Abstract：
:From 1967 to 1977, 72 patients with small cell carcinoma of the lung were seen. Thirty-five of these patients had unilaterally localized lesions (limited disease) and were treated with cobalt 60 radiation therapy (6,000 rad in six weeks) followed by chemotherapy consisting of cyclophosphamide (Cytoxan), vincristine, methotrexate and lomustine (CCNU) (Group A). The remaining 37 patients with extensive disease were treated with similar chemotherapy alone, or in combination with local palliative radiotherapy to the symptomatic area (Group B). For Group A the five-year survival rate was 20 percent, while for both groups combined, it was only 5 percent.During this same period 560 patients with non-small cell carcinomas were treated. The five-year survival rate for those patients with operable, resectable lesions was 33 percent, while for those with unilateral, inoperable, unresectable lesions, it was 10 percent. Thus, it would appear that the results in limited small cell and non-small cell carcinomas of the lung utilizing high-dose radiotherapy followed by chemotherapy are comparable, and that limited small cell carcinoma of the lung patients with high-dose radiotherapy followed by chemotherapy can survive longer than those patients with stage III, non-small cell lung carcinoma.While the two- to five-year survival rates in small cell carcinoma demonstrate no appreciable differences, in non-small cell carcinomas there are significant two- to five-year survival differences. These improved results probably are due to the increased sensitivity of small cell carcinoma to high-dose local radiotherapy and to the chemotherapeutic vulnerability of circulating and microscopic metastatic cancer cells.
journal_name
J Natl Med Assocjournal_title
Journal of the National Medical Associationauthors
Akbiyik N,Alexander LLsubject
Has Abstractpub_date
1986-03-01 00:00:00pages
219-23issue
3eissn
0027-9684issn
1943-4693journal_volume
78pub_type
临床试验,杂志文章abstract：:Many studies now demonstrate high overall response rates with concurrent chemotherapy and radiation (CCR) for locoregionally advanced or inoperable non-small cell lung carcinoma (NSCLC) but often with severe toxicity and only modest improvement in survival beyond 3 years. We report a simple CCR protocol for NSCLC that...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2000-03-01 00:00:00
abstract：:Bouveret's Syndrome is obstruction of the duodenum secondary to an impacted gallstone, usually without the presence of pneumobilia. With the steadily increasing life expectancy, greater numbers of these cases are being seen. Gallstones enter the gastrointestinal tract following fistula formation between the gallbladde...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：:Strangulated right Richter's inguinal hernia of the cecum is relatively rare. A case of this unusual hernia was successfully managed with a wedge resection and closure of the infarcted bowel wall in conjunction with complementary tube cecostomy. The procedure is easy to perform and relatively safe and is therefore rec...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:The purpose of this study is to examine intercategory agreement among the symptom clusters associated with diagnoses of affective disorder, schizoaffective disorder, and schizophrenia in 156 African-American patients. It is hypothesized that there will be greater agreement between diagnosed schizoaffective disorder an...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:Retroperitoneal fibrosis secondary to carcinoma of the gallbladder has not been reported previously. Such a combination is reported and a review of the pertinent literature presented. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1989-09-01 00:00:00
abstract：:Enlarged spleen without a clear-cut etiology, and believed to be related to malarial infestations, has been referred to as "tropical splenomegaly" and "cryptogenetic splenomegaly." Splenectomy performed in such cases after a failure of antimalarial therapy shows histopathologically, while some of these meet the criter...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
abstract：BACKGROUND:Although the prevalence of uremic pruritus has decreased compared to the past, the problem still remains as a matter of health and a major challenge of research in medical field, and has no effective treatment at present. This study aimed to investigate the effect of increasing blood flow rate on severity of...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jnma.2017.04.008
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To determine if African American and European American children with asthma admitted to an intensive care unit (ICU) had different characteristics, we conducted a retrospective chart review of asthma admissions to the region's only pediatric ICU. PATIENTS AND METHODS:A chart review was performed on 125 patie...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)31107-x
更新日期：2009-11-01 00:00:00
abstract：:Relatively low serum albumin is a predictor of increased mortality and coronary heart disease incidence. To shed light on the likelihood of confounding this association by high-density lipoprotein (HDL) cholesterol or other risk factors, data from the National Center for Health Statistics were examined. Serum albumin ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:The health and well-being of all individuals, independent of race, ethnicity, or gender, is a significant public health concern. Despite many improvements in the status of minority health, African American males continue to have the highest age-adjusted mortality rate of any race-sex group in the United States. Such d...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30361-8
更新日期：2011-06-01 00:00:00
abstract：:A 65-year-old man underwent coronary artery bypass graft surgery at our tertiary care hospital. Perioperatively, he was transfused with four units of nonirradiated whole blood from first-degree relatives and discharged from the hospital at postoperative day seven. He presented six days later with fever, skin rash, ele...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：UNLABELLED:Severe hyponatremia is associated with increased morbidity and mortality. Clinicians treating patients with severe hyponatremia are often torn between a desire to promptly raise serum sodium concentration to a "safe range," and at the same time, to avoid excessively rapid correction of hyponatremia. The aim ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to determine primary care pediatricians' level of awareness in the diagnosis and management of rickets. The information will be useful in assessing the need for provider education related to appropriate advice regarding vitamin D supplementation for infants. STUDY DESIGN:A one-pa...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:A day-long seminar was held at Wake Forest University School of Medicine to address barriers among ethnic minorities in cancer clinical trials and explore ways that individuals who design and conduct clinical trials could increase minority representation. Speakers addressed implications of under-representation of mino...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：:More than 250 cases of Cornelia de Lange syndrome have been reported in the medical literature, but not have described the use of hip reconstruction to correct the congenital dysplasia that may be associated with this condition. This article reports the application of a bipolar hemiarthroplasty and acetabular allograf...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVES:Intimate partner violence (IPV)during pregnancy is a significant public health problem. Approximately 324,000 IPV victimizations occur during pregnancy each year. However, research on the impact of IPV on birth outcomes yields conflicting findings. This study examines the association of IPV with birth outcom...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2017.06.017
更新日期：2017-01-01 00:00:00
abstract：:The data of the Third National Cancer Survey show for many cancer types, large differences in cancer incidence between Euro-Americans and Afro-Americans.(1) As in other racial studies, it is difficult to separate environmental and genetic factors. For the cancers which are more frequent among Afro-Americans, environme...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1981-08-01 00:00:00
abstract：:The achievements of 19th century medical education, practice, literature, and science and their affect on 20th century medicine are reviewed. The contributions made by 19th century physicians to change medical education are described, as well as the social processes that influenced medicine and science in both centuri...
journal_title：Journal of the National Medical Association
pub_type： 历史文章,杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：OBJECTIVE:To assess differences in self-reported health status and satisfaction between African-American and caucasian veterans with ischemic heart disease (IHD). DATA SOURCES/STUDY SETTING:African-American and caucasian patients enrolled in General Internal Medicine clinics at six Veteran Affairs Medical Centers. ST...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Many Native American tribes use acanthosis nigricans to screen for type 2 diabetes risk. We hypothesized that acanthosis nigricans misses many children at risk for type 2 diabetes. METHODS:We evaluated 5- to 18-year-old Native American children and youth to assess the sensitivity and specificity of acanthos...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/s0027-9684(15)30714-8
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:While African-American women tend to have greater bone mineral density (BMD) than caucasian women, they are still at risk of developing osteoporosis later in life. Clinical decision rules (i.e., algorithms) have been developed to assist clinicians identify women at greatest risk of low BMD. However, such tool...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:Pregnant women with sickle cell disease (SCD) are at increased risk of maternal and fetal complications. There are limited data on the outcome of the treatment of VOCs with opioids in relation to neonatal complications during pregnancy. METHODS:This is a retrospective cohort study of women with SCD from Jan...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2017.04.002
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:The purpose of this study was to explore the experiences of medical students who are underrepresented in medicine (UIM) from two urban medical centers with an interest in pursuing academic pediatrics. METHODS:Focus groups were conducted at Children's National Hospital (CN) at three different times with UIM med...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：10.1016/j.jnma.2020.07.014
更新日期：2020-08-05 00:00:00
abstract：:Comprehensive health care planning can augment the educational programming for children with exceptional health and/or learning needs. The coordination of medical service and education is critically needed to reduce the traditional gulf between these two essential disciplines. Bridging this gulf will enable patients a...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1982-10-01 00:00:00
abstract：:The author presents a four-year follow-up of a male patient with cancer of the breast. The lesion was large, fungating, and ulcerating. It was treated effectively with cobalt without mastectomy. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章,评审
doi：
更新日期：1987-08-01 00:00:00
abstract：:In 1994, it was estimated that about 44,500 American women would die from breast cancer and 7000 women from cervical cancer. While early detection methods (screening mammography, breast examinations, and pap smears) have proven to be effective means of decreasing these cancers, they are underused by all groups. In par...
journal_title：Journal of the National Medical Association
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-06-01 00:00:00
abstract：OBJECTIVE:To determine if a patient's degree of access to healthcare predicts his or her fund of knowledge about cardiovascular diseases. METHODS:Trained research associates at a public, urban emergency department in New York City administered cross-sectional surveys to selected patients from June 2005 to January 2007...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：2007-12-01 00:00:00
abstract：:A Nigerian school boy with the syndrome of multiple jaw cysts, skeletal anomalies, and basal cell nevi is described and discussed. To the authors' knowledge, this is the first report of this syndrome in a black African. ...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:Periodically, for the past two years, the editorial staff of the Journal of the National Association has attempted to-for history's sake--highlight physicians of color. In this vein, and in light of the current hostile activities in the Persian Gulf, we felt it important we our bring readers, in this issue, the backgr...
journal_title：Journal of the National Medical Association
pub_type： 传,历史文章,面试
doi：
更新日期：2005-05-01 00:00:00
abstract：:Colorectal cancer causes significant morbidity and mortality in the United States. Recommendations for colorectal cancer screening have been developed. This study evaluated the colorectal cancer screening practices of African-American and white patients by internal medicine resident physicians. A retrospective chart r...
journal_title：Journal of the National Medical Association
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
