Abstract:
AIMS:To determine the association between 20-year trajectories in insulin resistance (IR) since young adulthood and appendicular lean mass (ALM) at middle-age in adults without diabetes. METHODS:A prospective cohort study was designed among young and middle-aged US men (n = 925) and women (n = 1193). Fasting serum glucose and insulin were measured five times in 1985-2005. IR was determined using the homeostasis model assessment (HOMA). ALM was measured in 2005 and ALM adjusted for BMI (ALM/BMI) was the outcome. Sex-specific analyses were performed. RESULTS:Three HOMA-IR trajectories were identified. Compared to the low-stable group, the adjusted ALM/BMI difference was -0.041 (95% CI: -0.060 to -0.022) and -0.114 (-0.141 to -0.086) in men, and -0.052 (-0.065 to -0.039) and -0.043 (-0.063 to -0.023) in women, respectively, for the medium-increase and high-increase groups. Further adjusting for the treadmill test duration attenuated these estimates to -0.022 (-0.040 to -0.004) and -0.061 (-0.089 to -0.034) in men and -0.026 (-0.038 to -0.014) and -0.007 (-0.026 to 0.012) in women. CONCLUSIONS:Compared to the low-stable insulin resistance trajectory between early and middle adulthood, the high-increase trajectory was associated with lower ALM/BMI in middle-aged men, but not women, without diabetes, after adjusting for cardiorespiratory fitness.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Zhong VW,Bancks MP,Schreiner PJ,Lewis CE,Steffen LM,Meigs JB,Schrader LA,Schorr M,Miller KK,Sidney S,Carnethon MRdoi
10.1016/j.jdiacomp.2018.09.011subject
Has Abstractpub_date
2019-01-01 00:00:00pages
84-90issue
1eissn
1056-8727issn
1873-460Xpii
S1056-8727(18)30380-5journal_volume
33pub_type
杂志文章abstract:AIM:One putative determinant of diabetic nephropathy is the Pro12Ala (P12A) polymorphism in the gene encoding peroxisome proliferator-activated receptor gamma (PPARgamma). Previous research has found a "protective" role for the A12 allele in association with type 2 diabetes, atherosclerosis, and measures of kidney dama...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2006.02.006
更新日期:2007-05-01 00:00:00
abstract::The importance of routine screening for microalbuminuria in patients with diabetes has gained widespread acceptance. Since shortened collection times and random urine sampling facilitate outpatient testing for patients, it is necessary to establish whether a recent fluid intake might alter test results. Specifically, ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(01)00216-1
更新日期:2002-07-01 00:00:00
abstract::The mechanism(s) resulting in the premature atherosclerosis of diabetes is unknown. Increased phagocyte release of reactive oxygen species such as superoxide anion (O2.-), resulting in low-density lipoprotein (LDL) oxidation, could be one possible cause. The purpose of the present study was to compare the abilities of...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/1056-8727(95)00002-x
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effectiveness of the Semmes-Weinstein monofilament examination (SWME) for diabetic peripheral neuropathy (DPN) screening at an outpatient clinic. METHODS:Eighty-two type 2 diabetic outpatients were questioned about 13 subjective symptoms and tested for deep reflexes. They were examined using ...
journal_title:Journal of diabetes and its complications
pub_type: 临床试验,杂志文章
doi:10.1016/j.jdiacomp.2003.12.006
更新日期:2005-01-01 00:00:00
abstract::The aim was to evaluate the relative importance of an established battery of five function tests used in the assessment of cardiovascular autonomic neuropathy (CAN) in diabetes employing spectral analysis of heart rate variability (HRV) as the reference test. In a population-based sample of 178 diabetic persons and 19...
journal_title:Journal of diabetes and its complications
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s1056-8727(00)00062-3
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Digital toe amputation is a relatively minor surgical procedure but there is a historical view that it is the "first stage in a predictable clinical course" leading to eventual limb loss. There is a paucity of contemporaneous data on the long-term outcomes of patients undergoing toe amputation. We aim to stu...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2012.03.003
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Glomerular hyperfiltration is not able to be detected in clinical practice. We assessed whether hyperfiltration is associated with albuminuria progression among Indigenous Australians at high risk of diabetes and kidney disease to determine its role in kidney disease progression. METHODS:Longitudinal observ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2019.02.005
更新日期:2019-05-01 00:00:00
abstract:AIMS:To identify how efforts to control the diabetes epidemic and the resulting changes in diabetes mellitus, type II (T2D) incidence and survival have affected the time-trend of T2D prevalence. METHODS:A newly developed method of trend decomposition was applied to a 5% sample of Medicare administrative claims filed b...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.12.014
更新日期:2018-04-01 00:00:00
abstract::The role cardiac autonomic neuropathy (CAN) plays in diabetes is not well known. The aim of this study was to identify the factors involved in CAN in diabetic patients. One hundred patients, 44 insulin-dependent (IDDM) and 56 non-insulin-dependent (NIDDM), were investigated, using five standard tests. Three of these t...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(97)00005-6
更新日期:1997-05-01 00:00:00
abstract:AIM:To analyse the OGTT glycemic parameters - fasting, 1h and 2h plasma glucose values singly and in various combinations; with respect to their prediction of future dysglycemia in subjects with normal glucose tolerance (NGT). METHODS:Electronic medical records of individuals who underwent an OGTT between 1991 and 201...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.07.017
更新日期:2017-11-01 00:00:00
abstract:AIMS:The GLP-1 receptor agonist liraglutide improves impaired pancreatic β-cell function, thereby exerting glucose-lowering effects. However, the association of remaining β-cell function with long-term therapeutic efficacy of liraglutide remains largely unknown. METHODS:Patients with type 2 diabetes who started liragl...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2015.07.020
更新日期:2015-11-01 00:00:00
abstract:AIM:We conducted a systematic review of the use of continuous glucose monitoring (CGM) in older patients, in order to consolidate the growing evidence base in this area. METHODS:Our protocol was registered on PROSPERO (CRD42017068523). We searched SCI Web of Science, Ovid SP MEDLINE and EMBASE from January 2010 to Jun...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2018.05.005
更新日期:2018-08-01 00:00:00
abstract:AIMS:Determine the prevalence of glucocorticoid use in U.S. adults with diabetes and whether prevalence is associated with reduced skeletal health, as measured by fracture history and bisphosphonate use. METHODS:Participants were age≥20years from the cross-sectional National Health and Nutrition Examination Survey (19...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.06.021
更新日期:2017-02-01 00:00:00
abstract:AIM:To evaluate the risk of urinary tract infections (UTI) in subjects with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS:Subjects aged ≥18years and diagnosed with T2DM between 1/1/10 and 12/31/10 were identified using the MarketScan® databases, which are representative of the commercially insured US popula...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2014.06.009
更新日期:2014-11-01 00:00:00
abstract::The objective of this study was to investigate the efficacy, tolerability, and safety of acarbose in the improvement of glycemic control in Asian patients with type 2 diabetes inadequately controlled by diet and sulfonylureas. A 24-week, double-blind, placebo-controlled multicenter group comparison study was conducted...
journal_title:Journal of diabetes and its complications
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s1056-8727(02)00258-1
更新日期:2003-07-01 00:00:00
abstract::The study investigated the prevalence of incipient renal dysfunction in two cohorts with identical duration of type I diabetes but with childhood or adult onset of the disease. The pattern of glomerular (albumin, alb) and tubular (alpha(1)-microglobulin, alpha(1)-m, and N-acetyl-beta-D-glucosaminidase, NAG) urinary pr...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(99)00055-0
更新日期:1999-09-01 00:00:00
abstract:AIMS:The objective of this study was to determine whether baseline albuminuria predicts coronary artery calcification (CAC) progression in subjects with type 1 diabetes and whether angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin II type I receptor blocker (ARB) treatment is associated with lower odds of ...
journal_title:Journal of diabetes and its complications
pub_type: 临床试验,杂志文章
doi:10.1016/j.jdiacomp.2006.04.004
更新日期:2007-09-01 00:00:00
abstract:AIMS:To observe the natural history of hand function during a two-year period in participants with hand syndromes associated with diabetes and to determine factors related to changing function. METHODS:Hand function was measured over three annual visits using Disability of the Arm, Shoulder and Hand (DASH) and SF-36v2...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2012.04.009
更新日期:2012-07-01 00:00:00
abstract::A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGP...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2008.05.003
更新日期:2009-11-01 00:00:00
abstract::To investigate whether the two free-radical scavengers, Cu, Zn- and Mn-superoxide dismutase (SOD), are changed in leukocytes of diabetic patients, and the alteration of these enzymes correlates with the diabetic state, we measured the activity and concentration of these enzymes in leukocytes from diabetic patients. Bo...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(99)00053-7
更新日期:1999-09-01 00:00:00
abstract:AIMS:In the Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG) trial, empagliflozin reduced cardiovascular and all-cause mortality in type 2 diabetes (T2D) patients at high cardiovascular risk. We sought to estimate the cost-effectiveness of empagliflozin versus standard treatment for t...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.10.006
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Although lifestyle modifications are known to be effective in type 2 diabetes (T2D) as well as in prediabetes, adherence to a healthy diet is difficult for some, and interventions of lifestyle modifications need to be revised occasionally. Meal sequence has been gaining attention as a part of a healthy diet ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2019.107450
更新日期:2019-12-01 00:00:00
abstract::Increased extracellular matrix (ECM) is the ultrastructural hallmark of diabetic microangiopathy. Its accumulation within the kidney is directly linked to the clinical manifestations of diabetic nephropathy, namely proteinuria and declining renal function. The pathogenesis of ECM changes in diabetes is not well unders...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,评审
doi:10.1016/1056-8727(95)80015-7
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Lower serum concentrations of the osteoblast-derived protein, osteocalcin, have been associated with poorer glycemic control, insulin resistance and atherosclerosis, and with the development of type 2 diabetes (T2DM). METHODS:This study compares concentrations of two physiological forms of osteocalcin, carb...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2019.01.003
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Attenuated retinal vasoreactivity in patients with type 2 diabetes preceding diabetic retinopathy development has been proposed to reflect local endothelial dysfunction. Whether retinal vessel reactivity is associated with peripheral endothelial dysfunction and large artery stiffness in patients wit...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2019.05.024
更新日期:2019-09-01 00:00:00
abstract::The aim of this cross-sectional study was to determine the significant limitations, sensitivity, specificity, partial correlations, and odds ratios of nutrient intake in patients with and without hypertension with Type 2 diabetes mellitus. Diabetic patients (n=220) with clinical diagnosis of hypertension and diabetic ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2008.02.005
更新日期:2009-09-01 00:00:00
abstract:AIM:Investigate contributors to treatment satisfaction in type 1 diabetes (T1D). METHODS:Post-hoc analysis using the Diabetes Treatment Satisfaction Questionnaire status version (DTSQs) in 771 T1D patients from two 28-week trials comparing once-daily insulin glargine 100U/mL (Gla-100) with once- or twice-daily NPH neu...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.11.018
更新日期:2017-03-01 00:00:00
abstract:AIMS:To investigate the relationship of unawareness of hypoglycemia with spectral analysis of heart rate variability (HRV) and clinical variables in type 1 diabetes (T1D) individuals. METHODS:Participants with type 1 diabetes mellitus (type 1 diabetes) were prospectively assessed for hypoglycemia awareness using the P...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2020.107617
更新日期:2020-08-01 00:00:00
abstract::Currently, neither the American Diabetes Association nor the Kidney Foundation consider the results of a positive dipstick urine test for protein, a semi-quantitative measurement, in the final evaluation of diabetic nephropathy. Instead, they require a quantitative test. The object of this study was to assess whether ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(98)00017-8
更新日期:1999-01-01 00:00:00
abstract::The aim of our study was to compare ambulatory blood pressure monitoring (ABPM) measures (mean systolic/diastolic blood pressure, diurnal rhythm, and pressure burden) in matched normo- and microalbuminuric (IDDM) adolescents and healthy controls. Twenty-four hour monitoring was undertaken in 39 normotensive (normal cl...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(97)00050-0
更新日期:1998-01-01 00:00:00