Abstract:
BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR) has been reported to possess significant prognostic value in multiple types of cancer. We conducted a meta-analysis to evaluate the prognostic value of pretreatment NLR in soft tissue sarcoma (STS). METHODS:A systematic literature search through April 2018 was conducted to identify studies evaluating the prognostic value of the pretreatment NLR in STS patients. The end points were overall survival (OS), disease-free survival (DFS), progression-free survival (PFS), and clinicopathological parameters. All statistical analyses were conducted with Stata 13.0. RESULTS:Fourteen cohorts with 2820 patients were analyzed. Elevated NLR was significantly correlated with worse OS [hazard ratio (HR): 1.59, 95% confidence interval (95% CI): 1.28-1.97, P < .001] and DFS/PFS (HR = 1.28; 95% CI = 1.12-1.47; P < .001). In addition, elevated NLR was highly correlated with age (≥ 65 years), tumor size (>5 cm), tumor depth (deep), Grade (G3), and TNM stage (III-IV). CONCLUSION:Overall, pretreatment NLR could be an adverse prognostic biomarker for STS.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Liu G,Ke LC,Sun SRdoi
10.1097/MD.0000000000012176subject
Has Abstractpub_date
2018-09-01 00:00:00pages
e12176issue
36eissn
0025-7974issn
1536-5964pii
00005792-201809070-00062journal_volume
97pub_type
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