MRI measured liver stiffness does not predict focal liver lesions after the Fontan operation.


BACKGROUND:Focal liver lesions are common in children and adults after Fontan procedures. OBJECTIVE:To explore the relationship between liver shear stiffness, using magnetic resonance (MR) elastography, and the presence of focal liver lesions in patients after Fontan procedures (total cavopulmonary anastomosis). MATERIALS AND METHODS:The retrospective study was approved by the institutional review board and the requirement for informed consent was waived. By searching institutional electronic medical records, we identified all patients with a history of Fontan palliation of congenital heart disease who had undergone same-day liver MR elastography and liver MRI without and with intravenous contrast material between January 2012 and December 2017. Using imaging reports, patients were placed into two groups: 1) no focal liver lesions and 2) one or more focal liver lesions. Patient age, sex, mean liver shear stiffness (kPa) and maximum single anatomical level liver shear stiffness (kPa) were recorded. The Mann-Whitney U test was used to compare age and liver stiffness between groups, while the Fisher exact test was used to assess the impact of gender on liver lesions. RESULTS:Forty-eight patients met study inclusion criteria; 33 (69%) had one or more focal liver lesions. The median age was 20.0 years (IQR [interquartile range]: 10.8-29.1 years) for patients without liver lesions and 19.9 years (IQR: 17.2-27.0 years) for patients with liver lesions (P=0.49). Eleven of 21 male patients (52.4%) had liver lesions compared to 22 of 27 female patients (81.5%) (P=0.058). Mean (4.62 kPa [IQR: 4.10-5.59 kPa] vs. 4.10 kPa [IQR: 3.44-4.80 kPa]; P=0.02) and maximum (5.53 kPa [IQR: 4.64-6.56 kPa] vs. 4.50 kPa [IQR: 3.82-5.35 kPa]; P=0.009) liver stiffness were significantly higher in patients without liver lesions as compared to patients with liver lesions. CONCLUSION:Our study demonstrated a significant negative association between focal liver lesions and increased liver stiffness in patients following Fontan procedures.


Pediatr Radiol


Pediatric radiology


Diaz ES,Dillman JR,Veldtman GR,Trout AT




Has Abstract


2019-01-01 00:00:00














  • Primary thyroid dysfunction after single intravenous iodinated contrast exposure in young children: a propensity score matched analysis.

    abstract:BACKGROUND:Data suggest an increased risk of thyroid dysfunction following iodine-based contrast material (IBCM) in children. OBJECTIVE:To estimate the prevalence of thyroid stimulating hormone (TSH) abnormalities following exposure to a single dose of intravenous IBCM during computed tomography (CT) in young children...

    journal_title:Pediatric radiology

    pub_type: 杂志文章


    authors: Gilligan LA,Dillman JR,Su W,Zhang B,Chuang J,Trout AT

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  • The localization of urinary tract infection with 99mTc glucoheptonate scintigraphy.

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    authors: Traisman ES,Conway JJ,Traisman HS,Yogev R,Firlit C,Shkolnik A,Weiss S

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  • Abscess of the cavum septum pellucidum.

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    journal_title:Pediatric radiology

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    更新日期:2012-05-01 00:00:00

  • Value of emergent pediatric cardiac computed tomographic angiography service: initial experience at a large children's hospital.

    abstract:BACKGROUND:Demand for pediatric cardiac computed tomography (CT) angiography is increasing due to recent advances that reduce the need for sedation and radiation exposure while enhancing diagnostic accuracy. This has resulted in the increasing use of cardiac CT angiography emergently during weekends and after hours. Th...

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    abstract::One of the obstacles in discussing childhood tuberculosis (TB) is the lack of standard descriptive terminology to classify the diverse spectrum of disease. Accurate disease classification is important, because the correct identification of the specific disease entity has definite prognostic significance. Accurate clas...

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    更新日期:1997-08-01 00:00:00

  • Transient cortical blindness following vertebral angiography in a young adult with cerebellar haemangioblastoma.

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    abstract:BACKGROUND:Oral contrast preparation is fundamental to ensuring diagnostic examination quality for magnetic resonance enterography (MRE), yet little is known about the relative palatability and tolerability of various oral contrast agents in pediatric patients with known or suspected inflammatory bowel disease. OBJECT...

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