Abstract:
:The relationships between polypeptide composition, sequence, structure and function have been puzzling biologists ever since first protein sequences were determined. Here, we study the statistics of occurrence of all possible pentapeptide sequences in known proteins. To compensate for the non-uniform distribution of individual amino acid residues in protein sequences, we investigate separately all possible permutations of every given amino acid composition. For the majority of permutation groups we find that pentapeptide occurrences deviate strongly from the expected binomial distributions, and that the observed distributions are also characterized by high numbers of outlier sequences. An analysis of identified outliers shows they often contain known motifs and rare amino acids, suggesting that they represent important functional elements. We further compare the pentapeptide composition of regions known to correspond to protein domains with that of non-domain regions. We find that a substantial number of pentapeptides is clearly strongly favored in protein domains. Finally, we show that over-represented pentapeptides are significantly related to known functional motifs and to predicted ancient structural peptides.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Poznański J,Topiński J,Muszewska A,Dębski KJ,Hoffman-Sommer M,Pawłowski K,Grynberg Mdoi
10.1038/s41598-018-33433-8subject
Has Abstractpub_date
2018-10-11 00:00:00pages
15178issue
1issn
2045-2322pii
10.1038/s41598-018-33433-8journal_volume
8pub_type
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