Abstract:
:The EGFR inhibitor osimertinib may be an effective therapy for patients with untreated non-small cell lung cancer who have brain metastases. In a recent study, the drug extended median progression-free survival and increased objective response rates compared with the first-generation EGFR inhibitors gefitinib and erlotinib.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
doi
10.1158/2159-8290.CD-NB2018-121subject
Has Abstractpub_date
2018-11-01 00:00:00pages
OF3issue
11eissn
2159-8274issn
2159-8290pii
2159-8290.CD-NB2018-121journal_volume
8pub_type
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journal_title:Cancer discovery
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abstract:UNLABELLED:ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of fundamental clinical importance to understand its molecular functions and determine whether ARID1A deficiency can be exploited therapeutically. ...
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journal_title:Cancer discovery
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