TRPM2 activation: Paradigm shifted?

abstract：:The release of Ca2+ ions from the sarcoplasmic reticulum through ryanodine receptor calcium release channels represents the critical step linking electrical excitation to muscular contraction in the heart and skeletal muscle (excitation-contraction coupling). Two small Ca2+ binding proteins, S100A1 and calmodulin, hav...

journal_title：Cell calcium

authors： Prosser BL,Hernández-Ochoa EO,Schneider MF

更新日期：2011-10-01 00:00:00

abstract：:To characterize the effect that a phosphatidylinositol 3-kinase (PI3-kinase) inhibitor, LY294002, has on cytosolic calcium concentrations ([Ca2+]i), bovine airway smooth muscle cells (BASMC) and cultured human bronchial smooth muscle cells (HBSMC) were loaded with fura 2-AM, imaged as single cells and [Ca2+]i measured...

journal_title：Cell calcium

authors： Ethier MF,Madison JM

更新日期：2002-07-01 00:00:00

abstract：:The mammalian ryanodine receptor Ca2+ release channel (RyR) has a single conserved high affinity calmodulin (CaM) binding domain. However, the skeletal muscle RyR1 is activated and cardiac muscle RyR2 is inhibited by CaM at submicromolar Ca2+. This suggests isoform-specific domains are involved in RyR regulation by Ca...

journal_title：Cell calcium

authors： Xu L,Gomez AC,Pasek DA,Meissner G,Yamaguchi N

更新日期：2017-09-01 00:00:00

abstract：:Using whole cell patch clamp recordings on unfertilized eggs of the ascidian Ciona intestinalis, we are able to detect ryanodine receptors within the oocytes. Our approach is based on measurements of the voltage-activated inward calcium currents. Two types of Ca2+ currents have been described on the oocyte membrane of...

journal_title：Cell calcium

authors： Arnoult C,Albrieux M,Antoine AF,Grunwald D,Marty I,Villaz M

更新日期：1997-02-01 00:00:00

abstract：:Low-voltage-activated T-type calcium channels are expressed in various tissues, especially in the brain, where they promote neuronal firing and are involved in slow wave sleep and absence epilepsy. While the transduction pathways by which hormones and neurotransmitters modulate high-voltage-activated calcium channels ...

journal_title：Cell calcium

authors： Chemin J,Traboulsie A,Lory P

更新日期：2006-08-01 00:00:00

abstract：:Dynamic nuclear Ca(2+) signals play pivotal roles in diverse cellular functions including gene transcription, cell growth, differentiation, and apoptosis. Here we report a novel nuclear Ca(2+) regulatory mechanism mediated by inositol 1,4,5-trisphosphate receptors (IP(3)Rs) around the nucleus in developing cardiac myo...

journal_title：Cell calcium

authors： Luo D,Yang D,Lan X,Li K,Li X,Chen J,Zhang Y,Xiao RP,Han Q,Cheng H

更新日期：2008-02-01 00:00:00

abstract：:Atypical absence epilepsy (AAE) is an intractable disorder characterized by slow spike-and-wave discharges in electroencephalograms (EEGs) and accompanied by severe cognitive dysfunction and neurodevelopmental or neurological deficits in humans. Administration of the cholesterol biosynthesis inhibitor AY-9944 (AY) dur...

journal_title：Cell calcium

authors： Jung S,Jeong Y,Jeon D

更新日期：2015-05-01 00:00:00

abstract：:Ca2+ signals are known to mediate an array of cellular functions including secretion, contraction, and conductivity changes. In spite of the obvious role of Ca2+ in signalling, the control of Ca2+ within cells is known to be a complex phenomenon involving a number of distinct active and passive transport systems funct...

journal_title：Cell calcium

authors： Gill DL,Ghosh TK,Mullaney JM

更新日期：1989-07-01 00:00:00

abstract：:NAADP has been shown to act as a second messenger in a wide range of systems from plants to mammalian cells. Although it had always been considered as a canonical second messenger, recent work has shown that it is also active when applied extracellularly. It has also been suggested that NAADP might have a direct actio...

journal_title：Cell calcium

authors： Billington RA,Genazzani AA

更新日期：2007-06-01 00:00:00

abstract：:We have found that the changes in calcium metabolism in rabbit neutrophils produced by the chemotactic synthetic peptide f-Met-Leu-Phe are not sensitive to the calcium chelator EGTA. The present results demonstrate unambiguously that the previously described chemotactic factor induced changes in 45Ca fluxes in rabbit ...

journal_title：Cell calcium

authors： Molski TF,Naccache PH,Sha'afi RI

更新日期：1983-02-01 00:00:00

abstract：:Studies were conducted to examine the possible involvement of Na+-Ca2+ exchanger in determining the magnitude of the endothelin-1 (ET-1)-receptor-mediated calcium signal in porcine lens epithelial cells. Cytoplasmic calcium concentration was measured in primary cultured cells loaded with Fura-2. ET-1 (100 nM) caused c...

journal_title：Cell calcium

authors： Okafor M,Tamiya S,Delamere NA

更新日期：2003-09-01 00:00:00

abstract：:Cooling can induce Ca(2+) signaling via activation of temperature-sensitive ion channels such as TRPM8, TRPA1 and ryanodine receptor channels. Here we have studied the mechanism of cooling-evoked Ca(2+) signaling in mouse olfactory ensheathing cells (OECs), a specialized type of glial cells in the olfactory nerve laye...

journal_title：Cell calcium

authors： Stavermann M,Buddrus K,St John JA,Ekberg JA,Nilius B,Deitmer JW,Lohr C

更新日期：2012-08-01 00:00:00

abstract：:Specific sequences (cis-acting elements) in the 3'-untranslated region (UTR) of RNA, together with stabilizing and destabilizing proteins (trans-acting factors), determine the mRNA stability, and consequently, the level of expression of several proteins. Such interactions were discovered initially for short-lived mRNA...

journal_title：Cell calcium

authors： Misquitta CM,Chen T,Grover AK

更新日期：2006-10-01 00:00:00

abstract：:Cytosolic Ca(2+) signals are fundamental for the early and late steps of myoblast differentiation and are, as in many cells, generated by Ca(2+) release from internal stores as well as by plasma membrane Ca(2+) entry. Our recent studies identified the store-operated Ca(2+) channels, Orai1 and TRPC1&C4, as crucial for ...

journal_title：Cell calcium

authors： Antigny F,Konig S,Bernheim L,Frieden M

更新日期：2014-12-01 00:00:00

abstract：:Capacitative calcium entry is a process whereby the depletion of Ca(2+) from intracellular stores (likely endoplasmic or sarcoplasmic reticulum) activates plasma membrane Ca(2+) channels. Current research has focused on identification of capacitative calcium entry channels and the mechanism by which Ca(2+) store deple...

journal_title：Cell calcium

authors： Putney JW Jr

更新日期：2003-10-01 00:00:00

abstract：:It has been reported that leukotriene B4 can translocate calcium across model membranes (Serhan et. al., (1982) J. Biol. Chem., 257: 4746). Such ionophoretic behavior could account for its biological effects. We have examined the effect of chromatographically pure leukotriene B4 on Ca2+ permeability when added exogeno...

journal_title：Cell calcium

authors： Holmes RP,Yoss NL,Marshall LA

更新日期：1987-12-01 00:00:00

abstract：:Cellular Ca2+ signals are often constrained to cytosolic micro- or nano-domains where stochastic openings of Ca2+ channels cause large fluctuations in local Ca2+ concentration (Ca2+ 'noise'). With the advent of TIRF microscopy to image the fluorescence of Ca2+-sensitive probes from attoliter volumes it has become poss...

journal_title：Cell calcium

authors： Swaminathan D,Dickinson GD,Demuro A,Parker I

更新日期：2020-03-01 00:00:00

abstract：:There is controversy as to whether TRP channels participate in mediating store-operated current (I(SOC)) and store-operated Ca(2+) entry (SOCE). Our recent study has demonstrated that TRPC1 forms heteromeric channels with TRPV4 in vascular endothelial cells and that Ca(2+) store depletion enhances the vesicle traffick...

journal_title：Cell calcium

authors： Ma X,Cheng KT,Wong CO,O'Neil RG,Birnbaumer L,Ambudkar IS,Yao X

更新日期：2011-12-01 00:00:00

abstract：:Calcium dependence of bleb formation and cell death was evaluated in rat hepatocytes following ATP depletion by metabolic inhibition with KCN and iodoacetate ('chemical hypoxia'). Cytosolic free Ca2+ was measured in single cells by ratio imaging of Fura-2 fluorescence using multiparameter digitized video microscopy. C...

journal_title：Cell calcium

authors： Nieminen AL,Gores GJ,Wray BE,Tanaka Y,Herman B,Lemasters JJ

更新日期：1988-12-01 00:00:00

abstract：:Removal of the epithelium from preparations of guinea-pig airways in vitro increases the responsiveness of the smooth muscle of normal and ovalbumin-sensitized animals to a number of contractile agents. To determine if epithelium removal results in an increase in Ca2+ entry into the smooth muscle, the effect of removi...

journal_title：Cell calcium

authors： Raeburn D,Hay DW,Fedan JS

更新日期：1987-12-01 00:00:00

abstract：:There is a close association of peripheral sarcoplasmic reticulum (SR), containing IP3 receptors, and regions of the plasma membrane enriched in the Na+/Ca2+ exchanger in smooth muscle. We have tested the possibility in rat uterine smooth muscle that Ca2+ released from the SR is preferentially removed from the cytosol...

journal_title：Cell calcium

authors： Taggart MJ,Wray S

更新日期：1997-11-01 00:00:00

abstract：:Cultured rat cerebellar astrocytes, loaded with the Ca2+-sensitive fluorescent dyes Fura-2 or Fluo-3, responded with cytoplasmic Ca2+ transients, when the external K+ concentration was reduced from 5 mM to below 1 mM. Ca2+ transients were generated after changing to a saline containing 0.2 mM K+ in 82% of the cells (n...

journal_title：Cell calcium

authors： Dallwig R,Vitten H,Deitmer JW

更新日期：2000-10-01 00:00:00

abstract：:Ryanodine receptors plays a crucial role in skeletal muscle excitation-contraction coupling by releasing calcium ions required for muscle contraction from the sarcoplasmic reticulum. At least three phenotypes associated with more than 100 RYR1 mutations have been identified; in order to elucidate possible pathophysiol...

journal_title：Cell calcium

authors： Ghassemi F,Vukcevic M,Xu L,Zhou H,Meissner G,Muntoni F,Jungbluth H,Zorzato F,Treves S

更新日期：2009-02-01 00:00:00

abstract：:The mechanisms that regulate ion and fluid transport by the human intrahepatic bile duct have not been well defined. Human intrahepatic biliary cell lines that we have developed were used to identify and characterize purinoceptors based on increases in intracellular calcium in response to ATP and other nucleotides. In...

journal_title：Cell calcium

authors： Wolkoff LI,Perrone RD,Grubman SA,Lee DW,Soltoff SP,Rogers LC,Beinborn M,Fang SL,Cheng SH,Jefferson DM

更新日期：1995-05-01 00:00:00

abstract：:The highly selective fluorescent Ca2+ indicator 'quin 2' has been loaded into ram and boar spermatozoa as the acetoxymethyl ester, 'quin 2/AM', which is hydrolysed and trapped in the cytoplasm. Loadings of several mM were not toxic to spermatozoa as judged by motility. Fluorescence measurements (mean +/- S.E.M.) indic...

journal_title：Cell calcium

authors： Simpson AM,White IG

更新日期：1988-02-01 00:00:00

abstract：:In the complex signalling interplay that allows extracellular signals to be decoded into activation of apoptotic cell death, Ca(2+) plays a significant role. This is supported not only by evidence linking alterations in Ca(2+) homeostasis to the triggering of apoptotic (and in some cases necrotic) cell death, but also...

journal_title：Cell calcium

authors： Ferrari D,Pinton P,Szabadkai G,Chami M,Campanella M,Pozzan T,Rizzuto R

更新日期：2002-11-01 00:00:00

abstract：:A characteristic feature of developing neural networks is spontaneous periodic activity. In the developing retina, retinal ganglion cells fire bursts of action potentials that drive large increases in intracellular calcium concentration with a periodicity of minutes. These periodic bursts of action potentials propagat...

journal_title：Cell calcium

authors： Firth SI,Wang CT,Feller MB

更新日期：2005-05-01 00:00:00

abstract：:NADH:ubiquinone oxidoreductase or complex I is a large multisubunit assembly of the mitochondrial inner membrane that channels high-energy electrons from metabolic NADH into the electron transport chain (ETC). Its dysfunction is associated with a range of progressive neurological disorders, often characterized by a ve...

journal_title：Cell calcium

authors： Willems PH,Valsecchi F,Distelmaier F,Verkaart S,Visch HJ,Smeitink JA,Koopman WJ

更新日期：2008-07-01 00:00:00

abstract：:To determine the effects of exposure to reserpine on subcellular Ca2+ transporting systems, active Ca2+ uptake was measured with and without ruthenium red in submandibular gland vesicles obtained from rats after chronic treatment with reserpine. The properties of ruthenium red-sensitive Ca2+ uptake were similar to tho...

journal_title：Cell calcium

authors： Hurley TW,Martinez JR

更新日期：1987-10-01 00:00:00

abstract：:An inward current responsible for hormone regulated Ca2+ entry has been identified in cultured rat hepatocytes using whole cell patch clamp. Addition of 20 nM vasopressin or of 100 microM ATP induced the inward current, which could be observed more clearly after blocking an outward K+ current. This large outward K+ cu...

journal_title：Cell calcium

authors： Duszynski J,Elensky M,Cheung JY,Tillotson DL,LaNoue KF

更新日期：1995-07-01 00:00:00