Abstract:
BACKGROUND:The objective of this study was to investigate positive surgical margin (PSM) rates in patients with prostate cancer treated with radical prostatectomy (RP) and assess PSM impact on cancer-specific mortality (CSM). PATIENTS AND METHODS:Within the Surveillance, Epidemiology, and End Results (SEER) database (2004-2015), we identified men who underwent RP with pathologic T2 or T3a stage. Annual trends of PSM rates were plotted. Subgroups focused on geographic regions, namely the North Central, Northeast, South, and West. Cumulative incidence plots depicted other-cause mortality-adjusted CSM rates. Multivariable competing risks regression models tested the relationship between PSM and CSM. Subgroup analyses focused on pathologic stage, Gleason score, and geographic region. RESULTS:Of 153,329 patients treated with RP, 12.3% (n = 18,935) exhibited PSM. Overall, in pathologic T2 stage and pathologic T3a stage, PSM rates decreased during the study period from 18.7% to 9.7% (P < .001), 15.7% to 7.3% (P < .001), and 39.0% to 18.0% (P < .001), respectively. In subgroup analyses focusing on geographic regions, PSM rates universally decreased. However, the magnitude differed. In multivariable competing risks regression models, PSM rates were associated with higher CSM (hazard ratio, 1.45; P < .001). However, geographic regions failed to reach independent predictor status. Insufficient information about PSM focality, length, and associated Gleason score represent important limitations. CONCLUSION:It is encouraging that PSM rates decreased during the study period, even after stratification according to tumor stage. PSM decreased within the 4 examined geographic regions. However, the rate of decrease varied in magnitude, but geographic regions did not represent an independent predictor of PSM.
journal_name
Clin Genitourin Cancerjournal_title
Clinical genitourinary cancerauthors
Preisser F,Mazzone E,Knipper S,Nazzani S,Bandini M,Shariat SF,Tian Z,Saad F,Montorsi F,Zorn KC,Graefen M,Tilki D,Karakiewicz PIdoi
10.1016/j.clgc.2018.09.024subject
Has Abstractpub_date
2019-02-01 00:00:00pages
e130-e139issue
1eissn
1558-7673issn
1938-0682pii
S1558-7673(18)30581-0journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Neutrophil-to-lymphocyte ratio (NLR) might reflect an increased neutrophilic inflammatory response, and urothelial tumors with squamous-cell features (SqD) have been linked to inflammation. We hypothesized that NLR could be prognostic in these patients. PATIENTS AND METHODS:In patients with SqD muscle-invas...
journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2017.01.024
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION/BACKGROUND:The purpose of this study was to evaluate the prevalence of vitamin D (VitD) deficiency in men undergoing radical prostatectomy and determine whether an association exists between preoperative VitD levels and adverse pathologic features. PATIENTS AND METHODS:Patients scheduled to undergo radica...
journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2014.02.004
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journal_title:Clinical genitourinary cancer
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doi:10.1016/j.clgc.2018.02.006
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,多中心研究
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.3816/CGC.2007.n.020
更新日期:2007-09-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2017.05.013
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journal_title:Clinical genitourinary cancer
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journal_title:Clinical genitourinary cancer
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2018.07.005
更新日期:2018-12-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2012.11.003
更新日期:2013-06-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2019.03.006
更新日期:2019-08-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2020.09.006
更新日期:2020-10-13 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2019.01.018
更新日期:2019-06-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.3816/CGC.2009.n.035
更新日期:2009-10-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,评审
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更新日期:2020-12-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-08-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.3816/CGC.2006.n.006
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2019-02-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,多中心研究
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更新日期:2015-10-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2017-08-24 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2015.12.002
更新日期:2016-04-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2014.08.009
更新日期:2015-04-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2013.11.001
更新日期:2014-06-01 00:00:00