Abstract:
:We have examined by immunofluorescent antibody staining technique the expression of herpes simplex virus type 1 (HSV-1) in organ cultures of the normal human oral mucosa. The expression of HSV-1 antigen was found selectively in the epithelial cell layers in relatively undifferentiated states such as basal layer and lower prickle cell layer in addition to the basement membrane. When the epithelial cells dissociated from the oral mucosa were infected with HSV-1 and association of the HSV-1 expression with the cellular differentiation was examined, the epithelial cells containing laminin in an undifferentiated state were permissive for the expression of HSV-1 antigen whereas terminally differentiated epithelial cells with the cornified envelope did not express HSV-1 antigen. These findings indicate that the expression of HSV-1 antigen is restricted in the mucosal epithelial cells in a differentiated state, although the possibility that the cornified envelope might protect the cells from infection is not excluded.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Yura Y,Iga H,Terashima K,Yoshida H,Yanagawa T,Hayashi Y,Sato Mdoi
10.1007/BF01310061subject
Has Abstractpub_date
1987-01-01 00:00:00pages
41-53issue
1-2eissn
0304-8608issn
1432-8798journal_volume
92pub_type
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