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eLife文献大全abstract::Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown. In this study, we show that mouse Sema5A negatively regulates synaptogenesis in early, developmentally born, hippocampal dentate granule cells (GCs). Sema5A is strongly expressed by GCs and regulates d...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.04390
更新日期:2014-10-14 00:00:00
abstract::Rising and more variable global temperatures pose a challenge for biodiversity, with reproduction and fertility being especially sensitive to heat. Here, we assessed the potential for thermal adaptation in sperm and egg function using Tribolium flour beetles, a warm-temperate-tropical insect model. Following temperatu...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49452
更新日期:2019-10-01 00:00:00
abstract::Decisions are accompanied by a degree of confidence that a selected option is correct. A sequential sampling framework explains the speed and accuracy of decisions and extends naturally to the confidence that the decision rendered is likely to be correct. However, discrepancies between confidence and accuracy suggest ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12192
更新日期:2016-02-01 00:00:00
abstract::Malaria infection starts with injection of Plasmodium sporozoites by an Anopheles mosquito into the skin of the mammalian host. How sporozoites locate and enter a blood vessel is a critical, but poorly understood process. In this study, we examine sporozoite motility and their interaction with dermal blood vessels, us...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.07789
更新日期:2015-08-13 00:00:00
abstract::Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.50761
更新日期:2019-09-13 00:00:00
abstract::Cancer cells usually exhibit aberrant cell signaling and metabolic reprogramming. However, mechanisms of crosstalk between these processes remain elusive. Here, we show that in an in vivo tumor model expressing oncogenic Drosophila Homeodomain-interacting protein kinase (Hipk), tumor cells display elevated aerobic gly...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46315
更新日期:2019-07-01 00:00:00
abstract::Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Eur...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47788
更新日期:2019-11-05 00:00:00
abstract::How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples ligand binding and force to trigger a chemical event which controls the adhesive properties of the receptor. Our studies of the secreted platelet oxidoreductase, E...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34843
更新日期:2018-06-22 00:00:00
abstract::The multi-domain splicing factor RBM5 regulates the balance between antagonistic isoforms of the apoptosis-control genes FAS/CD95, Caspase-2 and AID. An OCRE (OCtamer REpeat of aromatic residues) domain found in RBM5 is important for alternative splicing regulation and mediates interactions with components of the U4/U...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14707
更新日期:2016-11-29 00:00:00
abstract::The choroid, which provides vascular supply to the outer retina, demonstrates progressive degeneration in aging and age-related macular degeneration (AMD). However mechanisms that maintain or compromise choroidal homeostasis are obscure. We discovered that the ablation of choroidal macrophages via CSF1R blockade was a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55564
更新日期:2020-04-01 00:00:00
abstract::Bone strength is determined by its dense cortical shell, generated by unknown mechanisms. Here we use the Dmp1Cre:Socs3f/f mouse, with delayed cortical bone consolidation, to characterise cortical maturation and identify control signals. We show that cortical maturation requires a reduction in cortical porosity, and a...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.56666
更新日期:2020-05-27 00:00:00
abstract::Most funding agencies rely on peer review to evaluate grant applications and proposals, but research into the use of this process by funding agencies has been limited. Here we explore if two changes to the organization of peer review for proposals submitted to various funding actions by the European Union has an influ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.59338
更新日期:2021-01-13 00:00:00
abstract::In complex biological systems, simple individual-level behavioral rules can give rise to emergent group-level behavior. While collective behavior has been well studied in cells and larger organisms, the mesoscopic scale is less understood, as it is unclear which sensory inputs and physical processes matter a priori. H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.43318
更新日期:2019-04-25 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Although rigorous efforts identified the presence of 'cancer stem cells (CSCs)' in PDAC and molecular markers for them, stem cell dynamics in vivo have not been clearly demonstrated. Here we focused on Doublecortin-like kinase 1 (Dclk1), known as a CSC ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55117
更新日期:2021-01-04 00:00:00
abstract::Motor cortex (M1) has lateralized outputs, yet neurons can be active during movements of either arm. What is the nature and role of activity across the two hemispheres? We recorded muscles and neurons bilaterally while monkeys cycled with each arm. Most neurons were active during movement of either arm. Responses were...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.46159
更新日期:2019-10-09 00:00:00
abstract::Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be uniquely sensitive to heat, which has been presumed to be due to the existence of an unidentified temperature-sensing domain. Here we report that the homologous...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.03255
更新日期:2014-07-16 00:00:00
abstract::Increasing evidence highlights the important roles of microRNAs in mediating p53's tumor suppression functions. Here, we report miR-139-5p as another new p53 microRNA target. p53 induced the transcription of miR-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein i...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15978
更新日期:2016-07-07 00:00:00
abstract::A key challenge in precise genome editing is the low efficiency of homology-directed repair (HDR). Here we describe a strategy for increasing the efficiency of HDR in cells by using a chromatin donor template instead of a naked DNA donor template. The use of chromatin, which is the natural form of DNA in the nucleus, ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.55780
更新日期:2020-04-28 00:00:00
abstract::Plasticity can put evolution on repeat if development causes species to generate similar morphologies in similar environments. Anolis lizards offer the opportunity to put this role of developmental plasticity to the test. Following colonization of the four Greater Antillean islands, Anolis lizards independently and re...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.57468
更新日期:2020-08-13 00:00:00
abstract::Understanding the molecular mechanism of glaucoma and development of neuroprotectants is significantly hindered by the lack of a reliable animal model that accurately recapitulates human glaucoma. Here, we sought to develop a mouse model for the secondary glaucoma that is often observed in humans after silicone oil (S...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.45881
更新日期:2019-05-15 00:00:00
abstract::Chemosensory neurons extract information about chemical cues from the environment. How is the activity in these sensory neurons transformed into behavior? Using Caenorhabditis elegans, we map a novel sensory neuron circuit motif that encodes odor concentration. Primary neurons, AWC(ON) and AWA, directly detect the foo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.10181
更新日期:2015-09-22 00:00:00
abstract::The time it takes a sound to travel from source to ear differs between the ears and creates an interaural delay. It varies systematically with spatial direction and is generally modeled as a pure time delay, independent of frequency. In acoustical recordings, we found that interaural delay varies with frequency at a f...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.06072
更新日期:2015-04-27 00:00:00
abstract::Cystic Fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, resulting in defective CFTR-mediated chloride and bicarbonate transport, with dysregulation of epithelial sodium channels (ENaC). These changes alter fluid and electrolyte homeostasis...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49248
更新日期:2019-09-18 00:00:00
abstract::In many daily tasks, we make multiple decisions before reaching a goal. In order to learn such sequences of decisions, a mechanism to link earlier actions to later reward is necessary. Reinforcement learning (RL) theory suggests two classes of algorithms solving this credit assignment problem: In classic temporal-diff...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.47463
更新日期:2019-11-11 00:00:00
abstract::While specific mutations allow organisms to adapt to stressful environments, most changes in an organism's DNA negatively impact fitness. The mutation rate is therefore strictly regulated and often considered a slowly-evolving parameter. In contrast, we demonstrate an unexpected flexibility in cellular mutation rates ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.22939
更新日期:2017-05-02 00:00:00
abstract::Cyanobacteria were responsible for the oxygenation of the ancient atmosphere; however, the evolution of this phylum is enigmatic, as relatives have not been characterized. Here we use whole genome reconstruction of human fecal and subsurface aquifer metagenomic samples to obtain complete genomes for members of a new c...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.01102
更新日期:2013-10-01 00:00:00
abstract::Advanced microscopy and labeling techniques reveal that bacteria localize mRNAs within their cells in a similar way to eukaryotes. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.16598
更新日期:2016-05-20 00:00:00
abstract::Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insight into the role of H3-G34R, we generated fission yeast that express o...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27406
更新日期:2017-07-18 00:00:00
abstract::The Reproducibility Project: Cancer Biology seeks to address growing concerns about reproducibility in scientific research by conducting replications of selected experiments from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012, were selected on the...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12470
更新日期:2016-03-01 00:00:00
abstract::The Deleted in Colorectal Carcinoma (Dcc) receptor plays a critical role in optic nerve development. Whilst Dcc is expressed postnatally in the eye, its function remains unknown as Dcc knockouts die at birth. To circumvent this drawback, we generated an eye-specific Dcc mutant. To study the organization of the retina ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.51275
更新日期:2020-02-25 00:00:00