Blue-light imaging compared with high-definition white light for real-time histology prediction of colorectal polyps less than 1 centimeter: a prospective randomized study.


BACKGROUND AND AIMS:Blue-light imaging (BLI) is a new chromoendoscopy technique, potentially useful for differentiating neoplastic from nonneoplastic lesions. The present study was aimed at comparing BLI with high-definition white light (HDWL) in the real-time histology prediction of colon polyps <10 mm. METHODS:Consecutive outpatients undergoing colonoscopy with the ELUXEO 7000 endoscopy platform and 760 series video colonoscopes (Fujifilm Co, Tokyo, Japan) who had at least 1 polyp <10 mm were randomized to BLI or HDWL for polyp characterization. The accuracy of high-confidence real-time histology prediction (adenoma vs not adenoma) by either BLI or HDWL for polyps <10 mm (primary end-point) and diminutive (≤5 mm) polyps was calculated, along with sensitivity, specificity, and positive and negative predictive values, with histopathology as the reference standard. RESULTS:A total of 483 polyps were detected in 245 randomized patients (125 and 120 in the BLI and HDWL arms, respectively). A total of 358 were diminutive, and 283 were adenomas. Overall, 222 (85.7%) and 193 (86.1%) polyps were characterized with high confidence by BLI and HDWL, respectively (P = .887), with an overall accuracy of 92% and 84%, respectively (P = .011). The accuracy was significantly higher by BLI than HDWL, also for diminutive polyps (92% vs 83%; P = .008). When BLI was used, the negative predictive value for diminutive rectosigmoid polyps was 88%, and the post-polypectomy surveillance interval was correctly attributed in 85.7% and 93.7% of patients, respectively, according to U.S. and European guidelines. CONCLUSION:BLI was superior to HDWL for the real-time prediction of histology in polyps <10 mm. A BLI-dedicated classification might further improve the endoscopist performance. (Clinical trial registration number: NCT03274115.).


Gastrointest Endosc


Rondonotti E,Paggi S,Amato A,Mogavero G,Andrealli A,Conforti FS,Conte D,Spinzi G,Radaelli F




Has Abstract


2019-03-01 00:00:00














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    abstract::This study determined the optimum laser energy for ablation of colonic mucosal lesions and small sessile polyps in the canine colon. Neodymium (Nd):YAG laser, argon laser, and monopolar electrocautery were applied to exposed canine colonic mucosa for various application times at various power settings. At the minimum ...

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    authors: Agostoni M,Fanti L,Gemma M,Pasculli N,Beretta L,Testoni PA

    更新日期:2011-08-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1993-05-01 00:00:00

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    更新日期:2011-03-01 00:00:00

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    更新日期:2007-09-01 00:00:00

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    pub_type: 临床试验,杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2003-01-01 00:00:00

  • The frequency of Barrett's esophagus in high-risk patients with chronic GERD.

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    更新日期:2007-09-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:1994-03-01 00:00:00

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    journal_title:Gastrointestinal endoscopy

    pub_type: 杂志文章,随机对照试验


    authors: Calderwood AH,Lai EJ,Fix OK,Jacobson BC

    更新日期:2011-02-01 00:00:00