Evaluation of drug resistance mutations in patients with chronic hepatitis B.

Abstract:

:Mutations occurring in viral polymerase gene of hepatitis B virus (HBV) due to the use of nucleos(t)id analogs reduce the activity of the drugs by causing antiviral resistance. In this study, it was aimed to evaluate mutations responsible for drug resistance and drug resistance mutation rates in patients followed up by the diagnosis of chronic hepatitis B (CHB). A total of 318 CHB patients were included in the study. HBV mutations were detected using the INNO-LiPA commercial kit based on the reverse hybridization principle. Drug resistance mutation was detected in 46.86% (149/318) of the patients. The rates of drug resistance were found 36.79% (117/318) for lamivudine resistance, 12.58% (40/318) for entecavir (ETV), and 7.86% (25/318) for adefovir. In 10 patients, the possible tenofovir (TDF) resistance (3.14%) was found. Single-drug and double-drug resistances were detected in 34.59% and in 11.01% of the patients, respectively. Triple drug resistance was detected in only 1.26% of the patients. Unlike various studies in Turkey and in other countries, remarkable resistance to ETV and TDF were found in this study. The high rate of the probable TDF resistance was striking, with 3.14%.

journal_title

Folia microbiologica

authors

Alacam S,Karabulut N,Yolcu A,Onel M,Atasoy A,Kaymakoglu S,Agacfidan A

doi

10.1007/s12223-018-0650-z

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

237-243

issue

2

eissn

0015-5632

issn

1874-9356

pii

10.1007/s12223-018-0650-z

journal_volume

64

pub_type

杂志文章
  • An insight into the distribution, genetic diversity, and mycotoxin production of Aspergillus section Flavi in soils of pistachio orchards.

    abstract::In the present study, 193 Aspergillus strains were isolated from a total of 100 soil samples of pistachio orchards, which all of them were identified as Aspergillus flavus as the most abundant species of Aspergillus section Flavi existing in the environment. Approximately 59%, 81%, and 61% of the isolates were capable...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-011-0090-5

    authors: Jamali M,Ebrahimi MA,Karimipour M,Shams-Ghahfarokhi M,Dinparast-Djadid N,Kalantari S,Pilehvar-Soltanahmadi Y,Amani A,Razzaghi-Abyaneh M

    更新日期:2012-01-01 00:00:00

  • Short-term stability of Borrelia garinii in cerebrospinal fluid.

    abstract::The aim of our study was to find out the optimal conditions for short-term storage of cerebrospinal fluid (CSF) samples for direct diagnosis of Lyme disease. A mixture of Borrelia-negative CSFs spiked with a defined amount of cultured Borrelia garinii was used. Borrelia stability was investigated over 7 days at four d...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-015-0408-9

    authors: Berenová D,Krsek D,Šípková L,Lukavská A,Malý M,Kurzová Z,Hořejší J,Kodym P

    更新日期:2016-01-01 00:00:00

  • Bone grafts as vancomycin carriers in local therapy of resistant infections.

    abstract::The level of an antibiotic capable of inhibiting the etiological agent at the site of infection is an essential prerequisite for successful antibiotic therapy. In some cases, locally applied antibiotics may compensate for limitations of systemic administration and shorten systemic therapy. We aimed at verifying to wha...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-011-0093-2

    authors: Melicherčík P,Jahoda D,Nyč O,Klapková E,Barták V,Landor I,Pokorný D,Judl T,Sosna A

    更新日期:2012-09-01 00:00:00

  • Different gut microbiome composition in obese Guizhou minipigs between female and castrated male.

    abstract::Gut microbiome lives in the intestinal tract of animals and plays an important role in almost all life processes. Gut microbiome balance is beneficial to health, and imbalance leads to many diseases, one of which is obesity epidemic. However, gut microbiome is also influenced by host hormone, and different gut microbi...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-019-00704-4

    authors: Yao G,Wu S,Zeng X,Zhao H,Wang G,Chen M,Qian N

    更新日期:2019-11-01 00:00:00

  • Rapid G+ count and subpopulation assessment of the intestinal bacteria in Apodemus sylvaticus and Mus musculus by flow cytometry.

    abstract::We report a novel application of calcein-acetomethyl ester in flow cytometry for rapid estimation of the number of G+-bacteria in rodent feces (Apodemus sylvaticus and Mus sp.f. muridae). We also use the combined application of flow cytometry and Syto-13 or Sypro Orange staining to count rapidly the total bacterial po...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02931538

    authors: Moragues M,Comas-Riu J,Vives-Rego J

    更新日期:2004-01-01 00:00:00

  • Plasmid profiles of bacteriocin-producing Lactobacillus isolates from African fermented foods.

    abstract::Fourteen of 200 Lactobacillus isolates from African fermented foods, viz. 'wara', 'kenkey', 'ugba', 'ogi', 'kunuzarki', 'fufu' and 'iru' were found to produce bacteriocins against L. plantarum and only three bacteriocinogenic isolates inhibited some of the food pathogens. Plasmid analysis of the 14 bacteriocin-produci...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02814645

    authors: Olasupo NA,Olukoya DK,Odunfa SA

    更新日期:1994-01-01 00:00:00

  • Regulation of inorganic pyrophosphatase in Escherichia coli: relationship between the synthesis of inorganic pyrophosphatase and the thymidine triphosphate pool.

    abstract::The activities of inorganic pyrophosphatase, thymidine kinase and thymidine phosphorylase were measured in Ter-mutants of E. coli K12 which have a higher or a lower dTTP pool than the parent strain. The levels of inorganic pyrophosphatase and thymidine kinase were changed in the same direction and that of thymidine ph...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02884076

    authors: Kukko E,Sundell L

    更新日期:1983-01-01 00:00:00

  • Some safety aspects of enterococci isolated from Slovak lactic acid dairy product "žinčica".

    abstract::In Slovakia, dairy products made from ewes' milk have a long tradition. These products include the lactic acid product called "žinčica" which is a by-product occurring during the preparation of ewes' lump cheese. There is no information in the literature regarding the special properties of the microbiota, especially l...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-019-00703-5

    authors: Lauková A,Kandričáková A,Bino E,Tomáška M,Kološta M,Kmeť V,Strompfová V

    更新日期:2020-02-01 00:00:00

  • Analysis of genetic variations of heat shock proteins Hsp70 and Hsp90 in Isaria farinosa strains from the Yunnan province of China.

    abstract::In the present study, the cDNA sequences of Hsp70 and Hsp90 genes of Isaria farinosa (designated IFHSP70 and IFHSP90) were cloned and characterized using multiple techniques of molecular biology and bioinformatics. The genetic differentiation of the two genes was investigated among 10 geographically separated populati...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-018-00676-x

    authors: He L,Yu H,Dai Y,Wang Y

    更新日期:2019-07-01 00:00:00

  • Cutaneous candidosis in immunosuppressed patients.

    abstract::One-hundred patients with candidosis of the skin, mucous membranes and nail plates (confirmed by cultivation) were examined. Topical or systemic antimycotic treatment was successful in 58 patients. After a complete evaluation, 42 patients were found to suffer from factors supporting candidosis--diabetes mellitus (12),...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02815627

    authors: Jautová J,Baloghová J,Dorko E,Pilipcinec E,Svický E,Danko J,Tkáciková L

    更新日期:2001-01-01 00:00:00

  • Biological function of DNA methylation.

    abstract::Structural and functional properties of prokaryotic DNA methyltransferases are summarized. The different aspects of the role of DNA methylation which influences DNA-protein interaction in restriction and modification of DNA and in mismatch repair, DNA replication and gene expression are discussed. ...

    journal_title:Folia microbiologica

    pub_type: 杂志文章,评审

    doi:10.1007/BF02815658

    authors: Hubácek J

    更新日期:1992-01-01 00:00:00

  • Nitrate reductase whole-cell assay: side effects associated with the use of benzyl viologen.

    abstract::A comparative examination of reduced methyl [MV·](+) and benzyl [BV·](+) viologens (as artificial electron donors for quantitative estimation of the respiratory periplasmic (Nap) and membrane-embedded (Nar) nitrate reductases) using a newly constructed nap mutant strain of Paracocccus denitrificans was done. The activ...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-011-0004-6

    authors: Illichmanová A,Janů M,Sedláček V,Kučera I

    更新日期:2011-01-01 00:00:00

  • Expression of alkaline proteinase gene in two recombinant Bacillus cereus feather-degrading strains.

    abstract::Two Bacillus cereus feather-degrading strains (23/1 and 6/2) were transformed using a recombinant plasmid p5.2 carrying the alkaline proteinase gene (aprE). A high level of the aprE gene expression was observed when the recombinant strains were grown on sporulation medium. The expression of the aprE gene proceeded dur...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-010-0004-y

    authors: Ouled-Haddar H,Zaghloul TI,Saeed HM

    更新日期:2010-01-01 00:00:00

  • Comparison of light and dark nitrogenase activity in selected soil cyanobacteria.

    abstract::Frequency of heterocytes and nitrogenase activity (NA) under light and dark cultivation conditions was determined in 12 cyanobacterial strains isolated from various soil habitats. In spite of a high variability, significant differences in NA among the strains were found in response of light and dark cultivation. Relat...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02931606

    authors: Hrouzek P,Lukesová A,Simek M

    更新日期:2004-01-01 00:00:00

  • The impact of zinc and lead concentrations and seasonal variation on bacterial and actinobacterial community structure in a metallophytic grassland soil.

    abstract::The diversity and structure of bacterial and actinobacteral diversity and communities were determined in a metallophytic grassland soil from an upland site in northern England. The community profiles were subjected to multivariate analyses using correspondence and cluster analyses. The total bacterial community divers...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-009-0042-5

    authors: Bamborough L,Cummings SP

    更新日期:2009-01-01 00:00:00

  • Correction to: Diversity of culturable bacterial communities in the intestinal tracts of goldfish (Carassius auratus) and their ability to produce N-acyl homoserine lactone.

    abstract::In the original publication, the number of the NCTC strain used was published incorrectly. The authors apologize for the error. The error has no effect on the validity of the results and is corrected for accuracy. ...

    journal_title:Folia microbiologica

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s12223-017-0558-z

    authors: Sugita H,Kitao S,Narisawa S,Minamishima R,Itoi S

    更新日期:2018-01-01 00:00:00

  • Arsenic-resistant Pseudomonas spp. and Bacillus sp. bacterial strains reducing As(V) to As(III), isolated from Alps soils, Italy.

    abstract::Five arsenic-resistant bacterial strains (designated MP1400, MP1400a, MP1400d, APSLA3, and BPSLA3) were isolated from soils collected at the Alps region (Italy), which showed no contamination by arsenic. Phylogenetic analysis of the 16S rRNA gene sequences assigned them to the genera Pseudomonas and Bacillus. Bacillus...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-011-0010-8

    authors: Pepi M,Protano G,Ruta M,Nicolardi V,Bernardini E,Focardi SE,Gaggi C

    更新日期:2011-01-01 00:00:00

  • alpha-Mannosidases of genera Aspergillus and Rhizopus. Activity and capacity to utilize Saccharomyces cerevisiae mannan of the best alpha-mannosidase producer Aspergillus flavus Link 69.

    abstract::Strains of fungi imperfecti of genera Aspergillus and Rhizopus were tested for the ability to produce alpha-mannosidases. The most suitable alpha-mannosidase producer of a total of 20 strains under study was Aspergillus Ravus Link 69. The parameters studied during the cultivation included the growth rate expressed as ...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02876433

    authors: Augustín J,Sikl D

    更新日期:1978-01-01 00:00:00

  • Extrusion of metabolites from baker's yeast during glucose-induced acidification.

    abstract::Extrusion of metabolites (glycerol, lactic, malic, and succinic acid) during the medium acidification caused by resting baker's yeast supplied with 200 mM glucose was studied under aerobic and anaerobic conditions and in the absence and presence of 14 mM KCl. The maximum levels of glycerol and of the sum of acids (abo...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02876611

    authors: Sigler K,Knotková A,Páca J,Wurst M

    更新日期:1980-01-01 00:00:00

  • Influence of a single gamma-irradiation on rat microflora.

    abstract::Changes in leukocyte counts and in the gut microflora of laboratory rats irradiated with single whole-body dose of gamma rays (5.0 Gy) were determined. The number of leukocytes was lower especially 1 and 2 weeks after irradiation. A significant decrease in lymphocytes was observed 1 week and in monocytes 1 and 2 weeks...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02818710

    authors: Benová K,Falis M,Toropila M,Sehnalková H,Pastvová L

    更新日期:2002-01-01 00:00:00

  • Effect of dithiocarbamates on citric acid production by Aspergillus niger.

    abstract::Dithiocarbamates were found to enhance the production of citric acid under solid-state fermentation conditions by Aspergillus niger. Maximum increase was observed with tetramethylthiuram disulfide (TMTD). Percent increases observed were 74.2% with 2.5 micrograms/mL of TMTD, 19.6% with 2.5 micrograms/mL of sodium dimet...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02926953

    authors: Khanna V,Gupta KG

    更新日期:1986-01-01 00:00:00

  • Isolation and identification of siderophores produced by cyanobacteria.

    abstract::Cyanobacteria are one of the most successful and oldest forms of life that are present on Earth. They are prokaryotic photoautotrophic microorganisms that colonize so diverse environments as soil, seawater, and freshwater, but also stones, plants, or extreme habitats such as snow and ice as well as hot springs. This d...

    journal_title:Folia microbiologica

    pub_type: 杂志文章,评审

    doi:10.1007/s12223-018-0626-z

    authors: Řezanka T,Palyzová A,Sigler K

    更新日期:2018-09-01 00:00:00

  • Rhizosphere microflora and colonization of wheat roots by Gaeumannomyces graminis var. tritici after foliar application of urea and benomyl.

    abstract::The effect of foliar application of 2% urea and 0.6% benomyl on changes in colonization of the rhizosphere by microorganisms and of roots by the fungus Gaeumannomyces graminis (Sacc.) Arx et Olivier var. tritici Walker was followed in vegetation glass-house experiments. Treatment with a urea solution resulted in incre...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02897213

    authors: Vraný J,Stanĕk M,Vancura V

    更新日期:1980-01-01 00:00:00

  • Candida albicans culture from a rectal swab can be associated with newly diagnosed colorectal cancer.

    abstract::Plenty of metagenomic studies have suggested possible associations between microbiome composition and colorectal cancer (CRC). However, these techniques are not economic enough for routine use so far. Therefore, we explored the possibility to detect species associated with colorectal cancer by conventional culture fro...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/s12223-020-00807-3

    authors: Starý L,Mezerová K,Vysloužil K,Zbořil P,Skalický P,Stašek M,Raclavský V

    更新日期:2020-12-01 00:00:00

  • Interactive effects of propionic acid and temperature on growth and ochratoxin a production by Penicillium aurantiogriseum.

    abstract::Propionate at concentrations up to 0.05% decreased at 25 degrees C the growth and sporulation of Penicillium aurantiogriseum. The standard size of conidiogenous structures (metulae, phialids) and conidia was diminished. The effect was more pronounced at a higher temperature (30 degrees C). Inhibition of ochratoxin pro...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02814202

    authors: Skrinjar M,Danev M,Dimić G

    更新日期:1995-01-01 00:00:00

  • Primary biodegradation of amine oxide and quaternary ammonium amphiphiles.

    abstract::Biodegradation of two amphiphilic "soft" antimicrobially active derivatives of lauric (dodecanoic) acid, a quaternary ammonium salt and an amine oxide bearing an amide or ester group, was followed using microorganisms from activated sludge. Primary biodegradation was determined by ion-selective electrodes, total biode...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02814548

    authors: Cupková V,Sirotková L,Mlynarcík D,Devínsky F,Lacko I,Kovacková Z

    更新日期:1993-01-01 00:00:00

  • Formation of extracellular neutral proteinase and the stringent response in Bacillus subtilis.

    abstract::The kinetics of extracellular neutral proteinase synthesis by an isogenic stringent (IS58) and a relaxed (IS56) strain of B. subtilis were compared. The specific enzyme formation rate by the stringent strain was higher than that of the relaxed one. Norvaline addition (1 mg/mL) induced the formation of pppGpp and ppGpp...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02883234

    authors: Riedel K,Schroeter A,Liebs P,Graba JP,Hecker M,Schrapel D

    更新日期:1987-01-01 00:00:00

  • Biological properties of acmycin, a new polyene antibiotic.

    abstract::Acmycin, a new polyene antibiotic, was fungistatic at low and fungicidal at high concentrations. It produced malformations in conidia of Helminthosporium oryzae and Curvularia lunata and caused leakage of yeast cells. Acmycin was fairly nontoxic to germinating seeds. The intravenous LD50 was 300-400 and intraperitonea...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02879559

    authors: Chakrabarti S,Chandra AL

    更新日期:1983-01-01 00:00:00

  • Ecological and physiological characterization shows that Fibrobacter succinogenes is important in rumen fiber digestion - review.

    abstract::Fibrobacter succinogenes is a major cellulolytic species in the rumen. On the basis of molecular data, this species can be classified into four phylogenetic groups. Recently gathered ecological and physiological data have revealed the importance of this species, particularly phylogenetic group 1, in rumen fiber digest...

    journal_title:Folia microbiologica

    pub_type: 杂志文章,评审

    doi:10.1007/s12223-008-0024-z

    authors: Kobayashi Y,Shinkai T,Koike S

    更新日期:2008-01-01 00:00:00

  • Purification and characterization of xylanases from Aspergillus giganteus.

    abstract::A strain of Aspergillus giganteus cultivated in a medium with xylan produced two xylanases (xylanase I and II) which were purified to homogeneity. Their molar mass, estimated by SDS-PAGE, were 21 and 24 kDa, respectively. Both enzymes are glycoproteins with 50 degrees C temperature optimum; optimum pH was 6.0-6.5 for ...

    journal_title:Folia microbiologica

    pub_type: 杂志文章

    doi:10.1007/BF02931639

    authors: Fialho MB,Carmona EC

    更新日期:2004-01-01 00:00:00