Curative-intent radiotherapy in patients with oligometastatic lesions from colorectal cancer: A single-center study.


:The purpose of the present study was to investigate the efficacy and safety of radiotherapy for patients with oligometastases from colorectal cancer (CRC).This was a retrospective cross-sectional study. Patients with liver and/or lung oligometastatic lesions from CRC treated with curative-intent radiotherapy in West China Hospital, Sichuan University, between 2009 and 2013 were included. Radiotherapy modality included 3-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), and stereotactic body radiation therapy (SBRT); simultaneous chemotherapies along with radiotherapy of metastasis were allowed. Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method. Local control (LC) rates, toxicities, and factors of prognostic significance were also assessed.A total of 40 CRC patients with 57 liver and/or lung oligometastatic lesions were included. Most of the patients (95%) had received at least 1 line of previous systemic chemotherapy. Among them, 19 patients with 26 lesions received 3D-CRT with a median dose of 51.5 Gy in 16.1 fractions, 7 patients with 11 lesions received IMRT with a median dose of 49.3 Gy in 10.4 fractions, and 14 patients with 20 lesions received SBRT with a median dose of 56.4 Gy in 6.7 fractions, respectively. The median follow-up time was 34 months (range, 9-86 months). Median OS and PFS for patients were 30.0 months [95% confidence interval (95% CI), 21.3-38.7] and 11.0 months (95% CI, 9-13), respectively. One, 3, and 5 years' LC rates for metastasis were 63.2%, 24.6%, and 16.9%, respectively. In subgroup analysis, patients with metachronous metastases had longer OS (median, 41.0 months; 95% CI, 33.3-48.7) than patients with synchronous lesions (median, 17.0 months; 95% CI, 7.4-26.6, P = .001). All patients tolerated the radiation treatment well, and there was no treatment-related death. Multivariate analysis showed that number of metastasis lesions and simultaneous liver and lung metastases were potential survival predictors.The study demonstrated that curative radiotherapy might be a tolerable and potential alternative for the treatment of patients with liver and/or lung oligometastases from CRC, and patients with metachronous lesions might have better survival than those with synchronous lesions when treated with curative-intent radiotherapy.


Medicine (Baltimore)




He X,Zhang P,Li Z,Bi F,Xu F,Wang X,Shen Y,Li Q,Qiu M




Has Abstract


2018-10-01 00:00:00
















  • Lymphodepletion chemotherapy revitalizes chimeric antigen receptor T cells contributing to regression of relapsed B-cell lymphoma: A case report.

    abstract:INTRODUCTION:Chimeric antigen receptor T cells (CAR-T) targeting CD19 have shown great potential for treatment of B-cell malignancies. For those patients who can not achieve complete remission (CR) or suffer from relapse after CAR-T therapy, further therapeutic strategies still remain elusive. Whether existing CAR-T ce...


    pub_type: 杂志文章


    authors: Liang Z,Zhang H,Shao M,Cui Q,Wu Z,Xiao L,Huang H,Hu Y

    更新日期:2020-10-23 00:00:00

  • Efficacy and safety of high-viscosity cement in percutaneous vertebroplasty for treatment of Osteoporotic vertebral compression fractures: A retrospective cohort study.

    abstract::To evaluate the efficacy and safety of high viscosity bone cement in the percutaneous vertebroplasty (PVP) for treatment of single-level osteoporotic vertebral compression fractures.Eighty patients were enrolled in this study. All patients were received PVP, and they were divided into 2 groups according to the viscosi...


    pub_type: 杂志文章


    authors: Li K,Feng H,Luo D,Zhang W,Yang K,Ji C,Liu J,Xu H

    更新日期:2020-06-05 00:00:00

  • Fecal microbiota transplantation treatment for refractory ulcerative colitis with allergy to 5-aminosalicylic acid: A case report.

    abstract:INTRODUCTION:Fecal microbiota transplantation (FMT) is currently being explored as a potential therapy for ulcerative colitis (UC). Here, we report the first case of a UC patient with allergy to 5-aminosalicylic acid (5-ASA) who underwent FMT and achieved clinical remission. CASE PRESENTATION:This patient had a 9-year...


    pub_type: 杂志文章


    authors: Wang HG,Liu SP,Ma TH,Yan W,Zhou JF,Shi YT,Shen P,Yang XZ,Wu SN

    更新日期:2018-05-01 00:00:00

  • The spectrum of invasive pneumococcal disease at an adult tertiary care hospital in the early 21st century.

    abstract::Despite widespread pneumococcal vaccination of children and adults, invasive pneumococcal disease (IPD) remains prominent. Using our database of all Streptococcus pneumoniae infections at the Veterans Affairs Medical Center, Houston, Texas, since 2000, we reviewed cases of IPD, defined as the isolation of pneumococci ...


    pub_type: 杂志文章


    authors: Rueda AM,Serpa JA,Matloobi M,Mushtaq M,Musher DM

    更新日期:2010-09-01 00:00:00

  • Clinical effects of Shou-Wu Jiang-Qi Decoction combined acupuncture on the treatment of Polycystic Ovarian Syndrome with kidney deficiency, phlegm and blood stasisness: Study protocol clinical trial (SPIRIT Compliant).

    abstract:BACKGROUND:Polycystic ovary syndrome (PCOS) is a female endocrine disease with a high incidence. At present, drug treatment is still the main therapeutic strategy for PCOS. Traditional Chinese medicine has a long history in the treatment of menstrual disorders. Shouwu Jiangqi Decoction (SWJQD) is a traditional herbal m...


    pub_type: 杂志文章,随机对照试验


    authors: Xu W,Tang M,Wang J,Wang L

    更新日期:2020-03-01 00:00:00

  • Effects of mitochondrial ATP-sensitive potassium channel activation (nicorandil) in patients with angina pectoris undergoing elective percutaneous coronary interventions: A meta-analysis of randomized controlled trials.

    abstract:AIMS:Nicorandil, which is a mitochondrial ATP-sensitive potassium channel opener, is believed to improve perioperative myocardial injury (PMI) in patients undergoing percutaneous coronary intervention (PCI), but recent studies have shown that nicorandil treatment did not improve functional and clinical outcomes in pati...


    pub_type: 杂志文章,meta分析,评审


    authors: Zhu H,Xu X,Fang X,Zheng J,Chen T,Huang J

    更新日期:2019-01-01 00:00:00

  • Interactive associations of sex and hyperlipidemia with calcific tendinitis of the shoulder in Taiwanese adults.

    abstract::Calcific tendinitis (CT) of the shoulder is a painful disorder usually identified in individuals aged 40 and 60 years. The estimated global prevalence of CT is 2.7% to 36%. We examined the association of hyperlipidemia and sex with CT of the shoulder using Taiwan Biobank (TWB) and the National Health Insurance Researc...


    pub_type: 杂志文章


    authors: Lin CC,Nfor ON,Su CL,Hsu SY,Tantoh DM,Liaw YP

    更新日期:2020-11-13 00:00:00

  • Calcified peripancreatic lymph nodes in pancreatic and hepatic tuberculosis mimicking pancreatic malignancy: A case report and review of literature.

    abstract:RATIONALE:Tuberculosis remains a serious menace to the health of people. Isolated hepatic tuberculosis is rare and pancreatic tuberculosis is extremely rare. The preoperative diagnosis of pancreatic tuberculosis remains a great challenge. PATIENT CONCERNS:A 58-year-old Asian woman was referred to our hospital for eval...


    pub_type: 杂志文章,评审


    authors: Liang X,Huang X,Yang Q,He J

    更新日期:2018-09-01 00:00:00

  • Late-Onset Immune Thrombocytopenic Purpura After Withdrawal of Interferon Treatment for Chronic Hepatitis C Infection: A Case Report.

    abstract::Immune thrombocytopenic purpura (ITP) is a life-threatening complication following pegylated interferon alpha (PEG-IFN) plus ribavirin treatment, the standard treatment for hepatitis C virus (HCV) infection. We reported a rare case with late-onset ITP after withdrawal of PEG-IFN treatment.A 53-year-old male with hepat...


    pub_type: 杂志文章


    authors: Hsiao CH,Tseng KC,Tseng CW,Tung CH

    更新日期:2015-08-01 00:00:00

  • Biomechanical effect of bone resorption of the spinous process after single-segment interspinous dynamic stabilization device implantation: A finite element analysis.

    abstract::This study aims to explore the influence of bone resorption of the spinous process after single-segment interspinous process device (IPD) implantation on the biomechanics of the lumbar spine.The 3D finite element model of the lumbar spine (L3-L5) was modified, and 2 models that simulated the presence and absence of bo...


    pub_type: 杂志文章


    authors: Zhu ZQ,Duan S,Wang KF,Liu HY,Xu S,Liu CJ

    更新日期:2018-07-01 00:00:00

  • Medical management of septic arthritis of sternoclavicular joint: A case report.

    abstract:RATIONALE:Sternoclavicular joint septic arthritis is an unusual disease in healthy adults, and Staphylococcus aureus is the most common causative pathogen. The current treatment of choice is surgery with sternoclavicular joint resection and pectoralis flap closure, especially when the disease is complicated by osteomye...


    pub_type: 杂志文章


    authors: Kwon HY,Cha B,Im JH,Baek JH,Lee JS

    更新日期:2020-10-30 00:00:00

  • Milk and yogurt intake and breast cancer risk: A meta-analysis.

    abstract::Different patterns of milk and breast cancer rates across countries suggest that several components of milk could affect breast cancer risk. However, the components of diet are complex including milk that could potentially influence risk. Some milk products such as whole milk and cheese have a high fat content which m...


    pub_type: 杂志文章,meta分析


    authors: Chen L,Li M,Li H

    更新日期:2019-03-01 00:00:00

  • Concomitant severe influenza and cryptococcal infections: A case report and literature review.

    abstract::Concomitant influenza and cryptococcal infections are rare. Herein, we describe an unusual case of an avian influenza A (H7N9) infection with several severe mixed bacterial infections and systemic super-infection with Cryptococcus neoformans presenting as ventilator-associated pneumonia (VAP) and bloodstream infection...


    pub_type: 杂志文章,评审


    authors: Huang J,Li H,Lan C,Zou S,Zhang H,Wang X,Weng H

    更新日期:2019-05-01 00:00:00

  • Use of siphon irrigation during burr-hole craniostomy to evacuate chronic subdural hematoma: A retrospective cohort comparison study.

    abstract::Burr-hole craniostomy (BHC) is a widely accepted treatment for chronic subdural hematomas (CSDHs). This study adopted siphon irrigation to evacuate CSDHs and investigated its efficacy and safety as compared with the traditional irrigation used in BHC.A retrospective cohort study was conducted at a center between Janua...


    pub_type: 杂志文章


    authors: Chen S,Chen Z,Yang B,Xu T,Tu XK

    更新日期:2020-05-22 00:00:00

  • Gemcitabine plus S-1 for metastatic pancreatic cancer.

    abstract::To investigate the treatment effects of gemcitabine plus S-1 (GS) for metastatic pancreatic cancer in our institution.Data from 41 patients with metastatic pancreatic cancer treated with GS regimen in West China Hospital, Sichuan University were reviewed. The therapeutic efficacy and toxicity were evaluated. The influ...


    pub_type: 杂志文章


    authors: Zhu H,Yi C,Zhao Y,Gou H

    更新日期:2018-10-01 00:00:00

  • The degree of intubation difficulties and the frequency of complications in obese patients at the Hospital Emergency Department and the Intensive Care Unit: Case-control study.

    abstract::The intubation difficulties in obese patients are not a new problem. They may result from an accumulation of fat in the oral cavity and cheeks. A thick tongue is also a significant factor. The literature reports that some tests to determine the intubation difficulties in obese people may be unreliable. The observed pr...


    pub_type: 杂志文章


    authors: Cierniak M,Sobczak R,Timler D,Wieczorek A,Borkowski B,Gaszyński T

    更新日期:2016-12-01 00:00:00

  • Erratum: Current challenges in providing bariatric surgery in France: A nationwide study: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000005314.]. ...


    pub_type: 已发布勘误



    更新日期:2017-03-24 00:00:00

  • Pedunculated carcinoma ex pleomorphic adenoma of the nasal cavity: A unique case report.

    abstract:BACKGROUND:A carcinoma ex pleomorphic adenoma (CXPA) is an epithelial malignancy arising in or from a benign pleomorphic salivary adenoma. The parotid gland is the most common location of CXPAs. Minor salivary gland CXPAs of the nasal cavity are exceedingly rare, with only 6 documented in the literature. METHODS AND R...


    pub_type: 杂志文章


    authors: Liao PW,Chen YL,Chen JW

    更新日期:2016-09-01 00:00:00

  • The prediction potential of neutrophil-to-lymphocyte ratio for the therapeutic outcomes of programmed death receptor-1/programmed death ligand 1 inhibitors in non-small cell lung cancer patients: A meta-analysis.

    abstract:BACKGROUND:Programmed death receptor-1 (PD-1)/programmed death ligand 1 (PD-L1) inhibitors have been demonstrated to improve the prognosis of patients with advanced non-small cell lung cancer (NSCLC) compared with chemotherapy. However, there were still some non-responders. Thus, how to effectively screen the responder...


    pub_type: 杂志文章,meta分析


    authors: Huang Y,Shen A

    更新日期:2020-08-21 00:00:00

  • Timescale of tumor volume of a young breast cancer patient with luminal B subtype: A case report.

    abstract:RATIONALE:It is largely unknown about the tumor growth of breast cancer naturally. We devised and analyzed an appropriate mathematical tool of the equations that describe how fast tumors grow without treatment on the basis of the ellipsoid shape of solid breast cancer. PATIENT CONCERNS:A 31-year-old woman presented wi...


    pub_type: 杂志文章


    authors: Mao X,Zhou M,Fan C,Chen B,Jin F

    更新日期:2019-10-01 00:00:00

  • Integrative exploration of genomic profiles for triple negative breast cancer identifies potential drug targets.

    abstract:BACKGROUND:Triple negative breast cancer (TNBC) is high-risk due to its rapid drug resistance and recurrence, metastasis, and lack of targeted therapy. So far, no molecularly targeted therapeutic agents have been clinically approved for TNBC. It is imperative that we discover new targets for TNBC therapy. OBJECTIVES:A...


    pub_type: 杂志文章


    authors: Wang X,Guda C

    更新日期:2016-07-01 00:00:00

  • Different clinical characteristics in sporadic young-age onset colorectal cancer.

    abstract::The incidence of colorectal cancer (CRC) is increasing in young-age patients, but the clinical history is not established. Authors analyzed the clinical characteristics of young-age onset CRC to support basic information for setting treatment policies.Between January 2006 to January 2014, 100 CRC patients diagnosed at...


    pub_type: 杂志文章


    authors: Lee J,Kim IH,Kim JS,Kim SW,Kim JG,Oh ST,Kang WK,Lee MA

    更新日期:2016-09-01 00:00:00

  • High plasma fibrinogen is correlated with poor response to trastuzumab treatment in HER2 positive breast cancer.

    abstract::Some of HER-2 positive breast cancer patients failed to trastuzumab treatment. Recent reports have indicated the correlation between plasma coagulation parameters and clinical characteristics in breast cancer. The aim of this study was to analyze the role of coagulation parameters in trastuzumab treated patients. Coag...


    pub_type: 杂志文章


    authors: Liu YL,Lu Q,Liang JW,Xia Y,Zhang W,Hu BQ,Shang FF,Ji YR,Wang J,Wang Q,Liang B

    更新日期:2015-02-01 00:00:00

  • Reconstruction of extensive plantar forefoot defects with free anterolateral thigh flap.

    abstract:PURPOSE:The aim of the soft tissue reconstruction of plantar forefoot should yield weight-bearing function and aesthetic contour, which poses a significant challenge for reconstructive surgeons to provide an appropriate flap according to the "like for like" reconstructive principle. Local flaps and pedicled flaps have ...


    pub_type: 杂志文章


    authors: Chen L,Zhang Z,Li R,Liu Z,Liu Y

    更新日期:2020-12-11 00:00:00

  • Pyoderma gangrenosum: clinical and laboratory findings in 15 patients with special reference to polyarthritis.

    abstract::Fifteen consecutive patients with PG have been studied during the period 1971-78. Systemic disease was found in 13 of the patients and preceded the skin disease in 10 patients by 1-25 years. Only two patients had ulcerative colitis. One patient had paroxysmal nocturnal hemoglobinuria and three patients had an IgA myel...


    pub_type: 杂志文章


    authors: Holt PJ,Davies MG,Saunders KC,Nuki G

    更新日期:1980-03-01 00:00:00

  • Diagnostic value of pentraxin 3 in respiratory tract infections: A meta-analysis.

    abstract:BACKGROUND:Pentraxin 3 is an acute inflammatory protein of the long pentraxin subfamily. A meta-analysis was performed to assess diagnostic accuracy of pentraxin 3 for respiratory tract infections. METHODS:We identify studies examining diagnostic value of pentraxin 3 for respiratory tract infections by searching Pubme...


    pub_type: 杂志文章,meta分析


    authors: Ye W,Huang QD,Tang TY,Qin GY

    更新日期:2020-04-01 00:00:00

  • Late-onset anastomotic leak following sweet esophagectomy: A case report and review of the literature.

    abstract:RATIONALE:Late-onset anastomotic leak (AL) is an uncommon but potentially lethal complication after esophagectomy. PATIENT CONCERNS:A 74-year-old male patient was readmitted due to chest distress and chills about 3 months after initial esophagectomy for cancer. DIAGNOSES:The previous endoscopic biopsy revealed primar...


    pub_type: 杂志文章


    authors: Kong FW,Wang WM,Liu L,Wu WB,Gong LB,Zhang M

    更新日期:2020-10-02 00:00:00

  • The hepatic protective effects of tacrolimus as a rinse solution in liver transplantation: A meta-analysis.

    abstract:BACKGROUND:Tacrolimus was used as a rinse solution against ischaemia-reperfusion injury (IRI) in liver transplantation for years but its protective effects remain controversies. METHODS:We conducted literature retrieval in electronic databases including MEDLINE, EMBASE and Cochrane Central to identify relevant randomi...


    pub_type: 杂志文章,meta分析


    authors: Guo T,Lei J,Gao J,Li Z,Liu Z

    更新日期:2019-05-01 00:00:00

  • Clinical Significance of the Prognostic Nutritional Index for Predicting Short- and Long-Term Surgical Outcomes After Gastrectomy: A Retrospective Analysis of 7781 Gastric Cancer Patients.

    abstract::To evaluate the predictive and prognostic significance of the prognostic nutritional index (PNI) in a large cohort of gastric cancer patients who underwent gastrectomy.Assessing a patient's immune and nutritional status, PNI has been reported as a predictive marker for surgical outcomes in various types of cancer.We r...


    pub_type: 杂志文章


    authors: Lee JY,Kim HI,Kim YN,Hong JH,Alshomimi S,An JY,Cheong JH,Hyung WJ,Noh SH,Kim CB

    更新日期:2016-05-01 00:00:00

  • Relationship of atopic dermatitis with stroke and myocardial infarction: A meta-analysis.

    abstract:BACKGROUND:Lots of previous reports have suggested a potential association of atopic dermatitis (AD) with stroke and myocardial infarction (MI). However, the result is still controversial, Consequently, we conducted this meta-analysis to estimate the relationship of AD with Stroke and MI. METHODS:PubMed, Embase, and W...


    pub_type: 杂志文章,meta分析


    authors: Yuan M,Cao WF,Xie XF,Zhou HY,Wu XM

    更新日期:2018-12-01 00:00:00