Remaining Puzzles about Morpheme Production in the Posterior Temporal Lobe.


:Using data from time-resolved cortical stimulation, intracranial neural recordings, and focal surgical resections, Lee et al. (2018) demonstrate that a small area within left posterior superior temporal gyrus (pSTG) supports the ability to produce functional morphemes but not other basic aspects of language production or comprehension. These findings are intriguing because they raise important questions about the functional architecture of language processing, including critically, the relationship between production and comprehension. Here, we highlight some of the puzzles that remain and that we hope will guide future empirical explorations of the cognitive and neural mechanisms that support our capacity for language.






Fedorenko E,Williams ZM,Ferreira VS




Has Abstract


2018-11-10 00:00:00












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    abstract::Nervous system formation integrates control of cellular proliferation and differentiation and is mediated by multipotent neural progenitor cells that become progressively restricted in their developmental potential before they give rise to differentiated neurons and glial cells. Evidence from different experimental sy...


    pub_type: 杂志文章


    authors: Spella M,Britz O,Kotantaki P,Lygerou Z,Nishitani H,Ramsay RG,Flordellis C,Guillemot F,Mantamadiotis T,Taraviras S

    更新日期:2007-06-29 00:00:00

  • Afferent subcortical connections into the motor cortical larynx area in the rhesus monkey.

    abstract::In three rhesus monkeys (Macaca mulatta), the inferior motor cortex was explored by electrical stimulation for sites yielding vocal fold adduction. The retrograde tracer wheat germ-agglutinin-conjugated horseradish peroxidase was injected into the effective sites. Within the forebrain, retrogradely labeled cells were ...


    pub_type: 杂志文章


    authors: Simonyan K,Jürgens U

    更新日期:2005-01-01 00:00:00

  • Stimulation of α1-adrenoceptors facilitates GABAergic transmission onto pyramidal neurons in the medial prefrontal cortex.

    abstract::Whereas activation of α1-adrenoceptors (α1-ARs) modulates glutamatergic transmission, the roles of α1-ARs in GABAergic transmission in the medial prefrontal cortex (mPFC) are elusive. Here, we examined the effects of the α1-AR agonist phenylephrine (Phe) on GABAergic transmission onto pyramidal neurons in the deep lay...


    pub_type: 杂志文章


    authors: Luo F,Tang H,Cheng ZY

    更新日期:2015-08-06 00:00:00

  • Blockade of excitatory amino acid receptors protects anoxic hippocampal slices.

    abstract::Experiments in a variety of preparations have indicated that excessive activation of receptors for the excitatory amino acids glutamate and aspartate may mediate irreversible anoxic neuronal injury. We investigated this hypothesis in the in vitro hippocampal slice. Rat hippocampal slices perfused for 40 min with buffe...


    pub_type: 杂志文章


    authors: Clark GD,Rothman SM

    更新日期:1987-06-01 00:00:00

  • Increasing sympathetic nerve terminal-dependent plasma extravasation correlates with decreased arthritic joint injury in rats.

    abstract::This study compared the pharmacology of adrenergic agents that influence plasma extravasation in normal animals with those agents that influence tissue injury in an inflammatory disease model. Specifically we studied the effects of beta 2- and alpha 2-adrenergic receptor agonists and antagonists on bradykinin-induced ...


    pub_type: 杂志文章


    authors: Coderre TJ,Chan AK,Helms C,Basbaum AI,Levine JD

    更新日期:1991-01-01 00:00:00

  • Innervation of different peptide-containing neurons in the hippocampus by GABAergic septal afferents.

    abstract::The termination pattern of septohippocampal axons visualized by anterograde transport of Phaseolus vulgaris leucoagglutinin was studied in the hippocampal formation in the rat, with special reference to the innervation of neurons immunoreactive for the neuroactive peptides cholecystokinin, somatostatin or vasoactive i...


    pub_type: 杂志文章


    authors: Gulyás AI,Görcs TJ,Freund TF

    更新日期:1990-01-01 00:00:00

  • Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex.

    abstract::Neuronal gap junctions in the brain, providing intercellular electrotonic signal transfer, have been implicated in physiological and behavioral correlates of learning and memory. In connexin31.1 (Cx31.1) knockout (KO) mice the coding region of the Cx31.1 gene was replaced by a LacZ reporter gene. We investigated the i...


    pub_type: 杂志文章


    authors: Dere E,Zheng-Fischhöfer Q,Viggiano D,Gironi Carnevale UA,Ruocco LA,Zlomuzica A,Schnichels M,Willecke K,Huston JP,Sadile AG

    更新日期:2008-05-02 00:00:00

  • Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum.

    abstract::Dopamine-mediated behaviors and certain biochemical and molecular events associated with these behaviors were examined following continuous infusion of the D1 dopamine agonist SKF38393 or the D2 dopamine agonist quinpirole into mice for six days. SKF38393 produced a transient grooming behavior while quinpirole initial...


    pub_type: 杂志文章


    authors: Chen JF,Aloyo VJ,Weiss B

    更新日期:1993-06-01 00:00:00

  • Estrogen therapy: does it help or hurt the adult and aging brain? Insights derived from animal models.

    abstract::Hormone therapy and estrogen therapy in postmenopausal women have been thought to ameliorate cognitive dysfunction and decrease the risk and/or progress of neurodegenerative conditions such as Alzheimer's disease and stroke. Furthermore, estrogens have been shown to exert neuroprotective actions in a variety of in vit...


    pub_type: 杂志文章


    authors: Wise PM

    更新日期:2006-01-01 00:00:00

  • A choice behavior for morphine reveals experience-dependent drug preference and underlying neural substrates in developing larval zebrafish.

    abstract::Transparent larval zebrafish offer the opportunity to unravel genetic and neuronal networks underlying behavior in a developing system. In this study, we developed a choice chamber paradigm to measure reward-associated behavior in larval zebrafish. In the chamber where larval zebrafish have a choice of spending their ...


    pub_type: 杂志文章


    authors: Bretaud S,Li Q,Lockwood BL,Kobayashi K,Lin E,Guo S

    更新日期:2007-05-25 00:00:00

  • Neuronal depolarization modifies motor protein mobility.

    abstract::Active neuronal transport along microtubules participates in the targeting of mRNAs, proteins and organelles to their sites of action. Cytoplasmic dynein represents a minus-end-directed microtubule-dependent motor protein. Due to the polarity of microtubules in axonal and distal dendritic compartments, with microtubul...


    pub_type: 杂志文章


    authors: Lardong K,Maas C,Kneussel M

    更新日期:2009-04-21 00:00:00

  • Two-stage model of memory trace formation: a role for "noisy" brain states.

    abstract::Review of the normally occurring neuronal patterns of the hippocampus suggests that the two principal cell types of the hippocampus, the pyramidal neurons and granule cells, are maximally active during different behaviors. Granule cells reach their highest discharge rates during theta-concurrent exploratory activities...


    pub_type: 杂志文章,评审


    authors: Buzsáki G

    更新日期:1989-01-01 00:00:00

  • Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

    abstract::The tight junctions found between cerebral vascular endothelial cells form the basis of the blood-brain barrier. Breakdown of the blood-brain barrier is a feature of a variety of CNS pathologies that are characterized by extensive leucocyte recruitment, such as multiple sclerosis and stroke. The molecular mechanisms a...


    pub_type: 杂志文章


    authors: Bolton SJ,Anthony DC,Perry VH

    更新日期:1998-10-01 00:00:00

  • Time required for transmitter accumulation inside monoaminergic storage vesicles differs in peripheral and in central systems.

    abstract::Monoamine storage vesicles accumulate transmitters via an active transport process which presents similar pharmacological and bioenergetic properties in all monoaminergic systems. Using [3H]reserpine, a specific ligand of the vesicular monoamine transporter on isolated storage vesicles, we have determined the molecula...


    pub_type: 杂志文章


    authors: Scherman D,Boschi G

    更新日期:1988-12-01 00:00:00

  • Microinjections of muscimol into lateral superior colliculus disrupt orienting and oral movements in the formalin model of pain.

    abstract::An important reaction in rodent models of persistent pain is for the animal to turn and bite/lick the source of discomfort (autotomy). Comparatively little is known about the supraspinal pathways which mediate this reaction. Since autotomy requires co-ordinated control of the head and mouth, it is possible that basal ...


    pub_type: 杂志文章


    authors: Wang S,Redgrave P

    更新日期:1997-12-01 00:00:00

  • Differential involvement of medial prefrontal cortex and basolateral amygdala extracellular signal-regulated kinase in extinction of conditioned taste aversion is dependent on different intervals of extinction following conditioning.

    abstract::Extinction reflects a decrease in the conditioned response (CR) following non-reinforcement of a conditioned stimulus. Behavioral evidence indicates that extinction involves an inhibitory learning mechanism in which the extinguished CR reappears with presentation of an unconditioned stimulus. However, recent studies o...


    pub_type: 杂志文章


    authors: Lin PY,Wang SP,Tai MY,Tsai YF

    更新日期:2010-11-24 00:00:00

  • Reduced sensory stimulation alters the molecular make-up of glutamatergic hair cell synapses in the developing cochlea.

    abstract::Neural activity during early development is known to alter innervation pathways in the central and peripheral nervous systems. We sought to examine how reduced sound-induced sensory activity in the cochlea affected the consolidation of glutamatergic synapses between inner hair cells (IHC) and the primary auditory neur...


    pub_type: 杂志文章


    authors: Barclay M,Constable R,James NR,Thorne PR,Montgomery JM

    更新日期:2016-06-14 00:00:00

  • Distinct roles of Eps8 in the maturation of cochlear and vestibular hair cells.

    abstract::Several genetic mutations affecting the development and function of mammalian hair cells have been shown to cause deafness but not vestibular defects, most likely because vestibular deficits are sometimes centrally compensated. The study of hair cell physiology is thus a powerful direct approach to ascertain the funct...


    pub_type: 杂志文章


    authors: Tavazzani E,Spaiardi P,Zampini V,Contini D,Manca M,Russo G,Prigioni I,Marcotti W,Masetto S

    更新日期:2016-07-22 00:00:00

  • M1 Muscarinic Receptor Activation Rescues β-Amyloid-Induced Cognitive Impairment through AMPA Receptor GluA1 Subunit.

    abstract::M1 muscarinic receptors have long been identified as a potential therapeutic target for the treatment of cognitive impairment in Alzheimer's disease (AD). Our previous study has shown that M1 receptors promote membrane insertion and synaptic delivery of AMPA receptor GluA1 subunit. In this study, we sought to determin...


    pub_type: 杂志文章


    authors: Zhao LX,Chen MW,Qian Y,Yang QH,Ge YH,Chen HZ,Qiu Y

    更新日期:2019-06-01 00:00:00

  • Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus.

    abstract::In several neurological disorders including hyperhomocysteinemia, homocysteine (Hcy) accumulates in the brain, and acts as a potent neurotoxin. However, the molecular mechanisms induced by increased levels of Hcy in brain are not well understood. Here we show an activation of the extracellular signal-regulated kinases...


    pub_type: 杂志文章


    authors: Robert K,Pagès C,Ledru A,Delabar J,Caboche J,Janel N

    更新日期:2005-01-01 00:00:00

  • Emergence of a synaptic neuronal network within primary striatal cultures seeded in serum-free medium.

    abstract::In order to investigate the basic cellular mechanisms involved in neuronal interactions within the striatum, we prepared a primary striatal cell culture from rat fetal brain in chemically defined medium. Using morphological and whole-cell recording methods, we observed that an intensive neuritic elongation with a prog...


    pub_type: 杂志文章


    authors: Kowalski C,Crest M,Vuillet J,Pin T,Gola M,Nieoullon A

    更新日期:1995-02-01 00:00:00

  • P2X7 receptor activation downmodulates Na(+)-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes.

    abstract::Sodium-dependent high-affinity amino-acid transporters play crucial roles in terminating synaptic transmission in the central nervous system (CNS). However, there is lack of information about the mechanisms underlying the regulation of amino-acid transport by fast-acting neuromodulators, like ATP. Here, we investigate...


    pub_type: 杂志文章


    authors: Barros-Barbosa AR,Lobo MG,Ferreirinha F,Correia-de-Sá P,Cordeiro JM

    更新日期:2015-10-15 00:00:00

  • Brain signal complexity rises with repetition suppression in visual learning.

    abstract::Neuronal activity associated with visual processing of an unfamiliar face gradually diminishes when it is viewed repeatedly. This process, known as repetition suppression (RS), is involved in the acquisition of familiarity. Current models suggest that RS results from interactions between visual information processing ...


    pub_type: 杂志文章


    authors: Lafontaine MP,Lacourse K,Lina JM,McIntosh AR,Gosselin F,Théoret H,Lippé S

    更新日期:2016-06-21 00:00:00

  • Somatotopic direct projections from orofacial areas of primary somatosensory cortex to pons and medulla, especially to trigeminal sensory nuclear complex, in rats.

    abstract::The primary somatosensory cortex (S1) projects to the thalamus and brainstem somatosensory nuclei and modulates somatosensory information ascending to the S1 itself. However, the projections from the S1 to the brainstem second-order somatosensory neuron pools have not been fully studied. To address this in rats, we fi...


    pub_type: 杂志文章


    authors: Tomita A,Kato T,Sato F,Haque T,Oka A,Yamamoto M,Ono T,Bae YC,Maeda Y,Sessle BJ,Yoshida A

    更新日期:2012-01-03 00:00:00

  • Attention modulates specific motor cortical circuits recruited by transcranial magnetic stimulation.

    abstract::Skilled performance and acquisition is dependent upon afferent input to motor cortex. The present study used short-latency afferent inhibition (SAI) to probe how manipulation of sensory afference by attention affects different circuits projecting to pyramidal tract neurons in motor cortex. SAI was assessed in the firs...


    pub_type: 杂志文章


    authors: Mirdamadi JL,Suzuki LY,Meehan SK

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    abstract::The cerebral peptidergic caudodorsal cells of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying behaviour by releasing peptides into (1) the haemolymph, from neurohaemal axon terminals in the periphery of the cerebral commissure and (2) the intercellular space of the central nervous system, from...


    pub_type: 杂志文章


    authors: Schmidt ED,Roubos EW

    更新日期:1988-07-01 00:00:00

  • Two types of neurotransmitter release patterns in isolectin B4-positive and negative trigeminal ganglion neurons.

    abstract::Mammalian nociceptors have been classified into subclasses based on differential neurotrophin sensitivity and binding of the plant isolectin B4 (IB4). Most of the nerve growth factor-responsive IB4-negative (IB4 (-)) nociceptors contain neuropeptides such as substance P and calcitonin gene-related peptide, whereas the...


    pub_type: 杂志文章


    authors: Matsuka Y,Edmonds B,Mitrirattanakul S,Schweizer FE,Spigelman I

    更新日期:2007-01-19 00:00:00

  • Individual Mesopontine Neurons Implicated in Anesthetic Loss-of-consciousness Employ Separate Ascending Pathways to the Cerebral Cortex.

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    authors: Lellouche Y,Minert A,Schreiber C,Aroch I,Vaso K,Fishman Y,Devor M

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  • Localization of glycine receptor alpha 1 subunit mRNA-containing neurons in the rat brain: an analysis using in situ hybridization histochemistry.

    abstract::The localization of glycine receptors in the rat brain was examined by means of in situ hybridization histochemistry using an oligonucleotide probe to the sequence of the alpha 1 subunit. Strongly- or moderately-labeled neurons were found in the cranial nuclei, sensory nuclei such as the spinal trigeminal nucleus, pri...


    pub_type: 杂志文章


    authors: Sato K,Zhang JH,Saika T,Sato M,Tada K,Tohyama M

    更新日期:1991-01-01 00:00:00

  • Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells.

    abstract::Granulocyte-colony stimulating factor (G-CSF) is a growth factor that regulates proliferation, differentiation and survival of hematopoietic progenitor cells. There is growing evidence to suggest that G-CSF exerts a powerful neuroprotective effect in different neurological disorders. However, it has remained to be elu...


    pub_type: 杂志文章


    authors: Liu H,Jia D,Fu J,Zhao S,He G,Ling EA,Gao J,Hao A

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