Abstract:
INTRODUCTION:While cognitive impairment is a recognised feature of Parkinson's disease (PD), few studies have evaluated the validity of brief cognitive screening measures compared to a comprehensive neuropsychological assessment. This studies aim was to evaluate the sensitivity and specificity of the Mini-Mental State Examination (MMSE), Modified Mini-Mental State Examination and Dementia Rating Scale (DRS-2) to detect cognitive impairment in individuals with PD. METHOD:Fifty-eight participants were administered the MMSE, 3MS, DRS-2 and a neuropsychological battery. ROC analyses were conducted to assess their effectiveness in classifying cognitive impairment. RESULTS:None of the three measures demonstrated good sensitivity or specificity to detect single domain cognitive impairment. For detecting impairment on two or more cognitive domains, the MMSE and DRS-2 yielded excellent sensitivity (88%) and specificity (78% and 76% respectively), at cut-off scores of 28 and 136 respectively. The 3MS demonstrated excellent sensitivity (88%) and good specificity (60%) at cut off score of 94. CONCLUSION:The MMSE and DRS-2 have excellent discriminant ability to classify multi-domain cognitive impairment in PD, however, their ability to detect more focal cognitive impairment is limited. Given that focal domain may be an indicator that could be useful in early detection of cognitive impairment for people with PD, this finding has implication for the use of these measures as screening tools in clinical practice.
journal_name
NeuroRehabilitationjournal_title
NeuroRehabilitationauthors
Foley T,McKinlay A,Warren N,Stolwyk RJdoi
10.3233/NRE-182433subject
Has Abstractpub_date
2018-01-01 00:00:00pages
491-500issue
4eissn
1053-8135issn
1878-6448pii
NRE182433journal_volume
43pub_type
杂志文章abstract:BACKGROUND:After cervical spinal cord injury, current options for treatment of upper extremity motor functions have been limited to traditional approaches. However, there is a substantial need to explore more rigorous alternative treatments to facilitate motor recovery. OBJECTIVE:To demonstrate whether anodal-primary ...
journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
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journal_title:NeuroRehabilitation
pub_type: 临床试验,杂志文章
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-131025
更新日期:2014-01-01 00:00:00
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journal_title:NeuroRehabilitation
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doi:10.3233/NRE-2010-0546
更新日期:2010-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2010-0556
更新日期:2010-01-01 00:00:00
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journal_title:NeuroRehabilitation
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析
doi:10.3233/NRE-2012-0725
更新日期:2012-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-1993-3107
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-192992
更新日期:2020-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:
更新日期:2005-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-192772
更新日期:2019-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2010-0574
更新日期:2010-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:10.3233/NRE-141145
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:10.3233/NRE-2009-0525
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pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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doi:10.3233/NRE-2012-0755
更新日期:2012-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2008-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
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journal_title:NeuroRehabilitation
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00