Leveraging Hypomethylating Agents for Better MDS Therapy.

Abstract:

PURPOSE OF REVIEW:Myelodysplastic syndrome (MDS) is a clinically and molecularly heterogeneous disease, which primarily occurs in older adults. Although hypomethylating agents have survival benefit and are the current standard of care, many MDS patients will not garner a response from therapy. For those who do respond, most responses are not durable, and the only hope for a cure is allogeneic stem cell transplant. New therapies to improve outcomes are urgently needed. RECENT FINDINGS:Clinical trials combining standard hypomethylating agents with novel experimental agents are underway in an effort to improve clinical outcomes in MDS patients. Several of these small molecules have demonstrated the ability to augment the response rates of hypomethylating agents alone, including complete remission rates, in both the front line and refractory settings. Combination approaches utilizing hypomethylating agents and novel-targeted therapies have demonstrated the ability to improve response rates in MDS patients in both the front line and salvage settings, and thus may change the standard of care.

journal_name

Curr Hematol Malig Rep

authors

Bradley TJ,Watts JM,Swords RT

doi

10.1007/s11899-018-0477-3

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

507-515

issue

6

eissn

1558-8211

issn

1558-822X

pii

10.1007/s11899-018-0477-3

journal_volume

13

pub_type

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