Abstract:
OBJECTIVE:Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). METHODS:This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits. RESULTS:The median serum GDF-15 level was found to be the highest in the EOPE group (EOPE: 441.7 pg/ml). The median serum GDF-15 levels were higher in women with preeclampsia than in the control group (309.7 pg/ml vs. 436.6 pg/ml, p: 0.009). CONCLUSION:Our findings suggest GDF-15 increased as a response to endothelial injury caused by cytokines triggered by preeclampsia.
journal_name
Hypertens Pregnancyjournal_title
Hypertension in pregnancyauthors
Temel Yuksel I,Mathyk BA,Aslan Cetin B,Turhan U,Okumus ZG,Yetkin Yildirim G,Acar DKdoi
10.1080/10641955.2018.1524477subject
Has Abstractpub_date
2018-11-01 00:00:00pages
192-196issue
4eissn
1064-1955issn
1525-6065journal_volume
37pub_type
杂志文章abstract:OBJECTIVE:Leukocytes are activated in women with preeclampsia, but the class of leukocytes that infiltrates the maternal vasculature and, therefore, is most likely to cause vascular dysfunction is not known. METHODS:Subcutaneous fat biopsies were obtained at Cesarean section or abdominal surgery from 7 normal non-preg...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950801958067
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE). METHODS:A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and materna...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2014.913615
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To compare fibrinogen concentration and factor VIII activity obtained from pregnant women with preeclampsia with those obtained from women with either normal pregnancies or with complications unrelated to preeclampsia. MATERIALS AND METHODS:Fibrinogen concentration and factor VIII activity were measured in t...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701548240
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To determine whether Chlamydia pneumoniae antibodies and highly sensitive C-reactive protein (hsCRP) levels in maternal sera are associated with preeclampsia or gestational hypertension. METHODS:C. pneumoniae antibodies and hsCRP levels were measured in maternal serum during first trimester (mean, 10.4 weeks...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701885188
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To investigate the importance of prostacyclin and nitric oxide synthesis in endothelium-dependent relaxation in myometrial resistance vessels, and to test the hypothesis that a deficiency in nitric oxide synthesis contributes to the known alterations in endothelial function in preeclampsia. METHODS:Thirty-si...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641959909009611
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:DNA methylation is an important epigenetic regulator of gene transcription, and is involved in many diseases, which has been researched recently. In this study, we aimed to investigate DNA methylation and gene expression in preeclampsia placenta. Preeclampsia has been observed in patients with molar pregnancy...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1117099
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we de...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1258411
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To provide long-term follow-up data on women with a history of hemolysis, elevated liver enzymes, and low platelets [(H)ELLP] syndrome regarding the risk of recurrence in subsequent pregnancies and disease in later life. METHODS:All women admitted to the Academic Medical Centre between January 1984 and Janua...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-100104168
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To assess hemodynamic and NT-proANP changes in women with chronic hypertension during pregnancy. METHODS:Stroke volume index (SI), heart rate (HR), cardiac output index (CI), systemic vascular resistance index (SVRI), pulse wave velocity (PWV), and left cardiac work index (LCWI) were measured using whole-bod...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950701436016
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES:A case-control study was conducted in Medani Hospital, Sudan...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1211676
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Preeclampsia and intrauterine growth retardation (IUGR) are associated with elevated concentrations of myeloperoxidase (MPO) and polymorphonuclear (PMN) elastase, which indicate maternal neutrophil activation. The aim of the study was to measure maternal MPO and PMN elastase plasma concentrations in second tr...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120024027
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS:A prospective case-control study included a study group consisting of 30 pregnant women with p...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1212872
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:To report a case of cardiac arrhythmia related to a low dose of endovenous lanatoside C. CASE REPORT:A 23-year-old pregnant woman with mitral regurgitation complicated with preeclampsia and pulmonary edema presented 2 episodes of atrial tachycardia induced by a intravenous digitalis (2 mg, IV and 1 mg, IV, r...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641950902928571
更新日期:2010-01-01 00:00:00
abstract::This study aimed to examine the incidence of hypertensive disorders of pregnancy (HDP) among Japanese women with oocyte donation pregnancy (ODP) aged 40 years or older and estimate whether the women with ODP were more likely to develop HDP than those with autologous oocyte pregnancy (AOP) and spontaneous pregnancy (SP...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2020.1861461
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy. METHOD:This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected wom...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2017.1280049
更新日期:2017-05-01 00:00:00
abstract::The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 1...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2017.1397690
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To determine whether the higher rate of preeclampsia previously reported in Black women is attributable to a higher rate of chronic hypertension in that group. METHODS:Rates and severity of pregnancy-related hypertensive disease in Black and White women with and without chronic hypertension were reviewed fro...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950500281134
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To evaluate Protein/Creatinine ratio on random urine samples for prediction of proteinuria in preeclampsia. MATERIALS AND METHODS:This study was performed on 150 pregnant women who were hospitalized as preeclampsia in Ghaem Hospital during 2006. At first, a 24-hours urine sample was collected for each patien...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2010.507838
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To identify parameters that may assist clinicians in predicting which women will develop preeclampsia (PE) after initially presenting with gestational hypertension (GH). METHODS:118 women were recruited to the study with GH or PE. They were divided into three groups based on their diagnosis at delivery- (1) ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950601147952
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). METHODS:In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase ch...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1250904
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Women with a history of preeclampsia have an increased risk of cardiovascular disease. Gynaecologists have an important role in the counselling and management of cardiovascular risk factors after preeclampsia. We aimed to assess the role of gynaecologists in informing women on interventions and risk factor fo...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2015.1100311
更新日期:2016-01-01 00:00:00
abstract::We examined neurological and intellectual outcome of growth-restricted newborns of pregnancies complicated with preeclampsia and without preeclampsia. Seventy-five consecutive growth restricted newborns (<5th percentile) were prospectively followed up at 6 months' intervals. Newborns with major congenital malformation...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120016791
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To investigate the intraplatelet cyclic guanosine-3',5'-monophosphate (cGMP) levels during normal pregnancy and preeclampsia. STUDY DESIGN:Pregnant women (n = 15), women with preeclampsia (n = 15), and nonpregnant, normotensive women (n = 15) were included. Intraplatelet cyclic guanosine-3',5'-monophosphate ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-200030860
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. METHODS:The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950802601187
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVES:Construct a new preeclampsia predicting algorithm in twins. METHODS:Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641955.2016.1242605
更新日期:2017-02-01 00:00:00
abstract:INTRODUCTION:Caesarean section (CS) is one of the most frequently performed surgical procedures worldwide. Surgical variants include closure and non-closure of the peritoneum: in case of non-suturing the visceral peritoneum (VP), abnormal fluid collections such as blood clots may lead to formation of a hematoperitoneum...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1080/10641950802601229
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study is to determine if heat shock protein 70 (Hsp 70), a marker of cellular stress, is elevated in pregnancies complicated by severe preeclampsia. METHODS:Maternal blood was collected from women with severe preeclampsia (n=47) matched for delivery gestational age to normotensive pregnan...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120004767
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE(S):We tested the hypothesis that twin pregnancies would lead to increased maternal plasma homocysteine. We further hypothesized that twin pregnancies complicated by preeclampsia would have increased plasma homocysteine compared to twin pregnancies without preeclampsia and normal singleton pregnancies. METHOD...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-45774
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:Chymase, a chymotrypsin-like protease, is a non-ACE angiotensin II (Ang II) generating enzyme. We determined if maternal chymotrypsin-like protease/chymase activity was increased in women with preeclampsia (PE). METHODS:Maternal plasma was extracted from venous blood of healthy nonpregnant women, women with ...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641950802001842
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:Assess the actual rate of eclampsia in Sweden, describe the clinical picture of the disease and the maternal and perinatal outcomes. METHODS:Analysis of data regarding incidence of eclampsia registered in the Swedish Medical Birth Register 1991-1992. The records of all the cases with the diagnosis of eclamps...
journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.1081/PRG-120002906
更新日期:2002-01-01 00:00:00