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Mapping of human X-linked hypophosphataemic rickets by multilocus linkage analysis.

Abstract：

:Eleven families with X-linked dominant hypophosphataemic rickets (HPDR) have been typed for a series of X chromosome markers. Linkage with probe 99.6 (DXS41) was demonstrated with a peak lod score of 4.82 at 10% recombination. Multilocus linkage analysis showed that HPDR maps distal to 99.6; this probe has previously been located at Xp22.31-p21.3 by in situ hybridisation. In the mouse hypophosphataemia (Hyp) maps to the distal part of the X chromosome; our location in man is consistent with a scheme which relates the mouse and human X chromosomes by two rearrangements. No marker has yet been found which shows no recombination with HPDR.

journal_name

Hum Genet

journal_title

Human genetics

authors

Read AP,Thakker RV,Davies KE,Mountford RC,Brenton DP,Davies M,Glorieux F,Harris R,Hendy GN,King A

doi

10.1007/BF00401242

subject

Has Abstract,Author List Incomplete

pub_date

1986-07-01 00:00:00

pages

267-70

issue

3

eissn

0340-6717

issn

1432-1203

journal_volume

73

pub_type

杂志文章

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