Abstract:
:Autoimmunity and hematological malignancies are often concomitant in patients. A causal bidirectional relationship exists between them. Loss of immunological tolerance with inappropriate activation of the immune system, likely due to environmental and genetic factors, can represent a breeding ground for the appearance of cancer cells and, on the other hand, blood cancers are characterized by imbalanced immune cell subsets that could support the development of the autoimmune clone. Considerable effort has been made for understanding the proteins that have a relevant role in both processes; however, literature advances demonstrate that microRNAs (miRNAs) surface as the epigenetic regulators of those proteins and control networks linked to both autoimmunity and hematological malignancies. Here we review the most up-to-date findings regarding the miRNA-based molecular mechanisms that underpin autoimmunity and hematological malignancies.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Di Marco M,Ramassone A,Pagotto S,Anastasiadou E,Veronese A,Visone Rdoi
10.3390/ijms19103139subject
Has Abstractpub_date
2018-10-12 00:00:00issue
10issn
1422-0067pii
ijms19103139journal_volume
19pub_type
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