Hemodynamic effects of ketamine in children with congenital heart disease and/or pulmonary hypertension.


INTRODUCTION:Ketamine is a drug often used for procedural sedation or as adjunct agent for general sedation in children with congenital heart disease. In the clinical realm, there is often confusion regarding the effects of ketamine on hemodynamics, particularly pulmonary vascular resistance and systemic vascular resistance. We performed a meta-analysis of studies investigating the effects of ketamine on hemodynamics. METHODS:A systematic review was conducted to identify studies characterizing the hemodynamic effects of ketamine in children with congenital heart disease. Studies were assessed for quality and those of satisfactory quality with pre- and postketamine hemodynamics for each patient were included in the final analyses. Those not limited to pediatric patients and those not limited to patients with congenital heart disease were excluded from the final analyses. RESULTS:A total of 7 studies with 139 patients were included in the final analyses. Pulmonary vascular resistance, systemic vascular resistance, mean pulmonary artery pressure, mean systemic pressure, heart rate, pH, and arterial oxygen concentration did not significantly change with administration of ketamine. Carbon dioxide concentration did increase significantly by a mean of 1.38 mm Hg with the administration of ketamine. CONCLUSION:Ketamine has minimal impact on hemodynamics in children with congenital heart disease when used at usual clinical doses. Systemic vascular resistance and pulmonary vascular resistance are not significantly altered. Blood gas values are also only minimally affected by ketamine.


Congenit Heart Dis


Congenital heart disease


Loomba RS,Gray SB,Flores S




Has Abstract


2018-09-01 00:00:00












  • Long-term outcome following pregnancy in women with a systemic right ventricle: is the deterioration due to pregnancy or a consequence of time?

    abstract:INTRODUCTION:The right ventricle (RV) supports the systemic circulation in patients who have had an intraatrial repair of transposition of the great arteries or have congenitally corrected transposition. There is concern about the ability of a systemic RV to support the additional volume load of pregnancy, and previous...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Bowater SE,Selman TJ,Hudsmith LE,Clift PF,Thompson PJ,Thorne SA

    更新日期:2013-07-01 00:00:00

  • A different therapeutic strategy for severe tetralogy of Fallot with origin of the left pulmonary artery from the ascending aorta: stenting of the right ventricular outflow tract before complete repair.

    abstract::The origin of pulmonary artery branches (particularly the left pulmonary artery) from the ascending aorta is a rare condition. We detected prominent hypoplasia of the main and right pulmonary arteries in a 3.5-month-old 3.7 kg female infant who had tetralogy of Fallot with origin of the left pulmonary artery in the as...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Saritas T,Erdem A,Karaci AR,Demir F,Celebi A

    更新日期:2012-05-01 00:00:00

  • Echocardiographic and Surgical Correlation of Coronary Artery Patterns in Transposition of the Great Arteries.

    abstract:OBJECTIVE:Determine the accuracy of echocardiography to diagnose coronary anatomy in transposition of the great arteries and to evaluate the effect of accuracy on surgical outcomes and changes in accuracy over time. DESIGN:Retrospective chart review of neonates admitted February 1999 to March 2013 with transposition. ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Fundora MP,Aregullin EO,Wernovsky G,Welch EM,Muniz JC,Sasaki N,Hannan RL,Burke RP,Lopez L

    更新日期:2016-12-01 00:00:00

  • Decreased inappropriate shocks with new generation ICDs in children and patients with congenital heart disease.

    abstract:OBJECTIVE:Inappropriate implantable cardioverter defibrillator (ICD) shocks in children and patients with congenital heart disease (CHD) remain a major complication of device therapy, occurring in as many as 50% of children with ICDs. New generation devices include algorithms designed to minimize inappropriate shocks. ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Goldstein SA,LaPage MJ,Dechert BE,Serwer GA,Yu S,Lowery RE,Bradley DJ

    更新日期:2018-05-01 00:00:00

  • Overview of transcatheter patent ductus arteriosus closure in preterm infants.

    abstract::Clinically significant patent ductus arteriosus (PDA) has been associated with significant morbidity in extremely low birth weight (ELBW) infants. Current management of ELBW infants with hemodynamically significant PDA includes supportive treatment, pharmacological therapy, and surgical ligation. All of these therapeu...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审


    authors: Almeida-Jones M,Tang NY,Reddy A,Zahn E

    更新日期:2019-01-01 00:00:00

  • Platelet activation markers in children with congenital heart disease associated with pulmonary arterial hypertension.

    abstract:BACKGROUND:Mean platelet volume (MPV), platecrit, and platelet distribution width (PDW) are markers of platelet activation. Previous studies have found that platelet activation occurs in patients with pulmonary arterial hypertension. Platelet indices including MPV, PDW, and platecrit have not been studied in children w...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Mese T,Guven B,Yilmazer MM,Karadeniz C,Ozdemir R,Doksoz O

    更新日期:2018-07-01 00:00:00

  • Endovascular stenting for native coarctation of the aorta is an effective alternative to surgical intervention in older children.

    abstract:OBJECTIVE:Assess the early and intermediate results with respect to blood pressure control in older children undergoing endovascular stenting for native coarctation of the aorta. DESIGN:Eleven hypertensive patients (10 +/- 3 years of age) underwent endovascular stenting via standard techniques for native coarctation o...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Weber HS,Cyran SE

    更新日期:2008-01-01 00:00:00

  • Isolated left ventricular apical hypoplasia.

    abstract::Isolated left ventricular (LV) apical hypoplasia is a recently described congenital abnormality characterized by: (1) a truncated and spherical LV configuration with rightward bulging of the interventricular septum, (2) deficiency of the myocardium within the LV apex with adipose tissue infiltrating the apex, (3) orig...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Vanhecke TE,Decker J,Leonowicz N,Chinnaiyan KM

    更新日期:2011-11-01 00:00:00

  • Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young.

    abstract:INTRODUCTION:Perturbations in the CACNA1C-encoded L-type calcium channel α-subunit have been linked recently to heritable arrhythmia syndromes, including Timothy syndrome, Brugada syndrome, early repolarization syndrome, and long QT syndrome. These heritable arrhythmia syndromes may serve as a pathogenic basis for auto...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Sutphin BS,Boczek NJ,Barajas-Martínez H,Hu D,Ye D,Tester DJ,Antzelevitch C,Ackerman MJ

    更新日期:2016-12-01 00:00:00

  • Longitudinal Strain by Speckle Tracking Echocardiography in Pediatric Heart Transplant Recipients.

    abstract:INTRODUCTION:Heart transplant recipients are at risk for developing left ventricular (LV) dysfunction. While traditional echocardiographic parameters have limitations, speckle tracking echocardiography (STE) is a novel technique shown to be more sensitive and accurate in adult studies for evaluating ventricular systoli...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Buddhe S,Richmond ME,Gilbreth J,Lai WW

    更新日期:2015-07-01 00:00:00

  • The impact of obesity on early postoperative outcomes in adults with congenital heart disease.

    abstract:BACKGROUND:As the prevalence of obesity continues to increase, it now includes the growing number of patients with congenital heart disease (CHD). This particular obese patient population may pose additional intraoperative as well as postoperative challenges that may contribute to poor outcomes. Our aims were to determ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Zaidi AN,Bauer JA,Michalsky MP,Olshove V,Boettner B,Phillips A,Cook SC

    更新日期:2011-05-01 00:00:00

  • The Electrocardiogram Is a Poor Diagnostic Tool to Detect Left Ventricular Hypertrophy in Children: A Comparison with Echocardiographic Assessment of Left Ventricular Mass.

    abstract:OBJECTIVE:The electrocardiogram (ECG) is used to detect left ventricular hypertrophy (LVH) in children and young adults, and it is considered an important screening tool for the most common causes of sudden cardiac arrest in the United States. However, the reliability and accuracy of the ECG in the detection of LVH are...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Bratincsák A,Williams M,Kimata C,Perry JC

    更新日期:2015-07-01 00:00:00

  • Comparison of extracardiac conduit and lateral tunnel for functional single-ventricle patients: A meta-analysis.

    abstract:OBJECTIVE:This study aims to assess and compare the early and long-term effects of extracardiac conduit (EC) and lateral tunnel (LT) in patients with a functional single ventricle through meta-analysis. DESIGN:A systematic search was performed in PubMed, Embase, Cochrane Library, CNKI, VIP, CBM, and WanFang databases ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,meta分析,评审


    authors: Lin Z,Ge H,Xue J,Wu G,Du J,Hu X,Zhao Q

    更新日期:2017-12-01 00:00:00

  • Pulmonary vein stenosis with Down syndrome: a rare and frequently fatal cause of pulmonary hypertension in infants and children.

    abstract::Down syndrome (DS) patients are prone to pulmonary hypertension (PHTN) due to various cardiopulmonary causes. However, the association of DS with pulmonary vein stenosis (PVS) is not adequately described. We illustrate three cases from our center and an additional 13 cases from an extensive review of the literature of...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审


    authors: Gowda S,Bhat D,Feng Z,Chang CH,Ross RD

    更新日期:2014-05-01 00:00:00

  • Current Practice and Utility of Chromosome Microarray Analysis in Infants Undergoing Cardiac Surgery.

    abstract:OBJECTIVE:Traditionally, karyotype and fluorescence in situ hybridization (FISH) were used for cytogenetic testing of infants with congenital heart disease (CHD) who underwent cardiac surgery at our institution. Recently, chromosome microarray analysis (CMA) has been performed in lieu of the traditional tests. A standa...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Buckley JR,Kavarana MN,Chowdhury SM,Scheurer MA

    更新日期:2015-05-01 00:00:00

  • Needles in Hay II: Detecting Cardiac Pathology by the Pediatric Chest Pain Standardized Clinical Assessment and Management Plan.

    abstract:OBJECTIVES:To determine if patients evaluated using the pediatric chest pain standardized clinical assessment and management plan (SCAMP) in cardiology clinic were later diagnosed with unrecognized cardiac pathology, and to determine if other patients with cardiac pathology not enrolled in the SCAMP would have been ide...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Kane DA,Friedman KG,Fulton DR,Geggel RL,Saleeb SF

    更新日期:2016-09-01 00:00:00

  • Preoperative echocardiographic measures in interrupted aortic arch: Which ones best predict surgical approach and outcome?

    abstract:OBJECTIVE:It is unclear whether neonates with interrupted aortic arch (IAA) and a smaller left ventricular outflow tract may have improved outcomes with a Yasui operation (ventricular outflow bypass procedure) over a primary complete repair. This study sought to identify preoperative echocardiographic parameters to dif...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Abarbanell G,Border WL,Schlosser B,Morrow G,Kelleman M,Sachdeva R

    更新日期:2018-05-01 00:00:00

  • Correlates of posttraumatic stress disorder in adults with congenital heart disease.

    abstract:OBJECTIVE:The aims of this study were to compare the level of posttraumatic stress disorder between adults with and without congenital heart disease, and to examine the correlates of posttraumatic stress disorder (e.g., sociodemographics). DESIGN:Cross-sectional. SETTING:Two university-affiliated heart hospitals in T...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Eslami B

    更新日期:2017-05-01 00:00:00

  • Absent aortic valve associated with double outlet right ventricle and aortopulmonary window: physiologic implications of a rare malformation in both the fetus and neonate.

    abstract::Absence of the aortic valve is a rare congenital heart defect that is detectable in the prenatal period. In this condition, functional aortic valve leaflets are absent; in their place are rudimentary, immobile noncoapting plate-like structures at the level of the annulus resulting in severe aortic regurgitation. We re...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Sabati AA,Wong PC,Randolph L,Pruetz JD

    更新日期:2014-05-01 00:00:00

  • Protein-losing enteropathy after the Fontan operation: associations and predictors of clinical outcome.

    abstract:OBJECTIVE:We sought to define what clinical parameters were related to the ultimate outcome in Fontan patients who had developed protein-losing enteropathy (PLE). BACKGROUND:PLE is a serious complication of the Fontan operation. Several preoperative and perioperative findings are associated with later PLE. However, th...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Silvilairat S,Cabalka AK,Cetta F,Grogan M,Hagler DJ,O'Leary PW

    更新日期:2008-07-01 00:00:00

  • Spontaneous closure of a symptomatic coronary artery fistula just within a few days of newborn period.

    abstract::We present a rare case of spontaneous closure of a fistula between the left coronary artery and the right ventricle (RV) within a few days of newborn period. A 14-day-old male newborn was referred to our clinic for investigation of tachypnea and cardiac murmur. A color flow Doppler echocardiography revealed turbulent ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Yilmazer MM,Demir F,Yolbaş I,Bilici M

    更新日期:2014-01-01 00:00:00

  • Echocardiography and management of sick neonates in the intensive care unit.

    abstract::To evaluate the influence of echocardiographic examination in the clinical management of the sick neonate, 241 patients, admitted to the neonatal intensive care unit of a tertiary referral center that had echocardiograms with data available for review, were enrolled in a retrospective study. Asymptomatic murmurs (45%)...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Kadivar M,Kiani A,Kocharian A,Shabanian R,Nasehi L,Ghajarzadeh M

    更新日期:2008-09-01 00:00:00

  • Experiences and Outcomes of Transition from Pediatric to Adult Health Care Services for Young People with Congenital Heart Disease: A Systematic Review.

    abstract::This review synthesizes the empirical literature on outcomes and experiences of transfer and transition from pediatric to adult care for young people with congenital heart disease. A systematic review of papers published between January 2001 and May 2013 that examined outcomes or experiences of transfer and transition...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审


    authors: Heery E,Sheehan AM,While AE,Coyne I

    更新日期:2015-09-01 00:00:00

  • Quadricuspid aortic valve with sinus of Valsalva rupture.

    abstract::A 22-year-old female with no medical history presented to the emergency room with 2 weeks of rapidly worsening dyspnea on exertion, orthopnea, and cough. On cardiac auscultation, she was noted to have to-and-fro murmurs and a continuous murmur with signs of right heart failure. Echocardiographic images obtained showed...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审


    authors: Yang EH,Rawal M,Pillutla P,Criley JM

    更新日期:2011-03-01 00:00:00

  • Transcatheter aortic valve implantation in surgically repaired double outlet right ventricle.

    abstract::A 52-year-old male patient, with a medical history of surgically repaired double outlet right ventricle presented with severe aortic stenosis (AS) and hepatitis C with cirrhosis, presented with New York Heart Association Class IV heart failure. During evaluation for a liver transplant, he was deemed a poor surgical ca...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审


    authors: Keswani A,Verma A,Dann K,Ventura L,Lucas V,Shah S,Ramee S

    更新日期:2014-09-01 00:00:00

  • Repair and follow-up of Tetralogy of Fallot with pulmonary stenosis.

    abstract::Tetralogy of Fallot is the most common cyanotic congenital heart defect. Advances in surgical technique and postoperative care have improved survival which is now very good. Patients now face long-term morbidities such as reduced exercise tolerance and arrthymias. Cardiologists caring for these patients are confronted...

    journal_title:Congenital heart disease

    pub_type: 杂志文章,评审


    authors: Hill G

    更新日期:2013-03-01 00:00:00

  • Acute and long-term effects of endovascular debanding of pulmonary arteries in a swine model.

    abstract:OBJECTIVES:The primary objective of this study was to demonstrate that pulmonary artery (PA) debanding via cardiac catheterization using balloon angioplasty is feasible and safe in swine. The secondary objectives were to determine the acute and long-term effects of this therapy. DESIGN:This is a chronic survival exper...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Perez M,Kumar TS,Hoskoppal D,Akkhawattanangkul Y,Allen K,Knott-Craig CJ,Waller BR,Sathanandam S

    更新日期:2017-05-01 00:00:00

  • Congenital left ventricular splint in an adult patient with unrepaired anomalous left coronary artery from the pulmonary artery.

    abstract::A 24-year-old woman presented with a recent increase in dyspnea on exertion and development of presyncope. The patient stated that she has reproducible episodes of dizziness and near fainting when she climbs a flight of stairs and activity is limited to a slow gait. ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Sabbath AM,Trivedi K,Klewer SE,Sorrell VL

    更新日期:2007-07-01 00:00:00

  • Determinants of right ventricular outflow tract conduit longevity: a multinational analysis.

    abstract:OBJECTIVE:The need for conduit replacement in the growing child remains a major problem after right ventricular outflow tract reconstruction. We compared two diverse surgical centers with considerable practice variation in Europe and the United States to identify modifiable risk factors that can increase conduit longev...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Niemantsverdriet MB,Ottenkamp J,Gauvreau K,Del Nido PJ,Hazenkamp MG,Jenkins KJ

    更新日期:2008-05-01 00:00:00

  • Device closure of a secundum atrial septal defect in a 4-month-old infant with a marginal left ventricle following coarctation repair.

    abstract::A male infant presented at birth with severe coarctation of the aorta and marginal left ventricular and mitral valve dimensions associated with a large secundum atrial septal defect. Following successful arch repair, the left ventricle remained small with preferential left-to-right atrial shunting and a dilated right ...

    journal_title:Congenital heart disease

    pub_type: 杂志文章


    authors: Jean-St-Michel E,Hosking MC,Potts JE,Sandor GG

    更新日期:2007-11-01 00:00:00