Maternal levels of growth differentiation factor-15 in patients with preeclampsia.

Abstract:

OBJECTIVE:Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). METHODS:This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits. RESULTS:The median serum GDF-15 level was found to be the highest in the EOPE group (EOPE: 441.7 pg/ml). The median serum GDF-15 levels were higher in women with preeclampsia than in the control group (309.7 pg/ml vs. 436.6 pg/ml, p: 0.009). CONCLUSION:Our findings suggest GDF-15 increased as a response to endothelial injury caused by cytokines triggered by preeclampsia.

journal_name

Hypertens Pregnancy

authors

Temel Yuksel I,Mathyk BA,Aslan Cetin B,Turhan U,Okumus ZG,Yetkin Yildirim G,Acar DK

doi

10.1080/10641955.2018.1524477

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

192-196

issue

4

eissn

1064-1955

issn

1525-6065

journal_volume

37

pub_type

杂志文章
  • Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia.

    abstract:OBJECTIVE:Leukocytes are activated in women with preeclampsia, but the class of leukocytes that infiltrates the maternal vasculature and, therefore, is most likely to cause vascular dysfunction is not known. METHODS:Subcutaneous fat biopsies were obtained at Cesarean section or abdominal surgery from 7 normal non-preg...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950801958067

    authors: Cadden KA,Walsh SW

    更新日期:2008-01-01 00:00:00

  • Maternal Serum Resistin Is Reduced in First Trimester Preeclampsia Pregnancies and Is a Marker of Clinical Severity.

    abstract:OBJECTIVE:To examine whether resistin levels in first trimester maternal serum are associated with insulin resistance or preeclampsia (PE). METHODS:A case-control study of maternal serum resistin concentration conducted using 285 normal pregnancies and 123 PE pregnancies matched for gestational age, parity and materna...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2014.913615

    authors: Christiansen M,Hedley PL,Placing S,Wøjdemann KR,Carlsen AL,Jørgensen JM,Gjerris AC,Shalmi AC,Rode L,Sundberg K,Tabor A

    更新日期:2015-11-01 00:00:00

  • Fibrinogen concentration and factor VIII activity in women with preeclampsia.

    abstract:OBJECTIVE:To compare fibrinogen concentration and factor VIII activity obtained from pregnant women with preeclampsia with those obtained from women with either normal pregnancies or with complications unrelated to preeclampsia. MATERIALS AND METHODS:Fibrinogen concentration and factor VIII activity were measured in t...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950701548240

    authors: Williams VK,Griffiths AB,Carbone S,Hague WM

    更新日期:2007-01-01 00:00:00

  • Maternal serum Chlamydia pneumoniae antibodies and CRP levels in women with preeclampsia and gestational hypertension.

    abstract:OBJECTIVE:To determine whether Chlamydia pneumoniae antibodies and highly sensitive C-reactive protein (hsCRP) levels in maternal sera are associated with preeclampsia or gestational hypertension. METHODS:C. pneumoniae antibodies and hsCRP levels were measured in maternal serum during first trimester (mean, 10.4 weeks...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950701885188

    authors: Karinen L,Leinonen M,Bloigu A,Paldanius M,Koskela P,Saikku P,Hartikainen AL,Jarvelin MR,Pouta A

    更新日期:2008-01-01 00:00:00

  • Mechanisms of endothelium-dependent relaxation in myometrial resistance vessels and their alteration in preeclampsia.

    abstract:OBJECTIVE:To investigate the importance of prostacyclin and nitric oxide synthesis in endothelium-dependent relaxation in myometrial resistance vessels, and to test the hypothesis that a deficiency in nitric oxide synthesis contributes to the known alterations in endothelial function in preeclampsia. METHODS:Thirty-si...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641959909009611

    authors: Ashworth JR,Baker PN,Warren AY,Johnson IR

    更新日期:1999-01-01 00:00:00

  • Comprehensive analysis of DNA methylation and gene expression of placental tissue in preeclampsia patients.

    abstract:OBJECTIVE:DNA methylation is an important epigenetic regulator of gene transcription, and is involved in many diseases, which has been researched recently. In this study, we aimed to investigate DNA methylation and gene expression in preeclampsia placenta. Preeclampsia has been observed in patients with molar pregnancy...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2015.1117099

    authors: Xuan J,Jing Z,Yuanfang Z,Xiaoju H,Pei L,Guiyin J,Yu Z

    更新日期:2016-01-01 00:00:00

  • Do racial differences exist in the association between pregnancy-induced hypertension and breast cancer risk?

    abstract:BACKGROUND:Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we de...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1258411

    authors: Lin LT,Hu LY,Tang PL,Tsui KH,Cheng JT,Huang WC,Chang HT

    更新日期:2017-05-01 00:00:00

  • Long-term follow-up in patients with a history of (H)ELLP syndrome.

    abstract:OBJECTIVE:To provide long-term follow-up data on women with a history of hemolysis, elevated liver enzymes, and low platelets [(H)ELLP] syndrome regarding the risk of recurrence in subsequent pregnancies and disease in later life. METHODS:All women admitted to the Academic Medical Centre between January 1984 and Janua...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-100104168

    authors: van Pampus MG,Wolf H,Mayruhu G,Treffers PE,Bleker OP

    更新日期:2001-01-01 00:00:00

  • Hemodynamic adaptation during pregnancy in chronic hypertension.

    abstract:OBJECTIVE:To assess hemodynamic and NT-proANP changes in women with chronic hypertension during pregnancy. METHODS:Stroke volume index (SI), heart rate (HR), cardiac output index (CI), systemic vascular resistance index (SVRI), pulse wave velocity (PWV), and left cardiac work index (LCWI) were measured using whole-bod...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950701436016

    authors: Tihtonen K,Kööbi T,Huhtala H,Uotila J

    更新日期:2007-01-01 00:00:00

  • Fibrinolysis parameters in Sudanese women with severe preeclampsia.

    abstract:BACKGROUND:Although preeclampsia remains a major cause of maternal and fetal morbidity and mortality, its pathogenesis is not fully understood. Coagulation and fibrinolysis changes were suggested to have a role in the pathogenesis of preeclampsia. OBJECTIVES:A case-control study was conducted in Medani Hospital, Sudan...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1211676

    authors: Elzein HO,Muddathir AR,Rida M,Rayis DA,Elhassan EM,Adam I

    更新日期:2016-11-01 00:00:00

  • Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.

    abstract:OBJECTIVE:Preeclampsia and intrauterine growth retardation (IUGR) are associated with elevated concentrations of myeloperoxidase (MPO) and polymorphonuclear (PMN) elastase, which indicate maternal neutrophil activation. The aim of the study was to measure maternal MPO and PMN elastase plasma concentrations in second tr...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120024027

    authors: Stepan H,Heihoff-Klose A,Faber R

    更新日期:2003-01-01 00:00:00

  • Preeclampsia with and without intrauterine growth restriction-Two pathogenetically different entities?

    abstract:OBJECTIVE:The objective of this study is to determine the differences in histopathological features of basal decidua and placenta in cases of preeclampsia with or without fetal intrauterine growth restriction (IUGR). METHODS:A prospective case-control study included a study group consisting of 30 pregnant women with p...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1212872

    authors: Milosevic-Stevanovic J,Krstic M,Radovic-Janosevic D,Stefanovic M,Antic V,Djordjevic I

    更新日期:2016-11-01 00:00:00

  • Digitalis-like induced arrhythmia in a patient with rheumatic mitral regurgitation complicated by preeclampsia.

    abstract:OBJECTIVE:To report a case of cardiac arrhythmia related to a low dose of endovenous lanatoside C. CASE REPORT:A 23-year-old pregnant woman with mitral regurgitation complicated with preeclampsia and pulmonary edema presented 2 episodes of atrial tachycardia induced by a intravenous digitalis (2 mg, IV and 1 mg, IV, r...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641950902928571

    authors: Roscani MG,Zanati SG,Magalhães CG,Borges VT,Matsubara BB

    更新日期:2010-01-01 00:00:00

  • Hypertensive disorders of pregnancy by oocyte donation pregnancy in Japanese women aged 40 years or older: a single-center retrospective cohort study.

    abstract::This study aimed to examine the incidence of hypertensive disorders of pregnancy (HDP) among Japanese women with oocyte donation pregnancy (ODP) aged 40 years or older and estimate whether the women with ODP were more likely to develop HDP than those with autologous oocyte pregnancy (AOP) and spontaneous pregnancy (SP...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2020.1861461

    authors: Gekka Y,Adachi T,Oi R,Nakayama S,Kawana Y,Takeda Y,Nomura S,Ozaki A,Tanimoto T,Sakamoto H,Yamashita T

    更新日期:2021-02-01 00:00:00

  • Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV associated preeclampsia.

    abstract:OBJECTIVE:The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy. METHOD:This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected wom...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1280049

    authors: Thakoordeen S,Moodley J,Naicker T

    更新日期:2017-05-01 00:00:00

  • ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.

    abstract::The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 1...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1397690

    authors: Namlı Kalem M,Kalem Z,Yüce T,Soylemez F

    更新日期:2018-02-01 00:00:00

  • Patterns of pregnancy-related hypertension in black and white women.

    abstract:OBJECTIVE:To determine whether the higher rate of preeclampsia previously reported in Black women is attributable to a higher rate of chronic hypertension in that group. METHODS:Rates and severity of pregnancy-related hypertensive disease in Black and White women with and without chronic hypertension were reviewed fro...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950500281134

    authors: Bryant AS,Seely EW,Cohen A,Lieberman E

    更新日期:2005-01-01 00:00:00

  • Protein/creatinine ratio on random urine samples for prediction of proteinuria in preeclampsia.

    abstract:OBJECTIVE:To evaluate Protein/Creatinine ratio on random urine samples for prediction of proteinuria in preeclampsia. MATERIALS AND METHODS:This study was performed on 150 pregnant women who were hospitalized as preeclampsia in Ghaem Hospital during 2006. At first, a 24-hours urine sample was collected for each patien...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2010.507838

    authors: Roudsari FV,Ayati S,Ayatollahi H,Shakeri MT

    更新日期:2012-01-01 00:00:00

  • Predicting transformation from gestational hypertension to preeclampsia in clinical practice: a possible role for 24 hour ambulatory blood pressure monitoring.

    abstract:OBJECTIVE:To identify parameters that may assist clinicians in predicting which women will develop preeclampsia (PE) after initially presenting with gestational hypertension (GH). METHODS:118 women were recruited to the study with GH or PE. They were divided into three groups based on their diagnosis at delivery- (1) ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950601147952

    authors: Davis GK,Mackenzie C,Brown MA,Homer CS,Holt J,McHugh L,Mangos G

    更新日期:2007-01-01 00:00:00

  • SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia.

    abstract:OBJECTIVE:We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). METHODS:In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase ch...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1250904

    authors: Karakus S,Bagci B,Bagci G,Sancakdar E,Yildiz C,Akkar O,Cetin A

    更新日期:2017-05-01 00:00:00

  • Counselling and management of cardiovascular risk factors after preeclampsia.

    abstract:OBJECTIVE:Women with a history of preeclampsia have an increased risk of cardiovascular disease. Gynaecologists have an important role in the counselling and management of cardiovascular risk factors after preeclampsia. We aimed to assess the role of gynaecologists in informing women on interventions and risk factor fo...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2015.1100311

    authors: van Kesteren F,Visser S,Hermes W,Teunissen PW,Franx A,van Pampus MG,Mol BW,de Groot CJ

    更新日期:2016-01-01 00:00:00

  • Neurodevelopmental and cognitive assessment of children born growth restricted to mothers with and without preeclampsia.

    abstract::We examined neurological and intellectual outcome of growth-restricted newborns of pregnancies complicated with preeclampsia and without preeclampsia. Seventy-five consecutive growth restricted newborns (<5th percentile) were prospectively followed up at 6 months' intervals. Newborns with major congenital malformation...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120016791

    authors: Many A,Fattal A,Leitner Y,Kupferminc MJ,Harel S,Jaffa A

    更新日期:2003-01-01 00:00:00

  • Intraplatelet cyclic guanosine-3',5'-monophosphate levels during pregnancy and preeclampsia.

    abstract:OBJECTIVE:To investigate the intraplatelet cyclic guanosine-3',5'-monophosphate (cGMP) levels during normal pregnancy and preeclampsia. STUDY DESIGN:Pregnant women (n = 15), women with preeclampsia (n = 15), and nonpregnant, normotensive women (n = 15) were included. Intraplatelet cyclic guanosine-3',5'-monophosphate ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-200030860

    authors: Teran E,Escudero C,Vivero S,Enriquez A,Calle A

    更新日期:2004-01-01 00:00:00

  • CA-125 and CRP are elevated in preeclampsia.

    abstract:OBJECTIVE:To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. METHODS:The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950802601187

    authors: Cebesoy FB,Balat O,Dikensoy E,Kalayci H,Ibar Y

    更新日期:2009-05-01 00:00:00

  • Developing a new algorithm for first and second trimester preeclampsia screening in twin pregnancies.

    abstract:OBJECTIVES:Construct a new preeclampsia predicting algorithm in twins. METHODS:Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1242605

    authors: Maymon R,Trahtenherts A,Svirsky R,Melcer Y,Madar-Shapiro L,Klog E,Meiri H,Cuckle H

    更新日期:2017-02-01 00:00:00

  • Closure versus non-closure of the visceral peritoneum (VP) in patients with gestational hypertension--an observational analysis.

    abstract:INTRODUCTION:Caesarean section (CS) is one of the most frequently performed surgical procedures worldwide. Surgical variants include closure and non-closure of the peritoneum: in case of non-suturing the visceral peritoneum (VP), abnormal fluid collections such as blood clots may lead to formation of a hematoperitoneum...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950802601229

    authors: Malvasi A,Tinelli A,Hudelist G,Vergara D,Martignago R,Tinelli R

    更新日期:2009-01-01 00:00:00

  • Heat shock protein 70 is not increased in women with severe preeclampsia.

    abstract:OBJECTIVE:The purpose of this study is to determine if heat shock protein 70 (Hsp 70), a marker of cellular stress, is elevated in pregnancies complicated by severe preeclampsia. METHODS:Maternal blood was collected from women with severe preeclampsia (n=47) matched for delivery gestational age to normotensive pregnan...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120004767

    authors: Livingston JC,Ahokas R,Haddad B,Sibai BM,Awaads R

    更新日期:2002-01-01 00:00:00

  • Maternal plasma homocysteine concentrations are not increased in twin pregnancies.

    abstract:OBJECTIVE(S):We tested the hypothesis that twin pregnancies would lead to increased maternal plasma homocysteine. We further hypothesized that twin pregnancies complicated by preeclampsia would have increased plasma homocysteine compared to twin pregnancies without preeclampsia and normal singleton pregnancies. METHOD...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-45774

    authors: Powers RW,Dunbar MS,Laivuori HM,Harger GF,Lykins DL,Roberts JM

    更新日期:2005-01-01 00:00:00

  • Elevated plasma chymotrypsin-like protease (chymase) activity in women with preeclampsia.

    abstract:OBJECTIVE:Chymase, a chymotrypsin-like protease, is a non-ACE angiotensin II (Ang II) generating enzyme. We determined if maternal chymotrypsin-like protease/chymase activity was increased in women with preeclampsia (PE). METHODS:Maternal plasma was extracted from venous blood of healthy nonpregnant women, women with ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641950802001842

    authors: Wang Y,Gu Y,Lewis DF,Alexander JS,Granger DN

    更新日期:2010-01-01 00:00:00

  • Eclampsia in Sweden.

    abstract:OBJECTIVE:Assess the actual rate of eclampsia in Sweden, describe the clinical picture of the disease and the maternal and perinatal outcomes. METHODS:Analysis of data regarding incidence of eclampsia registered in the Swedish Medical Birth Register 1991-1992. The records of all the cases with the diagnosis of eclamps...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120002906

    authors: Kullberg G,Lindeberg S,Hanson U

    更新日期:2002-01-01 00:00:00