Secukinumab for treatment of psoriasis: does secukinumab precipitate or promote the presentation of cutaneous T-cell lymphoma?


:Secukinumab is an interleukin (IL)-17 monoclonal antibody inhibiting T-helper (Th)1-mediated immune response. It has proven high efficacy for moderate to severe psoriasis but data on its long-term toxicities are limited. We describe two patients who received secukinumab for clinically presumed psoriasis, but were subsequently diagnosed with mycosis fungoides (MF) following skin biopsies triggered by skin deterioration while on secukinumab. Previous studies suggested decreased numbers of regulatory T cells (Tregs) with increasing stage of MF, which may lead to the shift in the Treg/Th17 balance towards the Th17 pathway. Theoretically, the use of IL-17 monoclonal antibodies to inhibit Th17 pathway may lead to further immunosuppression and disease progression in cutaneous T-cell lymphoma (CTCL) by shifting the balance towards Tregs, although this hypothesis has not been proven. With uncertainty over the role of IL-17 and Treg/Th17 as well as diagnostic challenges in CTCL, we recommend that patients should have a confirmatory skin biopsy prior to the commencement of biologic therapy.


Clin Exp Dermatol


Yoo J,Shah F,Velangi S,Stewart G,Scarisbrick JS




Has Abstract


2019-06-01 00:00:00












  • Facial leiomyomas.

    abstract::We present a patient with multiple leiomyomas confined to the left cheek, giving rise to an unusual clinical presentation of this condition. The lesions were cosmetically disfiguring and, because of their exposed location, were particularly painful in the winter months. The treatment of this condition is discussed. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Tatnall FM,Leigh IM

    更新日期:1990-07-01 00:00:00

  • Improvement of trigeminal neurotrophic ulceration with pimozide in a cognitively impaired elderly woman--a case report.

    abstract::Neurotrophic ulceration of the face is a rare but well recognized sequel to division of the trigeminal nerve. Trauma is an important contributory factor and thought to be due in part to paraesthesiae, which encourages picking and scratching, with resultant chronic and persistent ulceration. A case is described of an 8...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Mayer RD,Smith NP

    更新日期:1993-03-01 00:00:00

  • Co-occurrence of Aicardi-Goutières syndrome type 6 and dyschromatosis symmetrica hereditaria due to compound heterozygous pathogenic variants in ADAR1: a case series from India.

    abstract::Aicardi-Goutières syndrome type 6 (AGS6) and dyschromatosis symmetrica hereditaria (DSH) are allelic disorders caused respectively by biallelic and heterozygous pathogenic variants in ADAR1. We report three unrelated children presenting with features of both AGS6 and DSH, two of whom had compound heterozygous pathogen...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Sathishkumar D,Muthusamy K,Gupta A,Malhotra M,Thomas M,Koshy B,Jasper A,Danda S,George R

    更新日期:2020-12-07 00:00:00

  • A 20-year epidemiological study of cutaneous melanoma in the Rijeka district of Croatia.

    abstract::A retrospective study was made of the incidence of cutaneous melanoma among the population of the district of Rijeka (Croatia) during the period 1977-96. A total of 397 patients with cutaneous melanoma was documented during this period. Over the 20-year period the incidence of the tumour increased, the mean annual rat...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Zamolo G,Gruber F,Jonjić A,Cabrijan L,Palle M,Grubisić-Greblo H

    更新日期:2000-01-01 00:00:00

  • Solar urticaria successfully treated with intravenous immunoglobulin.

    abstract::Idiopathic solar urticaria (SU) is a rare, debilitating photodermatosis, which may be difficult to treat. First-line treatment with antihistamines is effective in mild cases, but remission after phototherapeutic induction of tolerance is often short-lived. Other treatment options include plasma exchange, photopheresis...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Hughes R,Cusack C,Murphy GM,Kirby B

    更新日期:2009-12-01 00:00:00

  • Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases.

    abstract::Malignant eccrine spiradenoma (MES) is an extremely rare cutaneous malignant tumour. An 86-year-old man presented at our hospital with an enlarging tumour on the dorsum of the left hand. An excisional biopsy was taken and histological examination showed a solid island of cells of two distinct types: cells with abundan...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Tanese K,Sato T,Ishiko A

    更新日期:2010-01-01 00:00:00

  • Multiple cutaneous and uterine leiomyomata resulting from missense mutations in the fumarate hydratase gene.

    abstract::Multiple cutaneous and uterine leiomyomata (MCL) is an autosomal dominant disorder characterized by the development of benign smooth muscle tumours (leiomyomas) in the skin and uterus of affected women, and in the skin of affected men. In rare cases, MCL has been associated with a predisposition to the rare type II pa...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Chuang GS,Martinez-Mir A,Engler DE,Gmyrek RF,Zlotogorski A,Christiano AM

    更新日期:2006-01-01 00:00:00

  • Amelanotic malignant melanoma following cryosurgery for atypical lentigo maligna.

    abstract::Cryosurgery is an alternative treatment option to surgical excision for lentigo maligna. Clinical evidence of recurrence is usually characterized by repigmentation at the treated site. We report two patients who developed amelanotic malignant melanoma following cryosurgery for a pigmented lentigo maligna. These cases ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: McKenna DB,Cooper EJ,Kavanagh GM,Davie RM,McLaren KM,Tidman MJ

    更新日期:2000-11-01 00:00:00

  • The course of pregnancy and childbirth in three mothers with recessive dystrophic epidermolysis bullosa.

    abstract:BACKGROUND:Recessive dystrophic epidermolysis bullosa (RDEB) is an autosomal recessive skin disease caused by mutations in the type VII collagen gene (COL7A1), resulting in detachment of the entire epidermis due to loss or hypoplasticity of the anchoring fibrils that normally secure the basement membrane to the underly...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Hanafusa T,Tamai K,Umegaki N,Yamaguchi Y,Fukuda S,Nishikawa Y,Yaegashi N,Okuyama R,McGrath JA,Katayama I

    更新日期:2012-01-01 00:00:00

  • Development of lichen planus and psoriasis on lesions of vitiligo vulgaris.

    abstract::This paper reports a unique case of coexistence of vitiligo vulgaris, lichen planus and psoriasis vulgaris in a 53-year-old man. Five years after the onset of vitiligo, lichen planus developed on his lower lip. Another 4 years after the onset of lichen planus, he also exhibited psoriasis on his upper arms and trunk. B...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ujiie H,Sawamura D,Shimizu H

    更新日期:2006-05-01 00:00:00

  • Use of a novel autologous cell-harvesting device to promote epithelialization and enhance appropriate pigmentation in scar reconstruction.

    abstract:BACKGROUND:Epidermal replacement is an important step in the management of patients with post-traumatic and iatrogenic scars. Skin-colour variation from disease or trauma causes significant changes in self-image and appearance. AIM:The aim of our study was to analyse the results obtained with a novel autologous cell-h...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Cervelli V,De Angelis B,Spallone D,Lucarini L,Arpino A,Balzani A

    更新日期:2010-10-01 00:00:00

  • Partial atrophic tongue other than median rhomboid glossitis.

    abstract::A group of 23 patients with partial atrophic change of the tongue was examined for candidiasis. All of them reported pain in the tongue on eating hot or spicy food. The intensity of the tongue pain was evaluated before and after treatment using a visual analogue scale. Of the 23 patients, 10 (43.5%) had predisposing f...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Terai H,Shimahara M

    更新日期:2007-07-01 00:00:00

  • Induction of hair growth in alopecia totalis with diphencyprone sensitization.

    abstract::The therapeutic use of the induction of an allergic contact sensitivity to diphencyprone in alopecia areata has been studied. Fourteen subjects had alopecia totalis and four had extensive and long-standing alopecia areata. Topical diphencyprone was capable of inducing an allergic contact sensitivity in 16 subjects (89...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Monk B

    更新日期:1989-03-01 00:00:00

  • CTLA-4 gene 49A/G polymorphism in Turkish patients with Behçet's disease.

    abstract::Genetic factors predisposing individuals to Behçet's disease (BD) are considered to play important roles in the development of the disease. Patients with BD exhibit elevated levels of pro-inflammatory cytokines, and affected organs show a significant neutrophil and lymphocyte infiltration. Current evidence suggests th...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Sallakci N,Bacanli A,Coskun M,Yavuzer U,Alpsoy E,Yegin O

    更新日期:2005-09-01 00:00:00

  • The under-reporting of skin disease in association with squamous cell carcinoma of the vulva.

    abstract::Histology sections from 61 cases of squamous cell carcinoma (SCC) of the vulva presenting after 1988 were reviewed for evidence of associated epithelial abnormality. Of the 50 patients with epithelium adjacent to the tumour, 24 had histological evidence of lichen sclerosus (LS), 20 of severe vulvar intraepithelial neo...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Zaki I,Dalziel KL,Solomonsz FA,Stevens A

    更新日期:1996-09-01 00:00:00

  • An overview of burning mouth syndrome for the dermatologist.

    abstract::Burning mouth syndrome is characterized by an idiopathic burning pain affecting the oral mucosa, with no clinically apparent changes. It can present to a variety of health professionals including dermatologists. This article summarizes the important aspects of the condition, including theories of pathogenesis, diagnos...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Lewis AK,Prime SS,Cohen SN

    更新日期:2016-03-01 00:00:00

  • Demyelination during anti-tumour necrosis factor therapy for psoriasis.

    abstract::Anti-tumour necrosis factor (anti-TNF) therapies have been associated with neurological complications, including in rare cases demyelinating disease. It is currently unknown whether patients who have received more than one immunosuppressive agent or anti-TNF have a greater risk of demyelination. We report the case of ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Boggs JME,Barnes L

    更新日期:2018-07-01 00:00:00

  • Patch testing for vulval symptoms: our experience with 282 patients.

    abstract:BACKGROUND:Vulval allergic contact dermatitis (ACD) may be a primary disorder or may be associated with an underlying vulval dermatosis. Few studies have looked at the incidence of ACD and the allergens responsible for it. AIMS:We report the incidence of vulval ACD and the responsible allergens in 282 patients investi...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Al-Niaimi F,Felton S,Williams J

    更新日期:2014-06-01 00:00:00

  • A novel, simple, validated and reproducible instrument for assessing provocation threshold levels in patients with symptomatic dermographism.

    abstract:BACKGROUND:Symptomatic dermographism is a common urticarial condition. There is a need for an objective method to determine the provocation threshold for patients, in order to facilitate individualized diagnosis and treatment. AIM:To compare the dermal responses evoked by a new type of dermographometer (FricTest) with...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Mlynek A,Vieira dos Santos R,Ardelean E,Weller K,Magerl M,Church MK,Maurer M

    更新日期:2013-06-01 00:00:00

  • Nutritional factors and hair loss.

    abstract::The literature reveals what little is known about nutritional factors and hair loss. What we do know emanates from studies in protein-energy malnutrition, starvation, and eating disorders. In otherwise healthy individuals, nutritional factors appear to play a role in subjects with persistent increased hair shedding. H...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Rushton DH

    更新日期:2002-07-01 00:00:00

  • The bare:ensheathed anagen root ratio as a function of the speed of epilation.

    abstract::Small tufts of chest hair were epilated at different rates and the roots classified as to growth phase, presence or absence of root sheaths and whether the shafts were fractured. With respect to anagen roots, a slow epilation gives bare roots whereas an increase in the rate of epilation increases the proportion of ens...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Chapman DM

    更新日期:1992-03-01 00:00:00

  • Porokeratosis ptychotropica: a lesser-known variant.

    abstract::We report a case of the rare porokeratosis variant porokeratosis ptychotropica (PP). A circumferential perianal plaque and the characteristic histology of multiple cornoid lamellae with underlying dermal amyloid deposition were seen. Amyloid deposition was seen in the biopsied intertriginous area of the plaque only, w...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Tallon B,Blumental G,Bhawan J

    更新日期:2009-12-01 00:00:00

  • Topical tretinoin: a new treatment for black hairy tongue (lingua villosa nigra).

    abstract::Black hairy tongue is the name given to the appearance of an abnormal coating of the tongue and occurs only in adults. It is the result of hyperkeratosis of the filiform lingual papillae which, on gross examination appear hair-like with a variable tinctorial aspect from yellow-brown to black. The pathogenesis is unkno...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Langtry JA,Carr MM,Steele MC,Ive FA

    更新日期:1992-05-01 00:00:00

  • Predictors of patient satisfaction with initial diagnosis and management of malignant melanoma.

    abstract:BACKGROUND:Malignant melanoma (MM), accounts for around 10% of skin cancers. To date, there have been few data on patient satisfaction with initial management of MM. OBJECTIVE:To identify the predictors of patient satisfaction with initial diagnosis and management of MM. METHODS:Data on 214 patients were collected us...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Sheth N,Sarker SJ,Harries M,Healy C,Russell-Jones R,Acland K

    更新日期:2010-08-01 00:00:00

  • Efficacy and safety of a lindane 1% treatment regimen for scabies, confirmed by dermoscopy-guided skin scraping with microscopic examination.

    abstract:BACKGROUND:This is the first study investigating scabies treatment since 1992 to involve examination of patients with microscopically confirmed scabies. AIM:To assess the efficacy of 1% lindane cream in treating microscopically confirmed scabies, and to determine the utility of dermoscopy-guided skin scraping with mic...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Park SE,Her Y,Kim SS,Kim CW

    更新日期:2015-08-01 00:00:00

  • The use of topical glycopyrrolate in the treatment of hyperhidrosis.

    abstract::The use of an aqueous solution of 0.5% topical glycopyrollate was effective in the treatment of hyperhidrosis of the scalp and forehead after other treatments had proved ineffective; this appears to be the first report of its use in this condition. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Seukeran DC,Highet AS

    更新日期:1998-09-01 00:00:00

  • Efficacy of imiquimod 5% cream for basal cell carcinoma in transplant patients.

    abstract::Imiquimod 5% cream has proven to be effective in superficial and nodular basal cell carcinomas in nonimmunosuppressed patients and treating squamous cell carcinomas in situ in transplant patients. The objective of this open-label study was to determine the efficacy of imiquimod 5% cream in treating basal cell carcinom...

    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章


    authors: Vidal D,Alomar A

    更新日期:2004-05-01 00:00:00

  • Efficacy of topical corticosteroids in nickel-induced contact allergy.

    abstract::In this study we used the nickel contact allergy patch (CAP) test to investigate the effect of topical corticosteroids on allergic contact dermatitis (ACD). On day 1, three CAP tests were applied for 48 h on the forearms of 20 female volunteers with a known nickel ACD. CAP of the right forearm contained 5% nickel, and...

    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hachem JP,De Paepe K,Vanpée E,Bogaerts M,Kaufman L,Rogiers V,Roseeuw D

    更新日期:2002-01-01 00:00:00

  • Multiple warty dyskeratomas of the scalp.

    abstract::Two patients presented with the unusual condition of multiple warty dyskeratomas on the scalp. Biopsies of affected skin stained positive with human keratin monoclonal antibodies HKN-6 and -7, specific for cortex and inner root sheath of normal human hair, respectively. Multiple warty dyskeratomas are a rare occurrenc...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Griffiths TW,Hashimoto K,Sharata HH,Ellis CN

    更新日期:1997-07-01 00:00:00

  • Squamous cell carcinoma arising in a venous ulcer as a complication of the Klippel-Trenaunay syndrome.

    abstract::Klippel-Trenaunay (KT) syndrome is a vascular malformation characterized by a port-wine stain, varicose veins and hypertrophy of the affected limb. Ulceration is considered an uncommon complication of KT syndrome and occurrence of skin cancer has been previously reported only in one case. We observed a case of KT synd...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: De Simone C,Giampetruzzi AR,Guerriero C,De Masi M,Amerio P,Cina G

    更新日期:2002-05-01 00:00:00