Abstract:
:How are decisions made between different goods? One theory spanning several fields of neuroscience proposes that their values are distilled to a single common neural currency, the calculation of which allows for rational decisions. The orbitofrontal cortex (OFC) is thought to play a critical role in this process, based on the presence of neural correlates of economic value in lateral OFC in monkeys and medial OFC in humans. We previously inactivated lateral OFC in rats without affecting economic choice behavior. Here we inactivated medial OFC in the same task, again without effect. Behavior in the same rats was disrupted by inactivation during progressive ratio responding previously shown to depend on medial OFC, demonstrating the efficacy of the inactivation. These results indicate that medial OFC is not necessary for economic choice, bolstering the proposal that classic economic choice is likely mediated by multiple, overlapping neural circuits.
journal_name
Elifejournal_title
eLifeauthors
Gardner MP,Conroy JC,Styer CV,Huynh T,Whitaker LR,Schoenbaum Gdoi
10.7554/eLife.38963subject
Has Abstractpub_date
2018-10-03 00:00:00issn
2050-084Xpii
38963journal_volume
7pub_type
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