Abstract:
:Alzheimer's disease (AD) is a neurodegenerative and non-curable disease, with serious cognitive impairment, such as dementia. Clinically, it is critical to study the disease with multi-source data in order to capture a global picture of it. In this respect, an adaptive ensemble manifold learning (AEML) algorithm is proposed to retrieve multi-source neuroimaging data. Specifically, an objective function based on manifold learning is formulated to impose geometrical constraints by similarity learning. The complementary characteristics of various sources of brain disease data for disorder discovery are investigated by tuning weights from ensemble learning. In addition, a generalized norm is explicitly explored for adaptive sparseness degree control. The proposed AEML algorithm is evaluated by the public AD neuroimaging initiative database. Results obtained from the extensive experiments demonstrate that our algorithm outperforms the traditional methods.
journal_name
IEEE J Biomed Health Informjournal_title
IEEE journal of biomedical and health informaticsauthors
Lei B,Yang P,Zhuo Y,Zhou F,Ni D,Chen S,Xiao X,Wang Tdoi
10.1109/JBHI.2018.2872581subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1661-1673issue
4eissn
2168-2194issn
2168-2208journal_volume
23pub_type
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