Abstract:
PURPOSE:The aim of this study was to evaluate and compare the toxicity of six different types of titanium dioxide (TiO2) nanoparticles (NP) on human epidermal keratinocytes (HEK). MATERIALS AND METHODS:Six TiO2 NP (A (10 nm), A*(32 nm), B (27.5 nm), C (200 nm), C*(30-40 nm), and D*(200-400 nm)) were suspended in water or culture medium and characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). In addition, these NP were assayed with cell viability, cytokine release and cellular uptake in HEK. RESULTS:TiO2NP did not change in shape in the culture medium when visualized by TEM. There was an increase in agglomeration with all TiO2NP in the medium when measured by DLS. Since TiO2NP interfered with the CellTiter 96®AQueous One and MTT assays but had a minimal effect on alamar Blue (aB). The aB viability assay was selected to assess all six types of TiO2NP and sample B had a statistically significant decrease in viability at 0.4 mg/ml. A slight increase in TNF-α was noted in sample A*, C, and D* at as low as 0.05 mg/ml. Sample A* and B at certain concentrations showed an increase in Interleukin (IL)-6. IL-10 and IL-1β release for all TiO2NP were noted around the detection limit with no significant changes compared to control. A statistically significant decrease in IL-8 was noted for all TiO2NP at the highest concentrations due to the adsorption of IL-8 by TiO2. All TiO2NP were localized within cytoplasmic vacuoles of HEK and the element Ti was detected by energy-dispersive x-ray spectroscopy analysis. CONCLUSIONS:Based on cell viability, only sample B was slightly cytotoxic to HEK and samples B and A* have the potential to cause inflammation indicated by an increase in IL-6.
journal_name
Cutan Ocul Toxicoljournal_title
Cutaneous and ocular toxicologyauthors
Zhang LW,Monteiro-Riviere NAdoi
10.1080/15569527.2018.1527848subject
Has Abstractpub_date
2019-03-01 00:00:00pages
66-80issue
1eissn
1556-9527issn
1556-9535journal_volume
38pub_type
杂志文章abstract::Patch testing is an important tool in the diagnosis of allergic contact dermatitis. Although this technique can be accurate, occasionally the results may be inconclusive. A previously positive result to an allergen may become negative upon repeat testing, and this may complicate the process of achieving a definitive d...
journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520701856757
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.1080/15569520701212316
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journal_title:Cutaneous and ocular toxicology
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abstract:PURPOSE:To find the abnormalities in various retinal layers caused by radiation retinopathy using spectral domain optical coherence tomography (SD-OCT). METHODS:We report a case of radiation retinopathy that was imaged using SD-OCT Copernicus (Optopol, Zawiercie, Poland). Analysis and synthesis of the OCT image were d...
journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2013.834499
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章
doi:10.3109/15569527.2010.484824
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pub_type: 临床试验,杂志文章
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journal_title:Cutaneous and ocular toxicology
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journal_title:Cutaneous and ocular toxicology
pub_type: 杂志文章,评审
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journal_title:Cutaneous and ocular toxicology
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doi:10.3109/15569527.2011.629384
更新日期:2012-09-01 00:00:00
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journal_title:Cutaneous and ocular toxicology
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doi:10.3109/15569527.2010.485285
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journal_title:Cutaneous and ocular toxicology
pub_type: 临床试验,杂志文章
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journal_title:Cutaneous and ocular toxicology
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更新日期:2015-01-01 00:00:00
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doi:10.3109/15569527.2013.808654
更新日期:2014-06-01 00:00:00