The initial deficiency of protein processing and flavonoids biosynthesis were the main mechanisms for the male sterility induced by SX-1 in Brassica napus.

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs that regulate genes at the post-transcriptional level in spatiotemporal manner. Several miRNAs are identified as prognostic and diagnostic markers in many human cancers. Estimation of the temporal activities of the miRNAs is an important step in the way to underst...

journal_title：BMC genomics

authors： Jayavelu ND,Bar N

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Microarray technology is limited to monitoring the expression of previously annotated genes that have corresponding probes on the array. Computationally annotated genes have not fully been validated, because ESTs and full-length cDNAs cannot cover entire transcribed regions. Here, mRNA-Seq (an Illumina cDNA ...

journal_title：BMC genomics

authors： Mizuno H,Kawahara Y,Sakai H,Kanamori H,Wakimoto H,Yamagata H,Oono Y,Wu J,Ikawa H,Itoh T,Matsumoto T

更新日期：2010-12-02 00:00:00

abstract：BACKGROUND:Epigenetic clocks have been recognized for their precise prediction of chronological age, age-related diseases, and all-cause mortality. Existing epigenetic clocks are based on CpGs from the Illumina HumanMethylation450 BeadChip (450 K) which has now been replaced by the latest platform, Illumina Methylation...

journal_title：BMC genomics

authors： Lee Y,Haftorn KL,Denault WRP,Nustad HE,Page CM,Lyle R,Lee-Ødegård S,Moen GH,Prasad RB,Groop LC,Sletner L,Sommer C,Magnus MC,Gjessing HK,Harris JR,Magnus P,Håberg SE,Jugessur A,Bohlin J

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Biologists need to perform complex queries, often across a variety of databases. Typically, each data resource provides an advanced query interface, each of which must be learnt by the biologist before they can begin to query them. Frequently, more than one data source is required and for high-throughput ana...

journal_title：BMC genomics

authors： Smedley D,Haider S,Ballester B,Holland R,London D,Thorisson G,Kasprzyk A

更新日期：2009-01-14 00:00:00

abstract：BACKGROUND:This paper presents a retrospective statistical study on the newly-released data set by the Stanley Neuropathology Consortium on gene expression in bipolar disorder and schizophrenia. This data set contains gene expression data as well as limited demographic and clinical data for each subject. Previous studi...

journal_title：BMC genomics

authors： Struyf J,Dobrin S,Page D

更新日期：2008-11-07 00:00:00

abstract：BACKGROUND:Second-generation sequencing technologies have revolutionized our ability to recover genetic information from the past, allowing the characterization of the first complete genomes from past individuals and extinct species. Recently, third generation Helicos sequencing platforms, which perform true Single-Mol...

journal_title：BMC genomics

authors： Ginolhac A,Vilstrup J,Stenderup J,Rasmussen M,Stiller M,Shapiro B,Zazula G,Froese D,Steinmann KE,Thompson JF,Al-Rasheid KA,Gilbert TM,Willerslev E,Orlando L

更新日期：2012-05-10 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provide new inf...

journal_title：BMC genomics

authors： Calligaris R,Banica M,Roncaglia P,Robotti E,Finaurini S,Vlachouli C,Antonutti L,Iorio F,Carissimo A,Cattaruzza T,Ceiner A,Lazarevic D,Cucca A,Pangher N,Marengo E,di Bernardo D,Pizzolato G,Gustincich S

更新日期：2015-10-28 00:00:00

abstract：BACKGROUND:To develop evolutionary models for the free living bacterium Alteromonas the genome sequences of isolates of the genus have been extensively analyzed. However, the main genetic exchange drivers in these microbes, conjugative elements (CEs), have not been considered in detail thus far. In this work, CEs have ...

journal_title：BMC genomics

authors： López-Pérez M,Ramon-Marco N,Rodriguez-Valera F

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Due to the predominant usage of short-read sequencing to date, most bacterial genome sequences reported in the last years remain at the draft level. This precludes certain types of analyses, such as the in-depth analysis of genome plasticity. RESULTS:Here we report the finalized genome sequence of the envir...

journal_title：BMC genomics

authors： Pfeiffer F,Zamora-Lagos MA,Blettinger M,Yeroslaviz A,Dahl A,Gruber S,Habermann BH

更新日期：2018-01-05 00:00:00

abstract：BACKGROUND:Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT). RESULTS:We analyzed the postnatal transformation of adipose in sheep with a time course study of the ...

journal_title：BMC genomics

authors： Basse AL,Dixen K,Yadav R,Tygesen MP,Qvortrup K,Kristiansen K,Quistorff B,Gupta R,Wang J,Hansen JB

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:The monophyly of flatfishes has not been supported in many molecular phylogenetic studies. The monophyly of Pleuronectoidei, which comprises all but one family of flatfishes, is broadly supported. However, the Psettodoidei, comprising the single family Psettodidae, is often found to be most closely related t...

journal_title：BMC genomics

authors： Shi W,Chen S,Kong X,Si L,Gong L,Zhang Y,Yu H

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Currently, diabetes has become one of the leading causes of death worldwide. Fasting plasma glucose (FPG) levels that are higher than optimal, even if below the diagnostic threshold of diabetes, can also lead to increased morbidity and mortality. Here we intend to study the magnitude of the genetic influence...

journal_title：BMC genomics

authors： Wang W,Zhang C,Liu H,Xu C,Duan H,Tian X,Zhang D

更新日期：2020-07-18 00:00:00

abstract：BACKGROUND:Accurate identification of synteny blocks is an important step in comparative genomics towards the understanding of genome architecture and expression. Most computer programs developed in the last decade for identifying synteny blocks have limitations. To address these limitations, we recently developed a ro...

journal_title：BMC genomics

authors： Vergara IA,Chen N

更新日期：2010-09-24 00:00:00

abstract：BACKGROUND:Plants respond to low temperature through an intricately coordinated transcriptional network. The CBF/DREB-regulated network of genes has been shown to play a prominent role in freeze-tolerance of Arabidopsis through the process of cold acclimation (CA). Recent evidence also showed that the CBF/DREB regulon ...

journal_title：BMC genomics

authors： Cheng C,Yun KY,Ressom HW,Mohanty B,Bajic VB,Jia Y,Yun SJ,de los Reyes BG

更新日期：2007-06-18 00:00:00

abstract：BACKGROUND:The European spruce bark beetle, Ips typographus, and the North American mountain pine beetle, Dendroctonus ponderosae (Coleoptera: Curculionidae: Scolytinae), are severe pests of coniferous forests. Both bark beetle species utilize aggregation pheromones to coordinate mass-attacks on host trees, while odora...

journal_title：BMC genomics

authors： Andersson MN,Grosse-Wilde E,Keeling CI,Bengtsson JM,Yuen MM,Li M,Hillbur Y,Bohlmann J,Hansson BS,Schlyter F

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:Malaria pathogenesis relies on sexual gametocyte forms of the malaria parasite to be transmitted between the infected human and the mosquito host but the molecular mechanisms controlling gametocytogenesis remains poorly understood. Here we provide a high-resolution transcriptome of Plasmodium falciparum as i...

journal_title：BMC genomics

authors： van Biljon R,van Wyk R,Painter HJ,Orchard L,Reader J,Niemand J,Llinás M,Birkholtz LM

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression implicated in multiple cellular processes. Cyclic stretch of alveoli is characteristic of mechanical ventilation, and is postulated to be partly responsible for the lung injury and inflammation in ventilator-induced lung injury. We pro...

journal_title：BMC genomics

authors： Yehya N,Yerrapureddy A,Tobias J,Margulies SS

更新日期：2012-04-26 00:00:00

abstract：BACKGROUND:The ability to identify regions of the genome inherited with a dominant trait in one or more families has become increasingly valuable with the wide availability of high throughput sequencing technology. While a number of methods exist for mapping of homozygous variants segregating with recessive traits in c...

journal_title：BMC genomics

authors： Levine AP,Connor TM,Oygar DD,Neild GH,Segal AW,Maxwell PH,Gale DP

更新日期：2015-03-10 00:00:00

abstract：BACKGROUND:Staphylococcus aureus or MRSA (Methicillin Resistant S. aureus), is an acquired pathogen and the primary cause of nosocomial infections worldwide. In S. aureus, teichoic acid is an essential component of the cell wall, and its biosynthesis is not yet well characterized. Studies in Bacillus subtilis have disc...

journal_title：BMC genomics

authors： Qian Z,Yin Y,Zhang Y,Lu L,Li Y,Jiang Y

更新日期：2006-04-05 00:00:00

abstract：UNLABELLED:Transcription-induced chimerism, a mechanism involving the transcription and intergenic splicing of two consecutive genes, has recently been estimated to account for approximately 5% of the human transcriptome. Despite this prevalence, the regulation and function of these fused transcripts remains largely un...

journal_title：BMC genomics

authors： Wang K,Ubriaco G,Sutherland LC

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:S. erythraea is a Gram-positive filamentous bacterium used for the industrial-scale production of erythromycin A which is of high clinical importance. In this work, we sequenced the whole genome of a high-producing strain (E3) obtained by random mutagenesis and screening from the wild-type strain NRRL23338, ...

journal_title：BMC genomics

authors： Li YY,Chang X,Yu WB,Li H,Ye ZQ,Yu H,Liu BH,Zhang Y,Zhang SL,Ye BC,Li YX

更新日期：2013-07-31 00:00:00

abstract：BACKGROUND:Bloodstream malaria parasites require Ca++ for their development, but the sites and mechanisms of Ca++ utilization are not well understood. We hypothesized that there may be differences in Ca++ uptake or utilization by genetically distinct lines of P. falciparum. These differences, if identified, may provide...

journal_title：BMC genomics

authors： Apolis L,Olivas J,Srinivasan P,Kushwaha AK,Desai SA

更新日期：2019-01-16 00:00:00

abstract：BACKGROUND:Many bacterial chromosomes display nucleotide asymmetry, or skew, between the leading and lagging strands of replication. Mutational differences between these strands result in an overall pattern of skew that is centered about the origin of replication. Such a pattern could also arise from selection coupled ...

journal_title：BMC genomics

authors： Morton RA,Morton BR

更新日期：2007-10-12 00:00:00

abstract：BACKGROUND:Advances in whole genome profiling have revolutionized the cancer research field, but at the same time have raised new bioinformatics challenges. For next generation sequencing (NGS), these include data storage, computational costs, sequence processing and alignment, delineating appropriate statistical measu...

journal_title：BMC genomics

authors： Rodriguez BA,Frankhouser D,Murphy M,Trimarchi M,Tam HH,Curfman J,Huang R,Chan MW,Lai HC,Parikh D,Ball B,Schwind S,Blum W,Marcucci G,Yan P,Bundschuh R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Although prokaryotic gene transcription has been studied over decades, many aspects of the process remain poorly understood. Particularly, recent studies have revealed that transcriptomes in many prokaryotes are far more complex than previously thought. Genes in an operon are often alternatively and dynamica...

journal_title：BMC genomics

authors： Li S,Dong X,Su Z

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Gene expression technologies have the ability to generate vast amounts of data, yet there often resides only limited resources for subsequent validation studies. This necessitates the ability to perform sorting and prioritization of the output data. Previously described methodologies have used functional pat...

journal_title：BMC genomics

authors： Schlicht M,Matysiak B,Brodzeller T,Wen X,Liu H,Zhou G,Dhir R,Hessner MJ,Tonellato P,Suckow M,Pollard M,Datta MW

更新日期：2004-08-20 00:00:00

abstract：BACKGROUND:Fusion genes are known to be drivers of many common cancers, so they are potential markers for diagnosis, prognosis or therapy response. The advent of paired-end RNA sequencing enhances our ability to discover fusion genes. While there are available methods, routine analyses of large number of samples are st...

journal_title：BMC genomics

authors： Vu TN,Deng W,Trac QT,Calza S,Hwang W,Pawitan Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Accurate de novo genome assembly has become reality with the advancements in sequencing technology. With the ever-increasing number of de novo genome assembly tools, assessing the quality of assemblies has become of great importance in genome research. Although many quality metrics have been proposed and sof...

journal_title：BMC genomics

authors： Yavas G,Hong H,Xiao W

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Drought is a lifestyle disease. Plant metabolomics has been exercised for understanding the fine-tuning of the potential pathways to surmount the adverse effects of drought stress. A broad spectrum of morphological and metabolic responses from seven Triticeae species including wild types with different droug...

journal_title：BMC genomics

authors： Ullah N,Yüce M,Neslihan Öztürk Gökçe Z,Budak H

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This stu...

journal_title：BMC genomics

authors： Ferrari F,Bortoluzzi S,Coppe A,Basso D,Bicciato S,Zini R,Gemelli C,Danieli GA,Ferrari S

更新日期：2007-08-03 00:00:00