Abstract:
:Mutations occurring in viral polymerase gene of hepatitis B virus (HBV) due to the use of nucleos(t)id analogs reduce the activity of the drugs by causing antiviral resistance. In this study, it was aimed to evaluate mutations responsible for drug resistance and drug resistance mutation rates in patients followed up by the diagnosis of chronic hepatitis B (CHB). A total of 318 CHB patients were included in the study. HBV mutations were detected using the INNO-LiPA commercial kit based on the reverse hybridization principle. Drug resistance mutation was detected in 46.86% (149/318) of the patients. The rates of drug resistance were found 36.79% (117/318) for lamivudine resistance, 12.58% (40/318) for entecavir (ETV), and 7.86% (25/318) for adefovir. In 10 patients, the possible tenofovir (TDF) resistance (3.14%) was found. Single-drug and double-drug resistances were detected in 34.59% and in 11.01% of the patients, respectively. Triple drug resistance was detected in only 1.26% of the patients. Unlike various studies in Turkey and in other countries, remarkable resistance to ETV and TDF were found in this study. The high rate of the probable TDF resistance was striking, with 3.14%.
journal_name
Folia Microbiol (Praha)journal_title
Folia microbiologicaauthors
Alacam S,Karabulut N,Yolcu A,Onel M,Atasoy A,Kaymakoglu S,Agacfidan Adoi
10.1007/s12223-018-0650-zsubject
Has Abstractpub_date
2019-03-01 00:00:00pages
237-243issue
2eissn
0015-5632issn
1874-9356pii
10.1007/s12223-018-0650-zjournal_volume
64pub_type
杂志文章abstract::In the present study, 193 Aspergillus strains were isolated from a total of 100 soil samples of pistachio orchards, which all of them were identified as Aspergillus flavus as the most abundant species of Aspergillus section Flavi existing in the environment. Approximately 59%, 81%, and 61% of the isolates were capable...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-011-0090-5
更新日期:2012-01-01 00:00:00
abstract::The aim of our study was to find out the optimal conditions for short-term storage of cerebrospinal fluid (CSF) samples for direct diagnosis of Lyme disease. A mixture of Borrelia-negative CSFs spiked with a defined amount of cultured Borrelia garinii was used. Borrelia stability was investigated over 7 days at four d...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-015-0408-9
更新日期:2016-01-01 00:00:00
abstract::The level of an antibiotic capable of inhibiting the etiological agent at the site of infection is an essential prerequisite for successful antibiotic therapy. In some cases, locally applied antibiotics may compensate for limitations of systemic administration and shorten systemic therapy. We aimed at verifying to wha...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-011-0093-2
更新日期:2012-09-01 00:00:00
abstract::Gut microbiome lives in the intestinal tract of animals and plays an important role in almost all life processes. Gut microbiome balance is beneficial to health, and imbalance leads to many diseases, one of which is obesity epidemic. However, gut microbiome is also influenced by host hormone, and different gut microbi...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-019-00704-4
更新日期:2019-11-01 00:00:00
abstract::We report a novel application of calcein-acetomethyl ester in flow cytometry for rapid estimation of the number of G+-bacteria in rodent feces (Apodemus sylvaticus and Mus sp.f. muridae). We also use the combined application of flow cytometry and Syto-13 or Sypro Orange staining to count rapidly the total bacterial po...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02931538
更新日期:2004-01-01 00:00:00
abstract::Fourteen of 200 Lactobacillus isolates from African fermented foods, viz. 'wara', 'kenkey', 'ugba', 'ogi', 'kunuzarki', 'fufu' and 'iru' were found to produce bacteriocins against L. plantarum and only three bacteriocinogenic isolates inhibited some of the food pathogens. Plasmid analysis of the 14 bacteriocin-produci...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02814645
更新日期:1994-01-01 00:00:00
abstract::The activities of inorganic pyrophosphatase, thymidine kinase and thymidine phosphorylase were measured in Ter-mutants of E. coli K12 which have a higher or a lower dTTP pool than the parent strain. The levels of inorganic pyrophosphatase and thymidine kinase were changed in the same direction and that of thymidine ph...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02884076
更新日期:1983-01-01 00:00:00
abstract::In Slovakia, dairy products made from ewes' milk have a long tradition. These products include the lactic acid product called "žinčica" which is a by-product occurring during the preparation of ewes' lump cheese. There is no information in the literature regarding the special properties of the microbiota, especially l...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-019-00703-5
更新日期:2020-02-01 00:00:00
abstract::In the present study, the cDNA sequences of Hsp70 and Hsp90 genes of Isaria farinosa (designated IFHSP70 and IFHSP90) were cloned and characterized using multiple techniques of molecular biology and bioinformatics. The genetic differentiation of the two genes was investigated among 10 geographically separated populati...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-018-00676-x
更新日期:2019-07-01 00:00:00
abstract::One-hundred patients with candidosis of the skin, mucous membranes and nail plates (confirmed by cultivation) were examined. Topical or systemic antimycotic treatment was successful in 58 patients. After a complete evaluation, 42 patients were found to suffer from factors supporting candidosis--diabetes mellitus (12),...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02815627
更新日期:2001-01-01 00:00:00
abstract::Structural and functional properties of prokaryotic DNA methyltransferases are summarized. The different aspects of the role of DNA methylation which influences DNA-protein interaction in restriction and modification of DNA and in mismatch repair, DNA replication and gene expression are discussed. ...
journal_title:Folia microbiologica
pub_type: 杂志文章,评审
doi:10.1007/BF02815658
更新日期:1992-01-01 00:00:00
abstract::A comparative examination of reduced methyl [MV·](+) and benzyl [BV·](+) viologens (as artificial electron donors for quantitative estimation of the respiratory periplasmic (Nap) and membrane-embedded (Nar) nitrate reductases) using a newly constructed nap mutant strain of Paracocccus denitrificans was done. The activ...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-011-0004-6
更新日期:2011-01-01 00:00:00
abstract::Two Bacillus cereus feather-degrading strains (23/1 and 6/2) were transformed using a recombinant plasmid p5.2 carrying the alkaline proteinase gene (aprE). A high level of the aprE gene expression was observed when the recombinant strains were grown on sporulation medium. The expression of the aprE gene proceeded dur...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-010-0004-y
更新日期:2010-01-01 00:00:00
abstract::Frequency of heterocytes and nitrogenase activity (NA) under light and dark cultivation conditions was determined in 12 cyanobacterial strains isolated from various soil habitats. In spite of a high variability, significant differences in NA among the strains were found in response of light and dark cultivation. Relat...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02931606
更新日期:2004-01-01 00:00:00
abstract::The diversity and structure of bacterial and actinobacteral diversity and communities were determined in a metallophytic grassland soil from an upland site in northern England. The community profiles were subjected to multivariate analyses using correspondence and cluster analyses. The total bacterial community divers...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-009-0042-5
更新日期:2009-01-01 00:00:00
abstract::In the original publication, the number of the NCTC strain used was published incorrectly. The authors apologize for the error. The error has no effect on the validity of the results and is corrected for accuracy. ...
journal_title:Folia microbiologica
pub_type: 杂志文章,已发布勘误
doi:10.1007/s12223-017-0558-z
更新日期:2018-01-01 00:00:00
abstract::Five arsenic-resistant bacterial strains (designated MP1400, MP1400a, MP1400d, APSLA3, and BPSLA3) were isolated from soils collected at the Alps region (Italy), which showed no contamination by arsenic. Phylogenetic analysis of the 16S rRNA gene sequences assigned them to the genera Pseudomonas and Bacillus. Bacillus...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-011-0010-8
更新日期:2011-01-01 00:00:00
abstract::Strains of fungi imperfecti of genera Aspergillus and Rhizopus were tested for the ability to produce alpha-mannosidases. The most suitable alpha-mannosidase producer of a total of 20 strains under study was Aspergillus Ravus Link 69. The parameters studied during the cultivation included the growth rate expressed as ...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02876433
更新日期:1978-01-01 00:00:00
abstract::Extrusion of metabolites (glycerol, lactic, malic, and succinic acid) during the medium acidification caused by resting baker's yeast supplied with 200 mM glucose was studied under aerobic and anaerobic conditions and in the absence and presence of 14 mM KCl. The maximum levels of glycerol and of the sum of acids (abo...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02876611
更新日期:1980-01-01 00:00:00
abstract::Changes in leukocyte counts and in the gut microflora of laboratory rats irradiated with single whole-body dose of gamma rays (5.0 Gy) were determined. The number of leukocytes was lower especially 1 and 2 weeks after irradiation. A significant decrease in lymphocytes was observed 1 week and in monocytes 1 and 2 weeks...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02818710
更新日期:2002-01-01 00:00:00
abstract::Dithiocarbamates were found to enhance the production of citric acid under solid-state fermentation conditions by Aspergillus niger. Maximum increase was observed with tetramethylthiuram disulfide (TMTD). Percent increases observed were 74.2% with 2.5 micrograms/mL of TMTD, 19.6% with 2.5 micrograms/mL of sodium dimet...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02926953
更新日期:1986-01-01 00:00:00
abstract::Cyanobacteria are one of the most successful and oldest forms of life that are present on Earth. They are prokaryotic photoautotrophic microorganisms that colonize so diverse environments as soil, seawater, and freshwater, but also stones, plants, or extreme habitats such as snow and ice as well as hot springs. This d...
journal_title:Folia microbiologica
pub_type: 杂志文章,评审
doi:10.1007/s12223-018-0626-z
更新日期:2018-09-01 00:00:00
abstract::The effect of foliar application of 2% urea and 0.6% benomyl on changes in colonization of the rhizosphere by microorganisms and of roots by the fungus Gaeumannomyces graminis (Sacc.) Arx et Olivier var. tritici Walker was followed in vegetation glass-house experiments. Treatment with a urea solution resulted in incre...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02897213
更新日期:1980-01-01 00:00:00
abstract::Plenty of metagenomic studies have suggested possible associations between microbiome composition and colorectal cancer (CRC). However, these techniques are not economic enough for routine use so far. Therefore, we explored the possibility to detect species associated with colorectal cancer by conventional culture fro...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/s12223-020-00807-3
更新日期:2020-12-01 00:00:00
abstract::Propionate at concentrations up to 0.05% decreased at 25 degrees C the growth and sporulation of Penicillium aurantiogriseum. The standard size of conidiogenous structures (metulae, phialids) and conidia was diminished. The effect was more pronounced at a higher temperature (30 degrees C). Inhibition of ochratoxin pro...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02814202
更新日期:1995-01-01 00:00:00
abstract::Biodegradation of two amphiphilic "soft" antimicrobially active derivatives of lauric (dodecanoic) acid, a quaternary ammonium salt and an amine oxide bearing an amide or ester group, was followed using microorganisms from activated sludge. Primary biodegradation was determined by ion-selective electrodes, total biode...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02814548
更新日期:1993-01-01 00:00:00
abstract::The kinetics of extracellular neutral proteinase synthesis by an isogenic stringent (IS58) and a relaxed (IS56) strain of B. subtilis were compared. The specific enzyme formation rate by the stringent strain was higher than that of the relaxed one. Norvaline addition (1 mg/mL) induced the formation of pppGpp and ppGpp...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02883234
更新日期:1987-01-01 00:00:00
abstract::Acmycin, a new polyene antibiotic, was fungistatic at low and fungicidal at high concentrations. It produced malformations in conidia of Helminthosporium oryzae and Curvularia lunata and caused leakage of yeast cells. Acmycin was fairly nontoxic to germinating seeds. The intravenous LD50 was 300-400 and intraperitonea...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02879559
更新日期:1983-01-01 00:00:00
abstract::Fibrobacter succinogenes is a major cellulolytic species in the rumen. On the basis of molecular data, this species can be classified into four phylogenetic groups. Recently gathered ecological and physiological data have revealed the importance of this species, particularly phylogenetic group 1, in rumen fiber digest...
journal_title:Folia microbiologica
pub_type: 杂志文章,评审
doi:10.1007/s12223-008-0024-z
更新日期:2008-01-01 00:00:00
abstract::A strain of Aspergillus giganteus cultivated in a medium with xylan produced two xylanases (xylanase I and II) which were purified to homogeneity. Their molar mass, estimated by SDS-PAGE, were 21 and 24 kDa, respectively. Both enzymes are glycoproteins with 50 degrees C temperature optimum; optimum pH was 6.0-6.5 for ...
journal_title:Folia microbiologica
pub_type: 杂志文章
doi:10.1007/BF02931639
更新日期:2004-01-01 00:00:00