Abstract：
:The telomerase RNA in yeasts is large, usually >1000 nt, and contains functional elements that have been extensively studied experimentally in several disparate species. Nevertheless, they are very difficult to detect by homology-based methods and so far have escaped annotation in the majority of the genomes of Saccharomycotina. This is a consequence of sequences that evolve rapidly at nucleotide level, are subject to large variations in size, and are highly plastic with respect to their secondary structures. Here, we report on a survey that was aimed at closing this gap in RNA annotation. Despite considerable efforts and the combination of a variety of different methods, it was only partially successful. While 27 new telomerase RNAs were identified, we had to restrict our efforts to the subgroup Saccharomycetacea because even this narrow subgroup was diverse enough to require different search models for different phylogenetic subgroups. More distant branches of the Saccharomycotina remain without annotated telomerase RNA.
journal_name
Genes (Basel)journal_title
Genesauthors
Waldl M,Thiel BC,Ochsenreiter R,Holzenleiter A,de Araujo Oliveira JV,Walter MEMT,Wolfinger MT,Stadler PFdoi
10.3390/genes9080372subject
Has Abstractpub_date
2018-07-26 00:00:00issue
8issn
2073-4425pii
genes9080372journal_volume
9pub_type
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