An investigation of the prolactin-thyroxine synergism in newt limb regeneration.

Abstract:

:The use of hormone replacement to support limb regeneration in hypophysectomized newts has been the subject of many investigations. Growth hormone, as well as prolactin (PL) in combination with exogenously supplied thyroxine, have all been shown to he effective. However, the bovine growth hormone used to support limb regeneration was contaminated by prolactin and thyroidstimulating hormone (TSH). The present investigation evaluates the significance of (1) prolactin contamination and (2) endogenous thyroxine synthesis resulting from TSH contamination on limb regeneration in hypophysectomized newts. The effect of supplying exogenous thyroxine was also evaluated. Our studies showed that when hypophysectomized newts were injected with contamination levels of PL and TSH, regeneration occurred, suggesting that the newt's thyroid synthesized sufficient thyroxine to support a prolactin-thyroxine synergism. The endogenous thyroxine was synthesized by thyroid glands that were indistinguishable from those of saline-injected, hypophysectomized controls.

journal_name

J Morphol

journal_title

Journal of morphology

authors

Hessler AC,Landesman R

doi

10.1002/jmor.1051670109

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

103-108

issue

1

eissn

0362-2525

issn

1097-4687

journal_volume

167

pub_type

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