Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception.

abstract：PURPOSE:Age-related macular degeneration (AMD), the most common cause of incurable blindness in the western world, is characterized by the dysfunction and eventual death of choroidal endothelial (CECs), RPE, and photoreceptor cells. Stem cell-based treatment strategies designed to replace photoreceptor and RPE cells cu...

journal_title：Investigative ophthalmology & visual science

authors： Songstad AE,Wiley LA,Duong K,Kaalberg E,Flamme-Wiese MJ,Cranston CM,Riker MJ,Levasseur D,Stone EM,Mullins RF,Tucker BA

更新日期：2015-12-01 00:00:00

abstract：Purpose:Sjögren syndrome (SS) is an autoimmune disease characterized by the inflammatory destruction of salivary and lacrimal glands (LG). Chloroquine (CQ) was known as an immunomodulatory drug and in the inhibition of autophagy. The purpose of the study is to investigate the effect of CQ on the development of dry eye ...

journal_title：Investigative ophthalmology & visual science

authors： Lee HJ,Shin S,Yoon SG,Cheon EJ,Chung SH

更新日期：2019-09-03 00:00:00

abstract：:Topical administration of 1% vanadate in a formulation designed to enhance penetration lowered intraocular pressure in monkeys' eyes. The decrease in intraocular pressure was associated with significant decreases in aqueous humor flow. Tonographic outflow facility was unaltered by topical vanadate. ...

journal_title：Investigative ophthalmology & visual science

authors： Podos SM,Lee PY,Severin C,Mittag T

更新日期：1984-03-01 00:00:00

abstract：PURPOSE:Leber hereditary optic neuropathy (LHON) is an inherited mitochondrial optic neuropathy characterized by bilateral, severe loss of central vision. In this study, the first formal assessment was conducted of visual disability in affected and unaffected individuals from molecularly confirmed LHON pedigrees. METH...

journal_title：Investigative ophthalmology & visual science

authors： Kirkman MA,Korsten A,Leonhardt M,Dimitriadis K,De Coo IF,Klopstock T,Griffiths PG,Hudson G,Chinnery PF,Yu-Wai-Man P

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To evaluate the effects of unilateral, stereotactic, posteroventral pallidotomy on saccadic eye movements in patients with Parkinson disease (PD). METHODS:Eye movements of 31 patients with moderate to advanced PD were recorded with an infrared system 1 month before and 3 months after pallidotomy. Two kinds of ...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Siemers E,Abel LA,Yee RD

更新日期：2000-07-01 00:00:00

abstract：:Scanning electron microscopic (SEM) observations of the rabbit retinal pigment epithelium (RPE) are reported both for normal tissue and for tissue subjected to laser radiation. In normal RPE, cells were observed to be closely packed and to have the characteristic hexagonal shape. The microvilli were abundant and of tw...

journal_title：Investigative ophthalmology & visual science

authors： Borwein B,Sanwal M,Medeiros JA,McGowan JW

更新日期：1977-08-01 00:00:00

abstract：PURPOSE:Adeno-associated viral (AAV) vectors have been used to express several different proteins in the eye. The purpose of this study was to determine whether AAV-mediated intraocular gene transfer of pigment epithelium-derived factor (PEDF) inhibits the development of choroidal neovascularization (CNV) in a murine m...

journal_title：Investigative ophthalmology & visual science

authors： Mori K,Gehlbach P,Yamamoto S,Duh E,Zack DJ,Li Q,Berns KI,Raisler BJ,Hauswirth WW,Campochiaro PA

更新日期：2002-06-01 00:00:00

abstract：:Chronic blepharitis has been a difficult disease to define either microbiologically or biochemically. Sterols from meibomian secretions of normal subjects and patients were analyzed, and important differences were observed. Based on analyses of these secretions, two significantly different (P less than 0.001) types of...

journal_title：Investigative ophthalmology & visual science

authors： Shine WE,McCulley JP

更新日期：1991-07-01 00:00:00

abstract：PURPOSE:To define rod and cone function further in terms of visual cycle mechanism, the retinal phenotype resulting from Rpe65 (retinoid isomerase I) deficiency in Nrl(-)(/)(-) mice having a single class of photoreceptors resembling wild-type cones was characterized and outcomes of retinoid supplementation evaluated. ...

journal_title：Investigative ophthalmology & visual science

authors： Feathers KL,Lyubarsky AL,Khan NW,Teofilo K,Swaroop A,Williams DS,Pugh EN Jr,Thompson DA

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:To develop a method to isolate human iris microvascular endothelial cells (HIECs) for exploring their constitutive and inflammatory agent-modulated expression of intercellular adhesion molecules (ICAM)-1 and -2, vascular cell adhesion molecule (VCAM)-1, and E-selectin. METHODS:Endothelial cells from collagenas...

journal_title：Investigative ophthalmology & visual science

authors： Silverman MD,Zamora DO,Pan Y,Texeira PV,Planck SR,Rosenbaum JT

更新日期：2001-11-01 00:00:00

abstract：Purpose:Suberoylanilide hydroxamic acid (SAHA) has been shown to support the maintenance of experimental filtration blebs in animal models. This study was performed to investigate the molecular mechanisms underlying the bleb-maintaining effects of SAHA in modulating wound healing activities of conjunctival fibroblasts....

journal_title：Investigative ophthalmology & visual science

authors： Futakuchi A,Inoue T,Fujimoto T,Kuroda U,Inoue-Mochita M,Takahashi E,Ohira S,Tanihara H

更新日期：2017-04-01 00:00:00

abstract：:Lymphocyte cultures were employed to assess the degree of spontaneous and induced chromosomal fragility in retinoblastoma. Sister chromatid exchange (SCEs) were scored in metaphases. Three unilateral, three bilateral, eleven family members and controls were studied. Retinoblastoma (RB) lymphocytes did not exhibit incr...

journal_title：Investigative ophthalmology & visual science

authors： Abramovsky-Kaplan I,Jones IS

更新日期：1984-06-01 00:00:00

abstract：:Scar formation and fibrosis are the most common causes of ultimate glaucoma filtration surgery failure. The authors used Coulter counter, hexosaminidase, and 3H-thymidine assays to evaluate the effects of mithramycin, mitomycin, daunorubicin, and bleomycin on human subconjunctival fibroblast growth in tissue culture. ...

journal_title：Investigative ophthalmology & visual science

authors： Lee DA,Lee TC,Cortes AE,Kitada S

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To determine the role of IL-33 in resistance to Pseudomonas aeruginosa keratitis. METHODS:Corneal IL-33 mRNA and protein levels were tested in susceptible C57BL/6 (B6) and resistant BALB/c mice. B6 mice were injected with recombinant mouse IL-33 (rmIL-33) and disease severity, bacterial load, polymorphonuclear...

journal_title：Investigative ophthalmology & visual science

authors： Hazlett LD,McClellan SA,Barrett RP,Huang X,Zhang Y,Wu M,van Rooijen N,Szliter E

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Lens case hygiene practices are important in maintaining safe contact lens wear. However, the effectiveness of various lens case cleaning practices have not been evaluated and compared. This in vitro study aimed to evaluate and compare the efficacy of cleaning practices that are most commonly carried out by len...

journal_title：Investigative ophthalmology & visual science

authors： Wu YT,Zhu H,Willcox M,Stapleton F

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To investigate the effects of adhesion promoting surgical adjuncts in Descemets stripping automated endothelial keratoplasty (DSAEK). The effects of air-fill pressure, duration, use of venting incisions and stromal roughening on fluid dispersion, and donor adhesion strength were examined in theoretical, optical...

journal_title：Investigative ophthalmology & visual science

authors： Bhogal MS,Angunawela RI,Bilotti E,Eames I,Allan BD

更新日期：2012-06-20 00:00:00

abstract：PURPOSE:To characterize the reactions of retinal glial cells (astrocytes and Müller cells) to retinal injury in mice that lack glial fibrillary acidic protein (GFAP) and vimentin (GFAP-/-Vim-/-) and to determine the role of glial cells in retinal detachment (RD)-induced photoreceptor degeneration. METHODS:RD was induc...

journal_title：Investigative ophthalmology & visual science

authors： Nakazawa T,Takeda M,Lewis GP,Cho KS,Jiao J,Wilhelmsson U,Fisher SK,Pekny M,Chen DF,Miller JW

更新日期：2007-06-01 00:00:00

abstract：:Interactions between direction-selective mechanisms for motion were examined in strabismic and anisometropic amblyopia. Amblyopes were found to have a marked reduction in sensitivity to flicker or movement when the amblyopic eye was presented with a combination of two gratings drifting in opposite directions at the sa...

journal_title：Investigative ophthalmology & visual science

authors： Schor CM,Levi DM

更新日期：1980-09-01 00:00:00

abstract：PURPOSE:To evaluate the performance of an automated retinal image quality assessment system for use in automated diabetic retinopathy grading. METHODS:Algorithmic methods have been developed for assessing the quality of 45 degrees single field retinal images for use in diabetic retinopathy screening. For this purpose,...

journal_title：Investigative ophthalmology & visual science

authors： Fleming AD,Philip S,Goatman KA,Olson JA,Sharp PF

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Lysophosphatidic acid (LPA) is a phospholipid growth factor that stimulates proliferation, chemotaxis, cation currents, and K(+) currents in retinal pigment epithelial (RPE) cells. LPA receptor transduction was analyzed in human and rat RPE cells. METHODS:Cells were cultured with standard methods, and signalin...

journal_title：Investigative ophthalmology & visual science

authors： Thoreson WB,Ryan JS,Shi C,Kelly ME,Bryson EJ,Toews ML,Ediger TL,Chacko DM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta-1 (TGF beta-1) can modulate inflammation. Endotoxin-induced uveitis (EIU) is characterized by acute ocular inflammation related to the release of cytokines, including interleukin (IL)-6. The authors investigated the effect of TGF beta-1 on EIU in mice. METHODS:Three independent ...

journal_title：Investigative ophthalmology & visual science

authors： Peng B,Li Q,Roberge FG,Chan CC

更新日期：1997-01-01 00:00:00

abstract：:The acute effect of topical epinephrine HCl 2% on macular capillary blood flow was studied in 18 healthy human volunteers using the blue-field simulation technique. This technique provides a method for quantifying the velocity of leukocytes flowing in macular capillaries. Subjects adjusted the velocity of simulated le...

journal_title：Investigative ophthalmology & visual science

authors： Robinson F,Chen S,Petrig BL,Grunwald JE,Riva CE

更新日期：1992-01-01 00:00:00

abstract：Purpose:The aim of the study was to investigate the signaling of growth hormone-releasing hormone receptor (GHRH-R) in the pathogenesis of pterygium and determine the apoptotic effect of GHRH-R antagonist on pterygium epithelial cells (PECs). Methods:Fourteen samples of primary pterygium of grade T3 with size of corne...

journal_title：Investigative ophthalmology & visual science

authors： Qin YJ,Chu WK,Huang L,Ng CHY,Chan TCY,Cao D,Yang C,Zhang L,Huang SP,Li J,Lin HL,Li WQ,Chen L,Schally AV,Chan SO,Zhang HY,Pang CP

更新日期：2018-10-01 00:00:00

abstract：Purpose:To give a European regulatory overview of the requirements on and the use of biomarkers or surrogate endpoints in the development of drugs for ocular disease. Methods:Definitions, methods to validate new markers, and circumstances where surrogate endpoints can be appropriate are summarized. Results:The key en...

journal_title：Investigative ophthalmology & visual science

authors： Wickström K,Moseley J

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Evidence suggests that altered metabolism of amyloid precursor protein (APP) may play a role in the pathophysiology of retinal ganglion cell (RGC) death in the etiology of glaucoma. The authors sought to determine the distribution of APP and amyloid-beta (Abeta) in DBA/2J glaucomatous mouse retinas. METHODS:Th...

journal_title：Investigative ophthalmology & visual science

authors： Goldblum D,Kipfer-Kauer A,Sarra GM,Wolf S,Frueh BE

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To develop and characterize a feline model of retinal degeneration induced by intravitreal injection of adenosine triphosphate (ATP). METHODS:Nineteen normally sighted adult cats received 100 μL intravitreal injections of ATP with a final concentration of 11, 22, or 55 mM at the retina. Four animals were eutha...

journal_title：Investigative ophthalmology & visual science

authors： Aplin FP,Luu CD,Vessey KA,Guymer RH,Shepherd RK,Fletcher EL

更新日期：2014-11-25 00:00:00

abstract：PURPOSE:Previous studies have shown that adenosine induces relaxation of isolated retinal arterioles mediated by the A2A receptor, but the contributions to tone regulation of adenosine receptors located both in and around the vascular wall have not been studied in detail. METHODS:Porcine retinal arterioles with preser...

journal_title：Investigative ophthalmology & visual science

authors： Riis-Vestergaard MJ,Misfeldt MW,Bek T

更新日期：2014-03-19 00:00:00

abstract：PURPOSE:Hypoxia and growth factors are postulated to be involved in the development of retinal neovascularization through the regulation of extracellular proteinase production. It has been shown that matrix metalloproteinases (MMPs) are elevated in the retina during the neovascularization process. However, the factors ...

journal_title：Investigative ophthalmology & visual science

authors： Majka S,McGuire PG,Das A

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To examine the expression of VEGF in extranodal marginal zone B-cell lymphoma (EMZL) and reactive lymphoid hyperplasia (RLH) of human ocular adnexa, and analyze the correlation with the intratumoral microvessel density (MVD). METHODS:Twenty-two EMZL and 16 RLH tissues were examined in this study. Paraformaldeh...

journal_title：Investigative ophthalmology & visual science

authors： Kinoshita S,Kase S,Ando R,Dong Z,Fukuhara J,Dong Y,Inafuku S,Noda K,Noda M,Kanda A,Ishida S

更新日期：2014-05-13 00:00:00

abstract：Purpose:To review the usefulness of local and systemic inflammatory biomarkers of diabetic retinopathy (DR) to implement a more personalized treatment. Methods:An integrated research (from ophthalmologist and diabetologist point of view) of most significant literature on serum, vitreous, and aqueous humor (AH) biochem...

journal_title：Investigative ophthalmology & visual science

authors： Vujosevic S,Simó R

更新日期：2017-05-01 00:00:00