Abstract:
BACKGROUND:A high prevalence of epilepsy has been observed in onchocerciasis endemic areas in the Democratic Republic of Congo (DRC). With this study we aimed to investigate whether Onchocerca volvulus infection is a risk factor for developing epilepsy in onchocerciasis endemic regions in the DRC. METHODS:Between October and December 2015, a multi-centre case control study was performed in onchocerciasis endemic health zones (HZ) in the DRC: one study site was situated in Tshopo Province in the HZ of Wanierukula (village of Salambongo) where there had been 13 annual community distributions of treatment with ivermectin (CDTI), a second was situated in Ituri Province in the HZ of Logo (village of Draju) where ivermectin had never been distributed and in the HZ of Rethy (village of Rassia) where there had been THREE CDTI annual campaigns before the study. Individuals with unprovoked convulsive epilepsy of unknown etiology were enrolled as cases (n = 175). Randomly selected healthy members of families without epilepsy cases from the same village and age-groups and were recruited as controls (n = 170). RESULTS:Onchocerciasis associated symptoms (e.g., itching and abnormal skin) were more often present in cases compared to controls (respectively, OR = 2.63, 95% CI: 1.63-4.23, P < 0.0001 and OR = 3.23, 95% CI: 1.48-7.09, P = 0.0034). A higher number of cases was found to present with microfilariae in skin snips and with O. volvulus IgG4 antibodies in the blood compared to controls. Moreover, the microfilariae load in skin snips was 3-10 times higher in cases than controls. CONCLUSIONS:This case control study confirms that O. volvulus is a risk factor for developing epilepsy in onchocerciasis endemic regions in the DRC.
journal_name
Infect Dis Povertyjournal_title
Infectious diseases of povertyauthors
Mandro M,Suykerbuyk P,Tepage F,Rossy D,Ngave F,Hasan MN,Hotterbeekx A,Mambandu G,Kashama JM,Laudisoit A,Colebunders Rdoi
10.1186/s40249-018-0465-9subject
Has Abstractpub_date
2018-10-08 00:00:00pages
79issue
1eissn
2095-5162issn
2049-9957pii
10.1186/s40249-018-0465-9journal_volume
7pub_type
杂志文章,多中心研究abstract::Brucellosis is one of the most widespread zoonoses in the world caused by several species of the genus Brucella. The disease, eradicated in many developed countries, is a re-emerging neglected zoonosis endemic in several zones especially in the Mediterranean region, impacting on human health and livestock production. ...
journal_title:Infectious diseases of poverty
pub_type: 历史文章,杂志文章,meta分析
doi:10.1186/s40249-015-0086-5
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:The data on hepatitis b virus (HBV) infection in immigrants population are scanty. The porpoise of this study was to define the demographic, virological, and clinical characteristics of subjects infected with HBV chronic infection in a cohort of immigrants living in Naples, Italy. METHODS:A screening for HB...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,多中心研究
doi:10.1186/s40249-016-0228-4
更新日期:2017-02-09 00:00:00
abstract:BACKGROUND:Brucellosis is a major public health issue in China, while its temporal and spatial distribution have not been studied in depth. This study aims to better understand the epidemiology of brucellosis in the mainland of China, by investigating the human, temporal and spatial distribution and clustering characte...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00754-8
更新日期:2020-10-13 00:00:00
abstract:BACKGROUND:In the Yunnan province of China, 18 counties in six prefectures border Myanmar. Due to its particular combination of geographic features, climate conditions, and cultural landscape, the area provides a suitable environment for the spread of insect-borne diseases such as malaria. In five identified Myanmar Sp...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0175-0
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:The pandemic of the coronavirus disease 2019 (COVID-19) has caused substantial disruptions to health services in the low and middle-income countries with a high burden of other diseases, such as malaria in sub-Saharan Africa. The aim of this study is to assess the impact of COVID-19 pandemic on malaria trans...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00788-y
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Over half the world's human populations are currently at risk from vector-borne diseases (VBDs), and the heaviest burden is borne by the world's poorest people, communities, and countries. The aim of this study was to conduct a review on VBD interventions relevant to housing and hygiene (including sanitation...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
doi:10.1186/s40249-018-0477-5
更新日期:2018-09-03 00:00:00
abstract:BACKGROUND:Access to clean and safe drinking water that is free from pathogenic protozoan parasites, especially Cryptosporidium parvum and Giardia lamblia that cause gastrointestinal illness in humans, is still an issue in Southeast Asia (SEA). This study is the first attempt to detect the aforementioned protozoan para...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0095-z
更新日期:2016-01-13 00:00:00
abstract:BACKGROUND:Avian influenza (AI) is a global public health threat. Understanding the knowledge that butchers have about it and the precautionary practices they take against it is crucial for designing future preparedness programs. This study aimed to identify the social determinants of knowledge and precautionary measur...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-2-10
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:The Qinghai-Tibet Plateau (QTP) of China is an extensive pastoral and semi-pastoral area, and because of poverty and bad hygiene conditions, Brucella is highly prevalent in this region. In order to adequately prevent this disease in the QTP region it is important to determine the identity of Brucella species...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0123-z
更新日期:2016-04-13 00:00:00
abstract:BACKGROUND:Strongyloidiasis is a gastrointestinal infection caused by the parasitic nematode Strongyloides stercoralis. It is estimated to infect up to 370 million people globally and is predominately found in tropical and subtropical areas of socioeconomic disadvantage. MAIN BODY:This systematic literature review ide...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0555-3
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:The development and spread of artemisinin-resistant Plasmodium falciparum malaria in Greater Mekong Subregion has created impetus for continuing global monitoring of efficacy of artemisinin-based combination therapies (ACTs). This post analyses is aimed to evaluate changes in early treatment response markers...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0577-x
更新日期:2019-08-06 00:00:00
abstract::The transmission of infectious diseases is a dynamic process determined by multiple factors originating from disease pathogens and/or parasites, vector species, and human populations. These factors interact with each other and demonstrate the intrinsic mechanisms of the disease transmission temporally, spatially, and ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0339-6
更新日期:2017-09-11 00:00:00
abstract::Mechanisms and outcomes of host-parasite interactions during malaria co-infections with gastrointestinal helminths are reasonably understood. In contrast, very little is known about such mechanisms in cases of malaria co-infections with tissue-dwelling parasites. This is lack of knowledge is exacerbated by misdiagnosi...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s40249-015-0070-0
更新日期:2015-08-29 00:00:00
abstract:BACKGROUND:Tuberculosis infection still places a great burden on HIV-infected individuals in China and other developing countries. Knowledge of the survival of HIV-infected patients with pulmonary tuberculosis (PTB) would provide important insights for the clinical management of this population, which remains to be wel...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0405-8
更新日期:2018-03-24 00:00:00
abstract:BACKGROUND:Control of snail intermediate hosts has been proved to be a fast and efficient approach for interrupting the transmission of schistosomiasis. Some plant extracts have shown obvious molluscicidal activity, and a new compound Luo-Wei, also named tea-seed distilled saponin (TDS), was developed based on the sapo...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0535-7
更新日期:2019-03-31 00:00:00
abstract:BACKGROUND:Given that increase in temperature may alter host-parasite relationships, the anticipated rise in temperature due to global warming might change transmission patterns of certain diseases. However, the extent to which this will happen is not well understood. METHODS:Using a host-parasite system involving Bul...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0260-z
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Foodborne trematodiasis (FBT) is a significant global health problem, with the liver flukes Opisthorchis viverrini, O. felineus, and Clonorchis sinensis contributing to half of the global burden of FBT. North-eastern Thailand where O. viverrini is endemic and un-cooked fish dishes remain an integral part of ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0281-7
更新日期:2017-04-04 00:00:00
abstract:BACKGROUND:National tuberculosis (TB) programs increasingly engage with international non-governmental organizations (INGOs), especially to provide TB care in complex settings where community involvement might be required. In Myanmar, however, there is limited data on how such INGO community-based programs are organize...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-017-0285-3
更新日期:2017-03-24 00:00:00
abstract:BACKGROUND:Female sex workers (FSW) who live in urban areas in Republic of Korea have a particularly high risk of sexually transmitted diseases (STD). We investigated the prevalence of s STDs in FSWs in order to determine the factors associated with sexually transmitted infections in Korea. METHODS:Study data were col...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-019-0516-x
更新日期:2019-01-22 00:00:00
abstract:BACKGROUND:Echinococcosis is a parasitic zoonosis caused by Echinococcus larvae parasitism causing high mortality. The Tibetan Region of Sichuan Province is a high prevalence area for echinococcosis in China. Understanding the geographic distribution pattern is necessary for precise control and prevention. In this stud...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0486-4
更新日期:2018-11-02 00:00:00
abstract:BACKGROUND:As part of an ongoing program that aims to use early detection and timely treatment to improve the control of echinococcosis, especially in younger age groups, we undertook a series of active surveys among Qinghai-Tibetan children in the Qinghai Province of Northwestern China in 2011 and 2012. The significan...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0455-y
更新日期:2018-07-12 00:00:00
abstract:BACKGROUND:Aedes borne viral diseases, notably dengue, are increasingly reported in Cameroon with Aedes aegypti being a major vector. Data on insecticide resistance of this vector and underlying mechanisms needed for outbreak preparedness remain scarce in Cameroon. Here, we present the nationwide distribution of insect...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-020-00769-1
更新日期:2020-11-02 00:00:00
abstract:BACKGROUND:There is accumulating evidence supporting the use of ivermectin as a malaria control tool. Recent findings from the repeat ivermectin mass drug administrations for control of malaria trial demonstrated a reduced incidence of malaria in villages which received repeated ivermectin mass drug administration (MDA...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-019-0588-7
更新日期:2019-08-23 00:00:00
abstract:BACKGROUND:Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are highly endemic in Xiji County of Ningxia Hui Autonomous Region (NHAR) in China where the control campaign based on dog de-worming with praziquantel has been undertaken over preceding decades. This study is to determine the current prevalence of ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-018-0458-8
更新日期:2018-08-09 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) patients face numerous difficulties adhering to the long-term, rigorous TB treatment regimen. Findings on TB patients' treatment adherence vary across existing literature and official reports. The present study attempted to determine the actual treatment adherence of new TB patients and to ...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/s40249-016-0134-9
更新日期:2016-05-05 00:00:00
abstract:BACKGROUND:Malaria is a major cause of morbidity and mortality in Northeast India. As there is limited information available on the potential influence of socio-economic variables on malaria risk, the present study was conducted to assess the influence of demographic factors, the socio-economic status, and knowledge, a...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-3-19
更新日期:2014-06-24 00:00:00
abstract::Zambia's estimated incidence of all forms of human tuberculosis (TB) is 707/100,000. High prevalence of bovine tuberculosis (BTB) - infection with Mycobacterium bovis - in cattle and the Kafue lechwe antelopes (Kobus leche Kafuensis) has been reported in the Kafue basin. Consumption of unpasteurised milk and meat prod...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章
doi:10.1186/2049-9957-2-13
更新日期:2013-07-09 00:00:00
abstract::Recently, the mortality of 240 causes in China including a subnational analysis during 1990-2013 was published in The Lancet. This comprehensive analysis will undoubtedly impact policymaking regarding public health in China. However, it is unfavourable in some degree to neglected tropical diseases, which is the subjec...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-017-0237-y
更新日期:2017-02-03 00:00:00
abstract:BACKGROUND:Following the West Africa Ebola virus disease (EVD) outbreak (2013-2016), WHO developed a preparedness checklist for its member states. This checklist is currently being applied for the first time on a large and systematic scale to prepare for the cross border importation of the ongoing EVD outbreak in the D...
journal_title:Infectious diseases of poverty
pub_type: 信件
doi:10.1186/s40249-020-00657-8
更新日期:2020-04-21 00:00:00
abstract:BACKGROUND:The damage inflicted by the coronavirus diseases 2019 (COVID-19) pandemic upon humanity is and will continue to be considerable. Unprecedented progress made in global health over the past 20 years has reverted and economic growth has already evaporated, giving rise to a global recession, the likes of which w...
journal_title:Infectious diseases of poverty
pub_type: 杂志文章,评审
doi:10.1186/s40249-020-00790-4
更新日期:2021-01-04 00:00:00