Abstract：
:Anthocyanins are responsible pigments for giving attractive colors of plant organs and nutraceutical benefits of grains. Anthocyanin biosynthesis is known to be regulated by transcription factors and other regulatory proteins. In rice (Oryza sativa), the R2R3 MYB transcription factor (TF) OsC1 and a bHLH TF, OsB2, were previously reported to control anthocyanin biosynthesis in vegetative tissues and seeds, respectively; however, the regulatory mechanisms of the anthocyanin biosynthesis by TFs remain largely unknown. In this study, we identified OsBBX14, a homolog of Arabidopsis thaliana B-box domain protein 22 (AtBBX22), and investigated its function. The transcript level of OsBBX14 was high in pigmented rice seeds and gradually increased as the seeds matured. The ectopic expression of OsBBX14 in Arabidopsis resulted in a dramatic increase in anthocyanin accumulation in its seedlings. Using a steroid receptor-based inducible activation system, OsBBX14 and OsHY5 were found to directly activate OsC1 or OsB2 in an independent or collaborative manner. Yeast two hybrid revealed that the second B-box domain of OsBBX14 physically interacts with the bZIP domain of OsHY5. These results suggest that the anthocyanin biosynthesis in rice is induced and finely tuned by OsBBX14 in collaboration with OsHY5.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kim DH,Park S,Lee JY,Ha SH,Lee JG,Lim SHdoi
10.3390/ijms19082190subject
Has Abstractpub_date
2018-07-27 00:00:00issue
8issn
1422-0067pii
ijms19082190journal_volume
19pub_type
杂志文章abstract：:Claudin-1 (CLDN1), a tight junctional protein, is highly expressed in lung cancer cells and may contribute to chemoresistance. A drug which decreases CLDN1 expression could be a chemosensitizer for enhancing the efficacy of anticancer drugs, but there is no such drug known. We found that PMTPV, a short peptide, which ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165909
更新日期：2020-08-17 00:00:00
abstract：:Aflatoxin B(1) (AFB(1)) is commonly found in cereals and animal feeds and causes a significant threat to the food industry and animal production. Several microbial isolates with high AFB(1) transformation ability have been identified in our previous studies. The aim of this research was to characterize one of those is...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11104063
更新日期：2010-10-20 00:00:00
abstract：:Tumors often show intra-tumor heterogeneity because of genotypic differences between all the cells that compose it and that derive from it. Recent studies have shown significant aspects of neuroblastoma heterogeneity that may affect the diagnostic-therapeutic strategy. Therefore, we developed a laboratory protocol, ba...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040893
更新日期：2019-02-19 00:00:00
abstract：:The current study examined the efficacy of royal jelly (RJ) against cadmium chloride (CdCl₂)-induced testicular dysfunction. A total of 28 Swiss male mice were allocated into four groups (n = 7), and are listed as follows: (1) the control group, who was intraperitoneally injected with physiological saline (0.9% NaCl) ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123979
更新日期：2018-12-10 00:00:00
abstract：BACKGROUND:P1G10 is a cysteine proteolytic fraction from Vasconcellea cundinamarcensis latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was sugg...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184373
更新日期：2019-09-06 00:00:00
abstract：:The solute carrier (SLC) family-38 of transporters has eleven members known to transport amino acids, with glutamine being a common substrate for ten of them, with SLC38A9 being the exception. In this study, we examine the subcellular localization of SNAT10 in several independent immortalized cell lines and stem cell-...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246265
更新日期：2019-12-12 00:00:00
abstract：:A new approach for encoding DNA sequences as input for DNA sequence analysis is proposed using the error correction coding theory of communication engineering. The encoder was designed as a convolutional code model whose generator matrix is designed based on the degeneracy of codons, with a codon treated in the model ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14048393
更新日期：2013-04-16 00:00:00
abstract：:Actomyosin-mediated contractility is required for the majority of force-driven cellular events such as cell division, adhesion, and migration. Under pathological conditions, the role of actomyosin contractility in malignant phenotypes of various solid tumors has been extensively discussed, but the pathophysiological r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103460
更新日期：2020-05-14 00:00:00
abstract：:Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and coating. However, the current coating technologies possess several drawbacks, including limited du...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197370
更新日期：2020-10-06 00:00:00
abstract：:Activated carbon honeycomb-monoliths with different textural properties were prepared by chemical activation of African palm shells with H(3)PO(4), ZnCl(2) and CaCl(2) aqueous solutions of various concentrations. The adsorbents obtained were characterized by N(2) adsorption at 77 K, and their carbon dioxide adsorption...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13078388
更新日期：2012-01-01 00:00:00
abstract：:SwissDrugDesign is an important initiative led by the Molecular Modeling Group of the SIB Swiss Institute of Bioinformatics. This project provides a collection of freely available online tools for computer-aided drug design. Some of these web-based methods, i.e., SwissSimilarity and SwissTargetPrediction, were especia...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20184612
更新日期：2019-09-18 00:00:00
abstract：:The medicinal herbal plant has been commonly used for prevention and intervention of disease and health promotions worldwide. Brazilein is a bioactive compound extracted from Caesalpinia sappan Linn. Several studies have showed that brazilein exhibited the immune suppressive effect and anti-oxidative function. However...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126048
更新日期：2015-11-18 00:00:00
abstract：:Ischemia-reperfusion injury (IRI) is a major cause of graft loss and dysfunction in clinical transplantation and organ resection. [...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms19124093
更新日期：2018-12-18 00:00:00
abstract：:Beclin 1 is a major regulator of autophagy, and it is a core component of the class III PI3K complexes. Beclin 1 is a highly conserved protein and its function is regulated in a number of ways, including post-translational modifications. Several studies indicate that receptor and non-receptor tyrosine kinases regulate...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239210
更新日期：2020-12-03 00:00:00
abstract：:TCDD-inducible poly-ADP-ribose polymerase (TIPARP) is an aryl hydrocarbon receptor (AHR) target gene that functions as part of a negative feedback loop to repress AHR activity. Tiparp-/- mice exhibit increased sensitivity to the toxicological effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), including lethal wast...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092312
更新日期：2019-05-10 00:00:00
abstract：:Ketamine, a multimodal anesthetic drug, has become increasingly popular in the treatment of pain following traumatic injury as well as treatment-resistant major depressive disorders. However, the psychological impact of this dissociative medication on the development of stress-related disorders such as post-traumatic ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21197173
更新日期：2020-09-28 00:00:00
abstract：:3,3'-Diindolylmethane (DIM) is a naturally derived chemopreventive compound. It comes from glucobrassicin, an indole glucosinolate enriched in cruciferous vegetables, and is formed in the acidic environment of the stomach after ingestion. Mouse double minute 2 homolog (MDM2) is an important, multi-functional oncogenic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134642
更新日期：2020-06-30 00:00:00
abstract：:The ageing of human populations has become a problem throughout the world. In this context, increasing the healthy lifespan of individuals has become an important target for medical research and governments. Cardiac disease remains the leading cause of morbidity and mortality in ageing populations and results in signi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239238
更新日期：2020-12-03 00:00:00
abstract：:Spinal cord injury (SCI) results in neuronal and glial death and the loss of axons at the injury site. Inflammation after SCI leads to the inhibition of tissue regeneration and reduced neuronal survival. In addition, the loss of axons after SCI results in functional loss below the site of injury accompanied by neurona...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms150813172
更新日期：2014-07-25 00:00:00
abstract：:Thyroid cancer incidence has increased worldwide; however, investigations of thyroid cancer-related factors as potential prognosis markers remain insufficient. Secreted proteins from the cancer secretome are regulators of several molecular mechanisms and are, thereby, ideal candidates for potential markers. We aimed t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249537
更新日期：2020-12-15 00:00:00
abstract：:The analgesic effect of venlafaxine (VLX), which is a selective serotonin and noradrenaline reuptake inhibitor (SNRI), has been observed on oxaliplatin-induced neuropathic pain in mice. Significant allodynia was shown after oxaliplatin treatment (6 mg/kg, i.p.); acetone and von Frey hair tests were used to assess cold...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071652
更新日期：2019-04-03 00:00:00
abstract：:The lignin-carbohydrate complex (LCC) was isolated from milled wood lignin of 2- and 24-month-old crude bamboo (Neosinocalamus affinis) culms using acetic acid (AcOH) and then characterized. The results have shown that the LCC preparation from 2-month-old bamboo (L₂) exhibited a slightly lower molecular weight than th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010001
更新日期：2017-12-21 00:00:00
abstract：:Human papillomavirus (HPV)(+) and HPV(-) head and neck cancer (HNC) cells' interactions with the host immune system are poorly understood. Recently, we identified molecular and functional differences in exosomes produced by HPV(+) vs. HPV(-) cells, suggesting that genetic cargos of exosomes might identify novel biomar...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228570
更新日期：2020-11-13 00:00:00
abstract：:Vascular inflammation plays a key role in the pathogenesis and progression of atherosclerosis, a main complication of diabetes. The present study investigated whether an aqueous extract of Portulaca oleracea (AP) prevents the TNF-α-induced vascular inflammatory process in the human umbilical vein endothelial cell (HUV...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13055628
更新日期：2012-01-01 00:00:00
abstract：:Estrogen nuclear receptors, represented by the canonical forms ERα66 and ERβ1, are the main mediators of the estrogen-dependent pathophysiology in mammals. However, numerous isoforms have been identified, stimulating unconventional estrogen response pathways leading to complex cellular and tissue responses. The estrog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21114116
更新日期：2020-06-09 00:00:00
abstract：:The TiO2-montmorillonite (TiO2-MMT) complex was prepared by blending TiO2 sol and MMT with certain ratio, and its properties as an enzyme immobilization support were investigated. The pristine MMT and TiO2-MMT calcined at 800 °C (TiO2-MMT800) were used for comparison to better understand the immobilization mechanism. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140612520
更新日期：2013-06-14 00:00:00
abstract：:Shellfish allergy affects 2% of the world's population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfis...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010032
更新日期：2020-12-22 00:00:00
abstract：:Fear extinction requires coordinated neural activity within the amygdala and medial prefrontal cortex (mPFC). Any behavior has a transcriptomic signature that is modified by environmental experiences, and specific genes are involved in functional plasticity and synaptic wiring during fear extinction. Here, we investig...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020810
更新日期：2021-01-15 00:00:00
abstract：:Synthesis and anticonvulsant potential of certain new 6-aryl-9-substituted-6,9-diazaspiro[4.5]decane-8,10-diones (6a-l) and 1-aryl-4-substituted-1,4-diazaspiro[5.5] undecane-3,5-diones (6m-x) are reported. The intermediates 1-[(aryl)(cyanomethyl)amino] cycloalkanecarboxamides (3a-f) were prepared via adopting Strecker...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150916911
更新日期：2014-09-23 00:00:00
abstract：:Tooth enamel is formed in an extracellular environment. Amelogenin, the major component in the protein matrix of tooth enamel during the developing stage, could assemble into high molecular weight structures, regulating enamel formation. However, the molecular structure of amelogenin protein assembly at the functional...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082946
更新日期：2020-04-22 00:00:00
