Secukinumab for treatment of psoriasis: does secukinumab precipitate or promote the presentation of cutaneous T-cell lymphoma?


:Secukinumab is an interleukin (IL)-17 monoclonal antibody inhibiting T-helper (Th)1-mediated immune response. It has proven high efficacy for moderate to severe psoriasis but data on its long-term toxicities are limited. We describe two patients who received secukinumab for clinically presumed psoriasis, but were subsequently diagnosed with mycosis fungoides (MF) following skin biopsies triggered by skin deterioration while on secukinumab. Previous studies suggested decreased numbers of regulatory T cells (Tregs) with increasing stage of MF, which may lead to the shift in the Treg/Th17 balance towards the Th17 pathway. Theoretically, the use of IL-17 monoclonal antibodies to inhibit Th17 pathway may lead to further immunosuppression and disease progression in cutaneous T-cell lymphoma (CTCL) by shifting the balance towards Tregs, although this hypothesis has not been proven. With uncertainty over the role of IL-17 and Treg/Th17 as well as diagnostic challenges in CTCL, we recommend that patients should have a confirmatory skin biopsy prior to the commencement of biologic therapy.


Clin Exp Dermatol


Yoo J,Shah F,Velangi S,Stewart G,Scarisbrick JS




Has Abstract


2019-06-01 00:00:00












  • A 20-year epidemiological study of cutaneous melanoma in the Rijeka district of Croatia.

    abstract::A retrospective study was made of the incidence of cutaneous melanoma among the population of the district of Rijeka (Croatia) during the period 1977-96. A total of 397 patients with cutaneous melanoma was documented during this period. Over the 20-year period the incidence of the tumour increased, the mean annual rat...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Zamolo G,Gruber F,Jonjić A,Cabrijan L,Palle M,Grubisić-Greblo H

    更新日期:2000-01-01 00:00:00

  • Pemphigus vulgaris following varicella infection.

    abstract::We describe a 26-year-old Indian man who presented with chickenpox and subsequently developed pemphigus vulgaris 17 days after initial resolution of lesions. The mechanism of progression from one disease to the other is postulated to be that of epitope spreading or molecular mimicry. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Goon AT,Tay YK,Tan SH

    更新日期:2001-11-01 00:00:00

  • Allergic airborne contact dermatitis from essential oils used in aromatherapy.

    abstract::Contact allergy to various essential oils used in aromatherapy was demonstrated on patch testing in a 53-year-old patient suffering from relapsing eczema resistant to therapy on various uncovered parts of the skin, in particular the scalp, neck and hands. Sensitization was due to previous exposure to lavender, jasmine...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Schaller M,Korting HC

    更新日期:1995-03-01 00:00:00

  • Co-existent primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis.

    abstract::We describe the case of a 37-year-old female with a history of psoriasiform dermatitis who presented with multicentric primary cutaneous CD30-positive anaplastic large T cell lymphoma (ALCL). Despite aggressive systemic therapy, the patient suffered multiple relapses and the lymphoma spread to cervical and inguinal ly...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Dawn G,Morrison A,Morton R,Bilsland D,Jackson R

    更新日期:2003-11-01 00:00:00

  • The role of cyclooxygenase-2 and prostaglandin E2 in the pathogenesis of cutaneous lichen planus.

    abstract:BACKGROUND:Lichen planus (LP) is an inflammatory disease of the skin and mucous membranes. Autoimmunity has been suggested as a possible cause of this disease. The cyclooxygenase enzymes (COX-1, COX-2) are the key enzymes in the conversion of arachidonic acid into prostaglandins. Prostaglandin E2 (PGE2), a key product ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: El-Rifaie AA,Rashed LA,Doss RW

    更新日期:2015-12-01 00:00:00

  • Health-related quality of life among patients with facial acne -- assessment of a new acne-specific questionnaire.

    abstract::The psychosocial effects of facial acne are well accepted but until recently few validated instruments existed which were suitable for use in clinical trials. The aim of this study was to assess measurement characteristics (reproducibility, correlation with acne severity, and sensitivity to detect change after acne th...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Martin AR,Lookingbill DP,Botek A,Light J,Thiboutot D,Girman CJ

    更新日期:2001-07-01 00:00:00

  • Metallothionein I and II gene knock-out mice exhibit reduced tolerance to 24-h sodium lauryl sulphate patch testing.

    abstract:BACKGROUND:Metallothioneins (MTs) are a group of proteins widely distributed in tissues regulating metal metabolism, scavenging free radicals, and taking part in immunological reactions. Knockout mice for MT genes I and II (MT(-/-)) exhibit reduced tolerance to ultraviolet B injury in vivo. Upregulation of MT proteins ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ma C,Li LF,Zhang BX

    更新日期:2007-07-01 00:00:00

  • An unusually extensive case of cutaneous anthrax in a patient with type II diabetes mellitus.

    abstract::Naturally acquired anthrax infection remains an important public-health problem in developing countries. Turkey is one of the countries in which the zoonotic form of anthrax may still be encountered. The most frequent portal of entry for anthrax spores is the skin. Although cutaneous anthrax is usually self-limiting, ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Erkek E,Ayaslioglu E,Beygo B,Ozluk U

    更新日期:2005-11-01 00:00:00

  • Chondrodermatitis nodularis helicis occurring with systemic sclerosis--an under-reported association?

    abstract::Three cases of chondrodermatitis nodularis helicis (CDNH) in patients with the limited form of systemic sclerosis are described. Two of the three cases were noted during regular follow-up visits and the third case was found as part of a survey of the 21 other patients with systemic sclerosis routinely seen in the depa...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Bottomley WW,Goodfield MD

    更新日期:1994-05-01 00:00:00

  • Simvastatin-induced lichenoid drug eruption.

    abstract::Cutaneous drug eruptions have a variety of clinical features. Lichenoid drug eruptions are rare and may be difficult to diagnose. A case of a simvastatin-induced lichenoid eruption with skin and mucosal involvement is reported. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Roger D,Rolle F,Labrousse F,Brosset A,Bonnetblanc JM

    更新日期:1994-01-01 00:00:00

  • First case of Rubinstein-Taybi syndrome with desquamation associated with a novel mutation in the bromodomain of the CREBBP gene.

    abstract::Rubinstein-Taybi syndrome (RSTS) is a rare congenital disorder, mainly characterized by postnatal growth retardation, intellectual disability, and facial and limb abnormalities. Although not considered as characteristic manifestations, numerous cutaneous anomalies have also been reported in patients with RSTS while th...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Wang L,Deng Y,Zhou XL,Ma JJ,Li W

    更新日期:2019-07-01 00:00:00

  • Ceramide profile in hypohidrotic ectodermal dysplasia.

    abstract:BACKGROUND:Hypohidrotic ectodermal dysplasia (HED) is a rare genetic disease. The clinical presentation includes lack of sweating ability, and an often widely spread dermatitis resembling atopic dermatitis (AD). In AD, the skin-barrier defect is partly ascribed to the altered lipid profile in the stratum corneum and pa...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Jungersted JM,Høgh JK,Hellgren LI,Agner T,Jemec GB

    更新日期:2012-03-01 00:00:00

  • Dermoscopic evaluation of two patients with lupus miliaris disseminatus faciei.

    abstract::Lupus miliaris disseminatus faciei (LMDF) is a chronic and uncommon inflammatory dermatosis, characterized by yellowish-red papules, especially on the face and around the eyelids. It is considered to be a reaction to destroyed hair follicles. We dermoscopically evaluated two patients diagnosed with LMDF. Dermoscopy re...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ayhan E,Alabalik U,Avci Y

    更新日期:2014-06-01 00:00:00

  • A trial of accelerated PUVA in psoriasis.

    abstract::Ten psoriatic patients were treated with an accelerated PUVA regimen. Nine patients cleared in an average of 13.7 treatments (range 4-24) after an average total UVA dose of 83 J/cm2 (range 18-186). One patient had to withdraw due to pruritus and burning and six others had burning problems. The high incidence of burnin...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Green C,George S,Lakshmipathi T,Ferguson J

    更新日期:1993-07-01 00:00:00

  • Induction of hair growth in alopecia totalis with diphencyprone sensitization.

    abstract::The therapeutic use of the induction of an allergic contact sensitivity to diphencyprone in alopecia areata has been studied. Fourteen subjects had alopecia totalis and four had extensive and long-standing alopecia areata. Topical diphencyprone was capable of inducing an allergic contact sensitivity in 16 subjects (89...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Monk B

    更新日期:1989-03-01 00:00:00

  • Squamous cell carcinoma arising in a venous ulcer as a complication of the Klippel-Trenaunay syndrome.

    abstract::Klippel-Trenaunay (KT) syndrome is a vascular malformation characterized by a port-wine stain, varicose veins and hypertrophy of the affected limb. Ulceration is considered an uncommon complication of KT syndrome and occurrence of skin cancer has been previously reported only in one case. We observed a case of KT synd...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: De Simone C,Giampetruzzi AR,Guerriero C,De Masi M,Amerio P,Cina G

    更新日期:2002-05-01 00:00:00

  • Development of lichen planus and psoriasis on lesions of vitiligo vulgaris.

    abstract::This paper reports a unique case of coexistence of vitiligo vulgaris, lichen planus and psoriasis vulgaris in a 53-year-old man. Five years after the onset of vitiligo, lichen planus developed on his lower lip. Another 4 years after the onset of lichen planus, he also exhibited psoriasis on his upper arms and trunk. B...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ujiie H,Sawamura D,Shimizu H

    更新日期:2006-05-01 00:00:00

  • Scoring the proliferative activity of haemangioma of infancy: the Haemangioma Activity Score (HAS).

    abstract:BACKGROUND:Haemangioma of infancy (HOI) is the most frequently occurring benign tumour of infancy. A good, reliable and objective scoring system for haemangioma activity is not yet available. AIM:We have developed a simple system called the Haemangioma Activity Score (HAS) for scoring the (disease) proliferative activ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Janmohamed SR,de Waard-van der Spek FB,Madern GC,de Laat PC,Hop WC,Oranje AP

    更新日期:2011-10-01 00:00:00

  • Intravenous cidofovir for resistant cutaneous warts in a patient with psoriasis treated with monoclonal antibodies.

    abstract::Human papilloma virus is a common and often distressing cutaneous disease. It can be therapeutically challenging, especially in immunocompromised patients. We report a case of recalcitrant cutaneous warts that resolved with intravenous cidofovir treatment. The patient was immunocompromised secondary to monoclonal anti...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: McAleer MA,Bourke J

    更新日期:2011-08-01 00:00:00

  • Psoriasis or crusted scabies.

    abstract::We describe a case of a 67-year-old woman with a 1-year history of nail thickening and a non-itchy erythematous scaly eruption on the fingertips. She was diagnosed with psoriasis and started on methotrexate after having had no response to topical calcipotriol. The diagnosis was reviewed after it was revealed by anothe...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Goyal NN,Wong GA

    更新日期:2008-03-01 00:00:00

  • Usefulness of ultrasonography in the diagnosis of ischaemic fasciitis.

    abstract::We present the case of a 68-year-old woman who developed a painful subcutaneous tumour in the sacral region. Histological examinations revealed a characteristic zonal pattern with a central zone of liquefactive necrosis, surrounded by proliferated atypical fibroblasts and prominent vessels, indicating ischaemic fascii...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Kaneko T,Rokunohe D,Takiyoshi N,Minakawa S,Nakano H,Sawamura D

    更新日期:2016-07-01 00:00:00

  • The Neil Smith Memorial Lecture: John Laws Milton. The Founder of St John's Hospital for Diseases of the Skin.

    abstract::John Laws Milton, a 19th-Century surgeon, founded the St John's Hospital for Diseases of the Skin close to Leicester Square in London in 1863. This article reviews his single-minded effort to establish dermatology as a medical subspeciality and to create a proper skin diseases hospital. The review also details his man...

    journal_title:Clinical and experimental dermatology

    pub_type: 传,历史文章


    authors: Black MM

    更新日期:2003-01-01 00:00:00

  • Pyoderma faciale in a patient with Crohn's disease.

    abstract::We wish to report the progress of a patient with pyoderma faciale and Crohn's disease. The patient is interesting in that on two occasions the relapse in her skin condition coincided with the introduction of non-steroidal anti-inflammatory drugs. Therapy with isotretinoin was effective and well tolerated. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: McHenry PM,Hudson M,Smart LM,Rennie JA,Mowat NA,White MI

    更新日期:1992-11-01 00:00:00

  • Stevens-Johnson syndrome and toxic epidermal necrolysis due to anticonvulsants share certain clinical and laboratory features with drug-induced hypersensitivity syndrome, despite differences in cutaneous presentations.

    abstract:BACKGROUND:Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is characterized by late disease onset, fever, rash, hepatic dysfunction, haematological abnormalities, lymphadenopathy and often, human herpesvirus (HHV) reactivation. The diagnosis of DIHS is ba...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Teraki Y,Shibuya M,Izaki S

    更新日期:2010-10-01 00:00:00

  • Demyelination during anti-tumour necrosis factor therapy for psoriasis.

    abstract::Anti-tumour necrosis factor (anti-TNF) therapies have been associated with neurological complications, including in rare cases demyelinating disease. It is currently unknown whether patients who have received more than one immunosuppressive agent or anti-TNF have a greater risk of demyelination. We report the case of ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Boggs JME,Barnes L

    更新日期:2018-07-01 00:00:00

  • Acantholytic dermatosis of the vagina: the diagnostic challenge of acantholytic disease in the genital region.

    abstract::We report the case of a 24-year-old woman with an 8-month history of deep pelvic pain and postcoital bleeding. Examination revealed desquamation of the vaginal epithelium with tender fissured plaques in the vagina, initially thought to be vaginal intraepithelial neoplasia. Histology showed squamous mucosa with supraba...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Kentley J,Cerio R,Khorshid M,Gibbon K

    更新日期:2017-03-01 00:00:00

  • Recalcitrant facial pemphigus vulgaris: correlation of skin lesions with the ratio of antidesmoglein antibodies 1 and 3.

    abstract::Pemphigus vulgaris (PV) is an autoimmune bullous disease characterized by autoantibodies against desmogleins. We report a case of recalcitrant PV, which progressed from the mucosal to the mucocutaneous type, with a corresponding increase in anti-desmoglein (Dsg)1 and decrease in anti-Dsg3 antibody titres. Thus, the cl...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Fujii M,Honma M,Iinuma S,Kaneta K,Komatsu S,Sato K,Takahashi H,Ishida-Yamamoto A,Iizuka H

    更新日期:2011-04-01 00:00:00

  • A tribute to Robert Willan in Bloomsbury Square.

    abstract::Robert Willan is commemorated by a blue plaque on the house in which he lived in Bloomsbury Square in London. He lived there during a productive period of his career, until ill-health caused him to travel to Madeira, where he died. This fitting tribute to Willan is the result of the efforts of Dr. Henry MacCormac, him...

    journal_title:Clinical and experimental dermatology

    pub_type: 传,历史文章,杂志文章


    authors: Walker SL

    更新日期:2011-08-01 00:00:00

  • Dyschromatosis universalis hereditaria.

    abstract::Dyschromatosis universalis hereditaria is a clinically heterogenous disorder. We report two unrelated Indian patients with dyschromatosis universalis hereditaria, who had generalized and progressive reticulate hyper- and hypo-pigmentation of the skin. The oral mucosa and tongue also showed mottled pigmentation. Intrig...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Sethuraman G,Srinivas CR,D'Souza M,Thappa DM,Smiles L

    更新日期:2002-09-01 00:00:00

  • Association between effective dose of prednisolone, alone or in conjunction with other immunosuppressants, and titre of anti-bullous pemphigoid 180 antibody: a retrospective study of 42 cases.

    abstract:BACKGROUND:Corticosteroids, especially prednisolone or prednisone, are the most commonly used drugs for the treatment of bullous pemphigoid (BP). However, the appropriate initial effective prednisolone dose has not been established. Recently, a highly sensitive and specific ELISA for detection of autoantibodies to the ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Miida H,Fujiwara H,Ito M

    更新日期:2011-07-01 00:00:00