MicroRNAs in Autoimmunity and Hematological Malignancies.

Abstract:

:Autoimmunity and hematological malignancies are often concomitant in patients. A causal bidirectional relationship exists between them. Loss of immunological tolerance with inappropriate activation of the immune system, likely due to environmental and genetic factors, can represent a breeding ground for the appearance of cancer cells and, on the other hand, blood cancers are characterized by imbalanced immune cell subsets that could support the development of the autoimmune clone. Considerable effort has been made for understanding the proteins that have a relevant role in both processes; however, literature advances demonstrate that microRNAs (miRNAs) surface as the epigenetic regulators of those proteins and control networks linked to both autoimmunity and hematological malignancies. Here we review the most up-to-date findings regarding the miRNA-based molecular mechanisms that underpin autoimmunity and hematological malignancies.

journal_name

Int J Mol Sci

authors

Di Marco M,Ramassone A,Pagotto S,Anastasiadou E,Veronese A,Visone R

doi

10.3390/ijms19103139

subject

Has Abstract

pub_date

2018-10-12 00:00:00

issue

10

issn

1422-0067

pii

ijms19103139

journal_volume

19

pub_type

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