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Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction.

Abstract：

:Gamma-glutamyl transferase (GGT) is involved in the pathogenesis of atherosclerosis and has been associated with adverse cardiovascular outcomes in patients with ischemic heart disease. However, the association between GGT and long-term mortality has not been studied in patients with acute myocardial infarction (AMI).A total of 2239 AMI patients for whom serum GGT values were available and who underwent percutaneous coronary intervention (PCI) were enrolled in the COREA-AMI (CardiOvascular Risk and idEntificAtion of potential high-risk population in Korean patients with AMI) registry. Patients with acute liver injury were excluded. Patients were classified into 2 groups according to normal (n = 1983) or elevated (n = 256) levels of serum GGT. The primary clinical outcome was all-cause mortality. The secondary outcome was cardiac death and recurrent non-fatal myocardial infarction (MI).The median follow-up period was 3.7 years, and both groups had similar characteristics. Patients with elevated GGT had significantly higher all-cause mortality compared to patients with normal GGT (21.9% vs. 14.4%, P = .001). The multivariate Cox proportional hazards model showed that elevated serum GGT level was independently correlated with mortality (hazard ratio 2.12[1.44-3.11]; P < .001). Although elevated serum GGT was independently associated with long-term mortality after 30 days after PCI, there was no association within 30 days after PCI. Elevated GGT was also associated with death of cardiac causes with statistical significance. In the subgroup analysis, stronger associations were observed in the young and female patients and in patients who had ST-segment elevation MI and preserved left ventricular ejection fraction at the first echocardiography after the indexed PCI.Elevated serum GGT is an independent predictor of long-term mortality in AMI patients.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Kim JG,Chang K,Choo EH,Lee JM,Seung KB

doi

10.1097/MD.0000000000011393

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

e11393

issue

eissn

0025-7974

issn

1536-5964

pii

00005792-201807200-00017

journal_volume

pub_type

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Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction.