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Region-specific and state-dependent action of striatal GABAergic interneurons.

Abstract：

:Striatum processes a wide range of functions including goal-directed behavior and habit formation, respectively encoded by the dorsomedial striatum (DMS) and dorsolateral striatum (DLS). GABAergic feedforward inhibition is known to control the integration of cortical information by striatal projection neurons (SPNs). Here we questioned whether this control is specific between distinct striatal functional territories. Using opto-activation and opto-inhibition of identified GABAergic interneurons, we found that different circuits are engaged in DLS and DMS, both ex vivo and in vivo: while parvalbumin interneurons efficiently control SPNs in DLS, somatostatin interneurons control SPNs in DMS. Moreover, both parvalbumin and somatostatin interneurons use a dual hyperpolarizing/depolarizing effect to control cortical input integration depending on SPN activity state: GABAergic interneurons potently inhibit spiking SPNs while in resting SPNs, they favor cortical activity summation via a depolarizing effect. Our findings establish that striatal GABAergic interneurons exert efficient territory-specific and state-dependent control of SPN activity and functional output.

journal_name

Nat Commun

journal_title

Nature communications

authors

Fino E,Vandecasteele M,Perez S,Saudou F,Venance L

doi

10.1038/s41467-018-05847-5

subject

Has Abstract

pub_date

2018-08-21 00:00:00

pages

3339

issue

1

issn

2041-1723

pii

10.1038/s41467-018-05847-5

journal_volume

9

pub_type

杂志文章

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