Screening for thoracic aortic pathology: Clinical practice in a single tertiary center.


OBJECTIVE:The aim is to present current clinical practice of thoracic aorta screening in a tertiary referral center. We identified how often imaging techniques were used for screening and established the value of transthoracic echocardiography (TTE) in comparison with computed tomography (CT) to detect aortic dilation. We also investigated which additional abnormalities of the heart, aorta or smaller arteries were discovered. DESIGN:All patients ≥15 years who visited our tertiary center in 2012-2016 for first thoracic aortic screening were retrospectively included. Diameters of the sinus of Valsalva (SoV) and maximum ascending aorta (AA) were compared between TTE and CT. The sensitivity and specificity of TTE to detect aortic dilation (≥40 mm) was assessed with CT as reference standard. Intracardiac abnormalities found with TTE and arterial abnormalities found with CT were identified. RESULTS:In total 349 patients (155 men, age 41 ± 15 years, 10% genetic mutation) were included. Screening was performed with TTE only in 35% and with TTE and CT in 65%. Patients who underwent TTE only were younger, had less often hypertension and less often a family history of aortic pathology. Although there was a good correlation between TTE and CT, the diameters measured with TTE were typically lower (SoV -1.0, 95%CI -6.6 to 4.7 and AA -0.4, 95%CI -6.5 to 5.8). Sensitivity of TTE for detecting aortic dilation was 61% (SoV) and 57% (AA) and specificity was 96% (SoV) and 100% (AA). Valve abnormalities, ventricular dilation or reduced ventricular function was found with TTE in 26 patients (7%). In 47 patients (13%) ascending aortic dilation was diagnosed and in 10 patients (4%) relevant peripheral arterial abnormalities were identified using CT. CONCLUSIONS:Most often patients received both TTE and CT (65%). Since TTE showed a low sensitivity to detect aortic dilation, CT imaging is advised at least once in patients referred for thoracic aortic screening.


Congenit Heart Dis


Congenital heart disease


Bons LR,Uchoa de Assis L,Dekker S,Kauling RM,Cuypers JAAE,Verhagen HJM,Budde RPJ,Roos-Hesselink JW




Has Abstract


2018-11-01 00:00:00












  • Correlates of posttraumatic stress disorder in adults with congenital heart disease.

    abstract:OBJECTIVE:The aims of this study were to compare the level of posttraumatic stress disorder between adults with and without congenital heart disease, and to examine the correlates of posttraumatic stress disorder (e.g., sociodemographics). DESIGN:Cross-sectional. SETTING:Two university-affiliated heart hospitals in T...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Eslami B

    更新日期:2017-05-01 00:00:00

  • Health care-associated infections are associated with increased length of stay and cost but not mortality in children undergoing cardiac surgery.

    abstract:INTRODUCTION:Health care-associated infections (HAIs) increase mortality, length of stay, and cost in hospitalized patients. The incidence of and risk factors for developing HAIs in the pediatric population after cardiac surgery have been studied. This study evaluates the impact of HAIs on length of stay, inpatient mor...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,多中心研究


    authors: Tweddell S,Loomba RS,Cooper DS,Benscoter AL

    更新日期:2019-09-01 00:00:00

  • Comprehensive evaluation of a patient with Kawasaki disease and giant coronary aneurysms with cardiac magnetic resonance.

    abstract::In patients with Kawasaki disease (KD) and coronary artery aneurysms (CAAs), serial evaluation with multiple imaging modalities is recommended to guide risk stratification and management. We present the case of a 7-year-old boy with a history of KD and multiple giant CAAs who developed thrombosis in one of the aneurys...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Prsa M,Hussain T,McCrindle BW,Grosse-Wortmann L

    更新日期:2014-11-01 00:00:00

  • Longitudinal Strain by Speckle Tracking Echocardiography in Pediatric Heart Transplant Recipients.

    abstract:INTRODUCTION:Heart transplant recipients are at risk for developing left ventricular (LV) dysfunction. While traditional echocardiographic parameters have limitations, speckle tracking echocardiography (STE) is a novel technique shown to be more sensitive and accurate in adult studies for evaluating ventricular systoli...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Buddhe S,Richmond ME,Gilbreth J,Lai WW

    更新日期:2015-07-01 00:00:00

  • On-table Extubation after Open Heart Surgery in Children: An Experience from a Tertiary Care Hospital in a Developing Country.

    abstract:BACKGROUND:Recent advances in various disciplines of medicine have significantly changed the courses following cardiac surgery in children. On-table extubation (OTE) after open heart surgery in children is evolving. OBJECTIVE:To assess the rate of postoperative complications in children extubated on table after open h...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Hoda M,Haque A,Aijaz F,Akhtar MI,Rehmat A,Amanullah M,Hasan BS

    更新日期:2016-01-01 00:00:00

  • Update on tetralogy of Fallot for the adult cardiologist including a brief historical and surgical perspective.

    abstract::There has been a steady rise in the prevalence of severe congenital heart disease (CHD) in adults because of improved treatment and survival during childhood. This has resulted in a shift in CHD morbidity and mortality beyond 18 years of age. The healthcare community must be prepared to meet this new challenge. Adult ...

    journal_title:Congenital heart disease

    pub_type: 历史文章,杂志文章,评审


    authors: Kalra N,Klewer SE,Raasch H,Sorrell VL

    更新日期:2010-05-01 00:00:00

  • Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta.

    abstract:OBJECTIVE:Patients undergoing surgical repair of aortic coarctation have a 50% risk of pathologic left ventricular remodeling (increased left ventricular mass or relative wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B-natriuretic peptide are biomarkers that have been associated with pathologic LV ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Frank BS,Urban TT,Lewis K,Tong S,Cassidy C,Mitchell MB,Nichols CS,Davidson JA

    更新日期:2019-05-01 00:00:00

  • Population-based assessment of familial inheritance and neurologic comorbidities among patients with an isolated atrial septal defect.

    abstract:BACKGROUND:Interatrial shunts, caused by either atrial septal defect (ASD) or patent foramen ovale, have been reported to have a familial association. We sought to examine the familial risk of isolated interatrial shunt and explore associated comorbidities of stroke, transient ischemic attack (TIA), and migraine using ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Steenblik MH,Mineau GP,Pimentel R,Michaels AD

    更新日期:2009-11-01 00:00:00

  • Impact of Coronary Artery Anatomy in Arterial Switch Procedure on Early Mortality and Morbidity.

    abstract:OBJECTIVE:Arterial switch operation has become the treatment of choice for neonates with transposition of the great arteries. The most important step of the procedure is transferring the coronary arteries to the neoaorta successfully. This study shows the impact of coronary anatomy on early mortality and morbidity afte...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Altin FH,Sengul FS,Yildiz O,Tosun O,Ozturk E,Kyaruzi M,Cine N,Guzeltas A,Yeniterzi M,Bakir İ

    更新日期:2016-03-01 00:00:00

  • Split-thickness cartilage grafts for chest wall reconstruction in pentalogy of Cantrell.

    abstract::We describe a simple technique for chest wall reconstruction in pentalogy of Cantrell using split-thickness cartilage grafts. This technique provides a robust reconstruction, gives immediate and excellent cosmetic results, allows for skeletal and tissue growth, and avoids the use of synthetic material. ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Grudziak J,Kogon B

    更新日期:2013-01-01 00:00:00

  • Pathologic features of dilated cardiomyopathy with localized noncompaction in a child with deletion 1p36 syndrome.

    abstract::Dilated cardiomyopathy and ventricular noncompaction have been reported in association with deletion 1p36 syndrome. Previous descriptions include echocardiographic and/or gross pathologic descriptions. There are no previous reports of microscopic findings. We report a case with descriptions of echocardiographic, gross...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Pearce FB,Litovsky SH,Dabal RJ,Robin N,Dure LJ,George JF,Kirklin JK

    更新日期:2012-01-01 00:00:00

  • Building a comprehensive team for the longitudinal care of single ventricle heart defects: Building blocks and initial results.

    abstract:INTRODUCTION:With increasing survival of children with HLHS and other single ventricle lesions, the complexity of medical care for these patients is substantial. Establishing and adhering to best practice models may improve outcome, but requires careful coordination and monitoring. METHODS:In 2013 our Heart Center beg...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Texter K,Davis JAM,Phelps C,Cheatham S,Cheatham J,Galantowicz M,Feltes TF

    更新日期:2017-07-01 00:00:00

  • Clinical, echocardiographic, and therapeutic aspects of congenital heart diseases of children at Douala General Hospital: A cross-sectional study in sub-Saharan Africa.

    abstract:INTRODUCTION:Cardiovascular diseases in pediatric pathologies have emerged in the recent years in sub-Saharan Africa (SSA), with congenital heart diseases (CHDs) being the most frequent. Unfortunately, their diagnosis is usually delayed, thereby increasing childhood morbidity and mortality. OBJECTIVES:Describe the cli...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Kamdem F,Kedy Koum D,Hamadou B,Yemdji M,Luma H,Doualla MS,Noukeu D,Barla E,Akazong C,Dzudie A,Ngote H,Monkam Y,Mouliom S,Kingue S

    更新日期:2018-01-01 00:00:00

  • Window-type patent ductus arteriosus with acquired rheumatic mitral stenosis.

    abstract::An 18-year-old patient with a window type of patent ductus arteriosus and acquired rheumatic mitral stenosis is reported for its rarity. The pitfalls in the diagnosis and surgical management of this condition are discussed. ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Talwar S,Upadhyay M,Ramakrishnan S,Gharade P,Choudhary SK,Airan B

    更新日期:2013-01-01 00:00:00

  • Comparison of the Effects of Dexmedetomidine and Propofol on Hemodynamics and Oxygen Balance in Children with Complex Congenital Heart Disease Undergoing Cardiac Surgery.

    abstract:OBJECTIVE:The aim of this study was to compare the effects of anesthesia by dexmedetomidine and propofol on the hemodynamics and oxygen balance in children with complex congenital heart disease who were undergoing cardiac surgery. METHODS:Fifty-seven children were randomized to receive either a continuous infusion of ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,随机对照试验


    authors: Cheng X,Zuo Y,Zhao Q,Gu E,Huang Y

    更新日期:2015-05-01 00:00:00

  • The impact of obesity on early postoperative outcomes in adults with congenital heart disease.

    abstract:BACKGROUND:As the prevalence of obesity continues to increase, it now includes the growing number of patients with congenital heart disease (CHD). This particular obese patient population may pose additional intraoperative as well as postoperative challenges that may contribute to poor outcomes. Our aims were to determ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Zaidi AN,Bauer JA,Michalsky MP,Olshove V,Boettner B,Phillips A,Cook SC

    更新日期:2011-05-01 00:00:00

  • Clinical Experience of Transcatheter Closure for Residual Ventricular Septal Defect in Pediatric Patients.

    abstract:BACKGROUND:Open cardiac surgery has traditionally been the gold standard for repair of ventricular septal defect (VSD). The inherent risks and complications associated with open surgery and the incidence of postoperative residual VSD are significant disadvantages of the open surgical approach. OBJECTIVE:To evaluate th...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Zhou W,Li F,Fu L,Gao W,Guo Y,Liu T,Huang M,Zhang Y

    更新日期:2016-07-01 00:00:00

  • Current Practice and Utility of Chromosome Microarray Analysis in Infants Undergoing Cardiac Surgery.

    abstract:OBJECTIVE:Traditionally, karyotype and fluorescence in situ hybridization (FISH) were used for cytogenetic testing of infants with congenital heart disease (CHD) who underwent cardiac surgery at our institution. Recently, chromosome microarray analysis (CMA) has been performed in lieu of the traditional tests. A standa...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Buckley JR,Kavarana MN,Chowdhury SM,Scheurer MA

    更新日期:2015-05-01 00:00:00

  • Platelet activation markers in children with congenital heart disease associated with pulmonary arterial hypertension.

    abstract:BACKGROUND:Mean platelet volume (MPV), platecrit, and platelet distribution width (PDW) are markers of platelet activation. Previous studies have found that platelet activation occurs in patients with pulmonary arterial hypertension. Platelet indices including MPV, PDW, and platecrit have not been studied in children w...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Mese T,Guven B,Yilmazer MM,Karadeniz C,Ozdemir R,Doksoz O

    更新日期:2018-07-01 00:00:00

  • Increased Body Mass Index Is Associated with Congestive Heart Failure and Mortality in Adult Fontan Patients.

    abstract:OBJECTIVE:Obesity affects adults with congenital heart disease (CHD). The effect of an increased body mass index (BMI) with respect to morbidity and mortality has not been evaluated in adults with complex CHD. Our objective was to evaluate the effects of increased BMI on heart failure and mortality in univentricular pa...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Martinez SC,Byku M,Novak EL,Cedars AM,Eghtesady P,Ludbrook PA,Billadello JJ

    更新日期:2016-01-01 00:00:00

  • Crisscross heart with tricuspid atresia diagnosed in utero.

    abstract::Crisscross heart is a rare congenital cardiac anomaly in which systemic and pulmonary venous streams cross without mixing at atrioventricular level. We report a case of crisscross heart with tricuspid atresia, double outlet right ventricle, and pulmonary stenosis, which was diagnosed prenatally. ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Ayabakan C,Binnetoğlu K,Sarısoy Ö,Tokel K

    更新日期:2013-09-01 00:00:00

  • Acute and long-term effects of endovascular debanding of pulmonary arteries in a swine model.

    abstract:OBJECTIVES:The primary objective of this study was to demonstrate that pulmonary artery (PA) debanding via cardiac catheterization using balloon angioplasty is feasible and safe in swine. The secondary objectives were to determine the acute and long-term effects of this therapy. DESIGN:This is a chronic survival exper...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Perez M,Kumar TS,Hoskoppal D,Akkhawattanangkul Y,Allen K,Knott-Craig CJ,Waller BR,Sathanandam S

    更新日期:2017-05-01 00:00:00

  • Hemodynamic effects of ketamine in children with congenital heart disease and/or pulmonary hypertension.

    abstract:INTRODUCTION:Ketamine is a drug often used for procedural sedation or as adjunct agent for general sedation in children with congenital heart disease. In the clinical realm, there is often confusion regarding the effects of ketamine on hemodynamics, particularly pulmonary vascular resistance and systemic vascular resis...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Loomba RS,Gray SB,Flores S

    更新日期:2018-09-01 00:00:00

  • Complete atrioventricular canal repair with a decellularized porcine small intestinal submucosa patch.

    abstract:BACKGROUND:Congenital heart defects affect nearly 1% of all children born per year in the United States, and complete atrioventricular canal (CAVC) accounts for 2%-9%. While several patch materials have been used for septal defect closure during CAVC repair, clear superiority of one material over another has yet to be ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Al Haddad E,LaPar DJ,Dayton J,Stephens EH,Bacha E

    更新日期:2018-11-01 00:00:00

  • Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young.

    abstract:INTRODUCTION:Perturbations in the CACNA1C-encoded L-type calcium channel α-subunit have been linked recently to heritable arrhythmia syndromes, including Timothy syndrome, Brugada syndrome, early repolarization syndrome, and long QT syndrome. These heritable arrhythmia syndromes may serve as a pathogenic basis for auto...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Sutphin BS,Boczek NJ,Barajas-Martínez H,Hu D,Ye D,Tester DJ,Antzelevitch C,Ackerman MJ

    更新日期:2016-12-01 00:00:00

  • Survival and health in liveborn infants with transposition of great arteries--a population-based study.

    abstract:OBJECTIVE:To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA). DESIGN:Population-based data from 7 European registries of congenital malformations (EUROCAT). RESULTS:Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Garne E,Loane MA,Nelen V,Bakker MK,Gener B,Abramsky L,Addor MC,Queisser-Luft A

    更新日期:2007-05-01 00:00:00

  • Echocardiographic evaluation of pressure gradient across the stent in patients treated for coarctation of the aorta.

    abstract:OBJECTIVE:Stent placement has become a widely used method of treatment for coarctation of the aorta (COA). Our goal was to find echocardiographic indices that would correlate best with directly measured gradients across the coarctation stent. MATERIAL AND METHODS:Pediatric patients with COA who underwent intra-aortic ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Tang L,Forbes TJ,Du W,Zilberman MV

    更新日期:2009-07-01 00:00:00

  • Congenital left ventricular splint in an adult patient with unrepaired anomalous left coronary artery from the pulmonary artery.

    abstract::A 24-year-old woman presented with a recent increase in dyspnea on exertion and development of presyncope. The patient stated that she has reproducible episodes of dizziness and near fainting when she climbs a flight of stairs and activity is limited to a slow gait. ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Sabbath AM,Trivedi K,Klewer SE,Sorrell VL

    更新日期:2007-07-01 00:00:00

  • Patient Preference and Perception of Care Provided by Advance Nurse Practitioners and Physicians in Outpatient Adult Congenital Clinics.

    abstract:OBJECTIVE:Nurse practitioners (NPs) have an established role for delivering competent care to patients in the primary care setting. The aim of this study was to compare satisfaction of patients managed by NPs vs. physicians in the outpatient adult congenital heart disease (CHD) clinic. DESIGN:A prospective study condu...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,多中心研究


    authors: Maul TM,Zaidi A,Kowalski V,Hickey J,Schnug R,Hindes M,Cook S

    更新日期:2015-09-01 00:00:00

  • Racial disparities in clinic follow-up early in life among survivors of congenital heart disease.

    abstract:OBJECTIVE:The current study aims to identify the rates of lapses in care and loss to follow-up before age one through age five for white and nonwhite congenital heart disease (CHD) survivors. Nonwhite CHD survivors were hypothesized to experience an earlier lapse in care and be lost to follow-up than whites. DESIGN:Pa...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Jackson JL,Morack J,Harris M,DeSalvo J,Daniels CJ,Chisolm DJ

    更新日期:2019-03-01 00:00:00