Abstract:
:The consanguinity of parents (born in France) of individuals who have a recessive disease has been studied. The frequency of first cousin marriages is less than 0.2% in the general French population. Among the parents of affected individuals the following frequencies of first cousin matings were observed: cystic fibrosis: 1.4% cystinosis: 7.1% nephronophtisis: 5.6% spinal muscular atrophy: 4.5% albinism: 5.0% achromatopsia: 12.5% (Albinism and spinal muscular atrophy are heterogeneous conditions). The increase in the frequency of first cousin marriage relative to that of the general population is much greater, as expected, in cystinosis, which is a rare disease, than in cystic fibrosis, which is the most frequent recessive disorder in France. Inbreeding in cystinosis and cystic fibrosis was also studied by computing the distance between parental birth places. This distance is smaller in cystinosis than in cystic fibrosis.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Tchen P,Bois E,Feingold J,Feingold N,Kaplan Jdoi
10.1007/BF00527398subject
Has Abstractpub_date
1977-09-22 00:00:00pages
163-7issue
2eissn
0340-6717issn
1432-1203journal_volume
38pub_type
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