MRI measured liver stiffness does not predict focal liver lesions after the Fontan operation.


BACKGROUND:Focal liver lesions are common in children and adults after Fontan procedures. OBJECTIVE:To explore the relationship between liver shear stiffness, using magnetic resonance (MR) elastography, and the presence of focal liver lesions in patients after Fontan procedures (total cavopulmonary anastomosis). MATERIALS AND METHODS:The retrospective study was approved by the institutional review board and the requirement for informed consent was waived. By searching institutional electronic medical records, we identified all patients with a history of Fontan palliation of congenital heart disease who had undergone same-day liver MR elastography and liver MRI without and with intravenous contrast material between January 2012 and December 2017. Using imaging reports, patients were placed into two groups: 1) no focal liver lesions and 2) one or more focal liver lesions. Patient age, sex, mean liver shear stiffness (kPa) and maximum single anatomical level liver shear stiffness (kPa) were recorded. The Mann-Whitney U test was used to compare age and liver stiffness between groups, while the Fisher exact test was used to assess the impact of gender on liver lesions. RESULTS:Forty-eight patients met study inclusion criteria; 33 (69%) had one or more focal liver lesions. The median age was 20.0 years (IQR [interquartile range]: 10.8-29.1 years) for patients without liver lesions and 19.9 years (IQR: 17.2-27.0 years) for patients with liver lesions (P=0.49). Eleven of 21 male patients (52.4%) had liver lesions compared to 22 of 27 female patients (81.5%) (P=0.058). Mean (4.62 kPa [IQR: 4.10-5.59 kPa] vs. 4.10 kPa [IQR: 3.44-4.80 kPa]; P=0.02) and maximum (5.53 kPa [IQR: 4.64-6.56 kPa] vs. 4.50 kPa [IQR: 3.82-5.35 kPa]; P=0.009) liver stiffness were significantly higher in patients without liver lesions as compared to patients with liver lesions. CONCLUSION:Our study demonstrated a significant negative association between focal liver lesions and increased liver stiffness in patients following Fontan procedures.


Pediatr Radiol


Pediatric radiology


Diaz ES,Dillman JR,Veldtman GR,Trout AT




Has Abstract


2019-01-01 00:00:00














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    abstract::A case of spontaneous disappearance of an intrathoracic meningocele following insertion of a ventriculo-venous shunt is reported. The shunt was performed for treatment of hydrocephalus secondary to Arnold-Chiari malformation. The intrathoracic meningocele reappeared when the shunt obstructed and decreased in size when...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Mahboubi S,Schut L

    更新日期:1977-03-17 00:00:00

  • Cortical hypoxic-ischemic brain damage in shaken-baby (shaken impact) syndrome: value of diffusion-weighted MRI.

    abstract::Shaken-baby syndrome (SBS) is a type of child abuse caused by violent shaking of an infant, with or without impact, and characterized by subdural hematomas, retinal hemorrhages, and occult bone fractures. Parenchymal brain lesions in SBS may be missed or underestimated on CT scans, but can be detected at an earlier st...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Parizel PM,Ceulemans B,Laridon A,Ozsarlak O,Van Goethem JW,Jorens PG

    更新日期:2003-12-01 00:00:00

  • Pyloric atresia with epidermolysis bullosa: fetal MRI diagnosis with postnatal correlation.

    abstract::Pyloric atresia is an uncommon congenital gastric outlet obstruction, accounting for only 1% of gastrointestinal atresias. Up to 55% of cases have associated anomalies, the most common of which is epidermolysis bullosa. Fetal MRI findings of the epidermolysis bullosa-pyloric atresia association have not been previousl...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Merrow AC,Frischer JS,Lucky AW

    更新日期:2013-12-01 00:00:00

  • Ultrasound and colour Doppler in infantile subglottic haemangioma.

    abstract:BACKGROUND:Subglottic haemangioma causes progressive and life-threatening stridor, typically manifesting at age 2-3 months. Standard diagnosis is by laryngoscopy. Larynx sonography is rarely used but allows assessment of the presence and extension of a mass that impinges on the subglottic airway. The additional use of ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Rossler L,Rothoeft T,Teig N,Koerner-Rettberg C,Deitmer T,Rieger CH,Hamelmann E

    更新日期:2011-11-01 00:00:00

  • Acute pyomyositis of the pelvis: the spectrum of clinical presentations and MR findings.

    abstract:BACKGROUND:Acute pelvic pyomyositis is uncommon in non-tropical areas. OBJECTIVE:To summarize the clinical and MR findings in children with acute pelvic pyomyositis. MATERIALS AND METHODS:We retrospectively identified 20 children (mean age 9.4 years) who were evaluated by MR and diagnosed with acute pelvis pyomyositi...

    journal_title:Pediatric radiology

    pub_type: 临床试验,杂志文章


    authors: Karmazyn B,Kleiman MB,Buckwalter K,Loder RT,Siddiqui A,Applegate KE

    更新日期:2006-04-01 00:00:00

  • Latex allergy in patients with myelomeningocele presenting for imaging studies of the urinary tract.

    abstract:OBJECTIVE:We prospectively surveyed patients with myelomeningocele who presented in our department over a 3-month period to determine the frequency of latex allergy in this population. MATERIALS AND METHODS:A questionnaire assessed history of allergy to latex and attitudes toward and use or avoidance of latex-containi...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Zerin JM,McLaughlin K,Kerchner S

    更新日期:1996-07-01 00:00:00

  • Arterial closure device to achieve hemostasis in children following percutaneous femoral arterial puncture.

    abstract:BACKGROUND:Percutaneous arterial closure devices have increasingly entered clinical practice to assist in achieving femoral arterial access site hemostasis. Prior studies have demonstrated the safety and efficacy of several arterial closure devices in adults. OBJECTIVE:To evaluate the efficacy of using an arterial clo...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Prabhu SJ,Padia SA,Valji K,McNeeley MF,Vaidya S,Vo NJ

    更新日期:2013-06-01 00:00:00

  • Osteogenic sarcoma of the neural arch.

    abstract::Osteogenic sarcoma arising in the spine, and in particular the neural arch, is rare. We present the case of a 4-year-old girl with an osteogenic sarcoma arising in the left transverse process of the second lumbar vertebra. The child received chemotherapy and delayed surgical excision was performed following a favourab...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Wright NB,Skinner R,Lee RE,Craft AW

    更新日期:1995-01-01 00:00:00

  • Septo-optic-dysplasia-schizencephaly. Radiographic and clinical features.

    abstract::The anatomical anomalies that characterize septo-optic-dysplasia (deMorsier Syndrome) are variable and often subtle. We report imaging studies of nine patients with septo-optic-dysplasia which provide radiologic and ultrasonographic clues to this disorder. In addition, we propose that cerebral schizencephaly may be a ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Kuban KC,Teele RL,Wallman J

    更新日期:1989-01-01 00:00:00

  • Assessment of increase in renal pelvic size on post-void sonography as a predictor of vesicoureteral reflux.

    abstract:BACKGROUND:During the course of our routine renal ultrasound examinations, we noticed that some children who developed dilatation of a renal pelvis following voiding had reflux found on voiding cystourethrography (VCUG). PURPOSE:To determine if increase in renal pelvic size on post-void ultrasound is an accurate predi...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Evans ED,Meyer JS,Harty MP,Bellah RD

    更新日期:1999-04-01 00:00:00

  • Combined asymptomatic congenital anterior and posterior deficiency of the atlas.

    abstract::Atlas anomalies in terms of clefts and aplasia are rare. They can sometimes simulate fractures and need further evaluation. Imaging in terms of CT and MR can help resolve diagnostic confusion and also outline associated neurological involvement. A rare anomaly of anterior and posterior atlas arch, previously unclassif...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Hosalkar HS,Gerardi JA,Shaw BA

    更新日期:2001-11-01 00:00:00

  • MR imaging of transient synovitis: differentiation from septic arthritis.

    abstract:BACKGROUND:Transient synovitis is the most common cause of acute hip pain in children. However, MR imaging findings in transient synovitis and the role of MR imaging in differentiating transient synovitis from septic arthritis have not been fully reported. OBJECTIVE:To describe the MR findings of transient synovitis a...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Yang WJ,Im SA,Lim GY,Chun HJ,Jung NY,Sung MS,Choi BG

    更新日期:2006-11-01 00:00:00

  • Pediatric blunt splenic trauma: a comprehensive review.

    abstract::Abdominal trauma is a leading cause of death in children older than 1 year of age. The spleen is the most common organ injured following blunt abdominal trauma. Pediatric trauma patients present unique clinical challenges as compared to adults, including different mechanisms of injury, physiologic responses, and indic...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审


    authors: Lynn KN,Werder GM,Callaghan RM,Sullivan AN,Jafri ZH,Bloom DA

    更新日期:2009-09-01 00:00:00

  • Congenital solitary nonparasitic cyst of the liver in a newborn.

    abstract::Congenital solitary nonparasitic cysts of the liver (CSNCL) are extremely rare causes of abdominal masses in newborns and infants. We describe a cystic abdominal mass virtually all extrahepatic in a newborn that proved to be a CSNCL. ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Quillin SP,McAlister WH

    更新日期:1992-01-01 00:00:00

  • Gadolinium-based contrast agents in pediatric magnetic resonance imaging.

    abstract::Gadolinium-based contrast agents can increase the accuracy and expediency of an MRI examination. However the benefits of a contrast-enhanced scan must be carefully weighed against the well-documented risks associated with administration of exogenous contrast media. The purpose of this review is to discuss commercially...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审


    authors: Gale EM,Caravan P,Rao AG,McDonald RJ,Winfeld M,Fleck RJ,Gee MS

    更新日期:2017-05-01 00:00:00

  • Neurofibromatosis involving the lower urinary tract in children. A report of three cases and a review of the literature.

    abstract::Three children with neurofibromatosis involving the lower urinary tract are reported and their clinical, radiological and pathological findings are described. Lower urinary tract involvement in neurofibromatosis has previously been reported in 17 children, 12 of whom had other stigmata of von Recklinghausens disease. ...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Daneman A,Grattan-Smith P

    更新日期:1976-04-14 00:00:00

  • Perinatal clinical and imaging features of CLOVES syndrome.

    abstract::We report a neonate with antenatal imaging features suggestive of CLOVES syndrome. Postnatal clinical and imaging findings confirmed the diagnosis, with the constellation of truncal overgrowth, cutaneous capillary malformation, lymphatic and musculoskeletal anomalies. The clinical, radiological and histopathological f...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Fernandez-Pineda I,Fajardo M,Chaudry G,Alomari AI

    更新日期:2010-08-01 00:00:00

  • Classic metaphyseal lesion of distal tibia following footling breech delivery.

    abstract::Classic metaphyseal lesions associated with childbirth are rare. We report a distal tibial metaphyseal fracture following a difficult breech delivery. Classic metaphyseal fractures are considered highly specific injuries associated with non-accidental trauma. This case depicts a classic metaphyseal lesion sustained du...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Lee GS,Methratta ST,Frasier LD

    更新日期:2019-12-01 00:00:00

  • Internal hernias in children: spectrum of clinical and imaging findings.

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    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Tang V,Daneman A,Navarro OM,Miller SF,Gerstle JT

    更新日期:2011-12-01 00:00:00

  • Radiological kidney size in childhood.

    abstract::Kidney length (KL), renal area and renal parenchymal area were measured on i.v. urograms of 255 children without apparent kidney disease age 0 to 14 years. These parameters were compared with age, body height, body surface area and the distance between the 1st and 4th lumbar vertebral body. In addition, renal parenchy...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Klare B,Geiselhardt B,Wesch H,Schärer K,Immich H,Willich E

    更新日期:1980-04-01 00:00:00

  • Mesomelic dysplasia of the upper extremities associated with other abnormalities: a new syndrome?

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    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Kozlowski K,Bacha L,Brachimi L,Massen R

    更新日期:1993-01-01 00:00:00

  • Hepatobiliary and pancreatic imaging in children-techniques and an overview of non-neoplastic disease entities.

    abstract::Imaging plays a major role in the diagnostic work-up of children with hepatobiliary or pancreatic diseases. It consists mainly of US, CT and MRI, with US and MRI being the preferred imaging modalities because of the lack of ionizing radiation. In this review the technique of US, CT and MRI in children will be addresse...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审


    authors: Nievelstein RA,Robben SG,Blickman JG

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  • MRI of the pulmonary artery after arterial switch operation for transposition of the great arteries.

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    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Beek FJ,Beekman RP,Dillon EH,Mali WP,Meiners LC,Kramer PP,Meyboom EJ

    更新日期:1993-01-01 00:00:00

  • Neonatal goiter: imaging findings in two children.

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    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Stoane JM,Haller JO,Price AF

    更新日期:1996-01-01 00:00:00

  • Gallbladder volvulus in a child with mild clinical presentation.

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    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Inoue S,Odaka A,Hashimoto D,Tamura M,Osada H

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  • Tradeoffs between image quality and dose.

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    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审


    authors: Seibert JA

    更新日期:2004-10-01 00:00:00

  • Transumbilical intravascular retrieval of an umbilical artery catheter.

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    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Murphy KD,Le VA,Encarnacion CE,Palmaz JC

    更新日期:1995-11-01 00:00:00

  • Transport, monitoring, and successful brain MR imaging in unsedated neonates.

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    journal_title:Pediatric radiology

    pub_type: 杂志文章,实务指引


    authors: Mathur AM,Neil JJ,McKinstry RC,Inder TE

    更新日期:2008-03-01 00:00:00

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    abstract::Fibroblast growth factor receptor mutations cause some of the main short-limb skeletal dysplasias and craniosynostosis syndromes, including achondroplasia, hypochondroplasia, thanatophoric dysplasia, Apert syndrome, Crouzon syndrome, Pfeiffer syndrome, and Jackson-Weiss syndrome. Much work remains to be done in unrave...

    journal_title:Pediatric radiology

    pub_type: 杂志文章,评审


    authors: Cohen MM Jr

    更新日期:1997-05-01 00:00:00

  • Inflammatory pseudotumour of the pancreas in a child.

    abstract::We describe a 4-year-old girl with an inflammatory pseudotumour of the pancreas, which was preceded by varicella-zoster infection. Inflammatory pseudotumour may involve a variety of tissues, the lungs and liver being typical sites of predilection. Imaging and laboratory tests are nonspecific, and for this reason the d...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Slavotinek JP,Bourne AJ,Sage MR,Freeman JK

    更新日期:2000-11-01 00:00:00