Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups.

abstract：:For a study of diversity and genetic structuring in Melipona quadrifasciata, 61 colonies were collected in eight locations in the state of Minas Gerais, Brazil. By means of PCR analysis, 119 ISSR bands were obtained, 80 (68%) being polymorphic. H(e) and H (B) were 0.20 and 0.16, respectively. Two large groups were obt...

journal_title：Genetics and molecular biology

authors： Nascimento MA,Batalha-Filho H,Waldschmidt AM,Tavares MG,Campos LA,Salomão TM

更新日期：2010-04-01 00:00:00

abstract：:Oral Lichen Planus (OLP) is an oral inflammatory condition, mediated by host immune system reaction, presenting basal membrane damages with inflammatory lesions in the mouth and/or skin. In this study, the role of functional polymorphisms in the MBL2 gene, encoding for Mannose-Binding Protein C (MBP-C), a member of th...

journal_title：Genetics and molecular biology

authors： Polesello V,Segat L,Biasotto M,Ottaviani G,Gobbo M,Di Lenarda R,Crovella S,Zupin L

更新日期：2019-01-01 00:00:00

abstract：:Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transc...

journal_title：Genetics and molecular biology

authors： Botto AEC,Muñoz JC,Giono LE,Nieto-Moreno N,Cuenca C,Kornblihtt AR,Muñoz MJ

更新日期：2020-03-27 00:00:00

abstract：:The aim of this study was to estimate the components of variance and genetic parameters for the visual scores which constitute the Morphological Evaluation System (MES), such as body structure (S), precocity (P) and musculature (M) in Nellore beef-cattle at the weaning and yearling stages, by using threshold Bayesian ...

journal_title：Genetics and molecular biology

authors： de Faria CU,Koury W Jr,Magnabosco CU,de Albuquerque LG,Bezerra LA,Lôbo RB

更新日期：2009-10-01 00:00:00

abstract：:The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the wor...

journal_title：Genetics and molecular biology

authors： Boldt AB,Culpi L,Tsuneto LT,Souza IR,Kun JF,Petzl-Erler ML

更新日期：2009-01-01 00:00:00

abstract：:The order Anguilliformes comprises 15 families, 141 genera and 791 fish species. Eight families had at least one karyotyped species, with a prevalence of 2n = 38 chromosomes and high fundamental numbers (FN). The only exception to this pattern is the family Muraenidae, in which the eight species analyzed presented 2n ...

journal_title：Genetics and molecular biology

authors： Vasconcelos AJ,Molina WF

更新日期：2009-01-01 00:00:00

abstract：:4-Coumaric acid: coenzyme A ligase (4CL) is a key enzyme in the phenylpropanoid metabolic pathway that regulates the biosynthesis of lignin and flavonoids. Therefore, the study of 4CL is important to explore the accumulation and regulation of metabolites. This study investigated the role that the 4CL2 gene from Dryopt...

journal_title：Genetics and molecular biology

authors： Li SS,Chang Y,Li B,Shao SL,Zhen-Zhu- Z

更新日期：2020-05-20 00:00:00

abstract：:Treatment of moderate and severe forms of osteogenesis imperfecta (OI) with cyclic pamidronate at the Reference Center for OI Treatment in Southern Brazil was studied. A retrospective cohort study was conducted from 2002 to 2012. Data were obtained during inpatient (drug infusion) and outpatient care. Clinical data, i...

journal_title：Genetics and molecular biology

authors： Pinheiro B,Zambrano MB,Vanz AP,Brizola E,Souza LT,Félix TM

更新日期：2019-01-01 00:00:00

abstract：:Since around 1723, on the occasion of its initial colonization by Europeans, Rondonia has received successive waves of immigrants. This has been further swelled by individuals from northeastern Brazil, who began entering at the beginning of the twentieth century. The ethnic composition varies across the state accordin...

journal_title：Genetics and molecular biology

authors： de Farias JD,Santos MG,de França AK,Delani D,Tada MS,Casseb AA,Simões AL,Engracia V

更新日期：2012-01-01 00:00:00

abstract：:The genus Phanaeus is included in the tribe Phanaeini, one of the most diverse tribes within the subfamily Scarabaeinae in terms of chromosomal characteristics. However, so far the species of this genus were not studied with differential cytogenetic techniques, limiting any inference of the probable mechanisms respons...

journal_title：Genetics and molecular biology

authors： Arcanjo A,Cabral-de-Mello DC,Martins C,de Cássia de Moura R,de Souza MJ

更新日期：2013-09-01 00:00:00

abstract：:We genotyped 15 microsatellite loci in order to evaluate the effects of habitat fragmentation, caused by flooding of the Tucuruí reservoir, on the genetic structure of Alouatta belzebul in eastern Amazonia. The analysis included two populations sampled in 1984, representing both margins of the Tocantins river, and thr...

journal_title：Genetics and molecular biology

authors： Bastos HB,Gonçalves EC,Ferrari SF,Silva A,Schneider MP

更新日期：2010-10-01 00:00:00

abstract：:Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performan...

journal_title：Genetics and molecular biology

authors： Miranda-Vilela AL,Ribeiro IF,Grisolia CK

更新日期：2016-10-01 00:00:00

abstract：:Ample evidence suggests that cancer is triggered by mutagenic damage and diets or supplements capable of reducing such incidences can be related to the prevention of neoplasy development or to an improvement in life quality of patients who undergo chemotherapy. This research aimed to evaluate the antimutagenic and ant...

journal_title：Genetics and molecular biology

authors： Oliveira RJ,Salles MJ,da Silva AF,Kanno TY,Lourenço AC,Leite Vda S,Matiazi HJ,Pesarini JR,Ribeiro LR,Mantovani MS

更新日期：2013-09-01 00:00:00

abstract：:Topoisomerase II inhibitors are effective chemotherapeutic agents in the treatment of cancer, in spite of being associated with the development of secondary leukemia. Our purpose was to determine the effects of etoposide on different genomic regions, aiming at discovering whether there are preferential sites which can...

journal_title：Genetics and molecular biology

authors： Brassesco MS,Montaldi AP,Sakamoto-Hojo ET

更新日期：2009-01-01 00:00:00

abstract：:The arylamine N-acetyltransferase 2 (NAT2) enzymes detoxify a wide range of naturally occurring xenobiotics including carcinogens and drugs. Point mutations in the NAT2 gene result in the variant alleles M1 (NAT2 *5A), M2 (NAT2*6A), M3 (NAT2*7) and M4 (NAT2 *14A) from the wild-type WT (NAT2 *4) allele. The current stu...

journal_title：Genetics and molecular biology

authors： Mahasneh A,Jubaili A,El Bateiha A,Al-Ghazo M,Matalka I,Malkawi M

更新日期：2012-12-01 00:00:00

abstract：:Tabebuia sp. is native to tropical rain forests throughout Central and South America. Although the biological and pharmacological effects of bark extracts have been intensely studied, little is known on the extract obtained from the flower. Herein, the genotoxic potential of a flower extract from T. impetiginosa ("ipê...

journal_title：Genetics and molecular biology

authors： Lemos OA,Sanches JC,Silva IE,Silva ML,Vinhólis AH,Felix MA,Santos RA,Cecchi AO

更新日期：2012-04-01 00:00:00

abstract：:Genetic variation was estimated in ten samples populations of Aedes aegypti from the Brazilian Amazon, by using a 380 bp fragment of the mitochocondrial NADH dehydrogenase subunit 4 (ND4) gene. A total of 123 individuals were analyzed, whereby 13 haplotypes were found. Mean genetic diversity was slightly high (h = 0.6...

journal_title：Genetics and molecular biology

authors： Lima RS Jr,Scarpassa VM

更新日期：2009-04-01 00:00:00

abstract：:The population of India harbors one of the world's most highly diverse gene pools, owing to the influx of successive waves of immigrants over regular periods in time. Several phylogenetic studies involving mitochondrial DNA and Y chromosomal variation have demonstrated Europeans to have been the first settlers in Indi...

journal_title：Genetics and molecular biology

authors： Tiwari SK,Sharma V,Sharma VK,Gopi M,Saikant R,Nandan A,Bardia A,Gunisetty S,Katikala P,Habeeb MA,Khan AA,Habibullah CM

更新日期：2011-04-01 00:00:00

abstract：:Alcohol dehydrogenases belong to the large superfamily of medium-chain dehydrogenases/reductases, which occur throughout the biological world and are involved with many important metabolic routes. We considered the phylogeny of 190 ADH sequences of animals, fungi, and plants. Non-class III Caenorhabditis elegans ADHs ...

journal_title：Genetics and molecular biology

authors： Thompson CE,Freitas LB,Salzano FM

更新日期：2018-01-01 00:00:00

abstract：:Hereditary cancer risk assessment is a multidisciplinary and dynamic process, with the purpose of estimating probabilities of germline mutations in cancer susceptibility genes and assessing empiric risks of cancer based on personal and family histories, in order to offer clinical and molecular diagnoses and clinical m...

journal_title：Genetics and molecular biology

authors： Gomy I,Diz Mdel P

更新日期：2016-05-13 00:00:00

abstract：:Autochthonous pig breeds represent an important genetic reserve to be utilized mainly for the production of typical products. To explore its genetic variability, here we present for the first time whole genome sequencing data and SNPs discovered in a male domestic Nero Siciliano pig compared to the last pig reference ...

journal_title：Genetics and molecular biology

authors： D'Alessandro E,Giosa D,Sapienza I,Giuffrè L,Cigliano RA,Romeo O,Zumbo A

更新日期：2019-07-01 00:00:00

abstract：:A detailed study of putative recombination events and their evolution frequency in the whole genome of the currently known members of the family Tombusviridae, comprising 79 accessions retrieved from the international databases, was carried out by using the RECCO and RDP version 3.31β algorithms. The first program all...

journal_title：Genetics and molecular biology

authors： Boulila M

更新日期：2011-10-01 00:00:00

abstract：:Seven polymorphic microsatellite loci were isolated and characterized for the snakehead murrel, Channa striata (Channidae), a valuable tropical freshwater fish species. Among 25 specimens collected from Kedah state in Malaysia, the number of alleles per locus ranged from 2 to 7. Observed and expected heterozygosities ...

journal_title：Genetics and molecular biology

authors： Jamsari AF,Min-Pau T,Siti-Azizah MN

更新日期：2011-04-01 00:00:00

abstract：:Catalase (CAT) is a common antioxidant enzyme in almost all living organisms. Currently, detailed reports on cucumber (Cucumis sativus L.) CAT (CsCAT) genes and tissue expression profiling are limited. In the present study, four candidate CsCAT genes were identified in cucumber. Phylogenetic analysis indicated that Cs...

journal_title：Genetics and molecular biology

authors： Hu L,Yang Y,Jiang L,Liu S

更新日期：2016-07-01 00:00:00

abstract：:This study shows that sampling maternal DNA from hatched and abandoned eggshells is a viable noninvasive strategy for studying the genetics of rare or endangered tropical birds, as exemplified here by the Brazilian Merganser (Mergus octosetaceus). Eighteen microsatellites were isolated from enriched libraries and nine...

journal_title：Genetics and molecular biology

authors： Maia TA,Vilaça ST,Silva LRD,Santos FR,Dantas GPM

更新日期：2017-10-01 00:00:00

abstract：:Phylogenetic niche conservatism can be investigated at multiple scales on an explicit geographical context. Haplotype-based comparative analyses of lineages occupying the same region, and thus subjected to similar environmental factors, allow decoupling shared evolutionary and ecological patterns, as well as multiple ...

journal_title：Genetics and molecular biology

authors： Barros MJF,Silva-Arias GA,Segatto ALA,Reck-Kortmann M,Fregonezi JN,Diniz-Filho JAF,Freitas LB

更新日期：2020-04-27 00:00:00

abstract：:The usefulness of IRAP (inter-retrotransposon amplified polymorphism) and ITS-RFLP (restriction of PCR-amplified internal transcribed spacers of the rDNA) markers in the analysis of 39 Pyrenophora graminea isolates was determined. Each marker system could discriminate between all of the isolates in detecting polymorph...

journal_title：Genetics and molecular biology

authors： Zein I,Jawhar M,Arabi MI

更新日期：2010-04-01 00:00:00

abstract：:Lupinus albescens is a resistant cover plant that establishes symbiotic relationships with bacteria belonging to the Bradyrhizobium genus. This symbiosis helps the development of these plants in adverse environmental conditions, such as the ones found in arenized areas of Southern Brazil. This work studied three Brady...

journal_title：Genetics and molecular biology

authors： Granada CE,Vargas LK,Sant'Anna FH,Balsanelli E,Baura VA,Oliveira Pedrosa F,Souza EM,Falcon T,Passaglia LMP

更新日期：2018-04-01 00:00:00

abstract：:This review summarizes the chromosomal changes detected by molecular cytogenetic approaches in esophageal squamous cell carcinoma (ESCC), the ninth most common malignancy in the world. Whole genome analyses of ESCC cell lines and tumors indicated that the most frequent genomic gains occurred at 1, 2q, 3q, 5p, 6p, 7, 8...

journal_title：Genetics and molecular biology

authors： Bellini MF,Silva AE,Varella-Garcia M

更新日期：2010-04-01 00:00:00

abstract：:Hereditary Sensory and Autonomic Neuropathies (HSANs) compose a heterogeneous group of genetic disorders characterized by sensory and autonomic dysfunctions. Familial Dysautonomia (FD), also known as HSAN III, is an autosomal recessive disorder that affects 1/3,600 live births in the Ashkenazi Jewish population. The m...

journal_title：Genetics and molecular biology

authors： Dietrich P,Dragatsis I

更新日期：2016-10-01 00:00:00