Oxidative status of cardinal ligament in pelvic organ prolapse.

abstract：:E-cadherin is a key cell adhesion molecule implicated in tumor suppression that is frequently altered in hepatocellular carcinoma (HCC), particularly in hepatitis B virus-related tumors. Here, we report that the epigenetic drugs 5-azacytidine and trichostatin A up-regulated E-cadherin expression in HCC cells. The depl...

journal_title：Experimental and therapeutic medicine

authors： Qiu X,Qiao F,Su X,Zhao Z,Fan H

更新日期：2010-05-01 00:00:00

abstract：:The aim of this study was to characterize the clinical and genetic features of a 4-year-old female with merosin-deficient congenital muscular dystrophy type 1A (MDC1A). MDC1A is the most common form of congenital muscular dystrophy. MDC1A is caused by mutation of the laminin α-2 gene (LAMA2), localized to chromosome 6...

journal_title：Experimental and therapeutic medicine

authors： He Z,Luo X,Liang L,Li P,Li D,Zhe M

更新日期：2013-11-01 00:00:00

abstract：:Schwann cell proliferation and differentiation is critical for the remyelination of injured peripheral nerves. Ferulic acid (FA) is a widely used antioxidant agent with neuroprotective properties. However, the potentially beneficial effects of FA on Schwann cells are unknown. Therefore, the present study was designed ...

journal_title：Experimental and therapeutic medicine

authors： Zhu X,Li K,Guo X,Wang J,Xiang Y

更新日期：2016-09-01 00:00:00

abstract：:It is understood that mechanical loading may affect tendon properties. However, how different mechanical loading conditions may affect tendons remains unknown. The present study aimed to investigate the effect of treadmill running at various intensities on rat Achilles tendon. A total of 18 male Wistar rats were rando...

journal_title：Experimental and therapeutic medicine

authors： Xu SY,He YB,Deng SY,Liu SY,Xu L,Ni GX

更新日期：2018-06-01 00:00:00

abstract：:Sustained-release (SR) formulations of metoprolol succinate (MS) may minimize fluctuations in plasma concentration and decrease the resulting adverse events. The aim of the present study was to optimize the loading capacity of microcapsules and the SR of MS. A uniform design method was applied to optimize the formulat...

journal_title：Experimental and therapeutic medicine

authors： Song L,He S,Ping Q

更新日期：2017-05-01 00:00:00

abstract：:Thalidomide (THD) exhibits antitumor effects in several types of cancer. However, the failure of THD to inhibit tumor growth has also been observed in a number of murine models in vivo. The mechanism involved in the therapeutic failure of THD remains unclear. The present study demonstrated that, accompanied by growth-...

journal_title：Experimental and therapeutic medicine

authors： Liu Q,Yin T,Wang G,Guo F,Ou Y,Li Y,Wang Y

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to assess miR-625 and Fas expression in normal and degenerative cervical cartilage endplate (CEP) tissues. Following biof-informatics analysis, the Fas gene was predicted to be one of the targets of miR-625. Quantitative PCR (qPCR) and western blotting were used to detect miR-625 and F...

journal_title：Experimental and therapeutic medicine

authors： Zhan B,Zhan Y,Wang W,Zhan Y,Liu B

更新日期：2018-01-01 00:00:00

abstract：:The abnormal expression of miRNAs (miRs) has previously been reported in respiratory syncytial virus (RSV) disease. However, to the best of our knowledge, the expression of miR-140-5p in patients with an RSV infection has never been explored. Reverse transcription-quantitative polymerase chain reaction was performed t...

journal_title：Experimental and therapeutic medicine

authors： Zhang Y,Shao L

更新日期：2018-08-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial proliferation and inflammation. Intra-articular corticosteroid injections are commonly used for the treatment of arthritis affecting one or two joints. Although corticosteroid injections are fast-acting, repeated usage can result in se...

journal_title：Experimental and therapeutic medicine

authors： Cho HK,Park GY,Sung WJ,Kawk SG,Jung WB

更新日期：2020-11-01 00:00:00

abstract：:Numerous studies have demonstrated that microRNAs (miRNAs) are dysregulated in esophageal squamous cell carcinoma (ESCC). Changes in miRNA expression may be associated with ESCC formation and progression. Therefore, the identification of ESCC-associated miRNAs may facilitate the development of effective therapeutic ap...

journal_title：Experimental and therapeutic medicine

authors： Zhen C,Huang J,Lu J

更新日期：2019-12-01 00:00:00

abstract：:This study aimed to investigate the correlations between the detection rate of mural coronary artery (MCA) by 128-slice CT and the MCA compression extent in systole with myocardial bridge (MB) length and thickness. A retrospective analysis was conducted for 580 patients receiving multislicespiral CT coronary angiograp...

journal_title：Experimental and therapeutic medicine

authors： Niu YJ,Zhang XL,Cao AD,Leng B

更新日期：2013-03-01 00:00:00

abstract：:The present study aimed to explore the treatment effects of Taohongsiwu decoction on the liver fibrosis in a rat model, as few prior studies have investigated the anti-fibrotic effects of Taohongsiwu decoction. High-performance liquid chromatography was used to measure the concentration of ferulic acid and hydrosafflo...

journal_title：Experimental and therapeutic medicine

authors： Wang T,Wu D,Li P,Zhang K,Tao S,Li Z,Li J

更新日期：2017-08-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of scopolamine and penehyclidine hydrochloride on acute cerebral ischemia-reperfusion injury after cardiopulmonary resuscitation, and the effect on cytokine levels. Eighty patients with cardiac arrest admitted to our hospital from June 2011 to Decem...

journal_title：Experimental and therapeutic medicine

authors： Wang D,Jiang Q,Du X

更新日期：2018-02-01 00:00:00

abstract：:The aim of the present study was to investigate whether the co-injection of hyaluronic acid (HA) and corticosteroids (CS) was superior to HA alone in the treatment of knee OA. A total of 120 participants with symptomatic knee OA were recruited and formed the intention-to-treat population for a 6-month follow-up. In th...

journal_title：Experimental and therapeutic medicine

authors： Wang SZ,Wu DY,Chang Q,Guo YD,Wang C,Fan WM

更新日期：2018-09-01 00:00:00

abstract：:Gorham-Stout syndrome (GSS) is a rare disease characterized by spontaneous and progressive osteolysis caused by benign proliferation of lymphatic vessels or capillaries. It most commonly occurs in children or young individuals without any inherited predisposition. GSS most commonly affects the shoulder girdle, pelvis,...

journal_title：Experimental and therapeutic medicine

authors： Chang KJ,Yang MH,Li B,Huang H

更新日期：2020-06-01 00:00:00

abstract：:One of the critical factors for predicting the success of percutaneous catheter drainage (PCD) is the mean CT density of collection. A higher CT density suggests more necrotic solid tissue within the collection. In the present study, a novel technique for PCD of the necrotic pancreatic collection with a higher mean CT...

journal_title：Experimental and therapeutic medicine

authors： Gupta P,Koshi S,Samanta J,Mandavdhare H,Sharma V,K Sinha S,Dutta U,Kochhar R

更新日期：2020-09-01 00:00:00

abstract：:Multi infarct dementia (MID) is a form of dementia that is preventable and treatable. However, at present, the drugs used in MID treatment were developed for Alzheimer's disease. While only a limited range of drugs is available, the incidence of MID is increasing year on year. The present study aimed to investigate th...

journal_title：Experimental and therapeutic medicine

authors： Fu Y,Wei J,Li B,Gao L,Xia P,Wen Y,Xu S

更新日期：2020-11-01 00:00:00

abstract：:The present study aimed to evaluate the clinical efficacy of hyperbaric oxygen (HBO) treatment for depression in the convalescent stage following cerebral hemorrhage. A total of 60 cases of patients with depression in the convalescent stage following cerebral hemorrhage (2-6 months) were randomly divided into the trea...

journal_title：Experimental and therapeutic medicine

authors： Cao H,Ju K,Zhong L,Meng T

更新日期：2013-06-01 00:00:00

abstract：:Adipose stem cell-conditioned medium may promote human dermal fibroblast (HDF) proliferation and migration by activating paracrine peptides during the re-epithelization phase of wound healing. Human antimicrobial peptide LL-37 is upregulated in the skin epithelium as part of the normal response to injury. The effects ...

journal_title：Experimental and therapeutic medicine

authors： Yang EJ,Bang SI

更新日期：2017-07-01 00:00:00

abstract：:At present, the majority of patients with breast cancer are diagnosed at early stages of disease development. However, a considerable number of such cases develop secondary malignancies after a relatively short period of time. The presence of circulating tumor cells (CTCs) has been proposed as a strong biomarker to pr...

journal_title：Experimental and therapeutic medicine

authors： Serrano MJ,Rovira PS,Martínez-Zubiaurre I,Rodriguez MD,Fernández M,Lorente JA

更新日期：2012-07-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) possess good proliferative and differentiative abilities, making then a promising candidate for the treatment of cartilage defects. However, local ischemia often causes apoptosis in ADSCs. Transforming growth factor-β3 (TGF-β3) is often used as a chondrogenic differentiation cytokine...

journal_title：Experimental and therapeutic medicine

authors： Wu F,Ye H,Lin J,Xu Y,Zhang Z,Xiong H,Laing M,Zhen Y,Chen S

更新日期：2018-05-01 00:00:00

abstract：:Aberrant methylation of gene promoter regions is one of the mechanisms for inactivation of tumor suppressor genes in human malignancies. In this study, the methylation pattern of 24 tumor suppressor genes was analyzed in 75 samples of ovarian cancer using the methylation-specific multiplex ligation-dependent probe amp...

journal_title：Experimental and therapeutic medicine

authors： Ozdemir F,Altinisik J,Karateke A,Coksuer H,Buyru N

更新日期：2012-12-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression and effect of rat mitofusin-2 (rMfn2) in the ovaries and other organs in rats. Rat models were developed by the intraovarian microinjection of an rMfn2-overexpressing lentiviral vector. Lenti-green fluorescent protein (GFP)-rMfn2 was microinjected into rat ov...

journal_title：Experimental and therapeutic medicine

authors： Hu X,Lei X,Wang J,Pan H,Li C,Yao Z

更新日期：2014-09-01 00:00:00

abstract：:Uterine cervical adenocarcinoma has a poor clinical prognosis when compared with squamous cell carcinoma. Therefore, the development of new treatment strategies for uterine cervical adenocarcinoma is necessary. Src is a proto-oncogene that is important in cancer progression. Dasatinib is a Src inhibitor that has been ...

journal_title：Experimental and therapeutic medicine

authors： Takiguchi E,Nishimura M,Mineda A,Kawakita T,Abe A,Irahara M

更新日期：2017-11-01 00:00:00

abstract：:Tumor hypoxia contributes to the development of resistance to chemotherapeutic drugs in several human cancer cell lines. Atovaquone, an anti-malaria drug approved by the US Food and Drug Administration, has recently demonstrated anti-cancer effects in vitro and in vivo in several cancer models. To assess the potential...

journal_title：Experimental and therapeutic medicine

authors： Fu C,Xiao X,Xu H,Lu W,Wang Y

更新日期：2020-12-01 00:00:00

abstract：:Limited studies have focused on mental symptoms (anxiety and depression) and their impact on quality of life (QoL) in patients with pulmonary hypertension (PH). The objective of the present study was to assess the prevalence of anxiety and depression and their association with QoL in patients with pulmonary arterial h...

journal_title：Experimental and therapeutic medicine

authors： Zhou X,Shi H,Yang Y,Zhang Z,Zhai Z,Wang C

更新日期：2020-04-01 00:00:00

abstract：:The epileptic state, or status epilepticus (SE), is the most serious situation manifested by individuals with epilepsy, and SE events can lead to neuronal damage. An understanding of the molecular, biochemical and physiopathological mechanisms involved in this type of neurological disease will enable the identificatio...

journal_title：Experimental and therapeutic medicine

authors： Carmona-Aparicio L,Zavala-Tecuapetla C,González-Trujano ME,Sampieri AI,Montesinos-Correa H,Granados-Rojas L,Floriano-Sánchez E,Coballase-Urrutía E,Cárdenas-Rodríguez N

更新日期：2016-10-01 00:00:00

abstract：:Psoriasis is a T cell mediated, chronic inflammatory autoimmune skin disease that affects up to 2-3% of the global population and leads to a decrease in quality of life. Experimental data accumulated in recent years highlighted the important role played by the immune system in the pathogenesis of this disease. Non-hum...

journal_title：Experimental and therapeutic medicine

authors： Surcel M,Huică RI,Munteanu AN,Isvoranu G,Pîrvu IR,Ciotaru D,Constantin C,Bratu O,Căruntu C,Neagu M,Ursaciuc C

更新日期：2019-02-01 00:00:00

abstract：:The present study aimed to determine the clinical characteristics and perinatal outcomes of females with severe preeclampsia according to their pre-pregnancy body mass index (BMI). Data from 233 patients with severe preeclampsia were reviewed from the Inpatient Obstetrics Department. The data were divided into 3 group...

journal_title：Experimental and therapeutic medicine

authors： Jiang L,Lin J,Yan J,Lin X,Han Q,Zhang H

更新日期：2020-07-01 00:00:00

abstract：:The present prospective, randomized, double-blinded, controlled study aimed to investigate the efficacy and safety of dexmedetomidine (DEX) combined with butorphanol for patient-controlled intravenous analgesia (PCIA) following total laparoscopic hysterectomy. A total of 88 patients undergoing total laparoscopic hyste...

journal_title：Experimental and therapeutic medicine

authors： Du J,Li JW,Jin J,Shi CX,Ma JH

更新日期：2018-11-01 00:00:00