showed potent antioxidative activity in three different tests, wi...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360802565072

    authors： Ahmad I,Ahmad N,Wang F

    更新日期：2009-08-01 00:00:00

  • Antioxidant properties of benzylchroman derivatives from Caesalpinia sappan L. against oxidative stress evaluated in vitro.

    abstract：:The antioxidant activity of extracts from Caesalpinia sappan L. (CSL) was studied in vitro by evaluating the total phenolics, measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) and on reactive nitrogen species (RNS), and measuring the inhibitory effect on Cu(2...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章,收录出版

    doi：10.3109/14756360903373376

    authors： Lee MJ,Lee HS,Kim H,Yi HS,Park SD,Moon HI,Park WH

    更新日期：2010-10-01 00:00:00

  • Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding.

    abstract：:In order to understand the binding modes of human DNA polymerase alpha (pol alpha) inhibitors on a molecular level, a 3D homology model of the active site of the enzyme was proposed based on the application of molecular modelling methods and molecular dynamic simulations using available crystal coordinates of pol alph...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360701433414

    authors： Richartz A,Höltje M,Brandt B,Schäfer-Korting M,Höltje HD

    更新日期：2008-02-01 00:00:00

  • Prediction of caspase-3 inhibitory activity of 1,3-dioxo-4-methyl-2,3-dihydro-1h-pyrrolo[3,4-c] quinolines: QSAR study.

    abstract：:Neurodegenerative disorders are consequences of progressive and irreversible loss of neurons due to unwanted apoptosis which involves caspases, a group of cysteine proteases that cleave other proteins and inactivate them. Among several different groups of caspase enzymes, caspases-3 plays a key role in apoptosis and a...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360701652476

    authors： Sharma S,Ravichandran V,Jain PK,Mourya VK,Agrawal RK

    更新日期：2008-06-01 00:00:00

  • Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells.

    abstract：:Novel 3(2H)-pyridazinone derivatives were designed, synthesised in satisfactory yields and evaluated in different experimental assays to assess their preliminary toxicity in vivo and anti-proliferative effects against HCT116 cell lines in vitro. Artemia salina lethality test provided LC50 values >100 µg/mL for all com...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756366.2020.1755670

    authors： Özdemir Z,Utku S,Mathew B,Carradori S,Orlando G,Di Simone S,Alagöz MA,Özçelik AB,Uysal M,Ferrante C

    更新日期：2020-12-01 00:00:00

  • Multicomponent synthesis of some new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro anti-proliferative activity against CaSki, MDA-MB-231 and SK-Lu-1 tumour cells as apoptosis inducing agents without necrosis.

    abstract：:Identification of a new class of antitumor agent capable to induce apoptosis without triggering necrotic cell death event is challenging. The present communication describes the multicomponent synthesis of seven new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro antiproliferative activity o...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756366.2017.1363197

    authors： Laskar S,Sánchez-Sánchez L,López-Ortiz M,López-Muñoz H,Escobar-Sánchez ML,Sánchez AT,Regla I

    更新日期：2017-12-01 00:00:00

  • Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2.

    abstract：:This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH₃)₂Cl₂, and [Pt(dach)Cl₂] on the activity of porcine pancreatic phospholipase A₂ (PLA₂). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The resu...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2012.666539

    authors： Radisavljević M,Kamčeva T,Bugarčić ŽD,Petković M

    更新日期：2013-08-01 00:00:00

  • Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis.

    abstract：:We report the biochemical and structural characterisation of a beta-carbonic anhydrase (β-CA) from Trichomonas vaginalis, a unicellular parasite responsible for one of the world's leading sexually transmitted infections, trichomoniasis. CAs are ubiquitous metalloenzymes belonging to eight evolutionarily divergent grou...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756366.2020.1774572

    authors： Urbański LJ,Di Fiore A,Azizi L,Hytönen VP,Kuuslahti M,Buonanno M,Monti SM,Angeli A,Zolfaghari Emameh R,Supuran CT,De Simone G,Parkkila S

    更新日期：2020-12-01 00:00:00

  • Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

    abstract：:Photodynamic molecules represent an alternative approach for cancer therapy for their property (i) to be photo-reactive; (ii) to be not-toxic for target cells in absence of light; (iii) to accumulate specifically into tumour tissues; (iv) to be activable by a light beam only at the tumour site and (v) to exert cytotox...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章,评审

    doi：10.1080/14756366.2017.1335310

    authors： Kusuzaki K,Matsubara T,Murata H,Logozzi M,Iessi E,Di Raimo R,Carta F,Supuran CT,Fais S

    更新日期：2017-12-01 00:00:00

  • 3-methyl-2-phenyl-1-substituted-indole derivatives as indomethacin analogs: design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents.

    abstract：:In a new group of 3-methyl-2-phenyl-1-substituted-indole derivatives (10a-f), the indomethacin analogs were prepared via the Fisher indole synthesis reaction of propiophenone with appropriately substituted phenylhydrazine hydrochloride. This is followed by the insertion of the appropriate benzyl or benzoyl fragment. A...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2015.1022174

    authors： Abdellatif KR,Lamie PF,Omar HA

    更新日期：2016-01-01 00:00:00

  • Kinetic and docking studies of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with some hydroxylic compounds.

    abstract：:A series of hydroxylic compounds (1-10, NK-154 and NK-168) have been assayed for the inhibition of three physiologically relevant carbonic anhydrase isozymes, the cytosolic isozymes I, II and tumor-associated isozyme IX. The investigated compounds showed inhibition constants in the range of 0.068-4003, 0.012-9.9 and 0...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2015.1114930

    authors： Durdagi S,Korkmaz N,Işık S,Vullo D,Astley D,Ekinci D,Salmas RE,Senturk M,Supuran CT

    更新日期：2016-12-01 00:00:00

  • Tyrosinase inhibitory activities of the compounds isolated from Neolitsea aciculata (Blume) Koidz.

    abstract：:This study was designed to investigate the mushroom tyrosinase inhibitory activity for the constituents isolated from Neolitsea aciculata. The stems of N. aciculata was extracted with aqueous ethanol and subjected to chromatographic separation, which led to the isolation of 11 compounds: methyl linoleate (1), catechin...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2012.670806

    authors： Kim SS,Hyun CG,Choi YH,Lee NH

    更新日期：2013-08-01 00:00:00

  • Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers.

    abstract：:A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six compounds demonstrated excellent inhibition activity against EGFRWT ...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756366.2018.1518957

    authors： Wang C,Xu S,Peng L,Zhang B,Zhang H,Hu Y,Zheng P,Zhu W

    更新日期：2019-12-01 00:00:00

  • Carbonic anhydrase inhibitors: guaiacol and catechol derivatives effectively inhibit certain human carbonic anhydrase isoenzymes (hCA I, II, IX and XII).

    abstract：:Carbonic anhydrases (CAs) are widespread metalloenzymes in higher vertebrates including humans. A series of phenolic compounds, including guaiacol, 4-methylguaiacol, 4-propylguaiacol, eugenol, isoeugenol, vanillin, syringaldehyde, catechol, 3-methyl catechol, 4-methyl catechol and 3-methoxy catechol were investigated ...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.3109/14756366.2014.956310

    authors： Scozzafava A,Passaponti M,Supuran CT,Gülçin İ

    更新日期：2015-01-01 00:00:00

  • Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial evaluation.

    abstract：:A series of azatricyclodiones and octahydro-benzo[f]isoindoles have been synthesized by (4+2) Diels-Alder cycloaddition of maleimides with furfuryl amine. Reaction of azatricyclodiones with isocyanates led to the respective ureides. All of the compounds were screened against a number of bacteria and fungi. One of the ...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360701709383

    authors： Saxena N,Singh NT,Mishra M,Keshava GB,Shukla PK,Tripathi RP

    更新日期：2008-08-01 00:00:00

  • Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1.

    abstract：:The inhibitory effects of 13-epimeric estrones, D-secooxime and D-secoalcohol estrone compounds on human placental 17β-hydroxysteroid dehydrogenase type 1 isozyme (17β-HSD1) were investigated. The transformation of estrone to 17β-estradiol was studied by an in vitro radiosubstrate incubation method. 13α-Estrone inhibi...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756366.2016.1204610

    authors： Herman BE,Szabó J,Bacsa I,Wölfling J,Schneider G,Bálint M,Hetényi C,Mernyák E,Szécsi M

    更新日期：2016-01-01 00:00:00

  • Measurement of antioxidant ability of melatonin and serotonin by the DMPD and CUPRAC methods as trolox equivalent.

    abstract：:Melatonin (N-acetyl-5-methoxytryptamine) is the chief secretory product of the pineal gland and synthesized enzymatically from serotonin (5-hydroxytryptamine). These indoleamine derivatives play an important role in the prevention of oxidative damage. In the present study, DMPD radical scavenging and cupric ion (Cu(2+...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360701626223

    authors： Gulçin I

    更新日期：2008-12-01 00:00:00

  • Synthesis and biological evaluation of some new N(4)-substituted isatin-3-thiosemicarbazones.

    abstract：:A new series of 12 N(4)-substituted isatin-3-thiosemicarbazones 2a-l has been synthesized, characterized and screened for in vitro cytotoxic, phytotoxic and urease inhibitory effects. All the compounds proved to be active in the brine shrimp bioassay; 2a, 2b, 2d, 2f and 2h-l exhibited a high degree of cytotoxic activi...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360802188420

    authors： Pervez H,Chohan ZH,Ramzan M,Nasim FU,Khan KM

    更新日期：2009-04-01 00:00:00

  • Carbonic anhydrase inhibitors: aliphatic N-phosphorylated sulfamates--a novel zinc-anchoring group leading to nanomolar inhibitors.

    abstract：:A small library of phosphorylated sulfamates (N-(O-alkylsulfamoyl)-phosphoramidic acids) incorporating long aliphatic chains (C8-C16) has been synthesized and investigated for their interaction with two physiologically relevant carbonic anhydrase (CA) isozymes. These compounds behaved as very potent inhibitors of both...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360410001689522

    authors： Bonnac L,Innocenti A,Winum JY,Casini A,Montero JL,Scozzafava A,Barragan V,Supuran CT

    更新日期：2004-06-01 00:00:00

  • Effects of hydroxybenzyl alcohols on melanogenesis in melanocyte-keratinocyte co-culture and monolayer culture of melanocytes.

    abstract：:In mammalian skin, melanocyte proliferation and melanogenesis can be stimulated by keratinocytes, fibroblasts and other regulatory factors. To determine whether hydroxybenzyl alcohols (HBAs) show more inhibitory in melanocytes cultured alone or in melanocytes co-cultured with keratinocytes, we developed a murine melan...

    journal_title：Journal of enzyme inhibition and medicinal chemistry

    pub_type： 杂志文章

    doi：10.1080/14756360701654894

    authors： Liu SH,Chu IM,Pan IH

    更新日期：2008-08-01 00:00:00