Case series and systematic review of acquired diaphragmatic hernia after liver transplantation.


BACKGROUND:ADH is a rare and potentially fatal complication following LT. In this study, a systematic review was completed to identify risk factors which may contribute to ADH. METHODS:Transplant databases at three LT programs were reviewed. Four pediatric and zero adult cases were identified. Next, a systematic review was completed. Fourteen studies describing 41 patients with ADH were identified. Patient demographics, transplant characteristics, and features of ADH diagnosis were examined. RESULTS:The majority (90.2%) of ADH were in children. In pediatric LT, 95.1% received a segmental allograft. ADH occurred in the right P diaphragm 92.7% of the time, and 87.8% were repaired primarily. Patient demographics, post-transplant complications, and immunosuppression regimens were broad and failed to predict ADH. Most patients presented with either respiratory or gastrointestinal symptoms. There were two pediatric deaths related to undiagnosed ADH. The combined worldwide incidence of ADH in pediatric LT is 1.5% (34/2319 patients). CONCLUSION:ADH is a rare complication post-LT that primarily occurs in pediatric recipients. When diagnosed early, ADH can be repaired primarily with good outcomes.


Pediatr Transplant


Emamaullee JA,Nekrasov V,Gilmour S,Kneteman N,Yanni G,Kohli R,Thomas D,Genyk Y




Has Abstract


2018-12-01 00:00:00












  • Transplanting patients with a positive donor-specific crossmatch: a single center's perspective.

    abstract::An increasing number of individuals with end-stage renal disease have become sensitized to human leukocyte antigens (HLA). Sensitization can have a profound impact on the likelihood of obtaining a requisite negative crossmatch (-XM) with a potential donor. Technologic breakthroughs in our ability to diagnose antibody-...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Montgomery RA,Zachary AA

    更新日期:2004-12-01 00:00:00

  • History of pediatric stem cell transplantation.

    abstract::During the past 50 yr, intensive studies into the use of hematopoietic cell transplantation (HCT) for therapy of cancer and non-malignant hematologic diseases have changed this treatment modality from one that was thought to be plagued by insurmountable complications to one that is now standard therapy for some diseas...

    journal_title:Pediatric transplantation

    pub_type: 历史文章,杂志文章


    authors: Storb R

    更新日期:2004-06-01 00:00:00

  • Outpatient pediatric renal transplant biopsy--is it safe?

    abstract::The safe observation time following pediatric renal transplant biopsy is unknown. To predict the safety of day-care pediatric renal transplant biopsy, we retrospectively evaluated the timing, incidence and severity of post-biopsy complications in children observed overnight. Biopsies were performed under real time ult...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Sweeney C,Geary DF,Hebert D,Robinson L,Langlois V

    更新日期:2006-03-01 00:00:00

  • Use of tissue expansion to facilitate liver and small bowel transplant in young children with contracted abdominal cavities.

    abstract::Liver and small bowel transplant is an established treatment for infants with IFALD. Despite organ reduction techniques, mortality on the waiting list remains high due to shortage of size-matched pediatric donors. Small abdominal cavity volume due to previous intestinal resection poses a significant challenge to achie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Vidyadharan R,van Bommel AC,Kuti K,Gupte GL,Sharif K,Richard BM

    更新日期:2013-11-01 00:00:00

  • Lifesaving liver transplantation for multi-organ failure caused by Bacillus cereus food poisoning.

    abstract::Bacillus cereus is a spore-forming, gram-positive bacterium that causes food poisoning presenting with either emesis or diarrhea. Diarrhea is caused by proteinaceous enterotoxin complexes, mainly hemolysin BL, non-hemolytic enterotoxin (NHE), and cytotoxin K. In contrast, emesis is caused by the ingestion of the depsi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Tschiedel E,Rath PM,Steinmann J,Becker H,Dietrich R,Paul A,Felderhoff-Müser U,Dohna-Schwake C

    更新日期:2015-02-01 00:00:00

  • Donor-specific HLA antibodies and graft function in kidney-transplanted children - the Vienna cohort.

    abstract::In the pediatric population, little is known on de novo DSA development, its impact on graft function, and association with suboptimal IS. We assessed the prevalence of de novo DSA in the Vienna cohort of 40 renal transplanted children and adolescents and prospectively followed its association with clinical parameters...

    journal_title:Pediatric transplantation

    pub_type: 临床试验,杂志文章


    authors: Rusai K,Dworak J,Potemkina A,Fischer G,Csaicsich D,Arbeiter K,Aufricht C,Müller-Sacherer T

    更新日期:2016-06-01 00:00:00

  • Extracorporeal membrane oxygenation use in the first 24 hours following pediatric heart transplantation: Incidence, risk factors, and outcomes.

    abstract::Primary graft dysfunction following HTx is associated with significant morbidity and mortality. This study aimed to assess the incidence of, risk factors for, and outcomes of children requiring ECMO within 24 hours of HTx. This study utilized a linked PHIS/SRTR database of pediatric HTx recipients (2002-2016). Post-HT...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Godown J,Bearl DW,Thurm C,Hall M,Feingold B,Soslow JH,Mettler BA,Smith AH,Profita EL,Singh TP,Dodd DA

    更新日期:2019-06-01 00:00:00

  • Successful treatment of influenza A virus by oseltamivir in bone marrow transplant recipients.

    abstract::INFVA is an important cause of pulmonary infections in patients receiving BMT, and is associated with considerable morbidity and mortality for a readily preventable and treatable infection. Few studies have addressed the impact of the new neuraminidase inhibitors in the prognosis of influenza after BMT. The aim of thi...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Mellouli F,Ouederni M,Dhouib N,Hajkacem MA,Slim A,Bejaoui M

    更新日期:2010-03-01 00:00:00

  • Parents in transition: Experiences of parents of young people with a liver transplant transferring to adult services.

    abstract::Predictors of successful transition from pediatric to adult services include ability to self-manage and engage with healthcare services. Parents have a key role in healthcare management throughout childhood and adolescence including encouraging development of self-management skills in their children. Transition to adu...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Wright J,Elwell L,McDonagh JE,Kelly DA,Wray J

    更新日期:2017-02-01 00:00:00

  • Tacrolimus-related seizure after pediatric liver transplantation--a single-center experience.

    abstract::To identify the risk factors for new-onset seizures after pediatric LT and to assess their clinical implications and long-term prognosis. The clinical and laboratory data of 27 consecutive children who underwent LT from January 2007 to December 2010 in our center were analyzed retrospectively. Patients were divided in...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Xie M,Rao W,Sun LY,Zhu ZJ,Deng YL,Shen ZY,Jia JD

    更新日期:2014-02-01 00:00:00

  • Arterioportal fistulae following segmental liver transplantation in a child.

    abstract::We report a case of arterio-portal fistulae in a 12-month-old-child following a segmental liver transplantation. The fistula, probably the result of mass ligature of a vascular pedicle during back table allograft reduction, is to our knowledge the first such case reported. Diagnosed on the third post-operative day, th...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Mieles LA,Waldman D,Orloff MS

    更新日期:2002-10-01 00:00:00

  • Gastrointestinal leukocytoclastic vasculitis: an adverse effect of sirolimus.

    abstract::An 18-yr-old Hispanic female with end-stage renal disease secondary to chronic glomerulonephritis of unknown etiology underwent cadaveric renal transplantation. She was placed on a steroid-free protocol with tacrolimus and mycophenolate mofetil (MMF) for maintenance immunosuppression. Approximately 8 months post-trans...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Nagarajan S,Friedrich T,Garcia M,Kambham N,Sarwal MM

    更新日期:2005-02-01 00:00:00

  • The SPLIT research agenda 2013.

    abstract::This review focuses on active clinical research in pediatric liver transplantation with special emphasis on areas that could benefit from studies utilizing the SPLIT infrastructure and data repository. Ideas were solicited by members of the SPLIT Research Committee and sections were drafted by members of the committee...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Alonso EM,Ng VL,Anand R,Anderson CD,Ekong UD,Fredericks EM,Furuya KN,Gupta NA,Lerret SM,Sundaram S,Tiao G,Studies of Pediatric Liver Transplantation (SPLIT) Research Group.

    更新日期:2013-08-01 00:00:00

  • Bilateral laparoscopic nephrectomy with simultaneous peritoneal dialysis catheter implantation.

    abstract::Bilateral nephrectomy prior to transplantation is indicated in some patients with end-stage renal disease. The indications for bilateral nephrectomy include persistent heavy proteinuria, refractory hypertension, and urinary tract infections. We report an eight-month-old baby with male pseudohermaphroditism and renal f...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Martínez Urrutia MJ,Olivares Arnal P,López Pereira P,Lobato Romera R,Alonso Melgar A,Jaureguizar Monereo E

    更新日期:2007-03-01 00:00:00

  • Successful second bone marrow transplantation in Omenn's syndrome after bone marrow aplasia: a case report.

    abstract::Omenn's syndrome is a rare inherited variant of SCID. It is inevitably fatal, unless treated by bone marrow or stem cell transplantation. However, treatment-related complications and graft rejection are major obstacles to the success of transplantation. In this report, we describe an eight-month-old baby with Omenn's ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Wahadneh A,Bin-Dahman H,Habahbeh Z,Abu-Shukear M,Ajarmeh M,Zyood R,Khaled A

    更新日期:2012-03-01 00:00:00

  • The efficacy of serum brain natriuretic peptide for the early detection of portopulmonary hypertension in biliary atresia patients before liver transplantation.

    abstract::Severe portopulmonary hypertension (POPH) is a contraindication for liver transplantation (LT) because of the high risk of postoperative heart failure. The early detection of POPH is important for patients with biliary atresia (BA). Brain natriuretic peptide (BNP) is known to be correlated with liver fibrosis in patie...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Yoshimaru K,Matsuura T,Takahashi Y,Yanagi Y,Nagata H,Ohga S,Taguchi T

    更新日期:2018-08-01 00:00:00

  • Health-related quality of life, clinical outcomes, and subjective experiences of parent donors of pediatric liver transplant recipients.

    abstract:PURPOSE:The understanding of the HRQOL issues for parent donors of children who underwent LDLT is lacking. We evaluated the HRQOL of donor and non-donor parents, described their subjective experiences and identified factors associated with lower HRQOL post-donation. METHODS:This is a cross-sectional study of parent do...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Yuen WY,Tan A,Karthik SV,Quak SH,Kow AW,Aw MM

    更新日期:2019-03-01 00:00:00

  • Immune-mediated hemolytic anemia in pediatric renal transplantation.

    abstract::The aim of the study was to demonstrate clinical course of the first reported cases of PLS in pediatric kidney transplantation and therapeutic outcome for such condition using a combination of high-dose corticosteroid and tacrolimus. We report a single case (a nine-year-old Thai boy) with end-stage kidney disease seco...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Pattaragarn A,Viprakasit V,Supavekin S,Sumboonnanonda A

    更新日期:2006-09-01 00:00:00

  • Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient.

    abstract::EBV is associated with various malignancies in patients with acquired or induced immune impairment. EBV-SMT is very uncommon in immunocompromised patients, and a kidney localization has been described only anecdotally. We report the case of a 17-yr-old kidney transplant recipient diagnosed as having an EBV-SMT inside ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Belingheri M,Comoli P,Locatelli F,Baldanti F,Martina V,Giani M,Ferraresso M,Cro L,Edefonti A,Ghio L

    更新日期:2010-12-01 00:00:00

  • Safety and utility of surveillance biopsies in pediatric kidney transplant patients.

    abstract::There is currently no way to diagnose a rejection before a change in serum creatinine. This had led some to start doing SB, but little data exist on the utility and safety of SB in pediatric patients. There is also little known on practice patterns of pediatric nephrologists. A retrospective review of pediatric kidney...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Nazario M,Nicoara O,Becton L,Self S,Hill J,Mack E,Evans M,Twombley K

    更新日期:2018-06-01 00:00:00

  • Post-transplantation growth among pediatric recipients of liver transplantation.

    abstract::Improving a patient's quality-of-life (QOL) post-liver transplantation is of great importance. An aspect of improved QOL is the restoration of normal growth patterns in pediatric patients. To describe the post-transplantation growth patterns of 72 children included in the National Institute of Diabetes and Digestive a...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Evans IV,Belle SH,Wei Y,Penovich C,Ruppert K,Detre KM,National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database Team.

    更新日期:2005-08-01 00:00:00

  • Prevalence and outcomes of renal transplantation in children with intellectual disability.

    abstract::To describe the prevalence and outcomes of renal transplantation in children with ID we performed a retrospective cohort analysis of all children receiving a first kidney-alone transplant in the UNOS dataset from 2008 to 2011. Recipients with definite, probable, and without ID were compared using chi-square tests. Kap...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Wightman A,Young B,Bradford M,Dick A,Healey P,McDonald R,Smith J

    更新日期:2014-11-01 00:00:00

  • Portal vein phlebolithiasis found post-liver transplantation in the native liver of a child with biliary atresia.

    abstract::Biliary atresia is defined as partial or total obliteration of the extra-hepatic bile ducts. In advanced cases, liver transplantation (LTx) is considered the most appropriate treatment. This report describes a female patient whose biliary atresia and subsequent cirrhosis required LTx at 1 yr of age. Macroscopic inspec...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Bilezikçi B,Demirhan B,Kiyici H,Haberal M

    更新日期:2001-02-01 00:00:00

  • Planning for the future of a pediatric kidney transplant recipient with special needs: A parent's perspective.

    abstract::I was asked to write this article to share with medical professionals, my view as a parent with a child who has special needs and needs a transplant. It is a detailed story from a parent's point of view on what it is like to have a child with special needs with serious medical complications and how I went about findin...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Carney MT

    更新日期:2021-02-01 00:00:00

  • Tacrolimus withdrawal and conversion to sirolimus at three months post-pediatric renal transplantation.

    abstract:UNLABELLED:Nephrotoxicity caused by CNI may adversely affect long-term graft outcomes. For this reason, we have adopted a protocol for withdrawing TAC and converting to SRL at three months post-renal transplantation. All recipients received basiliximab induction and TAC, MMF, and prednisone. Patients without acute reje...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Hymes LC,Warshaw BL,Amaral SG,Greenbaum LA

    更新日期:2008-11-01 00:00:00

  • Mycophenolate mofetil in pediatric renal transplantation: a single center experience.

    abstract::We assessed our long-term experience with regards to the safety and efficacy of MMF in our pediatric renal transplant population and compared it retrospectively to our previous non-MMF immunosuppressive regimen. Forty-seven pediatric renal transplants received MMF as part of their immunosuppressive protocol in the per...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Raheem OA,Kamel MH,Daly PJ,Mohan P,Little DM,Awan A,Hickey DP

    更新日期:2011-05-01 00:00:00

  • Parvovirus B19 infection in pediatric solid-organ and bone marrow transplantation.

    abstract::The clinical significance of parvovirus B19 infection in pediatric solid-organ and bone marrow transplanted patients is unclear. The overall prevalence of parvovirus B19 infection in these patients is about 1-2% during the first year after transplantation. The most common symptom is anemia, but leukopenia and thromboc...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章,评审


    authors: Broliden K

    更新日期:2001-10-01 00:00:00

  • Impact of pretransplant minimal residual disease on the post-transplant outcome of pediatric acute lymphoblastic leukemia.

    abstract::There are few reports on the clinical significance of MRD before HSCT in pediatric ALL. We retrospectively analyzed the clinical significance of FCM-based detection of MRD (FCM-MRD) before allogeneic HSCT in pediatric ALL. Of 38 pediatric patients who underwent allogeneic HSCT for the first time between 1998 and 2014,...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Umeda K,Hiramatsu H,Kawaguchi K,Iwai A,Mikami M,Nodomi S,Saida S,Heike T,Ohomori K,Adachi S

    更新日期:2016-08-01 00:00:00

  • Micronutrient deficiencies in pediatric and young adult intestinal transplant patients.

    abstract::Intestinal transplant recipients are at risk of micronutrient deficiency due to the slow process of post-transplant adaptation. Another contributing factor is calcineurin inhibitor-induced renal tubular dysfunction. Patients are typically supplemented with micronutrients during PN; however, the risk of deficiency may ...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Ubesie AC,Cole CR,Nathan JD,Tiao GM,Alonso MH,Mezoff AG,Henderson CJ,Kocoshis SA

    更新日期:2013-11-01 00:00:00

  • Infusion-related febrile reaction after haploidentical stem cell transplantation in children is associated with higher rates of engraftment syndrome and acute graft-versus-host disease.

    abstract::The clinical significance and prognostic impact of IRFR in pediatric recipients of haploidentical SCT are not clearly understood. Therefore, we attempted to determine how IRFR affects clinical outcomes in children. Clinical data from 100 consecutive pediatric patients (60 boys and 40 girls; median age, 12 yr [range, 2...

    journal_title:Pediatric transplantation

    pub_type: 杂志文章


    authors: Chen Y,Huang XJ,Liu KY,Chen H,Chen YH,Zhang XH,Wang FR,Han W,Wang JZ,Wang Y,Yan CH,Zhang YY,Sun YQ,Xu LP

    更新日期:2015-12-01 00:00:00