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Inhibition by monensin of human cytomegalovirus DNA replication.

Abstract：

:Monensin, at concentrations which depended on the multiplicity of infection, was found to prevent DNA replication of human cytomegalovirus (HCMV) as well as production of viral progeny in human foreskin fibroblasts. The drug did not affect DNA replication of herpes simplex virus. Inhibition of consecutive HCMV DNA synthesis was also observed following delayed addition of the drug within 12-24 hours postinfection, but was fully reversible upon its removal. Viral replication proceeded, however, without impairment in cultures treated with monensin prior to infection. Induction of viral DNA polymerase activity was not impeded by the inhibitor. Analysis of protein- and glycoprotein synthesis revealed that monensin interfered with the production of a number of HCMV-specific polypeptides. Furthermore, evidence was obtained that the drug may hinder intracellular transport of a 135 kd glycopolypeptide.

journal_name

Arch Virol

journal_title

Archives of virology

authors

Kaiser CJ,Radsak K

doi

10.1007/BF01310716

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

229-45

issue

3-4

eissn

0304-8608

issn

1432-8798

journal_volume

94

pub_type

杂志文章

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